[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609163":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":30,"locations":25,"responsibleParty":37,"collaborators":41,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":25,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":71,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":25},{"fullName":5,"class":6},"Sichuan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Ultrasound Therapy Will Enhance Bone Healing and Recovery After Jaw Cyst Surgery","EXPERIMENTAL","Ultrasound Therapy Arm (Intervention Group) Participants in this arm will undergo standard surgical treatment for jaw cysts (enucleation with curettage) followed by adjunctive low-intensity pulsed ultrasound (LIPUS) therapy. Starting on the third postoperative day, LIPUS will be delivered using the OSTEOTRON IV device (Japan) at a frequency of 1.5 MHz and an intensity of 30 mW\u002Fcm². Each treatment session will last 20 minutes, applied once daily for 10 consecutive days. A trained nurse will administer the therapy under standardized conditions, with patients in a supine position and a coupling gel applied to the skin overlying the surgical site.\n\nThe LIPUS intervention is expected to stimulate bone regeneration, reduce postoperative pain and numbness, and improve patients' overall recovery and quality of life compared with surgery alone.",[13],"Device: Low-Intensity Pulsed Ultrasound",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-LIPUS therapy","SHAM_COMPARATOR","Patients in the sham-LIPUS group underwent the same surgical procedure and received the same postoperative care as the ultrasound group. Beginning on the third day after surgery, they attended 10 daily sessions of sham treatment, each lasting 20 minutes. During these sessions, the same OSTEOTRON IV device was used, but it was deactivated so that no ultrasound waves were delivered. The device was applied to the skin over the cyst site with coupling gel in a controlled environment, mimicking the active treatment procedure.\n\nThis design ensured that patients experienced the same setup, duration, and sensations of treatment without receiving the therapeutic ultrasound, thereby maintaining blinding and allowing a direct comparison with the active LIPUS group.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Low-Intensity Pulsed Ultrasound","The LIPUS therapy protocol was administered by a trained nurse following standardized procedures. Starting on the third day post-enucleation, patients in the ultrasound group underwent LIPUS therapy using the OSTEOTRON IV device (Japan), set at a frequency of 1.5 MHz and an intensity of 30 mW\u002Fcm², with 20-minute sessions for 10 consecutive days (Fig. 1). Treatments were conducted in a temperature-controlled environment, with patients positioned supine. Prior to each session, the skin over the cyst site was cleansed and coated with ultrasound transmission gel (Hinuo, Qingdao, China).",[15,9],null,[27],{"name":28,"affiliation":5,"role":29},"long jie, PhD","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Sadam Ahmed Elayah, PhD","CONTACT","18682960907","0086","s.elayah90@gmail.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"SPONSOR_INVESTIGATOR","Sadam Elayah","Dr",[42],{"name":5,"class":6},"100609163","phase-3-low-intensity-pulsed-ultrasound-as-an-adjunctive-therapy-for-bone-regeneration-following-jaw-cyst-enucleation-100609163",false,"NCT07210983","Low-Intensity Pulsed Ultrasound as an Adjunctive Therapy for Bone Regeneration Following Jaw Cyst Enucleation","Low-Intensity Pulsed Ultrasound as an Adjunctive Therapy for Bone Regeneration Following Jaw Cyst Enucleation With Curettage: A Randomized Controlled Trial","LIPUS","Inclusion Criteria:\n\n* age ≥18 years.\n* having undergone cyst enucleation with curettage.\n* postoperative histopathological confirmation of a jaw cyst.\n* willingness to complete 10 days of standardized LIPUS therapy\n\nExclusion Criteria:\n\n* severe psychiatric disorders impairing compliance.\n* acute infection.\n* presence of a cardiac pacemaker.\n* osteoporosis.",true,"ALL","18 Years","60 Years",{"count":56,"type":57},29,"ESTIMATED","INTERVENTIONAL",[60],"PHASE3","This study tested whether low-intensity pulsed ultrasound (LIPUS) could help patients recover better after surgery to remove jaw cysts.\n\nA total of 29 patients with 33 jaw cysts were included. After surgery, they were randomly assigned to two groups:\n\nUltrasound group (17 patients, 18 cysts): received daily LIPUS therapy for 10 days.\n\nControl group (12 patients, 15 cysts): received the same care but with a sham (inactive) device.\n\nThe study was triple-blinded, meaning that the patients, the surgeon, and the evaluators did not know who was receiving real or sham treatment.\n\nResearchers measured recovery in several ways:\n\nPatient reports: pain, numbness, anxiety\u002Fdepression, and oral health-related quality of life.\n\nClinician monitoring: checked for any side effects (like infection or burns). Imaging tests (CBCT scans): tracked how well bone healed by measuring changes in cyst cavity size (volume reduction) and new bone density.\n\nAll patients had the same type of surgery, performed by the same surgeon, and all provided written informed consent. The study followed international ethics and trial registration standards.",[63,64],"Jaw Cysts","Curettage",[66,67,63,68,69,70],"Bone Regeneration","Hounsfield unit","Low-intensity pulsed ultrasound","Three-Dimensional Volumetric Analysis","Bone Density","NOT_YET_RECRUITING","2025-09-30",{"date":74,"type":75},"2025-10-07","ACTUAL",{"date":77,"type":57},"2025-10-22",{"date":79,"type":57},"2026-05-30",{"name":39,"class":6}]