[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100568333":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":323,"collaborators":325,"id":329,"slug":330,"hasResults":331,"nctId":332,"briefTitle":333,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":331,"sex":336,"minAge":25,"maxAge":337,"enrollmentInfo":338,"targetDuration":25,"studyType":341,"phases":342,"briefSummary":344,"conditions":345,"keywords":25,"overallStatus":76,"whyStopped":25,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":351,"completionDateStruct":353,"leadSponsor":355,"locationsCount":356},{"fullName":5,"class":6},"NICHD Neonatal Research Network","NETWORK",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","An iv infusion of placebo (0.9% saline) of equivalent volume will be administered. The infusion will be accompanied by an iv bolus of 10 mL\u002Fkg of 0.9% NaCl (administered over 60 minutes) to ensure blinding is maintained.",[13],"Drug: Placebo infusion",{"label":15,"type":16,"description":17,"interventionNames":18},"Milrinone","ACTIVE_COMPARATOR","An intravenous (iv) infusion of milrinone will be administered at an initial dose of 0.33 mcg\u002Fkg\u002Fmin and accompanied by an iv bolus of 10 mL\u002Fkg of 0.9% NaCl (administered over 60 minutes).",[19],"Drug: Milrinone infusion",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"DRUG","Milrinone infusion",[15],null,{"type":22,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"Placebo infusion",[9],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Patrick J McNamara","CONTACT","319-467-7435","patrick-mcnamara@uiowa.edu",{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},"Valerie Chock","650-723-5711","vchock@stanford.edu",[40,59,74,86,100,115,130,145,160,175,190,205,220,234,249,264,279,294,308],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"University of Alabama - Birmingham","NOT_YET_RECRUITING","Birmingham","Alabama","35249","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-86.80249,33.52066,{"lat":52,"lon":51},[55],{"name":56,"role":32,"phone":57,"phoneExt":25,"email":58},"Waldemar A Carlo","205-934-4680","wcarlo@peds.uab.edu",{"facility":60,"status":42,"city":61,"state":62,"zip":63,"country":46,"countryCode":47,"cosmosGeoPoint":64,"geoPoint":68,"contacts":69},"Children's Hospital of Orange County","Orange","California","92868",{"type":49,"coordinates":65},[66,67],-117.85311,33.78779,{"lat":67,"lon":66},[70],{"name":71,"role":32,"phone":72,"phoneExt":25,"email":73},"Amir H Ashrafi","714-509-4373","Aashrafi@choc.org",{"facility":75,"status":76,"city":77,"state":62,"zip":78,"country":46,"countryCode":47,"cosmosGeoPoint":79,"geoPoint":83,"contacts":84},"Stanford University","RECRUITING","Palo Alto","94304",{"type":49,"coordinates":80},[81,82],-122.14302,37.44188,{"lat":82,"lon":81},[85],{"name":36,"role":32,"phone":37,"phoneExt":25,"email":38},{"facility":87,"status":42,"city":88,"state":62,"zip":89,"country":46,"countryCode":47,"cosmosGeoPoint":90,"geoPoint":94,"contacts":95},"Sharp Mary Birch Hospital for Women & Newborns","San Diego","92123",{"type":49,"coordinates":91},[92,93],-117.16472,32.71571,{"lat":93,"lon":92},[96],{"name":97,"role":32,"phone":98,"phoneExt":25,"email":99},"Anup Katheria","858-939-4170","anup.katheria@sharp.com",{"facility":101,"status":76,"city":102,"state":103,"zip":104,"country":46,"countryCode":47,"cosmosGeoPoint":105,"geoPoint":109,"contacts":110},"Emory University","Atlanta","Georgia","30322",{"type":49,"coordinates":106},[107,108],-84.38798,33.749,{"lat":108,"lon":107},[111],{"name":112,"role":32,"phone":113,"phoneExt":25,"email":114},"Ravi M Patel","404-727-5905","rmpatel@emory.edu",{"facility":116,"status":76,"city":117,"state":118,"zip":119,"country":46,"countryCode":47,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Northwestern Lurie Children's Hospital of Chicago","Chicago","Illinois","60611",{"type":49,"coordinates":121},[122,123],-87.65005,41.85003,{"lat":123,"lon":122},[126],{"name":127,"role":32,"phone":128,"phoneExt":25,"email":129},"Aaron Hamvas","312-227-4190","ahamvas@luriechildrens.org",{"facility":131,"status":76,"city":132,"state":133,"zip":134,"country":46,"countryCode":47,"cosmosGeoPoint":135,"geoPoint":139,"contacts":140},"University of Iowa","Iowa City","Iowa","52242",{"type":49,"coordinates":136},[137,138],-91.53017,41.66113,{"lat":138,"lon":137},[141],{"name":142,"role":32,"phone":143,"phoneExt":25,"email":144},"Tarah Colaizy","319-356-3508","tarah-colaizy@uiowa.edu",{"facility":146,"status":76,"city":147,"state":148,"zip":149,"country":46,"countryCode":47,"cosmosGeoPoint":150,"geoPoint":154,"contacts":155},"Boston Children's Hospital","Boston","Massachusetts","02115",{"type":49,"coordinates":151},[152,153],-71.05977,42.35843,{"lat":153,"lon":152},[156],{"name":157,"role":32,"phone":158,"phoneExt":25,"email":159},"Philip Levy","617-919-2358","Philip.Levy@childrens.harvard.edu",{"facility":161,"status":42,"city":162,"state":163,"zip":164,"country":46,"countryCode":47,"cosmosGeoPoint":165,"geoPoint":169,"contacts":170},"University of Mississippi Medical Center","Jackson","Mississippi","39216",{"type":49,"coordinates":166},[167,168],-90.18481,32.29876,{"lat":168,"lon":167},[171],{"name":172,"role":32,"phone":173,"phoneExt":25,"email":174},"Abhay Bhatt","601-984-5263","abhatt@umc.edu",{"facility":176,"status":76,"city":177,"state":178,"zip":179,"country":46,"countryCode":47,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"University of New Mexico","Albuquerque","New Mexico","87131",{"type":49,"coordinates":181},[182,183],-106.65114,35.08449,{"lat":183,"lon":182},[186],{"name":187,"role":32,"phone":188,"phoneExt":25,"email":189},"Janell Fuller","505-272-6409","jafuller@salud.unm.edu",{"facility":191,"status":76,"city":192,"state":193,"zip":194,"country":46,"countryCode":47,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"Duke University","Durham","North Carolina","27705",{"type":49,"coordinates":196},[197,198],-78.89862,35.99403,{"lat":198,"lon":197},[201],{"name":202,"role":32,"phone":203,"phoneExt":25,"email":204},"Michael Cotten","919-681-0630","michael.cotten@duke.edu",{"facility":206,"status":76,"city":207,"state":208,"zip":209,"country":46,"countryCode":47,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Cincinnati Children's Hospital Medical Center","Cincinnati","Ohio","45229",{"type":49,"coordinates":211},[212,213],-84.51439,39.12711,{"lat":213,"lon":212},[216],{"name":217,"role":32,"phone":218,"phoneExt":25,"email":219},"Stephanie Merhar","513-803-5180","Stephanie.Merhar@cchmc.org",{"facility":221,"status":76,"city":222,"state":208,"zip":223,"country":46,"countryCode":47,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Case Western Reserve University","Cleveland","44106",{"type":49,"coordinates":225},[226,227],-81.69541,41.4995,{"lat":227,"lon":226},[230],{"name":231,"role":32,"phone":232,"phoneExt":25,"email":233},"Anna Maria Hibbs","216-844-3387","annamaria.hibbs@cwru.edu",{"facility":235,"status":76,"city":236,"state":237,"zip":238,"country":46,"countryCode":47,"cosmosGeoPoint":239,"geoPoint":243,"contacts":244},"University of Oklahoma Health Sciences","Oklahoma City","Oklahoma","73104",{"type":49,"coordinates":240},[241,242],-97.51643,35.46756,{"lat":242,"lon":241},[245],{"name":246,"role":32,"phone":247,"phoneExt":25,"email":248},"Marjorie Makoni","405-271-5215","Marjorie-Makoni@ouhsc.edu",{"facility":250,"status":76,"city":251,"state":252,"zip":253,"country":46,"countryCode":47,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":49,"coordinates":255},[256,257],-75.16362,39.95238,{"lat":257,"lon":256},[260],{"name":261,"role":32,"phone":262,"phoneExt":25,"email":263},"Sara DeMauro","215-590-3730","demauro@email.chop.edu",{"facility":265,"status":76,"city":266,"state":267,"zip":268,"country":46,"countryCode":47,"cosmosGeoPoint":269,"geoPoint":273,"contacts":274},"Le Bonheur Children's Hospital","Memphis","Tennessee","38103",{"type":49,"coordinates":270},[271,272],-90.04898,35.14953,{"lat":272,"lon":271},[275],{"name":276,"role":32,"phone":277,"phoneExt":25,"email":278},"Mark Weems","901-448-2262","mweems@uthsc.edu",{"facility":280,"status":76,"city":281,"state":282,"zip":283,"country":46,"countryCode":47,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"University of Texas Southwestern","Dallas","Texas","75390",{"type":49,"coordinates":285},[286,287],-96.80667,32.78306,{"lat":287,"lon":286},[290],{"name":291,"role":32,"phone":292,"phoneExt":25,"email":293},"Myra H Wyckoff","214-590-4003","myra.wyckoff@utsouthwestern.edu",{"facility":295,"status":76,"city":296,"state":282,"zip":297,"country":46,"countryCode":47,"cosmosGeoPoint":298,"geoPoint":302,"contacts":303},"University of Texas at Houston","Houston","77030",{"type":49,"coordinates":299},[300,301],-95.36327,29.76328,{"lat":301,"lon":300},[304],{"name":305,"role":32,"phone":306,"phoneExt":25,"email":307},"Matthew Rysavy","713-500-6643","matthew.a.rysavy@uth.tmc.edu",{"facility":309,"status":76,"city":310,"state":311,"zip":312,"country":46,"countryCode":47,"cosmosGeoPoint":313,"geoPoint":317,"contacts":318},"University of Utah","Salt Lake City","Utah","84108",{"type":49,"coordinates":314},[315,316],-111.89105,40.76078,{"lat":316,"lon":315},[319],{"name":320,"role":32,"phone":321,"phoneExt":25,"email":322},"Robin Ohls","801-213-1487","robin.ohls@hsc.utah.edu",{"type":324,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[326],{"name":327,"class":328},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100568333","phase-3-milrinone-for-prevention-of-post-ligation-cardiac-syndrome-trial-100568333",false,"NCT06679855","Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial","MIDAS","Inclusion Criteria:\n\n* Gestational age at birth ≤27 weeks (and 6 days) and postnatal age \\\u003C 3 months at intervention\n* Invasive or non-invasive positive pressure respiratory support (does not include low flow nasal cannula)\n* Hemodynamically significant PDA with minimum transductal diameter ≥1.0 mm within 2 days of intervention\n* Decision by clinical team to proceed with PDA closure via surgical ligation or percutaneous cardiac catheterization based on clinical and echocardiography features of hemodynamic significance.\n\nExclusion Criteria:\n\n* Any major congenital malformation\n* Congenital heart disease (except small (≤1mm) muscular ventricular septal defects, or small\u002Fmoderate (\\\u003C3mm) atrial septal defect)\n* Acute renal failure defined by urine output \\\u003C 0.5 mL\u002Fkg\u002Fhour OR rise of serum creatinine by 0.3 mg\u002FdL within 48 hours OR rise of serum creatinine more than 40% above baseline serum creatinine within prior 72 hours.\n* Systemic administration of vasodilator\u002Finodilator agents\n* Prior history of arrhythmia","ALL","3 Months",{"count":339,"type":340},316,"ESTIMATED","INTERVENTIONAL",[343],"PHASE3","The goal of this Phase 3, randomized, masked clinical trial is to is to find out whether milrinone, when given to infants after PDA closure, will help the heart work better by supplying oxygen to the lungs and tissues.\n\nThe main questions it aims to answer are:\n\n1. to determine if milrinone decreases the risk of death or PLCS within 7 days of the procedure, compared to standard treatment; and\n2. to determine the effects of milrinone on two-year survival and neurodevelopmental outcome.",[346],"Post-ligation Cardiac Syndrome","2026-06-29",{"date":349,"type":350},"2026-07-01","ACTUAL",{"date":352,"type":350},"2025-06-13",{"date":354,"type":340},"2029-06-30",{"name":5,"class":6},19]