[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502519":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":57,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"GPLET (Lenvatinib, Tislelizumab Plus Gemcitabine and Cisplatin)","EXPERIMENTAL","Intravenous injection: gemcitabine and cisplatin (CG)+ tislelizumab； Oral administration: lenvatinib.",[13],"Drug: Lenvatinib, tislelizumab, gemcitabine and cisplatin",{"label":15,"type":16,"description":17,"interventionNames":18},"CG (Gemcitabine and Cisplatin)","PLACEBO_COMPARATOR","Intravenous injection: gemcitabine and cisplatin (CG)+placebo； Oral administration: placebo.",[19],"Drug: Gemcitabine and cisplatin",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Lenvatinib, tislelizumab, gemcitabine and cisplatin","Intravenous injection: gemcitabine and cisplatin (CG) + tislelizumab； Oral administration: lenvatinib.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Gemcitabine and cisplatin","Intravenous injection: gemcitabine and cisplatin (CG) + placebo； Oral administration: placebo.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Weilin Wang, doctor","CONTACT","+86 0571 87783820","wam@zju.edu.cn",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"The Second Affiliated Hospital, Zhejiang University School of Medicine","RECRUITING","Hangzhou","Zhejiang","310009","China","CN",{"type":47,"coordinates":48},"Point",[49,50],120.16142,30.29365,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":35,"phoneExt":26,"email":36},"weilin wang, doctor",{"type":56,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[58,60],{"name":59,"class":6},"The First Affiliated Hospital of Zhengzhou University",{"name":61,"class":62},"The Affiliated Tumor Hospital of Xinjiang Medical University","UNKNOWN","100502519","phase-3-lenvatinib-tislelizumab-combined-with-gemcitabine-and-cisplatin-gplet-in-the-treatment-of-advanced-cholangiocarcinoma-100502519",false,"NCT05823311","Lenvatinib, Tislelizumab Combined with Gemcitabine and Cisplatin (GPLET) in the Treatment of Advanced Cholangiocarcinoma","A Randomized, Double-blind, Multicenter Study of Lenvatinib, Temalizumab Combined with Gemcitabine and Cisplatin (GPLET) in the Treatment of Advanced Cholangiocarcinoma","Inclusion Criteria:\n\n* Histologically proven, unresectable advanced or metastatic cholangiocarcinoma patients.\n* Expected survival period \\> 12 weeks.\n* The World Health Organization (WHO) \u002F ECOG physical status (PS) was 0 or 1.\n* There was at least one target lesion that matched the RECIST 1.1 criteria at baseline.\n* Not previously received immunotherapy, including but not limited to CTLA 4, PD-L1 or\u002Fand PD-1 inhibitors.\n* Adequate organ and bone marrow function, defined as follows: Hemoglobin (Hb)≥9.0g\u002FdL; Neutrophils (ANC) ≥ 1.5\\* 10\\^9\u002FL; Platelet (Pt) ≥ 50\\*10\\^9\u002FL; ALT≤2.5×ULN（Normal upper limit); AST≤2.5×ULN.\n* Voluntary participation and signing of informed consent.\n\nExclusion Criteria:\n\n* Active or previously documented autoimmune disease or inflammatory disease.\n* Uncontrolled complications.\n* History of other primary malignancies.\n* Active infection.\n* Women who are pregnant or breastfeeding.\n* Patients with severe allergic history or specific constitution.\n* Researchers consider it inappropriate to participate in the test.","ALL","18 Years","75 Years",{"count":74,"type":75},80,"ESTIMATED","INTERVENTIONAL",[78],"PHASE3","Cholangiocarcinoma (CCA) is a heterogeneous group of cancers arising from the epithelial cells of bile ducts. Because of highly aggressive malignancy, most of the patients are diagnosed at an advanced stage and lose the chance to undergo surgery.\n\nAs more effective and novel chemotherapy, targeted therapies, and immunotherapy become available, multiple treatments can be chosen for the patients with advanced CCA. Cytotoxic cell death during tumor chemotherapy triggers antigen release and induces strong anti-tumor effects of T cells. Tyrosine kinase inhibitors (TKI) can reduce the expression of PD-L1 and inhibit Treg cell infiltration, and together with immune checkpoint inhibitors, they can relieve tumor immunosuppressive microenvironment.\n\nTherefore, the study aims to investigate the safety and efficacy of Lenvatinib, Tislelizumab combined with Gemcitabine plus Cisplatin (GPLET) in the treatment of advanced cholangiocarcinoma.",[81],"Advanced Cholangiocarcinoma",[83,84,85],"Lenvatinib","Tislelizumab","Gemcitabine and Cisplatin","2025-02-05",{"date":88,"type":89},"2025-02-10","ACTUAL",{"date":91,"type":89},"2023-09-01",{"date":93,"type":75},"2027-12-31",{"name":5,"class":6},1]