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OBGYN","Falls Church","22042",{"type":48,"coordinates":662},[663,664],-77.17109,38.88233,{"lat":664,"lon":663},{"facility":667,"status":41,"city":668,"state":650,"zip":669,"country":45,"countryCode":46,"cosmosGeoPoint":670,"geoPoint":674,"contacts":26},"Virginia Women's Health Associates","Reston","20190",{"type":48,"coordinates":671},[672,673],-77.3411,38.96872,{"lat":673,"lon":672},{"facility":676,"status":101,"city":677,"state":678,"zip":679,"country":680,"countryCode":681,"cosmosGeoPoint":682,"geoPoint":686,"contacts":26},"The Ottawa Hospital, Riverside Campus - Department of Obstetrics, Gynecology and Newborn Care","Ottawa","Ontario","K1H 7W9","Canada","CA",{"type":48,"coordinates":683},[684,685],-75.69812,45.41117,{"lat":685,"lon":684},{"facility":688,"status":41,"city":689,"state":678,"zip":690,"country":680,"countryCode":681,"cosmosGeoPoint":691,"geoPoint":695,"contacts":26},"Mount Sinai Hospital Toronto | Gynecology","Toronto","M5G 1Z5",{"type":48,"coordinates":692},[693,694],-79.39864,43.70643,{"lat":694,"lon":693},{"facility":697,"status":101,"city":698,"state":699,"zip":700,"country":680,"countryCode":681,"cosmosGeoPoint":701,"geoPoint":705,"contacts":26},"Centres Investigation Clinique Mauricie","Trois-Rivières","Quebec","G8T 7A1",{"type":48,"coordinates":702},[703,704],-72.5477,46.34515,{"lat":704,"lon":703},{"facility":707,"status":101,"city":708,"state":709,"zip":710,"country":711,"countryCode":712,"cosmosGeoPoint":713,"geoPoint":717,"contacts":26},"China-Japan Friendship Hospital","Beijing","Beijing Municipality","100029","China","CN",{"type":48,"coordinates":714},[715,716],116.39723,39.9075,{"lat":716,"lon":715},{"facility":719,"status":101,"city":708,"state":709,"zip":720,"country":711,"countryCode":712,"cosmosGeoPoint":721,"geoPoint":723,"contacts":26},"Peking Union Medical College Hospital CAMS","100730",{"type":48,"coordinates":722},[715,716],{"lat":716,"lon":715},{"facility":725,"status":101,"city":726,"state":727,"zip":728,"country":711,"countryCode":712,"cosmosGeoPoint":729,"geoPoint":733,"contacts":26},"Chongqing Maternal and Child Health Care Hospital","Chongqing","Chongqing Municipality","401147",{"type":48,"coordinates":730},[731,732],106.55771,29.56026,{"lat":732,"lon":731},{"facility":735,"status":101,"city":736,"state":737,"zip":738,"country":711,"countryCode":712,"cosmosGeoPoint":739,"geoPoint":743,"contacts":26},"Xiamen Maternity and Child Health Care Hospital - Gynecology Department","Xiamen","Fujian","361003",{"type":48,"coordinates":740},[741,742],118.08187,24.47979,{"lat":742,"lon":741},{"facility":745,"status":41,"city":746,"state":747,"zip":748,"country":711,"countryCode":712,"cosmosGeoPoint":749,"geoPoint":753,"contacts":26},"Foshan Women and Child Health Care Hospital","Foshan","Guangdong","528000",{"type":48,"coordinates":750},[751,752],113.13148,23.02677,{"lat":752,"lon":751},{"facility":755,"status":101,"city":756,"state":747,"zip":757,"country":711,"countryCode":712,"cosmosGeoPoint":758,"geoPoint":762,"contacts":26},"The Third Affiliated Hospital of Southern Medical University - Gynecology Department","Guangzhou","510630",{"type":48,"coordinates":759},[760,761],113.25,23.11667,{"lat":761,"lon":760},{"facility":764,"status":101,"city":765,"state":747,"zip":766,"country":711,"countryCode":712,"cosmosGeoPoint":767,"geoPoint":771,"contacts":26},"Peking University Shenzhen Hospital","Shenzhen","518036",{"type":48,"coordinates":768},[769,770],114.0683,22.54554,{"lat":770,"lon":769},{"facility":773,"status":101,"city":774,"state":775,"zip":776,"country":711,"countryCode":712,"cosmosGeoPoint":777,"geoPoint":781,"contacts":26},"Tangshan Maternal and Child Health Care Hospital","Tangshan","Hebei","063014",{"type":48,"coordinates":778},[779,780],118.18319,39.64381,{"lat":780,"lon":779},{"facility":783,"status":101,"city":784,"state":785,"zip":786,"country":711,"countryCode":712,"cosmosGeoPoint":787,"geoPoint":791,"contacts":26},"Nanjing Maternity and Child Health Care Hospital","Nanjing","Jiangsu","210004",{"type":48,"coordinates":788},[789,790],118.77778,32.06167,{"lat":790,"lon":789},{"facility":793,"status":101,"city":784,"state":785,"zip":794,"country":711,"countryCode":712,"cosmosGeoPoint":795,"geoPoint":797,"contacts":26},"Nanjing Medical University (NMU) - The Second Affiliated Hospital","210011",{"type":48,"coordinates":796},[789,790],{"lat":790,"lon":789},{"facility":799,"status":101,"city":800,"state":801,"zip":802,"country":711,"countryCode":712,"cosmosGeoPoint":803,"geoPoint":807,"contacts":26},"Jiangxi Maternal and Child Health Hospital","Nanchang","Jiangxi","330006",{"type":48,"coordinates":804},[805,806],115.85306,28.68396,{"lat":806,"lon":805},{"facility":809,"status":101,"city":810,"state":811,"zip":812,"country":711,"countryCode":712,"cosmosGeoPoint":813,"geoPoint":817,"contacts":26},"Shaanxi Provincial People's Hospital","Xi'an","Shaanxi","710068",{"type":48,"coordinates":814},[815,816],108.92861,34.25833,{"lat":816,"lon":815},{"facility":819,"status":101,"city":820,"state":821,"zip":822,"country":711,"countryCode":712,"cosmosGeoPoint":823,"geoPoint":827,"contacts":26},"Women and Children's Hospital, Qingdao University - Gynecology department","Qingdao","Shandong","266034",{"type":48,"coordinates":824},[825,826],120.38042,36.06488,{"lat":826,"lon":825},{"facility":829,"status":101,"city":830,"state":831,"zip":832,"country":711,"countryCode":712,"cosmosGeoPoint":833,"geoPoint":837,"contacts":26},"Chengdu Women & Children's Central Hospital","Chengdu","Sichuan","610091",{"type":48,"coordinates":834},[835,836],104.06667,30.66667,{"lat":836,"lon":835},{"facility":839,"status":41,"city":840,"state":841,"zip":842,"country":711,"countryCode":712,"cosmosGeoPoint":843,"geoPoint":847,"contacts":26},"Women's Hospital School of Medicine Zhejiang University","Hangzhou","Zhejiang","310006",{"type":48,"coordinates":844},[845,846],120.16142,30.29365,{"lat":846,"lon":845},{"facility":849,"status":41,"city":850,"state":26,"zip":851,"country":852,"countryCode":853,"cosmosGeoPoint":854,"geoPoint":858,"contacts":26},"Solace Clinical Research","San Juan","00907","Puerto Rico","PR",{"type":48,"coordinates":855},[856,857],-66.10572,18.46633,{"lat":857,"lon":856},{"type":860,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100585585","phase-3-mirena-for-the-treatment-of-nonatypical-endometrial-hyperplasia-for-6-months-100585585",false,"NCT06904274","Mirena for the Treatment of Nonatypical Endometrial Hyperplasia for 6 Months","A Multi-center, Open Label, Randomized Parallel Group Study Evaluating the Proportion of Women With Complete Resolution of Nonatypical Endometrial Hyperplasia Treated With Mirena or Oral Medroxyprogesterone Acetate for 6 Months","SUNFLOWER","Inclusion Criteria:\n\n* Post-menarchal women (≥18 years) at the time of signing the informed consent.\n* Women with histologically confirmed NAEH independent of their parity or menopausal status. Endometrial samples will be obtained either at screening or no more than 42 days prior to the signing of the informed consent form.\n\nExclusion Criteria:\n\n* Any diseases or conditions that might interfere with the conduct of the study or the interpretation of the results.\n* Congenital or acquired uterine or cervical anomaly including fibroids, or cervical stenosis that in the opinion of the investigator, would interfere with insertion and\u002For retention of the intrauterine system (i.e., if they distort the uterine cavity).\n* Use of any long-acting injectable sex-hormone preparations within 6 months prior to the start of study intervention, and \u002For short acting hormonal medication within 6 weeks prior to the start of study intervention.\n* Pregnancy\n* Participants with either known family or personal history of genetic predisposition to uterine, ovarian or colorectal cancers (e.g. Lynch syndrome).","FEMALE","18 Years",{"count":872,"type":873},207,"ESTIMATED","INTERVENTIONAL",[876],"PHASE3","Researchers are looking for a better way to treat women with nonatypical endometrial hyperplasia (NAEH).\n\nEndometrial hyperplasia is a condition where the lining of the uterus (called the endometrium) becomes too thick. Nonatypical means that the condition is not cancerous. It is often caused by hormone imbalances in women. Symptoms can include abnormal vaginal bleeding or irregular periods. If this condition is not treated, then it may lead to cancer.\n\nCurrently, there are no approved treatments for NAEH and that is why there is still an unmet medical need.\n\nThe study treatment, Mirena (also known as BAY 865028), is already available as a type of birth control device. It is inserted into the uterus where it gradually releases progesterone.\n\nIn this study, researchers want to find out if Mirena works for women with NAEH. They believe it can help by keeping hormone levels balanced in the body.\n\nThe main purpose of this study is to show that uterine lining goes back to completely normal lining after treatment with Mirena and that its use is safe in this population.\n\nFor this, the researchers will compare the number of participants with benign endometrium after 6 months of treatment with Mirena or oral MPA.\n\nThe study participants will be randomly assigned into one of two treatment groups. The randomization will be done 2:1 ratio, meaning that for every two participants assigned to Mirena, one will be assigned to oral medroxyprogesterone acetate (MPA). Based on their group, participants will receive Mirena, which is inserted into the uterus at the start of the study, or they will take progestins once daily by mouth for 6 months.\n\nEach participant will be in the study for around 10 months with up to 5 visits to the study clinic\u002Fsite.\n\nParticipants will visit the study clinic:\n\n* once before the treatment starts\n* 3 times with a gap of 3 months between the visits during the treatment\n* then 1 more time after the treatment ends\n\nDuring the study, the doctors and their study team will:\n\n* check participant's health by performing tests such as blood and urine tests\n* perform vaginal ultrasound and hysteroscopy. Hysteroscopy is a minor surgical procedure where a thin camera will be inserted into the womb to check for any abnormality. Sampling of the endometrial lining (cells in the womb) will be done with a thin tube at the same time.\n* take samples of womb (endometrial) lining\n* ask the participants questions about how they are feeling and what adverse events they are having\n\nAn adverse event is any medical problem that a participant has during a study. Doctors keep track of all adverse events, irrespective if they think it is related or not to the study treatment.",[879],"Endometrial Hyperplasia","2026-06-22",{"date":882,"type":883},"2026-06-23","ACTUAL",{"date":885,"type":883},"2025-11-24",{"date":887,"type":873},"2027-11-01",{"name":5,"class":6},89]