[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100379473":3},{"organization":4,"armGroups":7,"interventions":37,"overallOfficials":127,"centralContacts":132,"locations":141,"responsibleParty":1918,"collaborators":73,"id":1920,"slug":1921,"hasResults":1922,"nctId":1923,"briefTitle":1924,"officialTitle":1924,"acronym":1925,"eligibilityCriteria":1926,"healthyVolunteers":1922,"sex":1927,"minAge":73,"maxAge":1928,"enrollmentInfo":1929,"targetDuration":73,"studyType":1932,"phases":1933,"briefSummary":1935,"conditions":1936,"keywords":73,"overallStatus":144,"whyStopped":73,"lastUpdateSubmitDate":1939,"lastUpdatePostDateStruct":1940,"startDateStruct":1943,"completionDateStruct":1945,"leadSponsor":1947,"locationsCount":1948},{"fullName":5,"class":6},"Gustave Roussy, Cancer Campus, Grand Paris","OTHER",[8,25,32],{"label":9,"type":10,"description":11,"interventionNames":12},"phase induction-R-I","EXPERIMENTAL","R-I: induction regimens RAPID COJEC vs GPOH Assuming a baseline 3-year EFS of 40%, with a sample size of 686 patients (343 in each arm) and a two-sided alpha=5% this trial will have 90% power to demonstrate an improvement of 12% in 3-year EFS, within a recruitment period of 3 years and a minimum follow up of 1.5 years.\n\nPatients with insufficient metastatic response at the end of induction chemotherapy, defined as SIOPEN score \\> 3 or less than 50% reduction in mIBG score (or \\> 3 bone lesions or less 50% reduction in number of FDG-PET-avid bone lesions for mIBG-non avid tumours), have a poorer prognosis.\n\nChemoimmunotherapy arm Metastatic response rate after 4 courses of irinotecan-temozolomide (TEMIRI) combined with dinutuximab beta (DB) in patients with insufficient metastatic response at the end of induction chemotherapy (TEMIRI\u002FDB).",[13,14,15,16,17,18,19,20,21,22,23,24],"Drug: Vincristine","Drug: Carboplatin","Drug: Etoposide","Drug: Vindesine","Drug: Dacarbazine","Drug: Ifosfamide","Drug: Doxorubicin","Drug: Dinutuximab Beta","Drug: Cisplatin","Drug: Temozolomide 100 MG","Drug: Irinotecan","Drug: Cyclophosphamid",{"label":26,"type":10,"description":27,"interventionNames":28},"Phase high dose chemotherapy consolidation","R-HDC: consolidation regimen Bu-Mel vs Thiotepa + Bu-Mel The 3-year EFS in the Bu-Mel arm (with immunotherapy) is estimated to be 55%. This study aims to show an improvement of 12% for the Thiotepa + Bu-Mel arm (3-year EFS of 67%). With a recruitment of 448 patients (224 in each arm) over a period of 3 years and a minimum follow-up of 2 years, the power to show a 12% difference is 80% (two-sided logrank test and α=5%).",[29,30,31],"Drug: Busulfan","Drug: Melphalan","Drug: Thiotepa",{"label":33,"type":10,"description":34,"interventionNames":35},"Phase of radiotherapy","R-RTx: 21.6 Gy radiotherapy vs 21.6 Gy + 14.4 Gy boost in patients with macroscopic residual disease",[36,20],"Radiation: Radiotherapy",[38,45,51,57,63,69,74,80,86,92,98,103,109,115,119,123],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"DRUG","Vincristine","1.5 mg\u002Fm2 (max dose 2 mg)",[9],[44],"L01CA02",{"type":39,"name":46,"description":47,"armGroupLabels":48,"otherNames":49},"Carboplatin","750 mg\u002Fm2",[9],[50],"LO1XA02",{"type":39,"name":52,"description":53,"armGroupLabels":54,"otherNames":55},"Etoposide","175 mg\u002Fm2",[9],[56],"L01CB01",{"type":39,"name":58,"description":59,"armGroupLabels":60,"otherNames":61},"Vindesine","3 mg\u002Fm2\u002Fday (max dose 6 mg)",[9],[62],"L01CA03",{"type":39,"name":64,"description":65,"armGroupLabels":66,"otherNames":67},"Dacarbazine","200 mg\u002Fm2\u002Fday",[9],[68],"L01AX04",{"type":39,"name":70,"description":71,"armGroupLabels":72,"otherNames":73},"Ifosfamide","1500 mg\u002Fm2\u002Fday",[9],null,{"type":39,"name":75,"description":76,"armGroupLabels":77,"otherNames":78},"Doxorubicin","30 mg\u002Fm2\u002Fdose",[9],[79],"L01DB01",{"type":39,"name":81,"description":82,"armGroupLabels":83,"otherNames":84},"Busulfan","\\\u003C 9kg: 1.0 mg\u002Fkg\u002Fdose 9 kg to \\\u003C 16 kg : 1.2 mg\u002Fkg\u002Fdose 16 kg to 23 kg : 1.1 mg\u002Fkg\u002Fdose \\>23 kg to 34 kg: 0.95 mg\u002Fkg\u002Fdose \\>34 kg: 0.8 mg\u002Fkg\u002Fdose Infusion IV over 2 hours Administration every 6 hours for a total of 16 doses",[26],[85],"L01AB01",{"type":39,"name":87,"description":88,"armGroupLabels":89,"otherNames":90},"Melphalan","140 mg\u002Fm2\u002Fdose IV short infusion (15'), at least 24 h after the last busulfan dose",[26],[91],"L01AA03",{"type":39,"name":93,"description":94,"armGroupLabels":95,"otherNames":96},"Thiotepa","300 mg\u002Fm2\u002Fday over 2 hours",[26],[97],"L01AC01",{"type":99,"name":100,"description":101,"armGroupLabels":102,"otherNames":73},"RADIATION","Radiotherapy","21.6 Gy 21.6 Gy + boost de 14.4 Gy",[33],{"type":39,"name":104,"description":105,"armGroupLabels":106,"otherNames":107},"Dinutuximab Beta","Patients \\>12 kg are dosed based on the BSA: 10 mg\u002Fm\\^2\u002Fday Patients ≤ 12 kg are dosed according to their body weight: 0.33 mg\u002Fkg\u002Fday",[33,9],[108],"L01XC16",{"type":39,"name":110,"description":111,"armGroupLabels":112,"otherNames":113},"Cisplatin","80 mg\u002Fm2\u002F24h",[9],[114],"L01XA01",{"type":39,"name":116,"description":117,"armGroupLabels":118,"otherNames":73},"Temozolomide 100 MG","100 mg\u002Fm²\u002FDay",[9],{"type":39,"name":120,"description":121,"armGroupLabels":122,"otherNames":73},"Irinotecan","50 mg\u002Fm²\u002Fjour de J0 à J4",[9],{"type":39,"name":124,"description":125,"armGroupLabels":126,"otherNames":73},"Cyclophosphamid","Cyclophosphamide has been demonstrated to have a cytostatic effect in many tumour types. The active metabolites of cyclophosphamide are alkylating agents which transfer alkyl groups to DNA during the process of cell division, thus preventing normal synthesis of DNA.",[9],[128],{"name":129,"affiliation":130,"role":131},"Claudia Pasqualini, MD PhD","Gustave roussy, Paris, France","STUDY_CHAIR",[133,137],{"name":129,"role":134,"phone":135,"phoneExt":73,"email":136},"CONTACT","+33 (0)1 42 11 42 11","claudia.pasqualini@gustaveroussy.fr",{"name":138,"role":134,"phone":139,"phoneExt":73,"email":140},"Habiba Attalah, PhD","+33 (0)1 42 11 64 46","habiba.attalah@gustaveroussy.fr",[142,161,174,184,198,204,212,221,235,247,259,271,290,306,317,331,345,359,374,389,404,418,432,448,461,474,487,500,516,529,541,553,566,575,588,596,604,613,625,633,642,654,666,678,690,702,714,726,731,739,748,760,769,781,793,801,810,822,834,842,854,859,871,876,888,904,918,934,944,955,965,979,993,1004,1018,1034,1048,1062,1076,1090,1099,1113,1127,1141,1155,1169,1183,1199,1210,1221,1239,1253,1266,1278,1290,1306,1319,1333,1349,1365,1379,1393,1407,1421,1432,1446,1460,1474,1488,1501,1515,1526,1538,1550,1562,1574,1590,1604,1618,1632,1646,1660,1674,1688,1702,1716,1728,1742,1747,1760,1772,1784,1796,1809,1821,1833,1845,1853,1866,1878,1892,1904],{"facility":143,"status":144,"city":145,"state":146,"zip":147,"country":148,"countryCode":149,"cosmosGeoPoint":150,"geoPoint":155,"contacts":156},"Sydney children Hospital","RECRUITING","Sydney","Randwick","NSW, 2031","Australia","AU",{"type":151,"coordinates":152},"Point",[153,154],151.20732,-33.86785,{"lat":154,"lon":153},[157],{"name":158,"role":134,"phone":159,"phoneExt":73,"email":160},"Toby Nicholas Trahair, Phd, MD","61 2 9382 2970","Toby.Trahair@health.nsw.gov.au",{"facility":162,"status":144,"city":163,"state":73,"zip":164,"country":148,"countryCode":149,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"Children's Cancer Centre, Monash Children's Hospital","Clayton","VIC 3168",{"type":151,"coordinates":166},[167,168],145.11667,-37.91667,{"lat":168,"lon":167},[171],{"name":172,"role":134,"phone":73,"phoneExt":73,"email":173},"Peter Downie, MD","Peter.Downie@monashhealth.org",{"facility":175,"status":176,"city":177,"state":73,"zip":178,"country":148,"countryCode":149,"cosmosGeoPoint":179,"geoPoint":183,"contacts":73},"Oncology\u002FHaematology Department, Perth Children's Hospital","SUSPENDED","Nedlands","WA, 6009",{"type":151,"coordinates":180},[181,182],115.8073,-31.98184,{"lat":182,"lon":181},{"facility":185,"status":144,"city":186,"state":73,"zip":187,"country":148,"countryCode":149,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"Children's Cancer & Haematology Services, John Hunter Children's Hospital","New Lambton Heights","NSW, 2305",{"type":151,"coordinates":189},[190,191],151.69364,-32.92466,{"lat":191,"lon":190},[194],{"name":195,"role":134,"phone":196,"phoneExt":73,"email":197},"Janis chamberlin, MD","61 2 4921 3080","Janis.Chamberlain@health.nsw.gov.au",{"facility":199,"status":200,"city":145,"state":73,"zip":147,"country":148,"countryCode":149,"cosmosGeoPoint":201,"geoPoint":203,"contacts":73},"Australian and New Zealand Children's Hematology\u002Foncology Group","ACTIVE_NOT_RECRUITING",{"type":151,"coordinates":202},[153,154],{"lat":154,"lon":153},{"facility":205,"status":144,"city":145,"state":73,"zip":147,"country":148,"countryCode":149,"cosmosGeoPoint":206,"geoPoint":208,"contacts":209},"sydney children Hospital",{"type":151,"coordinates":207},[153,154],{"lat":154,"lon":153},[210],{"name":211,"role":134,"phone":159,"phoneExt":73,"email":160},"toby trahair, MD",{"facility":213,"status":176,"city":214,"state":73,"zip":215,"country":148,"countryCode":149,"cosmosGeoPoint":216,"geoPoint":220,"contacts":73},"Cancer Centre for Children, The Children's Hospital","Westmead","NSW, 2145,",{"type":151,"coordinates":217},[218,219],150.98768,-33.80383,{"lat":219,"lon":218},{"facility":222,"status":144,"city":223,"state":73,"zip":73,"country":224,"countryCode":225,"cosmosGeoPoint":226,"geoPoint":230,"contacts":231},"Medical University Graz","Graz","Austria","AT",{"type":151,"coordinates":227},[228,229],15.44197,47.06733,{"lat":229,"lon":228},[232],{"name":233,"role":134,"phone":73,"phoneExt":73,"email":234},"Benesch Martin, MD","martin.benesch@klinikum-graz.at",{"facility":236,"status":144,"city":237,"state":73,"zip":73,"country":224,"countryCode":225,"cosmosGeoPoint":238,"geoPoint":242,"contacts":243},"Landeskrankenhaus-Universitätsklinikum Innsbruck","Innsbruck",{"type":151,"coordinates":239},[240,241],11.39454,47.26266,{"lat":241,"lon":240},[244],{"name":245,"role":134,"phone":73,"phoneExt":73,"email":246},"Roman Crazzolara, DR","roman.crazzolara@i-med.ac.at",{"facility":248,"status":144,"city":249,"state":73,"zip":73,"country":224,"countryCode":225,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"Kepler Universitatsklinikum Linz","Linz",{"type":151,"coordinates":251},[252,253],14.28611,48.30639,{"lat":253,"lon":252},[256],{"name":257,"role":134,"phone":73,"phoneExt":73,"email":258},"Barbara Winkler, DR","barbara.aistleitner@keplerklinikum.at",{"facility":260,"status":144,"city":261,"state":73,"zip":73,"country":224,"countryCode":225,"cosmosGeoPoint":262,"geoPoint":266,"contacts":267},"Universitastsklinikum Salzburg","Salzburg",{"type":151,"coordinates":263},[264,265],13.04399,47.79941,{"lat":265,"lon":264},[268],{"name":269,"role":134,"phone":73,"phoneExt":73,"email":270},"Neil Jones","n.jones@salk.at",{"facility":272,"status":144,"city":273,"state":73,"zip":274,"country":224,"countryCode":225,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"St Anna'S Children Hospital","Vienna","A-1090",{"type":151,"coordinates":276},[277,278],16.37208,48.20849,{"lat":278,"lon":277},[281,284,287],{"name":282,"role":134,"phone":73,"phoneExt":73,"email":283},"Ruth Ladenstein, Pr","ruth.ladenstein@ccri.at",{"name":285,"role":134,"phone":73,"phoneExt":73,"email":286},"Carina Rajner","carina.rajner@ccri.at",{"name":288,"role":289,"phone":73,"phoneExt":73,"email":73},"Heidrun Boztug, Dr","PRINCIPAL_INVESTIGATOR",{"facility":291,"status":144,"city":292,"state":73,"zip":293,"country":294,"countryCode":295,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"Hôpital Universitaire des Enfants Reine Fabiola (ULB)","Brussels","1020","Belgium","BE",{"type":151,"coordinates":297},[298,299],4.34878,50.85045,{"lat":299,"lon":298},[302],{"name":303,"role":134,"phone":304,"phoneExt":73,"email":305},"Safiato Diallo, MD","0032 2 477 26 78","safiatou.diallo@huderf.be",{"facility":307,"status":144,"city":292,"state":73,"zip":308,"country":294,"countryCode":295,"cosmosGeoPoint":309,"geoPoint":311,"contacts":312},"Cliniques Universitaires Saint-Luc (UCL)","1200",{"type":151,"coordinates":310},[298,299],{"lat":299,"lon":298},[313],{"name":314,"role":134,"phone":315,"phoneExt":73,"email":316},"Benedicte Brichard, MD","0032 2 764 23 50","benedicte.brichard@saintluc.uclouvain.be",{"facility":318,"status":144,"city":319,"state":73,"zip":320,"country":294,"countryCode":295,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"University Hospital Gent","Ghent","9000",{"type":151,"coordinates":322},[323,324],3.71667,51.05,{"lat":324,"lon":323},[327],{"name":328,"role":134,"phone":329,"phoneExt":73,"email":330},"Bram De Wilde, MD","0032 9 332 48 12","bram.dewilde@uzgent.be",{"facility":332,"status":144,"city":333,"state":73,"zip":334,"country":294,"countryCode":295,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"University Hospitals Leuven","Leuven","3000",{"type":151,"coordinates":336},[337,338],4.70093,50.87959,{"lat":338,"lon":337},[341],{"name":342,"role":134,"phone":343,"phoneExt":73,"email":344},"Marleen Renard, MD","0032 16 34 39 72","marleen.renard@uzleuven.be",{"facility":346,"status":144,"city":347,"state":73,"zip":348,"country":294,"countryCode":295,"cosmosGeoPoint":349,"geoPoint":353,"contacts":354},"CHR Citadelle","Liège","4000",{"type":151,"coordinates":350},[351,352],5.56749,50.63373,{"lat":352,"lon":351},[355],{"name":356,"role":134,"phone":357,"phoneExt":73,"email":358},"Sophie Gatineau, MD","0032 4 321 55 18","sophie.gatineau@chrcitadelle.be",{"facility":360,"status":144,"city":361,"state":361,"zip":362,"country":363,"countryCode":73,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"University Hospital Motol","Prague","15006","Czechia",{"type":151,"coordinates":365},[366,367],14.42076,50.08804,{"lat":367,"lon":366},[370],{"name":371,"role":134,"phone":372,"phoneExt":73,"email":373},"Josef Malis, MD","+420 224 436 401","josef.malis@fnmotol.cz",{"facility":375,"status":376,"city":377,"state":73,"zip":378,"country":363,"countryCode":73,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"Klinika dětské onkologie FN Brno","NOT_YET_RECRUITING","Brno","662 63",{"type":151,"coordinates":380},[381,382],16.60796,49.19522,{"lat":382,"lon":381},[385],{"name":386,"role":134,"phone":387,"phoneExt":73,"email":388},"Pavel Pavel, MD","+420 532 234 449","Mazanek.Pavel@fnbrno.cz",{"facility":390,"status":144,"city":391,"state":73,"zip":392,"country":393,"countryCode":394,"cosmosGeoPoint":395,"geoPoint":399,"contacts":400},"Aarhus University Hospital","Aarhus","DK-8200","Denmark","DK",{"type":151,"coordinates":396},[397,398],10.21076,56.15674,{"lat":398,"lon":397},[401],{"name":402,"role":134,"phone":73,"phoneExt":73,"email":403},"karin Bækgaard Nissen","karins@rm.dk",{"facility":405,"status":144,"city":406,"state":73,"zip":407,"country":393,"countryCode":394,"cosmosGeoPoint":408,"geoPoint":412,"contacts":413},"Department of Paediatrics and Adolescent Medicine, Rigshospitalet","Copenhagen","DK-2100",{"type":151,"coordinates":409},[410,411],12.56553,55.67594,{"lat":411,"lon":410},[414],{"name":415,"role":134,"phone":416,"phoneExt":73,"email":417},"jesper Sune Brok,, PhD","0045 35458270","jesper.sune.brok@regionh.dk",{"facility":419,"status":144,"city":420,"state":73,"zip":421,"country":393,"countryCode":394,"cosmosGeoPoint":422,"geoPoint":426,"contacts":427},"The Hans Christian Andersen Children's Hospital, University of Southern Denmark","Odense","DK-5000",{"type":151,"coordinates":423},[424,425],10.38831,55.39594,{"lat":425,"lon":424},[428],{"name":429,"role":134,"phone":430,"phoneExt":73,"email":431},"Mathias Rathe, PhD","0045 30296665","mathias.rathe@rsyd.dk",{"facility":433,"status":376,"city":434,"state":73,"zip":435,"country":436,"countryCode":437,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"New Children's Hospital, Helsinki University Hospital, Helsinki and Uusimaa Hospital District","Helsinki","00029","Finland","FI",{"type":151,"coordinates":439},[440,441],24.93545,60.16952,{"lat":441,"lon":440},[444],{"name":445,"role":134,"phone":446,"phoneExt":73,"email":447},"Minna Koskenvuo, MD","+358 50 427 0424","minna.koskenvuo@hus.fi",{"facility":449,"status":376,"city":450,"state":73,"zip":73,"country":436,"countryCode":437,"cosmosGeoPoint":451,"geoPoint":455,"contacts":456},"Kuopio University Hospital","Kuopio",{"type":151,"coordinates":452},[453,454],27.67703,62.89238,{"lat":454,"lon":453},[457],{"name":458,"role":134,"phone":459,"phoneExt":73,"email":460},"Kaisa Vepsäläinen, MD","+358 44 717 4964","kaisa.vepsalainen@kuh.fi",{"facility":462,"status":376,"city":463,"state":73,"zip":73,"country":436,"countryCode":437,"cosmosGeoPoint":464,"geoPoint":468,"contacts":469},"Oulu University Hospital","Oulu",{"type":151,"coordinates":465},[466,467],25.46816,65.01236,{"lat":467,"lon":466},[470],{"name":471,"role":134,"phone":472,"phoneExt":73,"email":473},"Hanna Juntti, MD","+358 50 579 4440","hanna.juntti@pohde.fi",{"facility":475,"status":376,"city":476,"state":73,"zip":73,"country":436,"countryCode":437,"cosmosGeoPoint":477,"geoPoint":481,"contacts":482},"Tampere University Hospital","Tampere",{"type":151,"coordinates":478},[479,480],23.78712,61.49911,{"lat":480,"lon":479},[483],{"name":484,"role":134,"phone":485,"phoneExt":73,"email":486},"Sauli Palmu, MD","+358 50 353 9956","sauli.palmu@tuni.fi",{"facility":488,"status":376,"city":489,"state":73,"zip":73,"country":436,"countryCode":437,"cosmosGeoPoint":490,"geoPoint":494,"contacts":495},"Turku University Hospital","Turku",{"type":151,"coordinates":491},[492,493],22.26869,60.45148,{"lat":493,"lon":492},[496],{"name":497,"role":134,"phone":498,"phoneExt":73,"email":499},"Marika Grönroos, MD","+358 2 3130646","marika.gronroos@varha.fi",{"facility":501,"status":144,"city":502,"state":503,"zip":504,"country":505,"countryCode":506,"cosmosGeoPoint":507,"geoPoint":511,"contacts":512},"Gustave Roussy","Villejuif","Val De Marne","94800","France","FR",{"type":151,"coordinates":508},[509,510],2.35992,48.7939,{"lat":510,"lon":509},[513,514],{"name":129,"role":134,"phone":135,"phoneExt":73,"email":136},{"name":515,"role":134,"phone":139,"phoneExt":73,"email":140},"Attalah Habiba, PhD",{"facility":517,"status":144,"city":518,"state":73,"zip":519,"country":505,"countryCode":506,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"CHU d'AMIENS","Amiens","80054",{"type":151,"coordinates":521},[522,523],2.3,49.9,{"lat":523,"lon":522},[526],{"name":527,"role":134,"phone":73,"phoneExt":73,"email":528},"Leslie Andry, MD","andry.leslie@chu-amiens.fr",{"facility":530,"status":144,"city":531,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":532,"geoPoint":536,"contacts":537},"CHU angers","Angers",{"type":151,"coordinates":533},[534,535],-0.55202,47.47156,{"lat":535,"lon":534},[538],{"name":539,"role":134,"phone":73,"phoneExt":73,"email":540},"Stéphanie Proust, MD","stproust@chu-angers.fr",{"facility":542,"status":144,"city":543,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":544,"geoPoint":548,"contacts":549},"CHU-Pôle Médico-Chirurgical de l'Enfant et l'Adolescant","Besançon",{"type":151,"coordinates":545},[546,547],6.01815,47.24878,{"lat":547,"lon":546},[550],{"name":551,"role":134,"phone":73,"phoneExt":73,"email":552},"Veronique LAITHIER, MD","vlaithier@chu-besancon.fr",{"facility":554,"status":144,"city":555,"state":73,"zip":556,"country":505,"countryCode":506,"cosmosGeoPoint":557,"geoPoint":561,"contacts":562},"CHU Bordeaux","Bordeaux","33600",{"type":151,"coordinates":558},[559,560],-0.58046,44.84124,{"lat":560,"lon":559},[563],{"name":564,"role":134,"phone":73,"phoneExt":73,"email":565},"Ayemeri Huchet, MD","ayemeri.huchet@chu-bordeaux.fr",{"facility":567,"status":144,"city":555,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":568,"geoPoint":570,"contacts":571},"Groupe Hospitalier Pellegrin - Chu - Bordeaux",{"type":151,"coordinates":569},[559,560],{"lat":560,"lon":559},[572],{"name":573,"role":134,"phone":73,"phoneExt":73,"email":574},"Julie Tandonnet, MD","julie.tandonnet@chu-bordeaux.fr",{"facility":576,"status":144,"city":577,"state":73,"zip":578,"country":505,"countryCode":506,"cosmosGeoPoint":579,"geoPoint":583,"contacts":584},"CHU Brest","Brest","29609",{"type":151,"coordinates":580},[581,582],-4.48628,48.39029,{"lat":582,"lon":581},[585],{"name":586,"role":134,"phone":73,"phoneExt":73,"email":587},"Liana Carausu, MD","liana.carausu@chu-brest.fr",{"facility":589,"status":144,"city":577,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":590,"geoPoint":592,"contacts":593},"CHU Brest - Hôpital du Morvan",{"type":151,"coordinates":591},[581,582],{"lat":582,"lon":581},[594],{"name":595,"role":134,"phone":73,"phoneExt":73,"email":587},"Liana CARAUSU, MD",{"facility":597,"status":200,"city":598,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":599,"geoPoint":603,"contacts":73},"Centre François Baclesse","Caen",{"type":151,"coordinates":600},[601,602],-0.35912,49.18585,{"lat":602,"lon":601},{"facility":605,"status":144,"city":598,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":606,"geoPoint":608,"contacts":609},"CHU de Caen",{"type":151,"coordinates":607},[601,602],{"lat":602,"lon":601},[610],{"name":611,"role":134,"phone":73,"phoneExt":73,"email":612},"Damien Bodet, MD","bodet-d@chu-caen.fr",{"facility":614,"status":144,"city":615,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":616,"geoPoint":620,"contacts":621},"CHU Estaing","Clermont-Ferrand",{"type":151,"coordinates":617},[618,619],3.08682,45.77969,{"lat":619,"lon":618},[622],{"name":623,"role":134,"phone":73,"phoneExt":73,"email":624},"justyna KANOLD, MD","jkanold@chu-clermontferrand.fr",{"facility":626,"status":200,"city":627,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":628,"geoPoint":632,"contacts":73},"Centre Georges-François Leclerc","Dijon",{"type":151,"coordinates":629},[630,631],5.01391,47.31344,{"lat":631,"lon":630},{"facility":634,"status":144,"city":627,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":635,"geoPoint":637,"contacts":638},"Hopital d'enfants Marechal de lattre",{"type":151,"coordinates":636},[630,631],{"lat":631,"lon":630},[639],{"name":640,"role":134,"phone":73,"phoneExt":73,"email":641},"claire BRIANDET, MD","claire.briandet@chu-dijon.fr",{"facility":643,"status":144,"city":644,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":645,"geoPoint":649,"contacts":650},"Hôpital Couple-Enfant CHU de Grenoble","Grenoble",{"type":151,"coordinates":646},[647,648],5.71479,45.17869,{"lat":648,"lon":647},[651],{"name":652,"role":134,"phone":73,"phoneExt":73,"email":653},"Dominique Plantaz, MD","dplantaz@chu-grenoble.fr",{"facility":655,"status":144,"city":656,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":657,"geoPoint":661,"contacts":662},"Chu de La Reunion - St Denis","La Réunion",{"type":151,"coordinates":658},[659,660],0.11776,44.29707,{"lat":660,"lon":659},[663],{"name":664,"role":134,"phone":73,"phoneExt":73,"email":665},"Yves REGUERRE, MD","yves.reguerre@chu-reunion.fr",{"facility":667,"status":144,"city":668,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":669,"geoPoint":673,"contacts":674},"centre Oscar lambert","Lille",{"type":151,"coordinates":670},[671,672],3.05512,50.63391,{"lat":672,"lon":671},[675],{"name":676,"role":134,"phone":73,"phoneExt":73,"email":677},"Anne-Sophie DEFACHELLES","AS-Defachelles@o-lambret.fr",{"facility":679,"status":144,"city":680,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":681,"geoPoint":685,"contacts":686},"Hôpital de la Mère et de l'Enfant - CHU Limoges","Limoges",{"type":151,"coordinates":682},[683,684],1.24759,45.83362,{"lat":684,"lon":683},[687],{"name":688,"role":134,"phone":73,"phoneExt":73,"email":689},"christophe PIGUET, MD","christophe.piguet@chu-limoges.fr",{"facility":691,"status":144,"city":692,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":693,"geoPoint":697,"contacts":698},"Centre Léon Berard","Lyon",{"type":151,"coordinates":694},[695,696],4.84789,45.74906,{"lat":696,"lon":695},[699],{"name":700,"role":134,"phone":73,"phoneExt":73,"email":701},"Benoit Dumond, MD","Benoit.DUMONT@ihope.fr",{"facility":703,"status":144,"city":704,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":705,"geoPoint":709,"contacts":710},"hopital la Timone","Marseille",{"type":151,"coordinates":706},[707,708],5.38107,43.29695,{"lat":708,"lon":707},[711],{"name":712,"role":134,"phone":73,"phoneExt":73,"email":713},"carole coze, MD","carole.coze@ap-hm.fr",{"facility":715,"status":144,"city":716,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":717,"geoPoint":721,"contacts":722},"CHRU Nancy-Hôpital Brabois Enfant","Nancy",{"type":151,"coordinates":718},[719,720],6.18496,48.68439,{"lat":720,"lon":719},[723],{"name":724,"role":134,"phone":73,"phoneExt":73,"email":725},"Ludovic Mansuy, MD","lu.mansuy@chru-nancy.fr",{"facility":727,"status":200,"city":716,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":728,"geoPoint":730,"contacts":73},"Institut de cancérologie de Loraine",{"type":151,"coordinates":729},[719,720],{"lat":720,"lon":719},{"facility":732,"status":200,"city":733,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":734,"geoPoint":738,"contacts":73},"Centre Antoine Lacassagne","Nice",{"type":151,"coordinates":735},[736,737],7.26608,43.70313,{"lat":737,"lon":736},{"facility":740,"status":144,"city":733,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":741,"geoPoint":743,"contacts":744},"CHU Nice-Hôpital d'Archet",{"type":151,"coordinates":742},[736,737],{"lat":737,"lon":736},[745],{"name":746,"role":134,"phone":73,"phoneExt":73,"email":747},"Joy Benadiba","benadiba.j@chu-nice.fr",{"facility":749,"status":144,"city":750,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":751,"geoPoint":755,"contacts":756},"Hôpital Armand Trousseau","Paris",{"type":151,"coordinates":752},[753,754],2.3488,48.85341,{"lat":754,"lon":753},[757],{"name":758,"role":134,"phone":73,"phoneExt":73,"email":759},"Arnaud Petit, MD","arnaud.petit@aphp.fr",{"facility":761,"status":144,"city":750,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":762,"geoPoint":764,"contacts":765},"institut Curie",{"type":151,"coordinates":763},[753,754],{"lat":754,"lon":753},[766],{"name":767,"role":134,"phone":73,"phoneExt":73,"email":768},"Gudrun SCHLEIERMACHER, MD ;PhD","gudrun.schleiermacher@curie.fr",{"facility":770,"status":144,"city":771,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":772,"geoPoint":776,"contacts":777},"CHU Poitiers","Poitiers",{"type":151,"coordinates":773},[774,775],0.34348,46.58261,{"lat":775,"lon":774},[778],{"name":779,"role":134,"phone":73,"phoneExt":73,"email":780},"Frederic Millot, MD","Frederic.MILLOT@chu-poitiers.fr",{"facility":782,"status":144,"city":783,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":784,"geoPoint":788,"contacts":789},"Hôpital Américain -CHU Reims","Reims",{"type":151,"coordinates":785},[786,787],4.02853,49.26526,{"lat":787,"lon":786},[790],{"name":791,"role":134,"phone":73,"phoneExt":73,"email":792},"Claire PLUCHART, MD","cpluchart@chu-reims.fr",{"facility":794,"status":200,"city":795,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":796,"geoPoint":800,"contacts":73},"Centre Eugène Marquis","Rennes",{"type":151,"coordinates":797},[798,799],-1.67431,48.11109,{"lat":799,"lon":798},{"facility":802,"status":144,"city":795,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":803,"geoPoint":805,"contacts":806},"CHU Rennes",{"type":151,"coordinates":804},[798,799],{"lat":799,"lon":798},[807],{"name":808,"role":134,"phone":73,"phoneExt":73,"email":809},"sophie taque, MD","sophie.taque@chu-rennes.fr",{"facility":811,"status":144,"city":812,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":813,"geoPoint":817,"contacts":818},"Hôpital des Enfants - CHU Rouen","Rouen",{"type":151,"coordinates":814},[815,816],1.09932,49.44313,{"lat":816,"lon":815},[819],{"name":820,"role":134,"phone":73,"phoneExt":73,"email":821},"cecile DUMESNIL DE MAURICOURT, MD","Cecile.Dumesnil@chu-rouen.fr",{"facility":823,"status":144,"city":824,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":825,"geoPoint":829,"contacts":830},"CHU Saint Etienne","Saint-Etienne",{"type":151,"coordinates":826},[827,828],4.39,45.43389,{"lat":828,"lon":827},[831],{"name":832,"role":134,"phone":73,"phoneExt":73,"email":833},"sandrine THOUVENIN-DOULET, MD","sandrine.thouvenin@chu-st-etienne.fr",{"facility":835,"status":200,"city":836,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":837,"geoPoint":841,"contacts":73},"Institut de cancérologie de l'Ouest - Sité René Gauducheau","Saint-Herblain",{"type":151,"coordinates":838},[839,840],-1.651,47.21154,{"lat":840,"lon":839},{"facility":843,"status":144,"city":844,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":845,"geoPoint":849,"contacts":850},"CHU Haute Pierre","Strasbourg",{"type":151,"coordinates":846},[847,848],7.74553,48.58392,{"lat":848,"lon":847},[851],{"name":852,"role":134,"phone":73,"phoneExt":73,"email":853},"catherine PAILLARD, MD","catherine.paillard@chru-strasbourg.fr",{"facility":855,"status":200,"city":844,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":856,"geoPoint":858,"contacts":73},"Institut de Cancérologie Strasbourg",{"type":151,"coordinates":857},[847,848],{"lat":848,"lon":847},{"facility":860,"status":144,"city":861,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":862,"geoPoint":866,"contacts":867},"Hopital des enfants-CHU Toulouse","Toulouse",{"type":151,"coordinates":863},[864,865],1.44367,43.60426,{"lat":865,"lon":864},[868],{"name":869,"role":134,"phone":73,"phoneExt":73,"email":870},"Marion Gambart, MD","gambart.m@chu-toulouse.fr",{"facility":872,"status":200,"city":861,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":873,"geoPoint":875,"contacts":73},"IUCT Oncopole",{"type":151,"coordinates":874},[864,865],{"lat":865,"lon":864},{"facility":877,"status":144,"city":878,"state":73,"zip":73,"country":505,"countryCode":506,"cosmosGeoPoint":879,"geoPoint":883,"contacts":884},"CHU Tours Hôpital Clocheville","Tours",{"type":151,"coordinates":880},[881,882],0.70398,47.39484,{"lat":882,"lon":881},[885],{"name":886,"role":134,"phone":73,"phoneExt":73,"email":887},"Pascal Blouin, MD","p.blouin@chu-tours.fr",{"facility":889,"status":144,"city":890,"state":73,"zip":891,"country":892,"countryCode":893,"cosmosGeoPoint":894,"geoPoint":898,"contacts":899},"charite universitatsmedizin Berlin","Berlin","13353","Germany","DE",{"type":151,"coordinates":895},[896,897],13.41053,52.52437,{"lat":897,"lon":896},[900],{"name":901,"role":134,"phone":902,"phoneExt":73,"email":903},"Angelika eggert, Pr","49 30 450 566 132","angelika.eggert@charite.de",{"facility":905,"status":376,"city":906,"state":73,"zip":907,"country":892,"countryCode":893,"cosmosGeoPoint":908,"geoPoint":912,"contacts":913},"Uniklinik Köln, Klinik und Poliklinik für Kinder und Jugendmedizin","Cologne","50937",{"type":151,"coordinates":909},[910,911],6.95,50.93333,{"lat":911,"lon":910},[914],{"name":915,"role":134,"phone":916,"phoneExt":73,"email":917},"Thorsten Simon, MD","+49 221 478 6853","thorsten.simon@uk-koeln.de",{"facility":919,"status":144,"city":920,"state":73,"zip":921,"country":922,"countryCode":923,"cosmosGeoPoint":924,"geoPoint":928,"contacts":929},"Children's General Hospital \"I AGHIA SOFIA\"","Athens","11527","Greece","GR",{"type":151,"coordinates":925},[926,927],23.72784,37.98376,{"lat":927,"lon":926},[930],{"name":931,"role":134,"phone":932,"phoneExt":73,"email":933},"Vassilios papadakis, MD","0030 210-7452020, 2018","vpapadak@otenet.gr",{"facility":935,"status":144,"city":920,"state":73,"zip":921,"country":922,"countryCode":923,"cosmosGeoPoint":936,"geoPoint":938,"contacts":939},"Children's General Hospital \"P. & A. KYRIAKOU\"",{"type":151,"coordinates":937},[926,927],{"lat":927,"lon":926},[940],{"name":941,"role":134,"phone":942,"phoneExt":73,"email":943},"Margarita BAKA, MD","0030 2107452219","margbaka@hotmail.com",{"facility":945,"status":144,"city":920,"state":73,"zip":946,"country":922,"countryCode":923,"cosmosGeoPoint":947,"geoPoint":949,"contacts":950},"\"MITERA\" Private, General, Obstetrics - Gynaecology, Paediatric Clinic S.A.","15123",{"type":151,"coordinates":948},[926,927],{"lat":927,"lon":926},[951],{"name":952,"role":134,"phone":953,"phoneExt":73,"email":954},"DANA ELENI, MD","0030 210 6869631","danaeleni@hotmail.gr",{"facility":956,"status":144,"city":920,"state":73,"zip":73,"country":922,"countryCode":923,"cosmosGeoPoint":957,"geoPoint":959,"contacts":960},"Children's General Hospital \"AGHIA SOFIA\"",{"type":151,"coordinates":958},[926,927],{"lat":927,"lon":926},[961],{"name":962,"role":134,"phone":963,"phoneExt":73,"email":964},"ANTONIOS KATTAMIS, MD","0030 2107452121","ankatt@med.uoa.gr",{"facility":966,"status":144,"city":967,"state":73,"zip":968,"country":922,"countryCode":923,"cosmosGeoPoint":969,"geoPoint":973,"contacts":974},"University General Hospital of Heraklion (UnGHH)","Heraklion","71500",{"type":151,"coordinates":970},[971,972],25.14341,35.32787,{"lat":972,"lon":971},[975],{"name":976,"role":134,"phone":977,"phoneExt":73,"email":978},"NIKOLAOS KATZILAKIS, MD","0030 2810 392630","katzilaher@yahoo.gr",{"facility":980,"status":144,"city":981,"state":73,"zip":982,"country":922,"countryCode":923,"cosmosGeoPoint":983,"geoPoint":987,"contacts":988},"University General Hospital of Thessaloniki \"AHEPA\"","Thessaloniki","54621",{"type":151,"coordinates":984},[985,986],22.93493,40.64072,{"lat":986,"lon":985},[989],{"name":990,"role":134,"phone":991,"phoneExt":73,"email":992},"EMMANOUEL HATZIPANTELIS, MD","0030 2310994810","hatzip@auth.gr",{"facility":994,"status":144,"city":981,"state":73,"zip":995,"country":922,"countryCode":923,"cosmosGeoPoint":996,"geoPoint":998,"contacts":999},"General Hospital of Thessaloniki \"IPPOKRATIO\"","54642",{"type":151,"coordinates":997},[985,986],{"lat":986,"lon":985},[1000],{"name":1001,"role":134,"phone":1002,"phoneExt":73,"email":1003},"EVGENIA PAPAKONSTANTINOU, MD","0030 2313312430","eugepapa@yahoo.gr",{"facility":1005,"status":144,"city":1006,"state":73,"zip":73,"country":1007,"countryCode":1008,"cosmosGeoPoint":1009,"geoPoint":1013,"contacts":1014},"RAMBAM Medical Center","Haifa","Israel","IL",{"type":151,"coordinates":1010},[1011,1012],34.99928,32.81303,{"lat":1012,"lon":1011},[1015],{"name":1016,"role":134,"phone":73,"phoneExt":73,"email":1017},"shifra Ash, Pr","S_ash@rmc.gov.il",{"facility":1019,"status":144,"city":1020,"state":73,"zip":1021,"country":1022,"countryCode":1023,"cosmosGeoPoint":1024,"geoPoint":1028,"contacts":1029},"A.O.U Policlinico di Bari","Bari","70124","Italy","IT",{"type":151,"coordinates":1025},[1026,1027],16.86982,41.12066,{"lat":1027,"lon":1026},[1030],{"name":1031,"role":134,"phone":1032,"phoneExt":73,"email":1033},"Nicola santoro, MD","0805593363","nico.santoro1956@libero.it",{"facility":1035,"status":144,"city":1036,"state":73,"zip":1037,"country":1022,"countryCode":1023,"cosmosGeoPoint":1038,"geoPoint":1042,"contacts":1043},"Spedali civili Ospedale Dei Bambini Oncoematologia pediatrica e TMO","Brescia","3995041",{"type":151,"coordinates":1039},[1040,1041],10.21472,45.53558,{"lat":1041,"lon":1040},[1044],{"name":1045,"role":134,"phone":1046,"phoneExt":73,"email":1047},"Fulvio porta","0303995711","fulvio.porta@asst-spedalicivili.it",{"facility":1049,"status":144,"city":1050,"state":73,"zip":1051,"country":1022,"countryCode":1023,"cosmosGeoPoint":1052,"geoPoint":1056,"contacts":1057},"policlinico rodolico San marco","Catania","95123",{"type":151,"coordinates":1053},[1054,1055],15.07041,37.49223,{"lat":1055,"lon":1054},[1058],{"name":1059,"role":134,"phone":1060,"phoneExt":73,"email":1061},"Andrea di cataldo, MD","095\u002F3782683","adicata@unict.it",{"facility":1063,"status":144,"city":1064,"state":73,"zip":1065,"country":1022,"countryCode":1023,"cosmosGeoPoint":1066,"geoPoint":1070,"contacts":1071},"Azienda ospedaliero universtaria Anna Meyer","Florence","50139",{"type":151,"coordinates":1067},[1068,1069],11.24626,43.77925,{"lat":1069,"lon":1068},[1072],{"name":1073,"role":134,"phone":1074,"phoneExt":73,"email":1075},"annalisa Tondo, MD","055\u002F56622739","annalisa.tondo@meyer.it",{"facility":1077,"status":144,"city":1078,"state":73,"zip":1079,"country":1022,"countryCode":1023,"cosmosGeoPoint":1080,"geoPoint":1084,"contacts":1085},"instituto Giannina Gaslini genova","Genova","16147",{"type":151,"coordinates":1081},[1082,1083],11.87211,45.21604,{"lat":1083,"lon":1082},[1086],{"name":1087,"role":134,"phone":1088,"phoneExt":73,"email":1089},"alberto garaventa, MD","010\u002F563662410","albertogaraventa@gaslini.org",{"facility":1091,"status":144,"city":1078,"state":73,"zip":1079,"country":1022,"countryCode":1023,"cosmosGeoPoint":1092,"geoPoint":1094,"contacts":1095},"IRCCS \"Istituto Giannina Gaslini\"",{"type":151,"coordinates":1093},[1082,1083],{"lat":1083,"lon":1082},[1096],{"name":1097,"role":134,"phone":1098,"phoneExt":73,"email":1089},"Garaventa Alberto, MD","01056362410",{"facility":1100,"status":144,"city":1101,"state":73,"zip":1102,"country":1022,"countryCode":1023,"cosmosGeoPoint":1103,"geoPoint":1107,"contacts":1108},"Azienda Policlinico di Modena","Modena","41100",{"type":151,"coordinates":1104},[1105,1106],10.92539,44.64783,{"lat":1106,"lon":1105},[1109],{"name":1110,"role":134,"phone":1111,"phoneExt":73,"email":1112},"ssa Monica Cellini, MD","059\u002F4224485-2837","cellini.monica@policlinico.mo.it",{"facility":1114,"status":144,"city":1115,"state":73,"zip":1116,"country":1022,"countryCode":1023,"cosmosGeoPoint":1117,"geoPoint":1121,"contacts":1122},"Azienda ospedaliero universitaria di Parma","Parma","43126",{"type":151,"coordinates":1118},[1119,1120],10.32618,44.79935,{"lat":1120,"lon":1119},[1123],{"name":1124,"role":134,"phone":1125,"phoneExt":73,"email":1126},"patrizia Bertolini, MD","0521\u002F702831","pbertolini@ao.pr.it",{"facility":1128,"status":144,"city":1129,"state":73,"zip":1130,"country":1022,"countryCode":1023,"cosmosGeoPoint":1131,"geoPoint":1135,"contacts":1136},"Policlino San matteo di Pavia","Pavia","27100",{"type":151,"coordinates":1132},[1133,1134],9.15917,45.19205,{"lat":1134,"lon":1133},[1137],{"name":1138,"role":134,"phone":1139,"phoneExt":73,"email":1140},"frederico Bonetti, MD","0382\u002F502607","f.bonetti@smatteo.pv.it",{"facility":1142,"status":144,"city":1143,"state":73,"zip":1144,"country":1022,"countryCode":1023,"cosmosGeoPoint":1145,"geoPoint":1149,"contacts":1150},"U.O Pediatria, SS Oncoematologia pediatrica","Rimini","47900",{"type":151,"coordinates":1146},[1147,1148],12.56528,44.05755,{"lat":1148,"lon":1147},[1151],{"name":1152,"role":134,"phone":1153,"phoneExt":73,"email":1154},"Roberta Pericoli, MD","0541\u002F705034","roberta.pericoli@auslromagna.it",{"facility":1156,"status":144,"city":1157,"state":73,"zip":1158,"country":1022,"countryCode":1023,"cosmosGeoPoint":1159,"geoPoint":1163,"contacts":1164},"IRCCS Burlo Garoflo oncoematologia","Trieste","34137",{"type":151,"coordinates":1160},[1161,1162],13.77678,45.64953,{"lat":1162,"lon":1161},[1165],{"name":1166,"role":134,"phone":1167,"phoneExt":73,"email":1168},"marco Rabusin","0403785563","marco.rabusin@burlo.triete.it",{"facility":1170,"status":144,"city":1171,"state":73,"zip":1172,"country":1022,"countryCode":1023,"cosmosGeoPoint":1173,"geoPoint":1177,"contacts":1178},"U.O.C oncoematologia pediatrica ospedale Donna Bambino","Verona","37126",{"type":151,"coordinates":1174},[1175,1176],10.9938,45.43854,{"lat":1176,"lon":1175},[1179],{"name":1180,"role":134,"phone":1181,"phoneExt":73,"email":1182},"simone cesaro, MD","0458127874","simone.cesaro@ospedaleuniverona.it",{"facility":1184,"status":376,"city":1185,"state":73,"zip":1186,"country":1187,"countryCode":1188,"cosmosGeoPoint":1189,"geoPoint":1193,"contacts":1194},"Vilnius University Hospital Santaros Klinikos","Vilnius","08406","Lithuania","LT",{"type":151,"coordinates":1190},[1191,1192],25.2798,54.68916,{"lat":1192,"lon":1191},[1195],{"name":1196,"role":134,"phone":1197,"phoneExt":73,"email":1198},"Jelena Rascon, Pr","+370 5 232 8703","jelena.rascon@santa.lt",{"facility":1200,"status":376,"city":1185,"state":73,"zip":1201,"country":1187,"countryCode":1188,"cosmosGeoPoint":1202,"geoPoint":1204,"contacts":1205},"National Cancer Institute","08660",{"type":151,"coordinates":1203},[1191,1192],{"lat":1192,"lon":1191},[1206],{"name":1207,"role":134,"phone":1208,"phoneExt":73,"email":1209},"Daiva Sendiuliene, MD","+370 5 274 6468","daiva.sendiuliene@nvi.lt",{"facility":1211,"status":200,"city":1212,"state":73,"zip":1213,"country":1214,"countryCode":1215,"cosmosGeoPoint":1216,"geoPoint":1220,"contacts":73},"Universitair Medisch Centrum Groningen","Groningen","9700","Netherlands","NL",{"type":151,"coordinates":1217},[1218,1219],6.56667,53.21917,{"lat":1219,"lon":1218},{"facility":1222,"status":144,"city":1223,"state":73,"zip":1224,"country":1214,"countryCode":1215,"cosmosGeoPoint":1225,"geoPoint":1229,"contacts":1230},"Princess Maxima center","Utrecht","3584CS",{"type":151,"coordinates":1226},[1227,1228],5.12222,52.09083,{"lat":1228,"lon":1227},[1231,1235],{"name":1232,"role":134,"phone":1233,"phoneExt":73,"email":1234},"Lieve TyTGAT, MD","+31 06-55234711","G.A.M.Tytgat@prinsesmaximacentrum.nl",{"name":1236,"role":134,"phone":1237,"phoneExt":73,"email":1238},"JAAP MUR","+31 06 5000 66 46","J.Mur@prinsesmaximacentrum.nl",{"facility":1240,"status":144,"city":1241,"state":73,"zip":73,"country":1242,"countryCode":1243,"cosmosGeoPoint":1244,"geoPoint":1248,"contacts":1249},"Haukeland University Hospital","Haukeland","Norway","NO",{"type":151,"coordinates":1245},[1246,1247],5.45139,60.36333,{"lat":1247,"lon":1246},[1250],{"name":1251,"role":134,"phone":73,"phoneExt":73,"email":1252},"Maria Winther Gunnes, MD","maria.gunnes@helse-bergen.no",{"facility":1254,"status":144,"city":1255,"state":73,"zip":1256,"country":1242,"countryCode":1243,"cosmosGeoPoint":1257,"geoPoint":1261,"contacts":1262},"Oslo University Hospital","Oslo","0424",{"type":151,"coordinates":1258},[1259,1260],10.74609,59.91273,{"lat":1260,"lon":1259},[1263],{"name":1264,"role":134,"phone":73,"phoneExt":73,"email":1265},"Maria Winther Gunnes","mawgun@ous-hf.no",{"facility":1267,"status":376,"city":1268,"state":73,"zip":73,"country":1242,"countryCode":1243,"cosmosGeoPoint":1269,"geoPoint":1273,"contacts":1274},"University Hospital Northern Norway, Tromsoe","Tromsø",{"type":151,"coordinates":1270},[1271,1272],18.95508,69.6489,{"lat":1272,"lon":1271},[1275],{"name":1276,"role":134,"phone":73,"phoneExt":73,"email":1277},"Trond Flaegstad, MD","trond.flaegstad@unn.no",{"facility":1279,"status":376,"city":1280,"state":73,"zip":73,"country":1242,"countryCode":1243,"cosmosGeoPoint":1281,"geoPoint":1285,"contacts":1286},"St Olavs Hospital,","Trondheim",{"type":151,"coordinates":1282},[1283,1284],10.39506,63.43049,{"lat":1284,"lon":1283},[1287],{"name":1288,"role":134,"phone":73,"phoneExt":73,"email":1289},"MOE Erling, MD","erling.moe@stolav.no",{"facility":1291,"status":376,"city":1292,"state":73,"zip":1293,"country":1294,"countryCode":1295,"cosmosGeoPoint":1296,"geoPoint":1300,"contacts":1301},"Children's University Hospital Banská Bystrica","Banská Bystrica","974 09","Slovakia","SK",{"type":151,"coordinates":1297},[1298,1299],19.14932,48.73947,{"lat":1299,"lon":1298},[1302],{"name":1303,"role":134,"phone":1304,"phoneExt":73,"email":1305},"pavel Bician, MD","421 907 808 363","pavel.bician@dfnbb.sk",{"facility":1307,"status":376,"city":1308,"state":73,"zip":1309,"country":1294,"countryCode":1295,"cosmosGeoPoint":1310,"geoPoint":1314,"contacts":1315},"NÚDCH- National Institute of Children's Diseases,","Bratislava","833 40",{"type":151,"coordinates":1311},[1312,1313],17.10674,48.14816,{"lat":1313,"lon":1312},[1316],{"name":1317,"role":134,"phone":73,"phoneExt":73,"email":1318},"Achbergerová Monika, MD","monika.achbergerova@fmed.uniba.sk",{"facility":1320,"status":376,"city":1321,"state":73,"zip":1322,"country":1294,"countryCode":1295,"cosmosGeoPoint":1323,"geoPoint":1327,"contacts":1328},"Children's University Hospital Košice","Košice","040 11",{"type":151,"coordinates":1324},[1325,1326],21.25802,48.71441,{"lat":1326,"lon":1325},[1329],{"name":1330,"role":134,"phone":1331,"phoneExt":73,"email":1332},"Halušková Viktória, MD","055 235 3227","viktoria.haluskova@dfnkosice.sk",{"facility":1334,"status":144,"city":1335,"state":73,"zip":1336,"country":1337,"countryCode":1338,"cosmosGeoPoint":1339,"geoPoint":1343,"contacts":1344},"University medical center Ljubljana, University Children's Hospital Ljubljana, Slovenia","Ljubljana","1000","Slovenia","SI",{"type":151,"coordinates":1340},[1341,1342],14.50513,46.05108,{"lat":1342,"lon":1341},[1345],{"name":1346,"role":134,"phone":1347,"phoneExt":73,"email":1348},"Cesen maja, MD",": 00 386 41 365 384","maja.cesenmazic@kclj.si",{"facility":1350,"status":144,"city":1351,"state":73,"zip":1352,"country":1353,"countryCode":1354,"cosmosGeoPoint":1355,"geoPoint":1359,"contacts":1360},"Hospital Universitario Son Espases","Balea","07010","Spain","ES",{"type":151,"coordinates":1356},[1357,1358],-8.79484,42.2531,{"lat":1358,"lon":1357},[1361],{"name":1362,"role":134,"phone":1363,"phoneExt":73,"email":1364},"samuel Navarro Noguera, MD","+34871205000","samuel.navarro@ssib.es",{"facility":1366,"status":144,"city":1367,"state":73,"zip":1368,"country":1353,"countryCode":1354,"cosmosGeoPoint":1369,"geoPoint":1373,"contacts":1374},"Hospital Universitario Vall D´Hebron","Barcelona","08035",{"type":151,"coordinates":1370},[1371,1372],2.15899,41.38879,{"lat":1372,"lon":1371},[1375],{"name":1376,"role":134,"phone":1377,"phoneExt":73,"email":1378},"Lucas Moreno Martin, MD","+34934893093","lucas.moreno@vallhebron.cat",{"facility":1380,"status":144,"city":1381,"state":73,"zip":1382,"country":1353,"countryCode":1354,"cosmosGeoPoint":1383,"geoPoint":1387,"contacts":1388},"Hospital Universitario Cruces","Cruces","48903",{"type":151,"coordinates":1384},[1385,1386],-8.17208,42.79471,{"lat":1386,"lon":1385},[1389],{"name":1390,"role":134,"phone":1391,"phoneExt":73,"email":1392},"Ricardo Lopez Almaraz, MD","+34946006289","RICARDO.LOPEZALMARAZ@osakidetza.eus",{"facility":1394,"status":144,"city":1395,"state":73,"zip":1396,"country":1353,"countryCode":1354,"cosmosGeoPoint":1397,"geoPoint":1401,"contacts":1402},"Hospital Clínico Universitario Virgen de la Arrixaca","El Palmar","30120",{"type":151,"coordinates":1398},[1399,1400],-0.3174,39.31305,{"lat":1400,"lon":1399},[1403],{"name":1404,"role":134,"phone":1405,"phoneExt":73,"email":1406},"Maria Del Mar Bermudez, MD","+34968929461","mariam.bermudez2@carm.es",{"facility":1408,"status":144,"city":1409,"state":73,"zip":1410,"country":1353,"countryCode":1354,"cosmosGeoPoint":1411,"geoPoint":1415,"contacts":1416},"Hospital Universitario Infantil Niño Jesús","Madrid","28009",{"type":151,"coordinates":1412},[1413,1414],-3.70256,40.4165,{"lat":1414,"lon":1413},[1417],{"name":1418,"role":134,"phone":1419,"phoneExt":73,"email":1420},"Alba Rubio San Simon, MD","+34915035900","alba.rubio@salud.madrid.org",{"facility":1422,"status":144,"city":1409,"state":73,"zip":1423,"country":1353,"countryCode":1354,"cosmosGeoPoint":1424,"geoPoint":1426,"contacts":1427},"Hospital Universitario La Paz","28046",{"type":151,"coordinates":1425},[1413,1414],{"lat":1414,"lon":1413},[1428],{"name":1429,"role":134,"phone":1430,"phoneExt":73,"email":1431},"Pedro rubio Aparicio, MD","+34912071116","pedro.rubio@salud.madrid.org",{"facility":1433,"status":144,"city":1434,"state":73,"zip":1435,"country":1353,"countryCode":1354,"cosmosGeoPoint":1436,"geoPoint":1440,"contacts":1441},"Hospital Regional Universitario de Málaga","Málaga","29010",{"type":151,"coordinates":1437},[1438,1439],-4.42034,36.72016,{"lat":1439,"lon":1438},[1442],{"name":1443,"role":134,"phone":1444,"phoneExt":73,"email":1445},"Laura Garcia Hidalgo, MD","+34662244641","laura.garcia.hidalgo.sspa@juntadeandalucia.es",{"facility":1447,"status":144,"city":1448,"state":73,"zip":1449,"country":1353,"countryCode":1354,"cosmosGeoPoint":1450,"geoPoint":1454,"contacts":1455},"Hospital Universitario Donostia","San Sebastián","20014",{"type":151,"coordinates":1451},[1452,1453],-5.9,43.56667,{"lat":1453,"lon":1452},[1456],{"name":1457,"role":134,"phone":1458,"phoneExt":73,"email":1459},"Miriam Abos Garcia, MD","+34943007176","miriam.garciaabos@osakidetza.eus",{"facility":1461,"status":144,"city":1462,"state":73,"zip":1463,"country":1353,"countryCode":1354,"cosmosGeoPoint":1464,"geoPoint":1468,"contacts":1469},"Hospital Clínico Universitario de Santiago","Santiago de Compostela","15706",{"type":151,"coordinates":1465},[1466,1467],-8.54569,42.88052,{"lat":1467,"lon":1466},[1470],{"name":1471,"role":134,"phone":1472,"phoneExt":73,"email":1473},"Manuel Fernández Sanmartín, MD","+34981951120","manuel.fernandez.sanmartin@sergas.es",{"facility":1475,"status":144,"city":1476,"state":73,"zip":1477,"country":1353,"countryCode":1354,"cosmosGeoPoint":1478,"geoPoint":1482,"contacts":1483},"Hospital Universitario Virgen del Rocío","Seville","41013",{"type":151,"coordinates":1479},[1480,1481],-5.97317,37.38283,{"lat":1481,"lon":1480},[1484],{"name":1485,"role":134,"phone":1486,"phoneExt":73,"email":1487},"catalina Marquez Vega, MD","+34955012921","catalina.marquez.sspa@juntadeandalucia.es",{"facility":1489,"status":144,"city":1490,"state":73,"zip":73,"country":1353,"countryCode":1354,"cosmosGeoPoint":1491,"geoPoint":1495,"contacts":1496},"Hospital Universitario Politécnico de La FE","Valencia",{"type":151,"coordinates":1492},[1493,1494],-0.37966,39.47391,{"lat":1494,"lon":1493},[1497],{"name":1498,"role":134,"phone":1499,"phoneExt":73,"email":1500},"Adela canete, MD","+34961244900","canyete_ade@gva.es",{"facility":1502,"status":376,"city":1503,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1506,"geoPoint":1510,"contacts":1511},"Sahlgrenska University Hospital","Gothenburg","Sweden","SE",{"type":151,"coordinates":1507},[1508,1509],11.96679,57.70716,{"lat":1509,"lon":1508},[1512],{"name":1513,"role":134,"phone":73,"phoneExt":73,"email":1514},"Torben Ek, MD","Torben.ek@vgregion.se",{"facility":1516,"status":376,"city":1517,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1518,"geoPoint":1522,"contacts":1523},"Linköping University Hospital","Linköping",{"type":151,"coordinates":1519},[1520,1521],15.62157,58.41086,{"lat":1521,"lon":1520},[1524],{"name":1525,"role":134,"phone":73,"phoneExt":73,"email":73},"Lisa Törnudd, MD",{"facility":1527,"status":376,"city":1528,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1529,"geoPoint":1533,"contacts":1534},"Skåne University Hospital","Lund",{"type":151,"coordinates":1530},[1531,1532],13.19321,55.70584,{"lat":1532,"lon":1531},[1535],{"name":1536,"role":134,"phone":73,"phoneExt":73,"email":1537},"Ingrid Øra Ingrid Øra, MD","Ingrid.ora@med.lu.se",{"facility":1539,"status":376,"city":1540,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1541,"geoPoint":1545,"contacts":1546},"Karolinska University Hospital, Stockholm","Stockholm",{"type":151,"coordinates":1542},[1543,1544],18.06871,59.32938,{"lat":1544,"lon":1543},[1547],{"name":1548,"role":134,"phone":73,"phoneExt":73,"email":1549},"Kleopatra Georgantzi, MD","kleopatra.georgantzi@regionstockholm.se",{"facility":1551,"status":376,"city":1552,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1553,"geoPoint":1557,"contacts":1558},"Norrland University Hospital","Umeå",{"type":151,"coordinates":1554},[1555,1556],20.25972,63.82842,{"lat":1556,"lon":1555},[1559],{"name":1560,"role":134,"phone":73,"phoneExt":73,"email":1561},"Caroline Björklund, MD","caroline.bjorklund@regionvasterbotten.se",{"facility":1563,"status":376,"city":1564,"state":73,"zip":73,"country":1504,"countryCode":1505,"cosmosGeoPoint":1565,"geoPoint":1569,"contacts":1570},"Uppsala University Hospital","Uppsala",{"type":151,"coordinates":1566},[1567,1568],17.63889,59.85882,{"lat":1568,"lon":1567},[1571],{"name":1572,"role":134,"phone":73,"phoneExt":73,"email":1573},"Träger Träger, MD","catarina.trager@akademiska.se",{"facility":1575,"status":144,"city":1576,"state":73,"zip":1577,"country":1578,"countryCode":1579,"cosmosGeoPoint":1580,"geoPoint":1584,"contacts":1585},"Kantonsspital Aarau AG Klinik für Kinder und Jugendliche","Aarau","CH-5001","Switzerland","CH",{"type":151,"coordinates":1581},[1582,1583],8.04422,47.39254,{"lat":1583,"lon":1582},[1586],{"name":1587,"role":134,"phone":1588,"phoneExt":73,"email":1589},"Andreas Klein-Franke, MD","41 62 838 92 45","Andreas.Klein-Franke@ksa.ch",{"facility":1591,"status":144,"city":1592,"state":73,"zip":1593,"country":1578,"countryCode":1579,"cosmosGeoPoint":1594,"geoPoint":1598,"contacts":1599},"Universitäts-Kinderspital beider Basel (UKBB)","Basel","CH-4031",{"type":151,"coordinates":1595},[1596,1597],7.57327,47.55839,{"lat":1597,"lon":1596},[1600],{"name":1601,"role":134,"phone":1602,"phoneExt":73,"email":1603},"Nicolas von der Weid, Pr","41 61 704 17 62","nicolas.vonderweid@ukbb.ch",{"facility":1605,"status":144,"city":1606,"state":73,"zip":1607,"country":1578,"countryCode":1579,"cosmosGeoPoint":1608,"geoPoint":1612,"contacts":1613},"Ospedale San Giovanni Pediatria, Emato-oncologia pediatrica","Bellinzona","CH-6500",{"type":151,"coordinates":1609},[1610,1611],9.01703,46.19278,{"lat":1611,"lon":1610},[1614],{"name":1615,"role":134,"phone":1616,"phoneExt":73,"email":1617},"Pierluigi Brazzola, MD","41 91 811 89 76","Pierluigi.Brazzola@eoc.ch",{"facility":1619,"status":144,"city":1620,"state":73,"zip":1621,"country":1578,"countryCode":1579,"cosmosGeoPoint":1622,"geoPoint":1626,"contacts":1627},"Inselspital, Universitätsklinik für Kinderheilkunde","Bern","CH-3010",{"type":151,"coordinates":1623},[1624,1625],7.44744,46.94809,{"lat":1625,"lon":1624},[1628],{"name":1629,"role":134,"phone":1630,"phoneExt":73,"email":1631},"Jochen Rößler, MD","41 31 632 94 95","jochen.roessler@insel.ch",{"facility":1633,"status":144,"city":1634,"state":73,"zip":1635,"country":1578,"countryCode":1579,"cosmosGeoPoint":1636,"geoPoint":1640,"contacts":1641},"HUG Hôpitaux Universitaires de Genève Unité d'Hémato-Oncologie Pédiatrique","Geneva","CH-1205",{"type":151,"coordinates":1637},[1638,1639],6.14569,46.20222,{"lat":1639,"lon":1638},[1642],{"name":1643,"role":134,"phone":1644,"phoneExt":73,"email":1645},"Fabienne Gumy Pause, MD","41 79 55 32 594","fabienne.gumypause@hcuge.ch",{"facility":1647,"status":144,"city":1648,"state":73,"zip":1649,"country":1578,"countryCode":1579,"cosmosGeoPoint":1650,"geoPoint":1654,"contacts":1655},"CHUV - Centre Hospitalier Universitaire Vaudois","Lausanne","CH-1011",{"type":151,"coordinates":1651},[1652,1653],6.63282,46.516,{"lat":1653,"lon":1652},[1656],{"name":1657,"role":134,"phone":1658,"phoneExt":73,"email":1659},"Maja Beck Popovic, Pr","41 21 314 35 67","maja.beck-popovic@chuv.ch",{"facility":1661,"status":144,"city":1662,"state":73,"zip":1663,"country":1578,"countryCode":1579,"cosmosGeoPoint":1664,"geoPoint":1668,"contacts":1669},"Luzerner Kantonsspital, Kinderspital pädiatrische Hämatologie\u002FOnkologie","Lucerne","CH-6000",{"type":151,"coordinates":1665},[1666,1667],8.30635,47.05048,{"lat":1667,"lon":1666},[1670],{"name":1671,"role":134,"phone":1672,"phoneExt":73,"email":1673},"Freimut H. Schilling, MD","+41 41 205 32 10","freimut.schilling@luks.ch",{"facility":1675,"status":144,"city":1676,"state":73,"zip":1677,"country":1578,"countryCode":1579,"cosmosGeoPoint":1678,"geoPoint":1682,"contacts":1683},"Ostschweizer Kinderspital Hämatologie\u002FOnkologie Claudiusstrasse 6","Sankt Gallen","CH-9006",{"type":151,"coordinates":1679},[1680,1681],9.37477,47.42391,{"lat":1681,"lon":1680},[1684],{"name":1685,"role":134,"phone":1686,"phoneExt":73,"email":1687},"Cornelia Vetter, MD","+41 71 243 13 48","cornelia.vetter@kispisg.ch",{"facility":1689,"status":144,"city":1690,"state":73,"zip":1691,"country":1578,"countryCode":1579,"cosmosGeoPoint":1692,"geoPoint":1696,"contacts":1697},"Division of Pediatric Oncology Universitäts-Kinderspital Zürich","Zurich","CH-8032",{"type":151,"coordinates":1693},[1694,1695],8.55,47.36667,{"lat":1695,"lon":1694},[1698],{"name":1699,"role":134,"phone":1700,"phoneExt":73,"email":1701},"Sabina Kroiss Benninger, MD","41 44 266 70 57","sabine.kroiss@kispi.uzh.ch",{"facility":1703,"status":144,"city":1704,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1707,"geoPoint":1711,"contacts":1712},"Royal Aberdeen Children's Hospital","Aberdeen","United Kingdom","UK",{"type":151,"coordinates":1708},[1709,1710],-2.09814,57.14369,{"lat":1710,"lon":1709},[1713],{"name":1714,"role":134,"phone":73,"phoneExt":73,"email":1715},"Fiona HERD, MD","fiona.herd2@nhs.scot",{"facility":1717,"status":376,"city":1718,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1719,"geoPoint":1723,"contacts":1724},"Royal Belfast Hospital for Sick Children","Belfast",{"type":151,"coordinates":1720},[1721,1722],-5.92541,54.59682,{"lat":1722,"lon":1721},[1725],{"name":1726,"role":134,"phone":73,"phoneExt":73,"email":1727},"Robert JOHNSTON, MD","Robert.johnston@belfasttrust.hscni.net",{"facility":1729,"status":144,"city":1730,"state":73,"zip":1731,"country":1705,"countryCode":1706,"cosmosGeoPoint":1732,"geoPoint":1736,"contacts":1737},"Birmingham children's Hospital","Birmingham","B46NH",{"type":151,"coordinates":1733},[1734,1735],-1.89983,52.48142,{"lat":1735,"lon":1734},[1738],{"name":1739,"role":134,"phone":1740,"phoneExt":73,"email":1741},"David Hobin, MD","01213338258","davidhobin@nhs.net",{"facility":1743,"status":200,"city":1730,"state":73,"zip":1731,"country":1705,"countryCode":1706,"cosmosGeoPoint":1744,"geoPoint":1746,"contacts":73},"University Hospitals Birmingham Queen Elisabeth Hospital(UHB)",{"type":151,"coordinates":1745},[1734,1735],{"lat":1735,"lon":1734},{"facility":1748,"status":144,"city":1749,"state":73,"zip":1750,"country":1705,"countryCode":1706,"cosmosGeoPoint":1751,"geoPoint":1755,"contacts":1756},"University Hospitals Bristol and Weston NHS Foundation Trust","Bristol","BS1 3NU",{"type":151,"coordinates":1752},[1753,1754],-2.59665,51.45523,{"lat":1754,"lon":1753},[1757],{"name":1758,"role":134,"phone":73,"phoneExt":73,"email":1759},"Antony NG, MD","antony.ng@uhbristol.nhs.uk",{"facility":1761,"status":144,"city":1762,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1763,"geoPoint":1767,"contacts":1768},"Addenbrookes Hospital, Cambridge","Cambridge",{"type":151,"coordinates":1764},[1765,1766],0.11667,52.2,{"lat":1766,"lon":1765},[1769],{"name":1770,"role":134,"phone":73,"phoneExt":73,"email":1771},"Matthew MURRAY, MD","matthew.murray1@nhs.net",{"facility":1773,"status":376,"city":1774,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1775,"geoPoint":1779,"contacts":1780},"Noah's Ark Children's Hospital for Wales - Cardiff","Cardiff",{"type":151,"coordinates":1776},[1777,1778],-3.18,51.48,{"lat":1778,"lon":1777},[1781],{"name":1782,"role":134,"phone":73,"phoneExt":73,"email":1783},"Cathy MORLEY-JACOB, MD","Charlotte.Chambers@wales.nhs.uk",{"facility":1785,"status":376,"city":1786,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1787,"geoPoint":1791,"contacts":1792},"Royal Hospital for Sick Children - Edinburgh","Edinburgh",{"type":151,"coordinates":1788},[1789,1790],-3.19648,55.95206,{"lat":1790,"lon":1789},[1793],{"name":1794,"role":134,"phone":73,"phoneExt":73,"email":1795},"Lesley SIMPSON, MD","Lesley.a.simpson@nhslothian.scot.nhs.uk",{"facility":1797,"status":144,"city":1798,"state":73,"zip":1799,"country":1705,"countryCode":1706,"cosmosGeoPoint":1800,"geoPoint":1804,"contacts":1805},"Royal Hospital for Children Glasgow","Glasgow","G34",{"type":151,"coordinates":1801},[1802,1803],-4.25763,55.86515,{"lat":1803,"lon":1802},[1806],{"name":1807,"role":134,"phone":73,"phoneExt":73,"email":1808},"Dermot Murphy, MD","Dermot.Murphy@ggc.scot.nhs.uk",{"facility":1810,"status":144,"city":1811,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1812,"geoPoint":1816,"contacts":1817},"Leeds General Infirmary","Leeds",{"type":151,"coordinates":1813},[1814,1815],-1.54785,53.79648,{"lat":1815,"lon":1814},[1818],{"name":1819,"role":134,"phone":73,"phoneExt":73,"email":1820},"Martin ELLIOTT, MD","martin.elliott1@nhs.net",{"facility":1822,"status":144,"city":1823,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1824,"geoPoint":1828,"contacts":1829},"Alder Hey Children's Hospital - Liverpool","Liverpool",{"type":151,"coordinates":1825},[1826,1827],-2.97794,53.41058,{"lat":1827,"lon":1826},[1830],{"name":1831,"role":134,"phone":73,"phoneExt":73,"email":1832},"Lisa HOWELL, MD","Lisa.Howell@alderhey.nhs.uk",{"facility":1834,"status":144,"city":1835,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1836,"geoPoint":1840,"contacts":1841},"Great Ormond Street Hospital - London","London",{"type":151,"coordinates":1837},[1838,1839],-0.12574,51.50853,{"lat":1839,"lon":1838},[1842],{"name":1843,"role":134,"phone":73,"phoneExt":73,"email":1844},"Giuseppe BARONE, MD","giuseppe.barone@gosh.nhs.uk",{"facility":1846,"status":144,"city":1847,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1848,"geoPoint":1852,"contacts":73},"Royal Manchester Children's Hospital","Manchester",{"type":151,"coordinates":1849},[1850,1851],-2.23743,53.48095,{"lat":1851,"lon":1850},{"facility":1854,"status":144,"city":1855,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1856,"geoPoint":1860,"contacts":1861},"Royal Victoria Infirmary, Newcastle","Newcastle",{"type":151,"coordinates":1857},[1858,1859],-5.88979,54.21804,{"lat":1859,"lon":1858},[1862],{"name":1863,"role":134,"phone":1864,"phoneExt":73,"email":1865},"Deborah Tweddle, MD","0912082230","deborah.tweddle@newcastle.ac.uk",{"facility":1867,"status":144,"city":1868,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1869,"geoPoint":1873,"contacts":1874},"Nottingham Children's Hospital","Nottingham",{"type":151,"coordinates":1870},[1871,1872],-1.15047,52.9536,{"lat":1872,"lon":1871},[1875],{"name":1876,"role":134,"phone":73,"phoneExt":73,"email":1877},"MADNI MADNI, MD","majid.madni@nuh.nhs.uk",{"facility":1879,"status":144,"city":1880,"state":73,"zip":1881,"country":1705,"countryCode":1706,"cosmosGeoPoint":1882,"geoPoint":1886,"contacts":1887},"Sheffield Children's Hospital","Sheffield","S102TH",{"type":151,"coordinates":1883},[1884,1885],-1.4659,53.38297,{"lat":1885,"lon":1884},[1888],{"name":1889,"role":134,"phone":1890,"phoneExt":73,"email":1891},"Dan Yeomanson, MD","01142717366","danyeomanson@nhs.net",{"facility":1893,"status":144,"city":1894,"state":73,"zip":73,"country":1705,"countryCode":1706,"cosmosGeoPoint":1895,"geoPoint":1899,"contacts":1900},"Southampton General Hospital","Southampton",{"type":151,"coordinates":1896},[1897,1898],-1.40428,50.90395,{"lat":1898,"lon":1897},[1901],{"name":1902,"role":134,"phone":73,"phoneExt":73,"email":1903},"Ramya RAMANUJACHAR, MD","ramya.ramanujachar@uhs.nhs.uk",{"facility":1905,"status":144,"city":1906,"state":73,"zip":1907,"country":1705,"countryCode":1706,"cosmosGeoPoint":1908,"geoPoint":1912,"contacts":1913},"Royal Marsden Hospital","Sutton","SM2 5PT",{"type":151,"coordinates":1909},[1910,1911],-0.2,51.35,{"lat":1911,"lon":1910},[1914],{"name":1915,"role":134,"phone":1916,"phoneExt":73,"email":1917},"Sucheta vaidya, MD","02086613635","sucheta.vaidya@icr.ac.uk",{"type":1919,"investigatorFullName":73,"investigatorTitle":73,"investigatorAffiliation":73,"oldNameTitle":73,"oldOrganization":73},"SPONSOR","100379473","phase-3-high-risk-neuroblastoma-study-2-of-siop-europa-neuroblastoma-siopen-100379473",false,"NCT04221035","High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)","HR-NBL2","Inclusion Criteria:\n\nEnrollment in HR-NBL2 will be performed:\n\n* at diagnosis before the beginning of chemotherapy or\n* up to 21 days after one course of Carboplatin-Etoposide for patients with localized neuroblastoma or infants with metastatic neuroblastoma with MYCN amplification or patients with metastatic neuroblastoma treated in emergency or\n* up to 21 days after one course of the current protocol for R-I randomisation (RAPID COJEC\u002FGPOH) low\u002Fintermediate risk neuroblastoma in Germany\u002FNetherlands for patients with localized neuroblastoma or infants with metastatic neuroblastoma with MYCN amplification\n\nHR-NBL2 eligibility criteria:\n\n1. Established diagnosis of neuroblastoma according to the SIOPEN- modified International Neuroblastoma Risk Group (INRG) criteria, High-risk neuroblastoma defined as:\n\n   * Stage M neuroblastoma above 365 days of age at diagnosis (no upper age limit) and Ms neuroblastoma 12-18 months old, any MYCN status or\n   * L2, M or Ms neuroblastoma any age with MYCN amplification, or focal high level MYC or MYCL amplification.\n\n   In Germany, patients aged less than 18 months with stage M and without MYCN amplification will not be enrolled in HR-NBL2 trial.\n2. No previous chemotherapy or up to 21 days after one cycle of Carboplatin-Etoposide chemotherapy for patients with localized neuroblastoma or infants with metastatic neuroblastoma with MYCN amplification or patients with metastatic neuroblastoma treated in emergency or up to 21 days after one course of the current protocol for low\u002Fintermediate risk neuroblastoma in Germany\u002FNetherlands for patients with localized neuroblastoma or infants with metastatic neuroblastoma with MYCN amplification\n3. Females of childbearing potential must have a negative serum or urine pregnancy test within 7 days prior to initiation of treatment. Sexually active patients must agree to use acceptable and appropriate contraception while on HR-NBL2 study and for one year after stopping the study. Acceptable contraception is defined in CTFG Guidelines \"Recommendations related to contraception and pregnancy testing in clinical trials\" (Appendix 11). Female patients who are lactating must agree to stop breast-feeding.\n4. Written informed consent to enter the HR-NBL2 protocol from patient or parents\u002Flegal representative, patient, and age-appropriate assent.\n5. Patient affiliated to a social security regimen or beneficiary of the same according to local requirements.\n6. Patients should be able and willing to comply with study visits and procedures as per protocol\n\nR-I eligibility criteria:\n\n\\- Written informed consent to enter the R-I randomisation from patient or parents\u002Flegal representative, patient, and age- appropriate assent.\n\nIn case of parents'\u002Fpatient's refusal to R-I, or Organ toxicity exclusion criteria at diagnosis, patients can still be enrolled in HR- NBL2 trial with parents'\u002Fpatient's consent before or within 3 weeks from the beginning of chemotherapy\n\nR-HDC randomisation (Single HDC Bu-Mel\u002F Tandem HDC Thiotepa+Bu-Mel) Etoposide or one course of the current protocol for low\u002Fintermediate risk neuroblastoma in Germany\u002FNetherlands). Patients will be treated with the standard induction regimen per country (Rapid COJEC or GPOH) and will be potentially eligible for subsequent randomisations.\n\nRandomisation for HDC strategy will be performed at the end of induction after the disease evaluation and after surgery of the primary tumour for those patients who will receive surgery before HDC.\n\nR-HDC eligibility criteria:\n\n1. \\- Stage M neuroblastoma above 365 days of age at diagnosis, any MYCN status, EXCEPT patients with stage M or Ms 12-18 months old with numerical chromosomal alterations only, and in complete metastatic response at the end of induction: in this case, patients will have surgery and no further treatment.\n\n   OR\n\n   \\- L2, M or Ms neuroblastoma, any age, with MYCN amplification, or focal high level MYC or MYCL amplification\n2. Age \\\u003C 21 years at the time of randomization\n3. Complete response (CR) or partial response (PR) at metastatic sites:\n\n   * Bone disease: mIBG uptake completely resolved or SIOPEN score ≤ 3 and at least 50% reduction in mIBG score (or ≤ 3 bone lesions and at least 50% reduction in number of FDG- PET-avid bone lesions for mIBG-nonavid tumours).\n   * Bone marrow disease: CR and\u002For minimal disease (MD) according to International Neuroblastoma Response Criteria\n   * Other metastatic sites: CR. (after induction chemotherapy +\u002F- surgery), except for distant lymph nodes for which PR is accepted with a possible secondary surgery\n4. Acceptable organ function and performance status:\n\n   * Performance status ≥ 50%.\n   * Hematological status: ANC\\>0.5x109\u002FL, platelets \\> 20x 109\u002FL\n   * Cardiac function: (\\\u003C grade 2)\n   * Normal chest X-Ray and oxygen saturation.\n   * Absence of any toxicity ≥ grade 3. 4) Sufficient collected stem cells available; a total harvest of at least 6 x 106\u002Fkg CD34+ cells, to be stored in at least 4 separate bags to administer at least 3 x 106\u002Fkg CD34+ cells per rescue.\n5. Written informed consent, including agreement of patient or parents\u002Flegal guardian for minors, to enter the R-HDC randomisation.\n6. Patient affiliated to a social security regimen or beneficiary of the same according to local requirements.\n7. Patients should be able and willing to comply with study visits and procedures as per protocol.\n\nIn case of parents'\u002Fpatient's refusal, or insufficient stem cells, collection for tandem HDC but with a minimum of 3 x 106 CD34+ cells\u002Fkg body weight, or in case of patients older than 21 years, or organ toxicity, HDC will consist on the standard HD Bu-Mel and patients will be eligible for the subsequent randomisation.\n\nR-RTx randomisation (Local Radiotherapy) Chemoimmunotherapy arm\n\nR-RTx eligibility criteria:\n\nAn evaluation of the local disease will be performed after HDC\u002FASCR and surgery:\n\n* In case of no local macroscopic disease, all patients will receive 21,6-Gy radiotherapy to the pre-operative tumour bed\n* In case of local macroscopic residual disease, patients will be eligible to R-RTx if the following criteria are met:\n\n  1. No evidence of disease progression after HDC\u002FASCR.\n  2. Interval between the last ASCR and radiotherapy start between 60 and 90 days.\n  3. Performance status greater or equal 50%.\n  4. Hematological status: ANC \\>0.5x109\u002FL, platelets \\> 20x109\u002FL.\n  5. Written informed consent, including agreement of patient or parents\u002Flegal guardian for minors, to enter the R-RTx randomisation.\n  6. Patient affiliated to a social security regimen or beneficiary of the same according to local requirements.\n  7. Patients should be able and willing to comply with study visits and procedures as per protocol.\n\nIn case of parents'\u002Fpatient's refusal of the randomisation, the patient will receive 21.6 Gy radiotherapy to the pre-operative tumour bed.\n\nChemoimmunotherapy arm eligibility criteria:\n\n1. Insufficient metastatic response at the end of induction chemotherapy, defined as:\n\n   * SIOPEN score \\> 3 or less than 50% reduction in mIBG score (or \\> 3 bone lesions or less 50% reduction in number of FDG-PET-avid bone lesions for mIBG-non avid tumours) OR\n   * Bone marrow disease: SD according to International Neuroblastoma Response Criteria OR\n   * Other metastatic sites: PR or SD. For distant lymph nodes: PR and not resectable or SD.\n2. Performance status ≥ 50%.\n3. Hematological status: ANC\\>0.75x109\u002FL without G-CSF for at least 48 hours (or ANC ≥ 0.50 x 109 \u002FL in case of bone marrow involvement), platelets \\> 50x 109\u002FL and rising, without platelets transfusion for 72 hours.\n4. AST or ALT ≤7.5 ULN and total bilirubin ≤1.5 ULN. In patients with liver metastases, total bilirubin ≤2.5 ULN is allowed.\n5. No active infection;\n6. No grade \\>2 gastrointestinal toxicity.\n7. No grade ≥ 3 toxicity related to previous treatment.\n8. Oxygen saturation \\> 94%\n\nNon-inclusion criteria for HR-NBL2:\n\n1. Any negative answer concerning the HR-NLB2 inclusion criteria\n2. Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving his consent.\n3. Participating in another clinical study with an IMP while on study treatment.\n4. Chronic inflammatory bowel disease and\u002For bowel obstruction.\n5. Pregnant or breastfeeding women.\n6. Known hypersensitivity to the active substance or to any of the excipients of the study drugs\n7. Concomitant self-medication medicine that in the investigator opinion could interact with study treatments, including herbal medicine (e.g. St John's Wort (Hypericum Perforatum).\n\nNon-inclusion criteria specific to the R-I randomisation (RAPID COJEC\u002FGPOH):\n\n1. Urinary tract obstruction ≥ grade 3\n2. Heart failure or myocarditis ≥ grade 2, any arrhythmia or myocardial infection\n3. Peripheral motor or sensory neuropathy ≥ grade 3\n4. Demyelinating form of Charcot-Marie-Tooth syndrome\n5. Hearing impairment ≥ grade 2\n6. Concurrent prophylactic use of phenytoin\n7. Cardiorespiratory disease that contraindicates hyperhydration\n\nNon-inclusion criteria common to all randomisations (R-I, R-HDC, and R-RTx):\n\n1. Any negative answer concerning the inclusion criteria of R-I or R- HDC or R-RTx will render the patient ineligible for the corresponding therapy phase randomisation. However, these patients may remain on study and be considered to receive standard treatment of the respective therapy phase, and may be potentially eligible for subsequent randomisations.\n2. Liver function: Alanine aminotransferase (ALT) \\> 3.0 x ULN and blood bilirubin \\> 1.5 x ULN (toxicity ≥ grade 2). In case of toxicity ≥ grade 2, call national principal investigator study coordinator to discuss the feasibility.\n3. Renal function: Creatinine clearance and\u002For GFR \\\u003C 60 ml\u002Fmin\u002F1.73m² (toxicity ≥ grade 2). If GFR \\\u003C 60ml\u002Fmin\u002F1.73m², call national principal investigator study coordinator to discuss about the treatment.\n4. Dyspnea at rest and\u002For pulse oximetry \\\u003C95% in air (only for R-HDC, and R-RTx)\n5. Any uncontrolled intercurrent illness or infection that in the investigator opinion would impair study participation.\n6. Concomitant use with yellow fever vaccine and with live virus or bacterial vaccines.\n7. Patient allergic to peanut or soya.\n\nNon-inclusion criteria to R-HDC:\n\n\\- Any negative answer concerning the R-HDC inclusion criteria\n\nNon-inclusion criteria to chemoimmunotherapy arm:\n\n\\- Any negative answer concerning the inclusion criteria of chemoimmunotherapy arm.","ALL","21 Years",{"count":1930,"type":1931},800,"ESTIMATED","INTERVENTIONAL",[1934],"PHASE3","This is an international multicenter, open-label, randomized phase III trial including three sequential randomizations to assess efficacy of induction and consolidation chemotherapies and radiotherapy for patients with high-risk neuroblastoma.",[1937,1938],"High-Risk Neuroblastoma","Patient With Insufficient Response Chemoimmunotherapy","2025-06-25",{"date":1941,"type":1942},"2025-06-26","ACTUAL",{"date":1944,"type":1942},"2019-11-05",{"date":1946,"type":1931},"2032-11",{"name":5,"class":6},142]