[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100590345":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":46,"responsibleParty":64,"collaborators":26,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"St. Joseph's Healthcare Hamilton","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Multiprofen-CC™","EXPERIMENTAL","Multiprofen-CC™ \\[ketoprofen (10%), baclofen (5%), amitriptyline (2%), and lidocaine (5%)\\] Dose: 1.0g, 3 times per day for 2 weeks",[13],"Drug: Multiprofen-CC™ plus standard treatment",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","The placebo is the base cream with no medicinal ingredients Dose: 1.0g, 3 times per day for 2 weeks",[19],"Other: Placebo plus standard treatment",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Multiprofen-CC™ plus standard treatment","Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo plus standard treatment","Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks",[15],[32],{"name":33,"affiliation":34,"role":35},"Carolyn Levis, MD, MSc, FRCS(C)","McMaster University","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Breanne Flood, MSc","CONTACT","905-870-1382","bflood@stjoes.ca",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Kim Irish, BSW","365-336-7598","irishkd@mcmaster.ca",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Hamilton","Ontario","L8N4A6","Canada","CA",{"type":55,"coordinates":56},"Point",[57,58],-79.84963,43.25011,{"lat":58,"lon":57},[61],{"name":38,"role":39,"phone":62,"phoneExt":26,"email":63},"9058701382","floodbl@mcmaster.ca",{"type":35,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Carolyn Levis","Principal Investigator","100590345","phase-3-multiprofen-cc-to-reduce-pain-in-hand-arthritis-100590345",false,"NCT06966206","Multiprofen-CC to Reduce Pain in Hand Arthritis","Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial","MRP-HAND","Inclusion Criteria:\n\n* Adults (18+)\n* Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria\n* Experience pain and\u002For loss of function in one or both hands that interferes with daily life\n* Provide informed consent\n\nExclusion Criteria:\n\n* Unable to consent\n* Unable or unwilling to follow study protocol\n* Known allergy or contraindication to any of the study drugs or their ingredients\n* Have open wounds\u002Fcuts and\u002For skin conditions on the hand area\n* Pregnant or breastfeeding\n* History of impaired kidney or liver function\n* Rheumatoid or other inflammatory arthropathy\n* Hand surgery within the past 6 months or planned within the study period.\n* Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis","ALL","18 Years",{"count":78,"type":79},42,"ESTIMATED","INTERVENTIONAL",[82],"PHASE3","This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects.\n\nParticipants will:\n\n* Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order.\n* Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions.\n* Attend a visit before starting the study, after 2 weeks, and after 6 weeks.\n* Report any symptoms they experience during the study.",[85],"Hand Osteoarthritis",[87,88,89,90,91],"hand osteoarthritis","osteoarthritis","arthritis","topical","multiprofen","2026-04-28",{"date":94,"type":95},"2026-05-04","ACTUAL",{"date":97,"type":95},"2026-03-09",{"date":99,"type":79},"2027-08-01",{"name":5,"class":6},1]