[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556602":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":60,"collaborators":25,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":25,"enrollmentInfo":72,"targetDuration":25,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ultrasound-guided betamethasone infiltration of the meniscal wall","EXPERIMENTAL","patients allocated to the experimental group will receive a single betamethasone infiltration (1mL) of the meniscal wall under ultrasound guidance.",[13],"Drug: ultrasound-guided betamethasone infiltration of the meniscal wall",{"label":15,"type":16,"description":17,"interventionNames":18},"ultrasound-guided physiological serum infiltration of the meniscal wall","PLACEBO_COMPARATOR","patients allocated to the control group will receive a single placebo infiltration of isotonic saline (1mL) of the meniscal wall under ultrasound guidance.",[19],"Drug: ultrasound-guided isotonic saline (placebo) infiltration of the meniscal wall",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","The perimeniscal injections will be guided by ultrasound with an 18 megahertz (MHz) linear probe under strict aseptic conditions. Doppler will be systematically used before the injection to identify the medial or lateral inferior geniculate artery. The first step will consist of local anesthesia with 2 ml of lidocaine injected into the subcutaneous tissues and close to the meniscus wall using a 25-gauge needle. Using an in-plane approach, a 21-gauge needle will be positioned under ultrasound guidance in the medial or lateral wall of the meniscus. Once the needle touches the meniscus wall, it will be withdrawn 1 mm, and a 1-ml injection of betamethasone into the meniscus wall will be performed.",[9],null,{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"ultrasound-guided isotonic saline (placebo) infiltration of the meniscal wall","The perimeniscal injections will be guided by ultrasound with an 18 MHz linear probe under strict aseptic conditions. Doppler will be systematically used before the injection to identify the medial or lateral inferior geniculate artery. The first step will consist of local anesthesia with 2 ml of isotonic saline injected into the subcutaneous tissues and close to the meniscus wall using a 25-gauge needle. Using an in-plane approach, a 21-gauge needle will be positioned under ultrasound guidance in the medial or lateral wall of the meniscus. Once the needle touches the meniscus wall, it will be withdrawn 1 mm, and a 1-ml injection of betamethasone into the meniscus wall will be performed.",[15],[31],{"name":32,"affiliation":5,"role":33},"Marie FARUCH, MD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":32,"role":36,"phone":37,"phoneExt":38,"email":39},"CONTACT","05 61 77 22 97","+33","faruch.m@chu-toulouse.fr",{"name":41,"role":36,"phone":25,"phoneExt":25,"email":25},"Virginie SICART",[43],{"facility":44,"status":45,"city":46,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"UHToulouse","RECRUITING","Toulouse","France","FR",{"type":50,"coordinates":51},"Point",[52,53],1.44367,43.60426,{"lat":53,"lon":52},[56,58],{"name":41,"role":36,"phone":25,"phoneExt":25,"email":57},"sicart.v@chu-toulouse.fr",{"name":59,"role":33,"phone":25,"phoneExt":25,"email":25},"Marie FARUCH, PU PH",{"type":61,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100556602","phase-3-meniscal-infiltration-of-corticosteroid-guided-with-ultra-sonography-100556602",false,"NCT06527235","Meniscal INfiltration of Corticosteroid Guided With Ultra Sonography","Efficacy of Ultrasound-monitored Meniscal Wall Betamethasone Infiltration on Pain in Relation to Degenerative Meniscal Injury: a Randomized, Double-blind, Placebo-controlled Multicenter Trial.","MINUS","Inclusion Criteria:\n\n* Localized knee pain with tenderness over the medial or lateral joint space reproduced on clinical examination\n* Pain assessed with a VAS score \\> 4\u002F10 despite first-line medical treatment including the use of tier I or II analgesics or NSAIDs.\n* An MRI of the knee performed in the 6 months preceding the operation as part of the pre-treatment assessment\n* Medial or lateral degenerative meniscal lesion on MRI consistent with pain, confirmed by an investigating physician\n* Affiliation to the Social Security\n* Free and informed consent signed by the patient\n\nExclusion Criteria:\n\n* Patient under curatorship, guardianship or safeguard of justice\n* Inability to speak, read or write French fluently\n* Patient deprived of liberty\n* Patients with psychiatric pathology\n* Patient who has had an MRI showing an unstable meniscal lesion: complete vertical tear of more than 10 mm in length, capsulomeniscal disinsertion of more than 10 mm in length, complex tear, T2 hypersignal tear of liquid type with passage of liquid testifying to the spreading of the edges, tear with displaced meniscal fragment, lesion of a posterior meniscal brake, lesion of the meniscotibial or meniscofemoral attachment\n* Patient with an MRI showing recent ligament injury(ies) (cruciate ligaments and\u002For collateral ligaments)\n* History of knee trauma less than 3 months\n* History of arthroscopy or open surgery of the involved knee,\n* History of corticosteroid injection in the knee concerned in the 3 months preceding inclusion,\n* Use of NSAIDs and oral corticosteroids during the 48 hours preceding inclusion\n* Use of tier 3 analgesics for gonalgia in the 3 months prior to inclusion\n* Episodes of knee instability or true locking\n* Radiographic gonarthrosis with a Kellgren Lawrence stage \\>1 authenticated on radiographic images taken within the last 6 months.\n* Known inflammatory rheumatism\n* Fibromyalgia as determined by the clinical investigator\n* Pregnancy and breastfeeding in progress\n* Contraindication to the use of injectable corticosteroids: septic arthritis, skin lesions at the injection site, severe coagulation disorders, hypersensitivity to one of the excipients\n* Contraindication to the use of systemic corticosteroids: acute infection, untreated and uncontrolled chronic infection, psychiatric or ophthalmological pathologies, unbalanced diabetes, uncontrolled hypertension\n* Contraindication to the use of lidocaine: known hypersensitivity to lidocaine hydrochloride, to local anaesthetics with an amide bond or to one of the excipients, patients with recurrent porphyrias\n* Patients on anticoagulants","ALL","18 Years",{"count":73,"type":74},152,"ESTIMATED","INTERVENTIONAL",[77],"PHASE3","The value of corticosteroid infiltration of the meniscus wall in the therapeutic strategy is not clearly defined: the data in the literature on the effectiveness of corticosteroid infiltration are heterogeneous and of low level of proof. We hypothesize that corticosteroid infiltration of the meniscal wall under ultrasound control would be effective for rapid relief of degenerative meniscal pain.\n\nThe main objective is to evaluate the efficacy of ultrasound-guided meniscal wall infiltration of betamethasone versus ultrasound-guided meniscal wall infiltration of placebo, at 1 month, on meniscal pain in the treatment of meniscal pain of degenerative origin in adult.",[80],"Meniscus Lesion",[82,83,84,85],"Betamethasone Injections","Meniscus","Ultrasonography","Randomized controlled Trial","2025-11-26",{"date":88,"type":89},"2025-12-04","ACTUAL",{"date":91,"type":89},"2025-03-06",{"date":93,"type":74},"2028-06-01",{"name":5,"class":6},1]