[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100500493":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":41,"centralContacts":45,"locations":54,"responsibleParty":71,"collaborators":74,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":31,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":31,"overallStatus":56,"whyStopped":31,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},{"fullName":5,"class":6},"Tampere University Hospital","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Guided physical exercise arm","EXPERIMENTAL","20 patients from each type of cancer (altogether 80) are randomized to a 3 months guided physical exercise arm. At the beginning of the intervention the patients' physical condition and body composition are measured. After that an exercise program begins. All subjects participate in physical exercise program twice a week for three months. At the end of the intervention, the physical condition and body composition are measured again. During the follow-up after the intervention the patients are advised to exercise regularly. Physical condition and body composition are measured again after 6 months. Exercise activity is asked during each follow-up visit.\n\nIn addition, as a separate group, 20 patients from each type of cancer (altogether 80) who are already using statin medication are randomized to this arm.",[13],"Behavioral: Guided physical exercise",{"label":15,"type":10,"description":16,"interventionNames":17},"Atorvastatin arm","20 patients from each type of cancer (altogether 80) are randomized to a 3 months guided physical exercise + atorvastatin (40 mg QD) arm. At the beginning of the intervention the patients' physical condition and body composition are measured. After that an exercise program begins. All subjects participate in physical exercise program twice a week for three months. At the end of the intervention, the physical condition and body composition are measured again. During the follow-up after the intervention the patients are advised to exercise regularly. Physical condition and body composition are measured again after 6 months. Exercise activity is asked during each follow-up visit.",[13,18],"Drug: Atorvastatin",{"label":20,"type":21,"description":22,"interventionNames":23},"Non-guided physical exercise arm","ACTIVE_COMPARATOR","20 patients from each type of cancer (altogether 80) are randomized to a non-guided physical exercise arm. The patients' physical condition and body composition are measured at baseline. The control group is advised of the benefits of physical exercise and they get an exercise program to follow. Participants in the control group exercise on their own. The physical condition and body composition of this group is also measured at three months and six months after baseline to detect changes. After that the patients are given advise to exercise regularly and this is asked during each follow-up visit.\n\nIn addition, as a separate group, 20 patients from each type of cancer (altogether 80) who are already using statin medication are randomized to this arm.",[24],"Other: Independent exercise",[26,32,37],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","Guided physical exercise","Patients will be participating in guided physical exercise program regularly two times \u002F week at a sports facility and guided by a professional trainer. They will participate in aerobic and resistance exercises during the sessions.",[15,9],null,{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":31},"DRUG","Atorvastatin","Patients will be participating in guided physical exercise program regularly two times \u002F week at a sports facility and guided by a professional trainer. They will participate in aerobic and resistance exercises during the sessions. In addition to the exercise program they will be given atorvastatin 40 mg QD medication.",[15],{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"Independent exercise","The control group is advised of the benefits of physical exercise and they get an exercise program to follow. Participants in the control group exercise on their own.",[20],[42],{"name":43,"affiliation":5,"role":44},"Teemu Murtola, MD PhD Prof","PRINCIPAL_INVESTIGATOR",[46,50],{"name":43,"role":47,"phone":48,"phoneExt":31,"email":49},"CONTACT","03-311611","teemu.murtola@tuni.fi",{"name":51,"role":47,"phone":52,"phoneExt":31,"email":53},"Jorma Sormunen, MD PhD MBA","0505001869","jorma.sormunen@fimnet.fi",[55],{"facility":5,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"RECRUITING","Tampere","Länsi-Suomi","33520","Finland","FI",{"type":63,"coordinates":64},"Point",[65,66],23.78712,61.49911,{"lat":66,"lon":65},[69,70],{"name":43,"role":47,"phone":31,"phoneExt":31,"email":49},{"name":51,"role":47,"phone":31,"phoneExt":31,"email":53},{"type":44,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"Teemu Murtola","Professor of Urology, Chief Physician",[75,77,79,81],{"name":76,"class":6},"Tampere University",{"name":78,"class":6},"Aalto University",{"name":80,"class":6},"University of Helsinki",{"name":82,"class":6},"University of Turku","100500493","phase-3-measuring-oncological-value-of-exercise-and-statin-100500493",false,"NCT05796973","Measuring Oncological Value of Exercise and Statin","Syöpäpotilaan Ennusteen Parantaminen Muuttamalla syövän mikroympäristöä ja Metaboliaa Liikunnalla ja lääkkeellisesti - Measuring Oncological Value of Exercise and Statin","MOVES","Inclusion Criteria:\n\n* The patient has metastatic prostate cancer, breast cancer, ovarian cancer or kidney cancer confirmed histologically and by imaging, for which 1st-line cancer drug treatment is started\n* Prostate cancer: First course of docetaxel treatment or second-generation antiandrogen treatment for metastatic prostate cancer.\n* Breast cancer: First-line medical treatment of metastatic breast cancer regardless of hormone receptor status.\n* Kidney cancer: Kidney cancer, for which 1st-line cancer drug treatment is started as tki monotherapy and\u002For IO monotherapy or as a combination therapy.\n* Ovarian cancer: stage III or IV cancer for which chemotherapy treatment is started.\n* The patient agrees to the study and signs a written informed consent.\n* Adult (18 years=\\>) women (breast, ovarian and kidney cancer) and men (prostate and kidney cancer) are recruited for the study.\n* In women, the use of a reliable contraceptive during the intervention\n\nExclusion Criteria:\n\n* High risk of bone fractures\n* Inability to physical exertion and\u002For unsuitability for cancer drug treatment\n* Poor co-operation ability for psychological reasons\n* Active use of cholesterol-lowering drugs\n* Severe liver or kidney failure\n* Troublesome side effects that occurred in the past during cholesterol medication\n* Continuous use of medicinal substances that interact with atorvastatin during the study period\n* A special group of subjects according to the EU Clinical Trials Regulation 536\u002F2014 (e.g. pregnant or lactating women)\n\nExclusion criteria in patients who are already using statin medication before the study:\n\n* High risk of bone fractures\n* Inability to physical exertion and\u002For unsuitability for cancer drug treatment\n* Poor co-operation ability for psychological reasons\n* Severe liver or kidney failure\n* A special group of subjects according to the EU Clinical Trials Regulation 536\u002F2014 (e.g. pregnant or lactating women)","ALL","18 Years","99 Years",{"count":95,"type":96},240,"ESTIMATED","INTERVENTIONAL",[99],"PHASE3","The aim of the study is to find out whether supervised physical exercise during cancer drug treatment improves the effectiveness of the treatment in metastasized breast, kidney, ovarian and prostate cancer compared to unsupervised exercise. In addition, the investigators are investigating whether the use of atorvastatin combined with guided group exercise training would further improve the response to cancer treatment.",[102,103,104,105,106,107,108,109,110,111,112,113],"Prostate Cancer","Breast Cancer","Kidney Cancer","Ovarian Cancer","Metastatic Breast Cancer","Metastatic Kidney Cancer","Metastatic Renal Cell Carcinoma","Metastatic Renal Cancer","Metastatic Prostate Cancer","Metastatic Prostate Adenocarcinoma","Metastatic Ovarian Cancer","Metastatic Ovary Cancer","2025-06-23",{"date":116,"type":117},"2025-06-27","ACTUAL",{"date":119,"type":117},"2023-03-31",{"date":121,"type":96},"2027-12-31",{"name":5,"class":6},1]