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Bais, MD","t.bais@umcg.nl",[44,59,70,83,94,107,118,129,142,152,163,176],{"facility":45,"status":46,"city":47,"state":26,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Cliniques Universitaires Saint-Luc","RECRUITING","Brussels","Belgium","BE",{"type":51,"coordinates":52},"Point",[53,54],4.34878,50.85045,{"lat":54,"lon":53},[57],{"name":58,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof. Nathalie Demoulin",{"facility":60,"status":46,"city":61,"state":26,"zip":26,"country":48,"countryCode":49,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"University Hospital Leuven","Leuven",{"type":51,"coordinates":63},[64,65],4.70093,50.87959,{"lat":65,"lon":64},[68],{"name":69,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof dr. B. 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Meijer",{"facility":153,"status":46,"city":154,"state":26,"zip":26,"country":132,"countryCode":133,"cosmosGeoPoint":155,"geoPoint":159,"contacts":160},"Erasmus University Medical Center","Rotterdam",{"type":51,"coordinates":156},[157,158],4.47917,51.9225,{"lat":158,"lon":157},[161],{"name":162,"role":37,"phone":26,"phoneExt":26,"email":26},"dr. M. Salih",{"facility":164,"status":46,"city":165,"state":26,"zip":26,"country":166,"countryCode":167,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Fundación Puigvert","Barcelona","Spain","ES",{"type":51,"coordinates":169},[170,171],2.15899,41.38879,{"lat":171,"lon":170},[174],{"name":175,"role":37,"phone":26,"phoneExt":26,"email":26},"Prof. dr. R. Torra",{"facility":177,"status":46,"city":178,"state":26,"zip":26,"country":166,"countryCode":167,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"La Fundación Jiménez Díaz","Madrid",{"type":51,"coordinates":180},[181,182],-3.70256,40.4165,{"lat":182,"lon":181},[185],{"name":186,"role":37,"phone":26,"phoneExt":26,"email":26},"María Vanessa Pérez Gómez",{"type":33,"investigatorFullName":188,"investigatorTitle":189,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ron Gansevoort","Prof. dr.","100467937","phase-3-hydrochlorothiazide-to-protect-polycystic-kidney-disease-patients-and-improve-their-quality-of-life-100467937",false,"NCT05373264","HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life","HYDRO-PROTECT","Inclusion Criteria:\n\n* ADPKD diagnosis (modified Ravine criteria)\n* ≥18 years old\n* eGFR \\> 25 mL\u002Fmin\u002F1.73m2\n* On stable treatment with the highest tolerated dose of V2RA for a minimum of 3 months\n\nExclusion Criteria:\n\n* Known intolerance to hydrochlorothiazide\n* Use of any diuretic\n* Orthostatic hypotension complaints or blood pressure \\\u003C105\u002F65mmHg during screening visit\n* Uncontrolled hypertension (blood pressure \\>160\u002F100mmHg)\n* Hypokalemia (\\\u003C3.5 mmol\u002FL)\n* History of active gout on maintenance preventive treatment for gout (allopurinol, desuric and\u002For colchicine), defined as ≥2 episodes during the last year\n* History of skin cancer (basal cell, squamous cell and melanoma)","ALL","18 Years","80 Years",{"count":201,"type":202},300,"ESTIMATED","INTERVENTIONAL",[205],"PHASE3","Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive formation of renal cysts which ultimately lead to a loss of renal function.\n\nTolvaptan (a V2R antagonist) is currently the only effective treatment for preserving renal function in ADPKD. However, side-effects such as polyuria limit its tolerability and thereby the therapeutic potential. This study will test whether co-administration with hydochlorothiazide can improve V2RA efficacy (slowing kidney function decline) and tolerability (quality of life) in ADPKD. Approximately 300 patients will be enrolled.",[208],"ADPKD",[208,210,9,211,212,213],"Tolvaptan","Quality of Life","Side effects","Polyuria","2026-02-23",{"date":216,"type":217},"2026-02-25","ACTUAL",{"date":219,"type":217},"2024-07-31",{"date":221,"type":202},"2031-07",{"name":5,"class":6},12]