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Duska",{"facility":3664,"status":276,"city":3665,"state":1931,"zip":3666,"country":259,"countryCode":260,"cosmosGeoPoint":3667,"geoPoint":3671,"contacts":3672},"Inova Schar Cancer Institute","Fairfax","22031",{"type":262,"coordinates":3668},[3669,3670],-77.30637,38.84622,{"lat":3670,"lon":3669},[3673,3675],{"name":269,"role":270,"phone":3674,"phoneExt":251,"email":3645},"703-720-5210",{"name":3647,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3677,"status":276,"city":3665,"state":1931,"zip":3678,"country":259,"countryCode":260,"cosmosGeoPoint":3679,"geoPoint":3681,"contacts":3682},"Inova Fair Oaks Hospital","22033",{"type":262,"coordinates":3680},[3669,3670],{"lat":3670,"lon":3669},[3683,3684],{"name":269,"role":270,"phone":3674,"phoneExt":251,"email":3645},{"name":3647,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3686,"status":276,"city":3687,"state":1931,"zip":3688,"country":259,"countryCode":260,"cosmosGeoPoint":3689,"geoPoint":3693,"contacts":3694},"Inova Fairfax Hospital","Falls Church","22042",{"type":262,"coordinates":3690},[3691,3692],-77.17109,38.88233,{"lat":3692,"lon":3691},[3695,3697],{"name":269,"role":270,"phone":3696,"phoneExt":251,"email":3645},"703-208-6650",{"name":3647,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3699,"status":276,"city":3700,"state":1931,"zip":3701,"country":259,"countryCode":260,"cosmosGeoPoint":3702,"geoPoint":3706,"contacts":3707},"Inova Loudoun Hospital","Leesburg","20176",{"type":262,"coordinates":3703},[3704,3705],-77.5636,39.11566,{"lat":3705,"lon":3704},[3708,3711],{"name":269,"role":270,"phone":3709,"phoneExt":251,"email":3710},"703-858-6000","Keary.janet@inova.org",{"name":3647,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3713,"status":276,"city":3714,"state":1931,"zip":3715,"country":259,"countryCode":260,"cosmosGeoPoint":3716,"geoPoint":3720,"contacts":3721},"VCU Massey Comprehensive Cancer Center","Richmond","23298",{"type":262,"coordinates":3717},[3718,3719],-77.46026,37.55376,{"lat":3719,"lon":3718},[3722,3725],{"name":269,"role":270,"phone":3723,"phoneExt":251,"email":3724},"804-628-6430","CTOclinops@vcu.edu",{"name":3726,"role":250,"phone":251,"phoneExt":251,"email":251},"Jaclyn Wall",{"facility":3728,"status":276,"city":3729,"state":1931,"zip":3730,"country":259,"countryCode":260,"cosmosGeoPoint":3731,"geoPoint":3735,"contacts":3736},"Carilion Roanoke Memorial Hospital","Roanoke","24033",{"type":262,"coordinates":3732},[3733,3734],-79.94143,37.27097,{"lat":3734,"lon":3733},[3737,3739],{"name":269,"role":270,"phone":3738,"phoneExt":251,"email":251},"540-981-7377",{"name":3726,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3741,"status":276,"city":3742,"state":3743,"zip":3744,"country":259,"countryCode":260,"cosmosGeoPoint":3745,"geoPoint":3749,"contacts":3750},"Legacy Salmon Creek Hospital","Vancouver","Washington","98686",{"type":262,"coordinates":3746},[3747,3748],-122.66149,45.63873,{"lat":3748,"lon":3747},[3751,3753],{"name":269,"role":270,"phone":3752,"phoneExt":251,"email":251},"503-413-2150",{"name":3026,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3755,"status":276,"city":3756,"state":3757,"zip":3758,"country":259,"countryCode":260,"cosmosGeoPoint":3759,"geoPoint":3763,"contacts":3764},"West Virginia University Healthcare","Morgantown","West Virginia","26506",{"type":262,"coordinates":3760},[3761,3762],-79.9559,39.62953,{"lat":3762,"lon":3761},[3765,3768],{"name":269,"role":270,"phone":3766,"phoneExt":251,"email":3767},"304-293-7374","cancertrialsinfo@hsc.wvu.edu",{"name":3769,"role":250,"phone":251,"phoneExt":251,"email":251},"Krista S. Pfaendler",{"facility":3771,"status":276,"city":3772,"state":3757,"zip":3773,"country":259,"countryCode":260,"cosmosGeoPoint":3774,"geoPoint":3778,"contacts":3779},"Camden Clark Medical Center","Parkersburg","26101",{"type":262,"coordinates":3775},[3776,3777],-81.56151,39.26674,{"lat":3777,"lon":3776},[3780,3781],{"name":269,"role":270,"phone":3766,"phoneExt":251,"email":3767},{"name":3769,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3783,"status":276,"city":3784,"state":3785,"zip":3786,"country":259,"countryCode":260,"cosmosGeoPoint":3787,"geoPoint":3791,"contacts":3792},"Duluth Clinic Ashland","Ashland","Wisconsin","54806",{"type":262,"coordinates":3788},[3789,3790],-90.8838,46.59244,{"lat":3790,"lon":3789},[3793,3794],{"name":269,"role":270,"phone":1869,"phoneExt":251,"email":1870},{"name":1872,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3796,"status":276,"city":3784,"state":3785,"zip":3786,"country":259,"countryCode":260,"cosmosGeoPoint":3797,"geoPoint":3799,"contacts":3800},"Northwest Wisconsin Cancer Center",{"type":262,"coordinates":3798},[3789,3790],{"lat":3790,"lon":3789},[3801,3802],{"name":269,"role":270,"phone":1869,"phoneExt":251,"email":1870},{"name":1872,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3804,"status":276,"city":3805,"state":3785,"zip":3806,"country":259,"countryCode":260,"cosmosGeoPoint":3807,"geoPoint":3811,"contacts":3812},"University of Wisconsin Carbone Cancer Center - Eastpark Medical Center","Madison","53718",{"type":262,"coordinates":3808},[3809,3810],-89.40123,43.07305,{"lat":3810,"lon":3809},[3813,3816],{"name":269,"role":270,"phone":3814,"phoneExt":251,"email":3815},"800-622-8922","clinicaltrials@cancer.wisc.edu",{"name":3817,"role":250,"phone":251,"phoneExt":251,"email":251},"Lisa M. Barroilhet",{"facility":3819,"status":276,"city":3805,"state":3785,"zip":3820,"country":259,"countryCode":260,"cosmosGeoPoint":3821,"geoPoint":3823,"contacts":3824},"University of Wisconsin Carbone Cancer Center - University Hospital","53792",{"type":262,"coordinates":3822},[3809,3810],{"lat":3810,"lon":3809},[3825,3826],{"name":269,"role":270,"phone":3814,"phoneExt":251,"email":3815},{"name":3817,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3828,"status":276,"city":3829,"state":3785,"zip":3830,"country":259,"countryCode":260,"cosmosGeoPoint":3831,"geoPoint":3835,"contacts":3836},"Medical College of Wisconsin","Milwaukee","53226",{"type":262,"coordinates":3832},[3833,3834],-87.90647,43.0389,{"lat":3834,"lon":3833},[3837,3839],{"name":269,"role":270,"phone":3838,"phoneExt":251,"email":251},"414-805-3666",{"name":3840,"role":250,"phone":251,"phoneExt":251,"email":251},"William H. Bradley",{"facility":3842,"status":276,"city":3843,"state":3785,"zip":3844,"country":259,"countryCode":260,"cosmosGeoPoint":3845,"geoPoint":3849,"contacts":3850},"ProHealth D N Greenwald Center","Mukwonago","53149",{"type":262,"coordinates":3846},[3847,3848],-88.33343,42.86668,{"lat":3848,"lon":3847},[3851,3853],{"name":269,"role":270,"phone":251,"phoneExt":251,"email":3852},"research.institute@phci.org",{"name":3854,"role":250,"phone":251,"phoneExt":251,"email":251},"Timothy R. Wassenaar",{"facility":3856,"status":276,"city":3857,"state":3785,"zip":3858,"country":259,"countryCode":260,"cosmosGeoPoint":3859,"geoPoint":3863,"contacts":3864},"ProHealth Oconomowoc Memorial Hospital","Oconomowoc","53066",{"type":262,"coordinates":3860},[3861,3862],-88.49927,43.11167,{"lat":3862,"lon":3861},[3865,3867],{"name":269,"role":270,"phone":3866,"phoneExt":251,"email":251},"262-928-7878",{"name":3854,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3869,"status":276,"city":3870,"state":3785,"zip":3871,"country":259,"countryCode":260,"cosmosGeoPoint":3872,"geoPoint":3876,"contacts":3877},"Essentia Health Saint Mary's Hospital - Superior","Superior","54880",{"type":262,"coordinates":3873},[3874,3875],-92.10408,46.72077,{"lat":3875,"lon":3874},[3878,3880],{"name":269,"role":270,"phone":3879,"phoneExt":251,"email":251},"701-364-6272",{"name":1872,"role":250,"phone":251,"phoneExt":251,"email":251},{"facility":3882,"status":276,"city":3883,"state":3785,"zip":3884,"country":259,"countryCode":260,"cosmosGeoPoint":3885,"geoPoint":3889,"contacts":3890},"UW Cancer Center at ProHealth Care","Waukesha","53188",{"type":262,"coordinates":3886},[3887,3888],-88.23148,43.01168,{"lat":3888,"lon":3887},[3891,3894],{"name":269,"role":270,"phone":3892,"phoneExt":251,"email":3893},"262-928-5539","Chanda.miller@phci.org",{"name":3854,"role":250,"phone":251,"phoneExt":251,"email":251},{"type":3896,"investigatorFullName":251,"investigatorTitle":251,"investigatorAffiliation":251,"oldNameTitle":251,"oldOrganization":251},"SPONSOR","100597706",false,"NCT07061977","Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer","NRG-GY037: A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab Versus Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer","Inclusion Criteria:\n\n* Patients must have pathologically confirmed newly diagnosed cervical cancer. Eligible pathologic types: squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma\n* Patients must have locally advanced cervical cancer (LACC) with T3 or T4 disease with or without lymph node involvement:\n\n  * IIIA (T3aN0M0)\n  * IIIB (T3bN0M0)\n  * IIIC1(T3aN1M0, T3bN1M0)\n  * IIIC2 (T3aN2M0, T3bN2M0)\n  * IVA (T4aN0M0, T4aN1M0, T4aN2M0) No prior hysterectomy defined as removal of the entire uterus.\n  * NOTE: prior partial\u002Fsubtotal hysterectomy for reasons other than cervical cancer are eligible to participate in the study. No plan to perform a hysterectomy as part of initial cervical cancer therapy.\n\nNo paraaortic lymph node (PALN) metastases above the T12\u002FL1 interspace.\n\n* Note: Nodal status can be confirmed by imaging (CT, MRI, or PET\u002FCT), fine needle aspirate\u002Fcore biopsy, extra peritoneal biopsy, laparoscopic biopsy, or lymphadenectomy.\n\nRadiologic definition of lymph node staging:\n\n* N1:\n\n  * One or more pelvic lymph nodes with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and\u002For\n  * One or more pelvic lymph nodes with short axis diameter of ≥ 10 mm and standardized uptake value maximum (SUVmax) ≥ 2.5 by fludeoxyglucose (FDG)-PET\n* N2:\n\n  * One or more para-aortic lymph node with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and\u002For\n  * One or more para-aortic lymph node with short axis diameter of ≥ 10 mm and SUVmax ≥ 2.5 by FDG-PET\n\n    * No prior definitive surgical, radiation, or systemic therapy for cervical cancer\n    * No prior immunotherapy\n    * No prior pelvic radiation therapy for any disease\n    * Age ≥ 18\n    * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2\n    * Not pregnant and not nursing\n    * Absolute neutrophil count (ANC) ≥ 1,500 cells\u002Fmm\\^3\n    * Platelets ≥ 100,000 cells\u002Fmm\\^3\n    * Hemoglobin ≥ 8 g\u002Fdl (Note: The use of transfusion or other intervention to achieve hemoglobulin \\[Hgb\\] ≥ 8 g\u002Fdl is acceptable)\n    * Creatinine clearance (CrCL) of ≥ 50 mL\u002Fmin by the Cockcroft-Gault formula\n    * Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled)\n    * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN\n    * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better\n    * No active infection requiring parenteral antibiotics\n    * No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella\u002Fzoster (chicken pox), yellow fever, rabies, Bacille Calmette Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines are live attenuated vaccines and are not allowed\n    * No diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior registration\n    * No active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed\n    * No history of (non-infectious) pneumonitis that required steroids, or current pneumonitis\n    * No history of allergic reaction to the study agent(s) or compounds of similar chemical or biologic composition to the study agent(s) (or any of its excipients)","FEMALE","18 Years",{"count":3906,"type":3907},336,"ESTIMATED","INTERVENTIONAL",[3910],"PHASE3","This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.",[3913,3914,3915,3916,3917,3918,3919,3920],"Locally Advanced Cervical Adenocarcinoma","Locally Advanced Cervical Adenosquamous Carcinoma","Locally Advanced Cervical Squamous Cell Carcinoma","Stage IIIA Cervical Cancer FIGO 2018","Stage IIIB Cervical Cancer FIGO 2018","Stage IIIC1 Cervical Cancer FIGO 2018","Stage IIIC2 Cervical Cancer FIGO 2018","Stage IVA Cervical Cancer FIGO 2018","2026-07-01",{"date":3923,"type":3924},"2026-07-02","ACTUAL",{"date":3926,"type":3924},"2025-11-05",{"date":3928,"type":3907},"2030-12-31",{"name":5,"class":6},290]