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Oblast","58013",{"type":121,"coordinates":648},[649,650],25.93241,48.29045,{"lat":650,"lon":649},[653],{"name":113,"role":99,"phone":654,"phoneExt":48,"email":48},"+380505144910",{"facility":656,"status":105,"city":657,"state":658,"zip":659,"country":632,"countryCode":633,"cosmosGeoPoint":660,"geoPoint":664,"contacts":665},"Medical Center \"Mriya Med-Service\" ( Site 1911)","Kryvyi Rih","Dnipropetrovsk Oblast","50000",{"type":121,"coordinates":661},[662,663],33.39404,47.90572,{"lat":663,"lon":662},[666],{"name":113,"role":99,"phone":667,"phoneExt":48,"email":48},"+380677490687",{"facility":669,"status":105,"city":670,"state":671,"zip":672,"country":632,"countryCode":633,"cosmosGeoPoint":673,"geoPoint":677,"contacts":678},"Communal Non-Commercial Enterprise Prykarpatski Clinical Oncological Center of Ivano-Frankivsk Regio ( Site 1900)","Ivano-Frankivsk","Ivano-Frankivsk Oblast","76018",{"type":121,"coordinates":674},[675,676],24.71248,48.92312,{"lat":676,"lon":675},[679],{"name":113,"role":99,"phone":680,"phoneExt":48,"email":48},"+380342507353",{"facility":682,"status":105,"city":683,"state":684,"zip":685,"country":632,"countryCode":633,"cosmosGeoPoint":686,"geoPoint":690,"contacts":691},"Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 1916)","Kropyvnytskyi","Kirovohrad Oblast","25006",{"type":121,"coordinates":687},[688,689],32.26618,48.50834,{"lat":689,"lon":688},[692],{"name":113,"role":99,"phone":693,"phoneExt":48,"email":48},"+380969680396",{"facility":695,"status":105,"city":683,"state":684,"zip":696,"country":632,"countryCode":633,"cosmosGeoPoint":697,"geoPoint":699,"contacts":700},"Ukrainian Center of Tomotherapy ( Site 1917)","25011",{"type":121,"coordinates":698},[688,689],{"lat":689,"lon":688},[701],{"name":113,"role":99,"phone":702,"phoneExt":48,"email":48},"+380958718674",{"facility":704,"status":105,"city":705,"state":706,"zip":707,"country":632,"countryCode":633,"cosmosGeoPoint":708,"geoPoint":712,"contacts":713},"Communal noncommercial enterprise of Lviv regional council \"Lviv oncological regional therapeutical ( Site 1908)","Lviv","Lviv Oblast","79031",{"type":121,"coordinates":709},[710,711],24.02324,49.83826,{"lat":711,"lon":710},[714],{"name":113,"role":99,"phone":715,"phoneExt":48,"email":48},"+380973342609",{"facility":717,"status":105,"city":705,"state":706,"zip":718,"country":632,"countryCode":633,"cosmosGeoPoint":719,"geoPoint":721,"contacts":722},"Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 1902)","79059",{"type":121,"coordinates":720},[710,711],{"lat":711,"lon":710},[723],{"name":113,"role":99,"phone":724,"phoneExt":48,"email":48},"+380977453295",{"facility":726,"status":105,"city":727,"state":728,"zip":729,"country":632,"countryCode":633,"cosmosGeoPoint":730,"geoPoint":734,"contacts":735},"Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 1913)","Odesa","Odesa Oblast","65025",{"type":121,"coordinates":731},[732,733],30.74383,46.48572,{"lat":733,"lon":732},[736],{"name":113,"role":99,"phone":737,"phoneExt":48,"email":48},"+380931860876",{"facility":739,"status":105,"city":740,"state":741,"zip":742,"country":632,"countryCode":633,"cosmosGeoPoint":743,"geoPoint":747,"contacts":748},"ME \"Rivne Regional Antitumor Center\" Rivne Regional Council ( Site 1912)","Rivne","Rivne Oblast","33010",{"type":121,"coordinates":744},[745,746],26.23695,50.62036,{"lat":746,"lon":745},[749],{"name":113,"role":99,"phone":750,"phoneExt":48,"email":48},"+380971921000",{"facility":752,"status":105,"city":753,"state":754,"zip":755,"country":632,"countryCode":633,"cosmosGeoPoint":756,"geoPoint":760,"contacts":761},"Communal Noncommercial Enterprise \"Podillia Regional Oncology Center Of Vinnytsia Regional Council\" ( Site 1903)","Vinnytsia","Vinnytsia Oblast","21029",{"type":121,"coordinates":757},[758,759],28.46871,49.2322,{"lat":759,"lon":758},[762],{"name":113,"role":99,"phone":763,"phoneExt":48,"email":48},"+380988936318",{"facility":765,"status":105,"city":766,"state":767,"zip":768,"country":632,"countryCode":633,"cosmosGeoPoint":769,"geoPoint":773,"contacts":774},"Municipal Enterprise \"Volyn Regional Clinical Hospital\" of Volyn Regional Council ( Site 1914)","Lutsk","Volyn Oblast","43018",{"type":121,"coordinates":770},[771,772],25.35024,50.75784,{"lat":772,"lon":771},[775],{"name":113,"role":99,"phone":776,"phoneExt":48,"email":48},"+380332773100",{"facility":778,"status":105,"city":779,"state":48,"zip":780,"country":632,"countryCode":633,"cosmosGeoPoint":781,"geoPoint":785,"contacts":786},"Medical Center \"Universal Clinic \"Oberig\" of Limited Liability Company \"Kapytal\" ( Site 1915)","Kyiv","03057",{"type":121,"coordinates":782},[783,784],30.5238,50.45466,{"lat":784,"lon":783},[787],{"name":113,"role":99,"phone":788,"phoneExt":48,"email":48},"+380669472333",{"facility":790,"status":105,"city":779,"state":48,"zip":791,"country":632,"countryCode":633,"cosmosGeoPoint":792,"geoPoint":794,"contacts":795},"Shalimov Institute of Surgery and Transplantation ( Site 1907)","03126",{"type":121,"coordinates":793},[783,784],{"lat":784,"lon":783},[796],{"name":113,"role":99,"phone":797,"phoneExt":48,"email":48},"+380444081800",{"type":799,"investigatorFullName":48,"investigatorTitle":48,"investigatorAffiliation":48,"oldNameTitle":48,"oldOrganization":48},"SPONSOR","100626145","phase-3-mk-3475acalderasib-mk-1084-in-completely-resected-stage-iia-iiib-n2-kras-g12cm-nsclc-mk-1084-013-100626145",false,"NCT07431827","MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)","A Phase 3, Randomized, Double-blind Study of Adjuvant MK-1084 Plus Subcutaneous Pembrolizumab and Berahyaluronidase Alfa (MK-3475A) Versus Adjuvant Placebo Plus MK-3475A in Participants With Completely Resected Stage IIA-IIIB (N2), KRAS G12C-mutant Non-small Cell Lung Cancer Following Receipt of Either Neoadjuvant Pembrolizumab Plus Chemotherapy or Adjuvant Chemotherapy (KANDLELIT-013)","KANDLELIT-013","Inclusion Criteria:\n\n* Has a histological\u002Fcytological diagnosis of non-small cell lung cancer (NSCLC) with predominantly nonsquamous histology and meets one of the following criteria:\n\n  * Has newly diagnosed, treatment-naïve, resectable, clinical Stage IIA-IIIB (N2) NSCLC\n  * Has completely resected, pathological Stage IIA-IIIB (N2) NSCLC, including those previously treated outside the study with neoadjuvant platinum-doublet chemotherapy plus pembrolizumab or MK-3475A, or those who received adjuvant platinum-doublet chemotherapy.\n* Tumor tissue shows the presence of Kirsten rat sarcoma viral oncogene homolog G12C (KRAS G12C) mutation\n* No more than 12 weeks have elapsed between either the surgery following neoadjuvant treatment or last dose of adjuvant platinum-based chemotherapy and the first dose of investigational adjuvant study intervention.\n* Has no evidence of disease based on postsurgical radiological assessment as documented by contrast-enhanced chest\u002Fabdomen computed tomography (or magnetic resonance imaging) within 28 days before randomization\n* Has an Eastern Cooperative Oncology Group performance status of 0 or 1 within 10 days before the first dose of the study intervention\n* Human immunodeficiency virus-infected participants must have well controlled HIV on antiretroviral therapy\n* Participants who are Hepatitis B surface antigen positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load\n* Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable\n\nExclusion Criteria:\n\n* Has a diagnosis of any 1 of the following tumor types\u002Flocations: small cell lung cancer or, for mixed tumors, presence of small cell elements, neuroendocrine tumor with large cell components, sarcomatoid carcinoma, or NSCLC involving the superior sulcus\n* HIV-infected participants with a history of Kaposi's sarcoma and\u002For Multicentric Castleman's Disease\n* Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, chronic diarrhea)\n* Has uncontrolled, significant cardiovascular disease or cerebrovascular disease within the 6 months preceding study intervention\n* Is unable to swallow orally administered medication, or has a gastrointestinal disorder affecting absorption (e.g. gastrectomy, partial bowel obstruction, or malabsorption)\n* Has known additional malignancy that is progressing or has required active treatment within the past 3 years\n* Has an active autoimmune disease that has required systemic treatment in the past 2 years except replacement therapy\n* Has a history of (noninfectious) pneumonitis\u002Finterstitial lung disease that required steroids or has current pneumonitis\u002Finterstitial lung disease\n* Has active infection requiring systemic therapy\n* Has not adequately recovered from major surgery or has ongoing surgical complications","ALL","18 Years",{"count":811,"type":812},400,"ESTIMATED","INTERVENTIONAL",[815],"PHASE3","This is a phase 3, randomized, double-blind study of adjuvant calderasib plus subcutaneous pembrolizumab and berahyaluronidase alfa (MK-3475A) versus adjuvant placebo plus MK-3475a in participants with completely resected stage IIA-IIIB (N2), KRAS G12C-mutant non-small cell lung cancer following receipt of either neoadjuvant pembrolizumab plus chemotherapy or adjuvant chemotherapy. The primary goal of the study is to compare adjuvant calderasib plus MK-3475A to adjuvant placebo plus MK-3475A with respect to disease-free survival (DFS) as assessed by the investigator.",[818],"Non-small Cell Lung Cancer","2026-06-25",{"date":821,"type":822},"2026-06-26","ACTUAL",{"date":824,"type":822},"2026-03-18",{"date":826,"type":812},"2039-10-26",{"name":5,"class":6},58]