[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573026":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":22,"centralContacts":25,"locations":31,"responsibleParty":53,"collaborators":22,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":22,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":22,"enrollmentInfo":66,"targetDuration":22,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":75,"overallStatus":34,"whyStopped":22,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Siriraj Hospital","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"81-mg aspirin once daily","ACTIVE_COMPARATOR",[12],"Drug: 81-mg aspirin once daily",{"label":14,"type":15,"description":14,"interventionNames":16},"81-mg aspirin twice daily","EXPERIMENTAL",[17],"Drug: 81-mg aspirin twice daily",[19,23],{"type":20,"name":9,"description":9,"armGroupLabels":21,"otherNames":22},"DRUG",[9],null,{"type":20,"name":14,"description":14,"armGroupLabels":24,"otherNames":22},[14],[26],{"name":27,"role":28,"phone":29,"phoneExt":22,"email":30},"Yingyong Chinthammitr, MD, RCPT, Thai board of hemato","CONTACT","+66 + 0814264252","dryingyong@gmail.com",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital","RECRUITING","Bangkok Noi","Bangkok","10700","Thailand","TH",{"type":41,"coordinates":42},"Point",[43,44],100.47798,13.76266,{"lat":44,"lon":43},[47,49],{"name":48,"role":28,"phone":29,"phoneExt":22,"email":30},"Yingyong Chinthammitr, MD",{"name":50,"role":28,"phone":51,"phoneExt":22,"email":52},"Tarinee Rungjirajitttranon, MD, Thai board of hematology","+66-097-051-2132","taitharee@gmail.com",{"type":54,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Yingyong Chinthammitr","Assistant Professor","100573026","phase-3-long-term-efficacy-of-once-daily-versus-twice-daily-aspirin-in-high-risk-mpn-patients-with-aspirin-resistance-100573026",false,"NCT06740916","Long-term Efficacy of Once Daily Versus Twice Daily Aspirin in High-risk MPN Patients With Aspirin Resistance","Long-term Efficacy of Once Daily Versus Twice Daily Aspirin in High-risk Myeloproliferative Neoplasms Patients With Aspirin Resistance","Inclusion Criteria:\n\n* Philadelphia negative Myeloproliferative neoplasms aged at least 18 years old\n\nExclusion Criteria:\n\n* Concomitant other active malignancy or cured less than 6 months\n* Platelet count less than 50,000\u002FmicroL\n* Receiving anticoagulant\n* Active peptic ulcer\n* Active bleeding or Planning to undergo procedure\u002Foperation with bleeding risk\n* No laboratory aspirin resistance with LTA method","ALL","18 Years",{"count":67,"type":68},240,"ESTIMATED","INTERVENTIONAL",[71],"PHASE3","Patients with myeloproliferative neoplasm (MPN) could have laboratory aspirin resistance and then increasing dose of aspirin from once daily to twice daily regimen is suggested. However, it is not routinely recommended to perform platelet function testing to determine aspirin resistance in MPN patients. Moreover, it is not known whether increasing dose of aspirin would always correct aspirin resistance and significantly prevent the thrombotic events in MPN patients. Therefore, this study aims to compare the efficacy of once daily versus twice daily aspirin in high-risk MPN patients with aspirin resistance. MPN patients with laboratory aspirin resistance will be included in this prospective randomized study and platelet function testing will be repeated at one and six months later. Clinical thrombosis and side effect from aspirin will be recorded for at least 2 years after intervention.",[74],"Myeloproliferative Neoplasms (MPN)",[76,77],"myeloproliferative neoplasm","aspirin resistance","2024-12-23",{"date":80,"type":81},"2024-12-27","ACTUAL",{"date":83,"type":81},"2024-12-12",{"date":85,"type":68},"2030-12-31",{"name":5,"class":6},1]