[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578831":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":28,"centralContacts":36,"locations":42,"responsibleParty":59,"collaborators":28,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":28,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":28,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":45,"whyStopped":28,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Future University in Egypt","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Control arm","PLACEBO_COMPARATOR","Standard care",[13],"Other: Standard Care",{"label":15,"type":16,"description":15,"interventionNames":17},"Prucalopride 2mg","EXPERIMENTAL",[18,13],"Drug: Prucalopride 2mg",{"label":20,"type":16,"description":20,"interventionNames":21},"Prucalopride 4mg",[22,13],"Drug: Prucalopride 4mg",[24,29,32],{"type":25,"name":15,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","Prucalopride 2mg taken preoperatively",[15],null,{"type":25,"name":20,"description":30,"armGroupLabels":31,"otherNames":28},"Prucalopride 4mg taken preoperatively",[20],{"type":6,"name":33,"description":34,"armGroupLabels":35,"otherNames":28},"Standard Care","Standard Supportive care",[9,15,20],[37],{"name":38,"role":39,"phone":40,"phoneExt":28,"email":41},"Amir Samy Hanna","CONTACT","01227933624","amireskanderhanna@gmail.com",[43],{"facility":44,"status":45,"city":46,"state":28,"zip":28,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Matareya Hospital","RECRUITING","Cairo","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56],{"name":57,"role":39,"phone":58,"phoneExt":28,"email":41},"Eskandar","+201227933624",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"PRINCIPAL_INVESTIGATOR","Nouran Omar El Said","Assistant Lecturer","100578831","phase-3-impact-of-varying-doses-of-prucalopride-on-improving-gut-function-recovery-after-elective-colorectal-surgery-100578831",false,"NCT06816407","Impact of Varying Doses of Prucalopride on Improving Gut Function Recovery After Elective Colorectal Surgery","The Effect of Different Doses of Prucalopride on Improving Gut Function Recovery Following Elective Colorectal Surgery: a Randomized, Double-blind Study","Inclusion Criteria:\n\n* undergoing elective colorectal surgery, including but not limited to colectomy, rectal resection, and sigmoid resection.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Total colectomy\n* Creation of a stoma\n* Pre-existing gastrointestinal disorders\n* Severe renal or hepatic impairment\n* Known hypersensitivity to prucalopride.","ALL","18 Years","75 Years",{"count":74,"type":75},180,"ESTIMATED","INTERVENTIONAL",[78],"PHASE3","Postoperative ileus (POI) is a common complication after abdominal surgery, causing symptoms like nausea, vomiting, abdominal distension, and delayed passage of flatus and stool. Management remains challenging, with limited pharmacological options available. Prucalopride, a selective serotonin 5-HT4 receptor agonist, has shown promise in accelerating gastrointestinal recovery after surgery. However, the optimal timing and dosing for preventing POI remains unclear. Higher doses may provide more potent prokinetic effects in the postoperative setting. his study investigates if higher doses of prucalopride (4 mg) improve bowel function return and hospital stay in elective colorectal surgery patients compared to standard doses and placebo.",[81],"Post-Op Complication",[83,84],"pro kinetic","gut function recovery","2025-03-15",{"date":87,"type":88},"2025-03-19","ACTUAL",{"date":90,"type":88},"2025-03-02",{"date":92,"type":75},"2025-05",{"name":5,"class":6},1]