[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561707":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":30,"locations":40,"responsibleParty":72,"collaborators":23,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":23,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":23,"overallStatus":43,"whyStopped":23,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Indiana University","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Intrathecal Morphine","Intrathecal preservative free morphine (duramorph) 200 mcg with 7.5mg of hyperbaric bupivacaine placed by a spinal needle prior to induction of general anesthesia (n=71)",[12],"Drug: Inrathecal Morphine",{"label":14,"type":6,"description":15,"interventionNames":16},"Intravenous Methadone","Intravenous methadone dosed at 0.2 mg\u002Fkg Ideal Body weight up to a maximum dose of 20mg, rounded to the nearest milligram, for all patients given during the induction of general anesthesia (n=71)",[17],"Drug: Intravenous Methadone",[19,24],{"type":20,"name":21,"description":10,"armGroupLabels":22,"otherNames":23},"DRUG","Inrathecal Morphine",[9],null,{"type":20,"name":14,"description":15,"armGroupLabels":25,"otherNames":23},[14],[27],{"name":28,"affiliation":5,"role":29},"Gulraj S Chawla, MD","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":23,"email":35},"Lyla S Farlow","CONTACT","3179489804","lychrist@iu.edu",{"name":37,"role":33,"phone":38,"phoneExt":23,"email":39},"Angie Plummer","3179447293","plummera@iu.edu",[41,65],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Indiana Univeristy","RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-86.15804,39.76838,{"lat":53,"lon":52},[56,60,64],{"name":57,"role":33,"phone":58,"phoneExt":23,"email":59},"Lyla Farlow, LPN","317-984-9804","lychrist@iupui.edu",{"name":61,"role":33,"phone":62,"phoneExt":23,"email":63},"Angie Plummer, LPN","317-944-7239","plummera@iupui.edu",{"name":28,"role":29,"phone":23,"phoneExt":23,"email":23},{"facility":66,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"Indiana University Hospital",{"type":50,"coordinates":68},[52,53],{"lat":53,"lon":52},[71],{"name":23,"role":33,"phone":34,"phoneExt":23,"email":59},{"type":29,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Kevin Michael Backfish-White, MD","Dept. of Anesthesiology, Asst. Professor","100561707","phase-3-intrathecal-morphine-versus-intravenous-methadone-for-postoperative-analgesia-following-retroperitoneal-lymph-node-dissection-100561707",false,"NCT06593665","Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.","Randomized Prospective Study Comparing Intrathecal Morphine vs Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection (RPLND)","RPLND","Inclusion Criteria:\n\n* Patients undergoing a virgin (chemotherapy has not been used) or post- chemotherapy retroperitoneal lymph node dissection for primary testicular cancer at IU Health AAHC\n* ASA Class 1, 2, 3\n* Age 18 to 80 years; Male\n* BMI less than 50kg\u002Fm2\n\nExclusion Criteria:\n\n* Any contraindication for neuraxial analgesia\n* Patient on home methadone at any dose\n* Any physical, mental or medical conditions which, in the opinion of the investigators, may confound quantifying postoperative pain resulting from surgery.\n* Known true allergy to the study medications (morphine, bupivacaine, acetaminophen, methadone)\n* Any history of substance abuse in the past 6 months which would include heroin or any other illegal street drugs\n* End stage liver disease, end stage renal disease\n* Patient staying intubated after surgery\n* Patient (home dose) taking more than 30mg PO morphine equivalent (PME) per day\n* Any additional surgical procedures to the patient with a different surgical incision compared to the standard laparotomy for the RPLND procedure, i.e. thoracic tumor reduction","MALE","18 Years","80 Years",{"count":87,"type":88},142,"ESTIMATED","INTERVENTIONAL",[91],"PHASE3","This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular cancer. Investigators plan to compare their analgesic effectiveness at different postoperative time intervals.",[94],"Testicular Cancer","2026-02-11",{"date":97,"type":98},"2026-02-13","ACTUAL",{"date":100,"type":98},"2024-09-10",{"date":102,"type":88},"2026-12-31",{"name":5,"class":6},2]