[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622421":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":25,"responsibleParty":35,"collaborators":25,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":40,"sex":46,"minAge":47,"maxAge":25,"enrollmentInfo":48,"targetDuration":25,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":25,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":25},{"fullName":5,"class":6},"St. Paul's Hospital, Canada","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Povidone-Iodine and Budesonide Gel-Forming Suspension","ACTIVE_COMPARATOR","Participants randomized to this arm will receive an intra-sinus gel-forming suspension containing povidone-iodine and budesonide administered at the completion of endoscopic sinus surgery.",[13],"Drug: Povidone-Iodine and Budesonide Gel-Forming Suspension",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Gel-Forming Suspension","PLACEBO_COMPARATOR","Participants randomized to this arm will receive an intra-sinus placebo gel-forming suspension without active drug administered at the completion of endoscopic sinus surgery.",[19],"Drug: Placebo Gel-Forming Suspension",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","A gel-forming suspension containing povidone-iodine and budesonide administered intra-sinus at the completion of endoscopic sinus surgery, intended to reduce postoperative inflammation and improve sinus cavity healing.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"A gel-forming suspension without povidone-iodine or budesonide administered intra-sinus at the completion of endoscopic sinus surgery.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Amin Javer","CONTACT","604-806-9926","sinusdoc@me.com",{"type":36,"investigatorFullName":31,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","MD","100622421","phase-3-intra-sinus-povidone-iodine-and-budesonide-after-endoscopic-sinus-surgery-for-chronic-rhinosinusitis-100622421",false,"NCT07383402","Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis","The Efficacy of Intra-sinus Povidone-iodine\u002FBudesonide Gel Forming Suspension Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis: a Randomized, Double Blind, Placebo-controlled Trial","PVP-I","Inclusion Criteria:\n\nAge 19 years or older Scheduled for Endoscopic Sinus Surgery (ESS)\n\nExclusion Criteria:\n\nCystic fibrosis Systemic vasculitis Known or suspected hypersensitivity to povidone iodine Inhaled drug use (i.e., cocaine) in the preceding 6 months Nasal tumors Known or suspected immunodeficiencies Pregnant women Breast feeding women","ALL","19 Years",{"count":49,"type":50},180,"ESTIMATED","INTERVENTIONAL",[53],"PHASE3","Endoscopic sinus surgery (ESS) is commonly performed in patients with chronic rhinosinusitis (CRS) to improve sinus drainage and allow better delivery of topical therapies after surgery. Despite surgery, postoperative inflammation can persist and negatively affect healing and outcomes.\n\nThis randomized, double-blind, placebo-controlled clinical trial will evaluate whether intra-sinus administration of a gel-forming suspension containing povidone-iodine and budesonide improves postoperative endoscopic outcomes of the sinus cavities three months following ESS, compared with placebo.",[56],"Chronic Rhinosinusitis (CRS)",[58,59],"Povidone Iodine","Budesonide","NOT_YET_RECRUITING","2026-01-26",{"date":63,"type":64},"2026-02-03","ACTUAL",{"date":66,"type":50},"2026-03-30",{"date":68,"type":50},"2028-01-01",{"name":31,"class":6}]