[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100337120":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":26,"responsibleParty":47,"collaborators":25,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":25,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":29,"whyStopped":25,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"CNS Onlus","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active cTBS treatment","ACTIVE_COMPARATOR","Active cTBS will be administered with a Magventure MagPro Stimulator R30 using a butterfly coil. TBS consists of bursts of 3 pulses separated by 20ms (i.e. 50 Hz), with each triplet being repeated every 200 ms (i.e. 5 Hz). Stimulus intensities will be set at 80% of AMT. The investigators will use 2 trains of 600 pulses each separated by 1 minute (a total of 1200 pulses).",[13],"Device: Transcranial Magnetic stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham cTBS treatment","SHAM_COMPARATOR","Sham cTBS will be administered with a Magventure MagPro Stimulator R30 using a butterfly sham coil. The same active cTBS configuration will be used.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Transcranial Magnetic stimulation","Neuromodulation tool",[9,15],null,[27],{"facility":28,"status":29,"city":30,"state":25,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"CNSOnlus, Institute of Neuroscience","RECRUITING","Florence","50100","Italy","IT",{"type":35,"coordinates":36},"Point",[37,38],11.24626,43.77925,{"lat":38,"lon":37},[41],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Stefano Pallanti, M.D.","CONTACT","55 587889","0039","stefanopallanti@yahoo.it",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Stefano Pallanti","Professor","100337120","phase-3-modulating-inhibitory-control-networks-in-gambling-disorder-with-theta-burst-stimulation-100337120",false,"NCT03669315","Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation","TMS-GD","Inclusion Criteria:\n\n1. DSM-5 diagnosis of Gambling Disorder\n2. Age between 18 and 65 years\n\nExclusion Criteria:\n\n1. any additional current psychiatric comorbidity, except for nicotine addiction;\n2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition;\n3. serious suicide risk;\n4. illness duration less than two years;\n5. hospitalization in the last 6 months;\n6. the inability to receive TMS because of metallic implants, or history of seizures (personal or family history of seizure in first degree relatives);\n7. any major medical disease;\n8. pregnancy or nursing of an infant;\n9. the inability or refusal to provide written informed consent.","ALL","18 Years","65 Years",{"count":62,"type":63},40,"ESTIMATED","INTERVENTIONAL",[66],"PHASE3","In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.",[69],"Gambling Disorder",[69,71],"Transcranial Magnetic Stimulation","2018-09-11",{"date":74,"type":75},"2018-09-13","ACTUAL",{"date":77,"type":75},"2018-05-20",{"date":79,"type":63},"2019-12-01",{"name":5,"class":6},1]