[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643816":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":50,"locations":59,"responsibleParty":73,"collaborators":54,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":54,"enrollmentInfo":85,"targetDuration":54,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":98,"whyStopped":54,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"Wake Forest University Health Sciences","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Arm One, Magnesium Sulfate 2g followed by metoprolol 5 mg","EXPERIMENTAL","Study drug (Magnesium Sulfate 2 gram\u002F50ml 0.9% NaCl) will be administered over a time interval of 15 minutes. Immediately after study drug administration, intravenous metoprolol 5 mg will be administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of study drug will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.",[13],"Drug: Magnesium Sulfate 2g",{"label":15,"type":10,"description":16,"interventionNames":17},"Experimental Arm Two, Magnesium Sulfate 4g followed by metoprolol","Study drug (Magnesium Sulfate 4 gram\u002F50ml 0.9% NaCl) will be administered over a time interval of 15 minutes. Immediately after study drug administration, intravenous metoprolol 5 mg will be administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of study drug will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.",[18],"Drug: Magnesium Sulfate 4g",{"label":20,"type":21,"description":22,"interventionNames":23},"Control Arm, normal saline followed by metoprolol","PLACEBO_COMPARATOR","50ml 0.9% NaCl will be administered over a time interval of 15 minutes. Intravenous metoprolol 5 mg will be immediately administered as an IV push over 2 minutes. Additional doses of metoprolol 5 mg as an IV push over 1 minute permissible, however additional doses of saline will not be administered. Emergency Medicine physician may provide additional doses of intravenous metoprolol every 5 minutes based on clinical necessity.",[24],"Drug: Saline (0.9% NaCl)",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Magnesium Sulfate 2g","Magnesium Sulfate 2g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)",[9],[32],"Magnesium Sulfate 2 gram\u002F50ml 0.9% NaCl",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Magnesium Sulfate 4g","Magnesium Sulfate 4g for the treatment of atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR)",[15],[38],"Magnesium Sulfate 4 gram\u002F50ml 0.9% NaCl",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Saline (0.9% NaCl)","The control group will receive a bolus of normal saline of the same volume and infused over 15 minutes.",[20],[44],"Control (50ml 0.9% NaCl)",[46],{"name":47,"affiliation":48,"role":49},"Marc McDowell, PharmD","Advocate Christ Medical Center Emergency Department","PRINCIPAL_INVESTIGATOR",[51,56],{"name":47,"role":52,"phone":53,"phoneExt":54,"email":55},"CONTACT","(708) 684-1078",null,"marc.mcdowell@aah.org",{"name":57,"role":52,"phone":54,"phoneExt":54,"email":58},"Thomas Szwajnos","Thomas.Szwajnos@aah.org",[60],{"facility":61,"status":54,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":54},"Advocate Christ Medical Center Emergency Department (ACMC ED)","Oak Lawn","Illinois","60453","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-87.75811,41.71087,{"lat":71,"lon":70},{"type":74,"investigatorFullName":54,"investigatorTitle":54,"investigatorAffiliation":54,"oldNameTitle":54,"oldOrganization":54},"SPONSOR","100643816","phase-3-magnesium-with-metoprolol-for-rate-control-in-atrial-fibrillation-100643816",false,"NCT07632157","MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation","MAGNEsium With meToprolol for Rate Control In Atrial Fibrillation (MAGNETIC-AF)","MAGNETIC-AF","Inclusion Criteria:\n\n* Age \\> 18 years or older\n* Able to provide informed consent\n* Primary diagnosis atrial fibrillation or atrial flutter with rapid ventricular response (AFF RVR) greater than or equal to 120 beats per minute\n* Metoprolol as rate control agent\n* English speaking\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients (SBP \\\u003C90, MAP \\\u003C65)\n* Impaired consciousness\n* Acute heart failure exacerbation based on clinical diagnosis, physician exam, bedside echo, and\u002For additional imaging\n* Patient in AFF RVR that is highly suspected to be a compensatory mechanism for an alternative clinical diagnosis\n* Rhythms other than atrial fibrillation, such as sick sinus syndrome or wide-complex ventricular response\n* Acute myocardial infarction\n* Contraindications to magnesium sulfate (including myasthenia gravis)\n* Allergy or sensitivity to any study drugs\n* Previously enrolled in this trial during a different patient encounter\n* Withdrew from study","ALL","18 Years",{"count":86,"type":87},196,"ESTIMATED","INTERVENTIONAL",[90],"PHASE3","The purpose of this research study is to find out if the use of magnesium in addition to Metoprolol, a rate controlling medication that you would be offered in the Emergency Department today unrelated to this study, will help reduce your high heart rate (rapid ventricular response).",[93],"Atrial Flutter With Rapid Ventricular Response",[95,96,97],"AFF RVR","intravenous magnesium","atrial flutter","NOT_YET_RECRUITING","2026-06-24",{"date":101,"type":102},"2026-06-29","ACTUAL",{"date":104,"type":87},"2026-10",{"date":106,"type":87},"2028-12",{"name":5,"class":6},1]