[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100433759":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":38,"locations":44,"responsibleParty":62,"collaborators":42,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":42,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":42,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":42,"overallStatus":47,"whyStopped":42,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group D","EXPERIMENTAL","Dexmedetomidine infusion IV for 5 days.",[13],"Drug: Dexmedetomidine",{"label":15,"type":16,"description":17,"interventionNames":18},"Group C","PLACEBO_COMPARATOR","The same dose and duration of normal saline will be given.",[19],"Other: 0.9% saline",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Dexmedetomidine","low dose dexmedetomidine infusion 0.2 µ\u002Fkg\u002Fhour IV for 5 days.",[9],[27],"Precedex",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"0.9% saline","the same dose and duration of normal saline will be given for 5 days.",[15],[33],"Normal saline",[35],{"name":36,"affiliation":5,"role":37},"Omar Soliman, MD","STUDY_DIRECTOR",[39],{"name":36,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","01101266040",null,"omarmakram347@yahoo.com",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Assiut university hospital","RECRUITING","Asyut","Assuit","Assuit universi","Egypt","EG",{"type":54,"coordinates":55},"Point",[56,57],31.18368,27.18096,{"lat":57,"lon":56},[60],{"name":61,"role":40,"phone":41,"phoneExt":42,"email":43},"Omar Soliman",{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":42,"oldOrganization":42},"PRINCIPAL_INVESTIGATOR","Omar Makram Soliman","Lecturer of anesthesia and ICU","100433759","phase-3-low-dose-dexmedetomidine-versus-normal-saline-in-multiple-fracture-ribs-100433759",false,"NCT04928300","Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs","Diaphragmatic Function, Pain Quality & Anti-inflammatory Properties: A Low Dose Dexmedetomidine Versus Ketamine in Patients With Multiple Fracture Ribs Needing Conservative Treatment","Inclusion Criteria:\n\n* Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II\n* Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT\n* Undergoing conservative treatment (chest strappings)\n* Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies\n* Glasgow Coma Scale (GCS) ≥ 13.\n\nExclusion Criteria:\n\n* Multiple traumas to body parts other than chest with an abbreviated injury scale over 3\n* Serious head trauma with a Glasgow coma scale lower than 13\n* Mechanically ventilated patients\n* Massive hemothorax\n* Injury to the trachea or bronchus with requirement for immediate surgery\n* Dementia\n* Use of corticosteroids during ICU stay\n* Sepsis\n* Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity\n* Contraindication to the study drugs.","ALL","18 Years","65 Years",{"count":77,"type":78},60,"ESTIMATED","INTERVENTIONAL",[81],"PHASE3","In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.",[84],"Rib Fractures","2025-12-27",{"date":87,"type":88},"2026-01-02","ACTUAL",{"date":90,"type":88},"2021-06-12",{"date":92,"type":78},"2027-07-25",{"name":5,"class":6},1]