[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100482153":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":45,"centralContacts":62,"locations":72,"responsibleParty":943,"collaborators":945,"id":953,"slug":954,"hasResults":955,"nctId":956,"briefTitle":957,"officialTitle":958,"acronym":959,"eligibilityCriteria":960,"healthyVolunteers":955,"sex":961,"minAge":962,"maxAge":963,"enrollmentInfo":964,"targetDuration":32,"studyType":967,"phases":968,"briefSummary":970,"conditions":971,"keywords":32,"overallStatus":75,"whyStopped":32,"lastUpdateSubmitDate":973,"lastUpdatePostDateStruct":974,"startDateStruct":977,"completionDateStruct":979,"leadSponsor":981,"locationsCount":982},{"fullName":5,"class":6},"PETHEMA Foundation","OTHER",[8,17,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Control arm (A)","ACTIVE_COMPARATOR","INDUCTION: Isatuximab + VRD, 4 cycles. Isatuximab (IV) 10 mg\u002FKg, 1st cycle D: 1,8,15, 22. Cycles 2-4: D 1,15. Bortezomib (SC) 1.3 mg\u002Fm2, D:1, 4, 8, 11. Lenalidomide (PO) 25mg, D:1-21. Dexamethasone (PO) 40 mg, D: 1-4, 9-12.\n\nASCT. The conditioning regimen is melphalan 200 mg\u002Fm2.\n\nCONSOLIDATION: Isatuximab + VRD, 2 cycles. Isatuximab (IV) 10 mg\u002FKg. D 1-15. Bortezomib (SC) 1.3 mg\u002Fm2, D:1, 4, 8, 11. Lenalidomide (PO) 25mg, D:1-21. Dexamethasone (PO) 40 mg, D: 1-4, 9-12.\n\nCONTINUOUS TREATMENT: Lenalidomide and monthly Isatuximab until progression, unacceptable toxicity, patient withdrawal, loss to follow up or death. During continuous treatment, dexamethasone 40 mg is used as a standardized premedication for Isatuximab.",[13,14,15,16],"Drug: Bortezomib","Drug: Isatuximab","Drug: Lenalidomide","Drug: Dexamethasone",{"label":18,"type":19,"description":20,"interventionNames":21},"EXPERIMENTAL ARM (B): Extended VRD and Early Rescue Intervention","EXPERIMENTAL","INDUCTION: Includes two experimental lines:\n\n1. VRD extended to 18 cycles: Induction (VRDx6): Bortezomib (SC) 1.3 mg\u002Fm2, D: 1, 4, 8, and 11 (Q4W). Lenalidomide 25 mg (PO), D: 1-21 (Q4W). Dexamethasone 40 mg (PO) D 1 to 4 and 9 to 12 (Q4W). Isatuximab (IV) 10 mg\u002Fkg, D: 1, 8, 15, and 22 (Q4W) and D: 1-15 in subsequent cycles.\n2. Early detection of treatment failure and Early Rescue Intervention (ERI): Isatuximab-Iberdomide-Dexamethasone in continuous treatment. Isatuximab (IV) 10mg\u002Fkg Cycle 1: Days 1, 8, 15, and 22 (Q4W). Cycles 2 onwards: Days 1 and 15 (Q4W). Isatuximab will be infused monthly after 1 year treatment (Day 1 Q4W) including ASCT. Iberdomide (PO) 1,6 mg. D: 1-21 (Q4W). Dexamethasone (PO) 40 mg. D: 1, 8, 15, and 22 (Q4W).\n\nASCT. The conditioning regimen is melphalan 200 mg\u002Fm2. CONSOLIDATION (VRDx2)- Extended VRD: VDx10, followed by lenalidomide plus dexamethasone maintenance.\n\nCONTINUOUS TREATMENT: Lenalidomide 15 mg, D: 1-21, and dexamethasone 20 mg, D: 1-4 (Q4W).",[13,14,22,15,16],"Drug: Iberdomide",{"label":24,"type":19,"description":25,"interventionNames":26},"EXPLORATORY ARM (C)","INDUCTION: Iberdomide plus Isatuximab, bortezomib and dexamethasone (four cycles). Isatuximab (IV) 10 mg\u002Fkg D 1, 8, 15, and 22 in the first Q4W; and days 1-15 in subsequent cycles. Iberdomide (PO) at 1.6 mg on days 1-21 of every 4-week cycle. Bortezomib (SC) at 1.3 mg\u002Fm2 on days 1, 4, 8, and 11 of every 4-week cycle. Dexamethasone 40 mg (PO) D 1-4, 9-12 (Q4W).\n\nASCT. The conditioning regimen is melphalan 200 mg\u002Fm2.\n\nCONSOLIDATION: two cycles (Q4W) of Isatuximab, Iberdomide, Bortezomib and Dexamethasone, as in induction, starting approximately 2 months after hospital discharge or 3 months after transplantation. Isatuximab will be infused monthly since the start of continuous therapy (after the second cycle of consolidation).\n\nCONTINUOUS TREATMENT: Iberdomide and monthly Isatuximab until progression, unacceptable toxicity, patient withdrawal, loss to follow up or death. During continuous treatment, dexamethasone 40 mg is used as a standardized premedication for Isatuximab.",[13,14,22,16],[28,33,36,39,42],{"type":29,"name":30,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Bortezomib",[9,18,24],null,{"type":29,"name":34,"description":34,"armGroupLabels":35,"otherNames":32},"Isatuximab",[9,18,24],{"type":29,"name":37,"description":37,"armGroupLabels":38,"otherNames":32},"Iberdomide",[18,24],{"type":29,"name":40,"description":40,"armGroupLabels":41,"otherNames":32},"Lenalidomide",[9,18],{"type":29,"name":43,"description":43,"armGroupLabels":44,"otherNames":32},"Dexamethasone",[9,18,24],[46,50,53,56,59],{"name":47,"affiliation":48,"role":49},"Juan José Lahuerta Palacios, Dr","Hospital Universitario 12 de Octubre","STUDY_CHAIR",{"name":51,"affiliation":52,"role":49},"Joan Bladé, Dr","Hospital Clinic of Barcelona",{"name":54,"affiliation":55,"role":49},"Mª Victoria Mateos, Dr","Hospital Clínico Universitario de Salamanca",{"name":57,"affiliation":58,"role":49},"Enrique M Ocio, Dr","Hospital Universitario Marqués de Valdecilla",{"name":60,"affiliation":61,"role":49},"Jesús San Miguel, Dr","Clínica Universitaria de Navarra",[63,68],{"name":64,"role":65,"phone":66,"phoneExt":32,"email":67},"Carmen López-Carrero","CONTACT","0034 699 835 437","carmen@fundacionpethema.es",{"name":69,"role":65,"phone":70,"phoneExt":32,"email":71},"Roberto Maldonado","0034 683 15 66 87","roberto.maldonado@fundacionpethema.es",[73,93,107,122,135,148,163,175,187,199,214,228,243,257,272,285,298,312,327,340,355,370,383,393,403,414,424,436,447,453,465,475,485,495,505,517,532,542,554,567,580,590,595,603,620,633,645,657,672,687,702,717,730,745,758,771,786,800,810,821,835,850,865,880,892,904,918,933],{"facility":74,"status":75,"city":76,"state":77,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":85,"contacts":86},"Hospital Principe de Asturias","RECRUITING","Alcalá de Henares","Madrid","Spain","ES",{"type":81,"coordinates":82},"Point",[83,84],-3.35996,40.48205,{"lat":84,"lon":83},[87,90],{"name":88,"role":65,"phone":32,"phoneExt":32,"email":89},"Julio García Suárez","jgsuarez@salud.madrid.org",{"name":91,"role":92,"phone":32,"phoneExt":32,"email":32},"Julio García Suárez, Dr","PRINCIPAL_INVESTIGATOR",{"facility":94,"status":75,"city":95,"state":77,"zip":96,"country":78,"countryCode":79,"cosmosGeoPoint":97,"geoPoint":101,"contacts":102},"Hospital Universitario Quirón Salud Madrid","Pozuelo de Alarcón","28223",{"type":81,"coordinates":98},[99,100],-3.81338,40.43293,{"lat":100,"lon":99},[103,106],{"name":104,"role":65,"phone":32,"phoneExt":32,"email":105},"Carmen Martínez Chamorro","carmenmartinezchamorro@quironsalud.es ; carmenmartinezchanomorro@hotmail.com",{"name":104,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":108,"status":75,"city":109,"state":110,"zip":111,"country":78,"countryCode":79,"cosmosGeoPoint":112,"geoPoint":116,"contacts":117},"Clinica Universidad Navarra (CUN)","Pamplona","Navarre","31008",{"type":81,"coordinates":113},[114,115],-1.64323,42.81687,{"lat":115,"lon":114},[118,121],{"name":119,"role":65,"phone":32,"phoneExt":32,"email":120},"Jesus San Miguel Izquierdo","sanmiguel@unav.es",{"name":119,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":123,"status":75,"city":124,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":125,"geoPoint":129,"contacts":130},"Hospital General Universitario de Albacete","Albacete",{"type":81,"coordinates":126},[127,128],-1.85643,38.99424,{"lat":128,"lon":127},[131,134],{"name":132,"role":65,"phone":32,"phoneExt":32,"email":133},"Irene Gómez Catalán","irenevonu12@gmail.com",{"name":132,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":136,"status":75,"city":137,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":138,"geoPoint":142,"contacts":143},"Hospital Germans Trias i Pujol (ICO BADALONA)","Badalona",{"type":81,"coordinates":139},[140,141],2.24741,41.45004,{"lat":141,"lon":140},[144,147],{"name":145,"role":65,"phone":32,"phoneExt":32,"email":146},"Albert Oriol Rocafiguera","aoriol@iconcologia.net",{"name":145,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":149,"status":75,"city":150,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":151,"geoPoint":155,"contacts":156},"Hospital Clinic i Provincial de Barcelona","Barcelona",{"type":81,"coordinates":152},[153,154],2.15899,41.38879,{"lat":154,"lon":153},[157,161],{"name":158,"role":65,"phone":159,"phoneExt":32,"email":160},"Laura Rosiñol, Dr","93 2275400","LROSINOL@clinic.cat",{"name":162,"role":92,"phone":32,"phoneExt":32,"email":32},"Laura Rosiñol",{"facility":164,"status":75,"city":150,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":165,"geoPoint":167,"contacts":168},"Hospital de la Santa Creu i Sant Pau",{"type":81,"coordinates":166},[153,154],{"lat":154,"lon":153},[169,173],{"name":170,"role":65,"phone":171,"phoneExt":32,"email":172},"Miguel Granell Gorrochategui, Dr","93 5565647","MGranell@santpau.cat",{"name":174,"role":92,"phone":32,"phoneExt":32,"email":32},"Miguel Granell Gorrochategui",{"facility":176,"status":75,"city":150,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":177,"geoPoint":179,"contacts":180},"Hospital Universitari Vall d´Hebron",{"type":81,"coordinates":178},[153,154],{"lat":154,"lon":153},[181,185],{"name":182,"role":65,"phone":183,"phoneExt":32,"email":184},"Mercedes Gironella Mesa, Dr","93 2746100","mgironel@gmail.com; mgironel@vhebron.net",{"name":186,"role":92,"phone":32,"phoneExt":32,"email":32},"Mercedes Gironella Mesa",{"facility":188,"status":75,"city":150,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":189,"geoPoint":191,"contacts":192},"ICO L´Hospitalet",{"type":81,"coordinates":190},[153,154],{"lat":154,"lon":153},[193,197],{"name":194,"role":65,"phone":195,"phoneExt":32,"email":196},"Anna Sureda Balari, Dr","93 2607750","asureda@iconcologia.net",{"name":198,"role":92,"phone":32,"phoneExt":32,"email":32},"Anna Sureda Balari",{"facility":200,"status":75,"city":201,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":202,"geoPoint":206,"contacts":207},"Hospital Universitario de Cruces","Bilbao",{"type":81,"coordinates":203},[204,205],-2.92528,43.26271,{"lat":205,"lon":204},[208,212],{"name":209,"role":65,"phone":210,"phoneExt":32,"email":211},"Elena Amutio Díez, Dr","946 006320","mariaelena.amutiodiez@osakidetza.net",{"name":213,"role":92,"phone":32,"phoneExt":32,"email":32},"Elena Amutio Díez",{"facility":215,"status":75,"city":216,"state":32,"zip":217,"country":78,"countryCode":79,"cosmosGeoPoint":218,"geoPoint":222,"contacts":223},"Hospital Universitario de Burgos","Burgos","09006",{"type":81,"coordinates":219},[220,221],-3.70184,42.34106,{"lat":221,"lon":220},[224,227],{"name":225,"role":65,"phone":32,"phoneExt":32,"email":226},"Francisco Javier Díaz Gálvez","fcdiaz@saludcastillayleon.es",{"name":225,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":229,"status":75,"city":230,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":231,"geoPoint":235,"contacts":236},"Complejo Hospitalario de Cáceres","Cáceres",{"type":81,"coordinates":232},[233,234],-6.37224,39.47649,{"lat":234,"lon":233},[237,241],{"name":238,"role":65,"phone":239,"phoneExt":32,"email":240},"Ignacio Casas Avilés, Dr","927 256200","ignacio.casas@salud-juntaex.es",{"name":242,"role":92,"phone":32,"phoneExt":32,"email":32},"Ignacio Casas Avilés",{"facility":244,"status":75,"city":245,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Hospital Universitario de Cabueñes","Gijón",{"type":81,"coordinates":247},[248,249],-5.66152,43.53573,{"lat":249,"lon":248},[252,256],{"name":253,"role":65,"phone":254,"phoneExt":32,"email":255},"María Esther González García","+ 34 985 18 50 00","esthergongar@yahoo.es",{"name":253,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":258,"status":75,"city":259,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":260,"geoPoint":264,"contacts":265},"Hospital Universitari Dr. Josep Trueta (ICO Girona)","Girona",{"type":81,"coordinates":261},[262,263],2.82493,41.98311,{"lat":263,"lon":262},[266,270],{"name":267,"role":65,"phone":268,"phoneExt":32,"email":269},"Yolanda González Montes, Dr","972 225833","ygonzalez@iconcologia.net",{"name":271,"role":92,"phone":32,"phoneExt":32,"email":32},"Yolanda González Montes",{"facility":273,"status":75,"city":274,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":275,"geoPoint":279,"contacts":280},"Hospital Universitario Virgen de las Nieves","Granada",{"type":81,"coordinates":276},[277,278],-3.60667,37.18817,{"lat":278,"lon":277},[281,284],{"name":282,"role":65,"phone":32,"phoneExt":32,"email":283},"María Esther Clavero Sánchez","eclaverosa@hotmail.com",{"name":282,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":286,"status":75,"city":287,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":288,"geoPoint":292,"contacts":293},"Hospital Universitario de Guadalajara","Guadalajara",{"type":81,"coordinates":289},[290,291],-3.16185,40.62862,{"lat":291,"lon":290},[294,297],{"name":295,"role":65,"phone":32,"phoneExt":32,"email":296},"Dunia de Miguel Llorente","duniamll@hotmail.com",{"name":295,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":299,"status":75,"city":300,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":301,"geoPoint":305,"contacts":306},"H.Universitario de Jerez de la Frontera","Jerez de la Frontera",{"type":81,"coordinates":302},[303,304],-6.13606,36.68645,{"lat":304,"lon":303},[307,310],{"name":308,"role":65,"phone":32,"phoneExt":32,"email":309},"Sebastián Garzón López, Dr","sebastianf.garzon.sspa@juntadeandalucia.es",{"name":311,"role":92,"phone":32,"phoneExt":32,"email":32},"Sebastian Garzón López",{"facility":313,"status":75,"city":314,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":315,"geoPoint":319,"contacts":320},"Complejo Asistencial Universitario de León","León",{"type":81,"coordinates":316},[317,318],-5.57032,42.60003,{"lat":318,"lon":317},[321,325],{"name":322,"role":65,"phone":323,"phoneExt":32,"email":324},"Fernando Escalante Barrigón, Dr","987 237400","fescalanteb@yahoo.es",{"name":326,"role":92,"phone":32,"phoneExt":32,"email":32},"Fernando Escalante Barrigón",{"facility":328,"status":75,"city":329,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":330,"geoPoint":334,"contacts":335},"Hospital Arnau de Vilanova (Lleida)","Lleida",{"type":81,"coordinates":331},[332,333],0.62218,41.61674,{"lat":333,"lon":332},[336,339],{"name":337,"role":65,"phone":32,"phoneExt":32,"email":338},"Antoni Garcia Guiñon","agarciag.lleida.ics@gencat.cat",{"name":337,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":341,"status":75,"city":342,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":343,"geoPoint":347,"contacts":348},"Hospital San Pedro","Logroño",{"type":81,"coordinates":344},[345,346],-2.45115,42.46615,{"lat":346,"lon":345},[349,353],{"name":350,"role":65,"phone":351,"phoneExt":32,"email":352},"María José Nájera Irazu, Dr","941 298000","mjnajera@riojasalud.es",{"name":354,"role":92,"phone":32,"phoneExt":32,"email":32},"María José Nájera Irazu",{"facility":356,"status":75,"city":357,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":358,"geoPoint":362,"contacts":363},"Complejo Hospitalario Lucus Augusti","Lugo",{"type":81,"coordinates":359},[360,361],-7.55602,43.00992,{"lat":361,"lon":360},[364,368],{"name":365,"role":65,"phone":366,"phoneExt":32,"email":367},"Esperanza Lavilla Rubia, Dr","982 296000","Esperanza.Lavilla.Rubira@sergas.es",{"name":369,"role":92,"phone":32,"phoneExt":32,"email":32},"Esperanza Lavilla Rubia",{"facility":371,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":372,"geoPoint":376,"contacts":377},"Fundación Jiménez Díaz-Ute",{"type":81,"coordinates":373},[374,375],-3.70256,40.4165,{"lat":375,"lon":374},[378,381],{"name":379,"role":65,"phone":32,"phoneExt":32,"email":380},"Elena Prieto Pareja, Dr","eprieto@fjd.es",{"name":382,"role":92,"phone":32,"phoneExt":32,"email":32},"Elena Prieto Pareja",{"facility":384,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":385,"geoPoint":387,"contacts":388},"Hospital General Universitario Gregorio Marañón",{"type":81,"coordinates":386},[374,375],{"lat":375,"lon":374},[389,392],{"name":390,"role":65,"phone":32,"phoneExt":32,"email":391},"Cristina Encinas Rodríguez","crisenro@hotmail.com",{"name":390,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":394,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":395,"geoPoint":397,"contacts":398},"Hospital HLA Universitario Moncloa",{"type":81,"coordinates":396},[374,375],{"lat":375,"lon":374},[399,402],{"name":400,"role":65,"phone":32,"phoneExt":32,"email":401},"María Concepción Alaez Usón","concha.alaez@gmail.com",{"name":400,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":404,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":405,"geoPoint":407,"contacts":408},"Hospital Universitario 12 de octubre",{"type":81,"coordinates":406},[374,375],{"lat":375,"lon":374},[409,412],{"name":410,"role":65,"phone":32,"phoneExt":32,"email":411},"Joaquín Martínez López, Dr","jmarti01@med.ucm.es",{"name":413,"role":92,"phone":32,"phoneExt":32,"email":32},"Joaquín Martínez López",{"facility":415,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":416,"geoPoint":418,"contacts":419},"Hospital Universitario Clínico San Carlos",{"type":81,"coordinates":417},[374,375],{"lat":375,"lon":374},[420,423],{"name":421,"role":65,"phone":32,"phoneExt":32,"email":422},"Celina María Benavente Cuesta","celinamaria.benavente@salud.madrid.org",{"name":421,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":425,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":426,"geoPoint":428,"contacts":429},"Hospital Universitario de Fuenlabrada",{"type":81,"coordinates":427},[374,375],{"lat":375,"lon":374},[430,434],{"name":431,"role":65,"phone":432,"phoneExt":32,"email":433},"Pilar Bravo Barahona, Dr","91 6006379","pilar.bravo@salud.madrid.org; pilarbravob@gmail.com",{"name":435,"role":92,"phone":32,"phoneExt":32,"email":32},"Pilar Bravo Barahona",{"facility":437,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":438,"geoPoint":440,"contacts":441},"Hospital Universitario de la Princesa",{"type":81,"coordinates":439},[374,375],{"lat":375,"lon":374},[442,445],{"name":443,"role":65,"phone":32,"phoneExt":32,"email":444},"Adrián Alegre Amor, Dr","adrian.alegre@telefonica.net; aalegre.hlpr@salud.madrid.org",{"name":446,"role":92,"phone":32,"phoneExt":32,"email":32},"Alegre Adrián Amor, Dr",{"facility":448,"status":449,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":450,"geoPoint":452,"contacts":32},"Hospital Universitario Fundación Alcorcón","COMPLETED",{"type":81,"coordinates":451},[374,375],{"lat":375,"lon":374},{"facility":454,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":455,"geoPoint":457,"contacts":458},"Hospital Universitario HM Sanchinarro",{"type":81,"coordinates":456},[374,375],{"lat":375,"lon":374},[459,463],{"name":460,"role":65,"phone":461,"phoneExt":32,"email":462},"Jaime Pérez de Oteyza, Dr","+ 34 902 08 98 00","jperezoteyza@hmhospitales.com",{"name":464,"role":92,"phone":32,"phoneExt":32,"email":32},"Jaime Pérez de Oteyza",{"facility":466,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":467,"geoPoint":469,"contacts":470},"Hospital Universitario Infanta Leonor",{"type":81,"coordinates":468},[374,375],{"lat":375,"lon":374},[471,474],{"name":472,"role":65,"phone":32,"phoneExt":32,"email":473},"Jose Ángel Hernández Rivas","jahernandezr@salud.madrid.org; jahr_jahr2006@yahoo.es",{"name":472,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":476,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":477,"geoPoint":479,"contacts":480},"Hospital Universitario La Paz",{"type":81,"coordinates":478},[374,375],{"lat":375,"lon":374},[481,484],{"name":482,"role":65,"phone":32,"phoneExt":32,"email":483},"Ana López de la Guía","lopguia@gmail.com",{"name":482,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":486,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":487,"geoPoint":489,"contacts":490},"Hospital Universitario La Zarzuela",{"type":81,"coordinates":488},[374,375],{"lat":375,"lon":374},[491,494],{"name":492,"role":65,"phone":32,"phoneExt":32,"email":493},"Daniel García Belmonte","dgarciabe@sanitas.es",{"name":492,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":496,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":497,"geoPoint":499,"contacts":500},"Hospital Universitario Puerta del Hierro",{"type":81,"coordinates":498},[374,375],{"lat":375,"lon":374},[501,504],{"name":502,"role":65,"phone":32,"phoneExt":32,"email":503},"Rafael Ríos Tamayo","rriost33@gmail.com",{"name":502,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":506,"status":75,"city":77,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":507,"geoPoint":509,"contacts":510},"Hospital Universitario Ramón y Cajal",{"type":81,"coordinates":508},[374,375],{"lat":375,"lon":374},[511,515],{"name":512,"role":65,"phone":513,"phoneExt":32,"email":514},"María Jesús Blanchard Rodríguez, Dr","+ 34 913 36 80 00","mjesusblanchard@yahoo.es",{"name":516,"role":92,"phone":32,"phoneExt":32,"email":32},"María Jesús Blanchard Rodríguez",{"facility":518,"status":75,"city":519,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":520,"geoPoint":524,"contacts":525},"Hospital Costa del Sol","Málaga",{"type":81,"coordinates":521},[522,523],-4.42034,36.72016,{"lat":523,"lon":522},[526,530],{"name":527,"role":65,"phone":528,"phoneExt":32,"email":529},"María Casanova Espinosa, Dr","951 976798","mariacasanova@yahoo.com",{"name":531,"role":92,"phone":32,"phoneExt":32,"email":32},"María Casanova Espinosa",{"facility":533,"status":75,"city":519,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":534,"geoPoint":536,"contacts":537},"Hospital Regional de Málaga",{"type":81,"coordinates":535},[522,523],{"lat":523,"lon":522},[538,541],{"name":539,"role":65,"phone":32,"phoneExt":32,"email":540},"María Magdalena Alcalá Peña","kikistrata@hotmail.com",{"name":539,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":543,"status":75,"city":519,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":544,"geoPoint":546,"contacts":547},"Hospital U Niversitario Virgen de La Victoria",{"type":81,"coordinates":545},[522,523],{"lat":523,"lon":522},[548,552],{"name":549,"role":65,"phone":550,"phoneExt":32,"email":551},"Ricarda García Sánchez, Dr","+ 34 951 03 20 00","ricarda_g@yahoo.es",{"name":553,"role":92,"phone":32,"phoneExt":32,"email":32},"Ricarda García Sánchez",{"facility":555,"status":75,"city":556,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":557,"geoPoint":561,"contacts":562},"Hospital Universitario Rey Juan Carlos","Móstoles",{"type":81,"coordinates":558},[559,560],-3.86496,40.32234,{"lat":560,"lon":559},[563,566],{"name":564,"role":65,"phone":32,"phoneExt":32,"email":565},"Alberto Velasco Valdazo","alberto.velasco@hospitalreyjuancarlos.es",{"name":564,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":568,"status":75,"city":569,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":570,"geoPoint":574,"contacts":575},"H. Morales Meseguer","Murcia",{"type":81,"coordinates":571},[572,573],-1.13004,37.98704,{"lat":573,"lon":572},[576,579],{"name":577,"role":65,"phone":32,"phoneExt":32,"email":578},"Felipe de Arriba de la Fuente","farriba@um.es",{"name":577,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":581,"status":75,"city":569,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":582,"geoPoint":584,"contacts":585},"H. Un. Virgen de la Arrixaca",{"type":81,"coordinates":583},[572,573],{"lat":573,"lon":572},[586,589],{"name":587,"role":65,"phone":32,"phoneExt":32,"email":588},"Valentín Cabañas Perianes","valentin.cabanas@gmail.com",{"name":587,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":591,"status":449,"city":569,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":592,"geoPoint":594,"contacts":32},"Hospital General Universitario Santa Lucía",{"type":81,"coordinates":593},[572,573],{"lat":573,"lon":572},{"facility":596,"status":449,"city":597,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":598,"geoPoint":602,"contacts":32},"Complejo Hospitalario Universitario de Ourense","Ourense",{"type":81,"coordinates":599},[600,601],-7.86407,42.33669,{"lat":601,"lon":600},{"facility":604,"status":75,"city":605,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":606,"geoPoint":610,"contacts":611},"Hospital Universitario Central de Asturias","Oviedo",{"type":81,"coordinates":607},[608,609],-5.84476,43.36029,{"lat":609,"lon":608},[612,616,618],{"name":613,"role":65,"phone":614,"phoneExt":32,"email":615},"Ana Pilar González Rodríguez, Dr","+34 985 108 000","anapilargonzalez@gmail.com; apayer.angel@gmail.com",{"name":617,"role":92,"phone":32,"phoneExt":32,"email":32},"Ana Pilar González Rodríguez",{"name":619,"role":92,"phone":32,"phoneExt":32,"email":32},"Ángel Ramírez Payer",{"facility":621,"status":75,"city":622,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":623,"geoPoint":627,"contacts":628},"Hospital Son Llatzer","Palma de Mallorca",{"type":81,"coordinates":624},[625,626],2.65024,39.56939,{"lat":626,"lon":625},[629,632],{"name":630,"role":65,"phone":32,"phoneExt":32,"email":631},"Joan Bargay Llenonart","jbargay@hsll.es",{"name":630,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":634,"status":75,"city":622,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":635,"geoPoint":637,"contacts":638},"Hospital Universitari Son Espases",{"type":81,"coordinates":636},[625,626],{"lat":626,"lon":625},[639,643],{"name":640,"role":65,"phone":641,"phoneExt":32,"email":642},"Antonia Sampol Mayol, Dr","971 175000","antonia.sampolm@ssib.es",{"name":644,"role":92,"phone":32,"phoneExt":32,"email":32},"Antonia Sampol Mayol",{"facility":646,"status":75,"city":109,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":647,"geoPoint":649,"contacts":650},"Complejo Hospitalario de Navarra",{"type":81,"coordinates":648},[114,115],{"lat":115,"lon":114},[651,655],{"name":652,"role":65,"phone":653,"phoneExt":32,"email":654},"Jose María Arguiñano Pérez, Dr","948 25 54 00","jm.arguinano.perez@cfnavarra.es",{"name":656,"role":92,"phone":32,"phoneExt":32,"email":32},"Jose María Arguiñano Pérez",{"facility":658,"status":75,"city":659,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":660,"geoPoint":664,"contacts":665},"Complejo Hospitalario de Pontevedra","Pontevedra",{"type":81,"coordinates":661},[662,663],-8.64435,42.431,{"lat":663,"lon":662},[666,670],{"name":667,"role":65,"phone":668,"phoneExt":32,"email":669},"Ana María Dios Loureiro, Dr","986 800050","adiolou@gmail.com",{"name":671,"role":92,"phone":32,"phoneExt":32,"email":32},"Ana María Dios Loureiro",{"facility":673,"status":75,"city":674,"state":32,"zip":675,"country":78,"countryCode":79,"cosmosGeoPoint":676,"geoPoint":680,"contacts":681},"Hospital Clinico Universitario Salamanca","Salamanca","37007",{"type":81,"coordinates":677},[678,679],-5.66388,40.96882,{"lat":679,"lon":678},[682,685],{"name":683,"role":65,"phone":32,"phoneExt":32,"email":684},"Mª Victoria Mateos Manteca, Dr","mvmateos@usal.es",{"name":686,"role":92,"phone":32,"phoneExt":32,"email":32},"Mª Victoria Mateos Manteca",{"facility":688,"status":75,"city":689,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":690,"geoPoint":694,"contacts":695},"Hospital Universitario de Canarias","San Cristóbal de La Laguna",{"type":81,"coordinates":691},[692,693],-16.32014,28.4853,{"lat":693,"lon":692},[696,699,700],{"name":697,"role":65,"phone":32,"phoneExt":32,"email":698},"Sunil Lakhwani","mthernan@ull.es\u002Fmailto:sunillakhwani@hotmail.com",{"name":697,"role":92,"phone":32,"phoneExt":32,"email":32},{"name":701,"role":92,"phone":32,"phoneExt":32,"email":32},"Miguel Teodoro Hernández",{"facility":703,"status":75,"city":704,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":705,"geoPoint":709,"contacts":710},"Hospital Universitario de Donostia","San Sebastián",{"type":81,"coordinates":706},[707,708],-5.9,43.56667,{"lat":708,"lon":707},[711,715],{"name":712,"role":65,"phone":713,"phoneExt":32,"email":714},"Maialen Sirvent Auzmendi, Dr","943 007000","MAIALEN.SIRVENTAUZMENDI@osakidetza.eus",{"name":716,"role":92,"phone":32,"phoneExt":32,"email":32},"Maialen Sirvent Auzmendi",{"facility":718,"status":75,"city":719,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":720,"geoPoint":724,"contacts":725},"Hospital Universitario Infanta Sofía","San Sebastián de los Reyes",{"type":81,"coordinates":721},[722,723],-3.62733,40.55555,{"lat":723,"lon":722},[726,729],{"name":727,"role":65,"phone":32,"phoneExt":32,"email":728},"Eugenio Giménez Mesa","gimenezeu@yahoo.es",{"name":727,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":731,"status":75,"city":732,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":733,"geoPoint":737,"contacts":738},"Complejo Hospitalario Universitario Nuestra Señora de la Candelaria","Santa Cruz de Tenerife",{"type":81,"coordinates":734},[735,736],-16.25462,28.46824,{"lat":736,"lon":735},[739,743],{"name":740,"role":65,"phone":741,"phoneExt":32,"email":742},"Pablo Ríos Rull, Dr","Pablo","pablo.riosrull@gmail.com; priosrul@ull.es",{"name":744,"role":92,"phone":32,"phoneExt":32,"email":32},"Pablo Ríos Rull",{"facility":746,"status":75,"city":747,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":748,"geoPoint":752,"contacts":753},"H. Universitario Marqués de Valdecilla","Santander",{"type":81,"coordinates":749},[750,751],-3.80493,43.46589,{"lat":751,"lon":750},[754,757],{"name":755,"role":65,"phone":32,"phoneExt":32,"email":756},"Enrique Ocio","Enriquem.ocio@scsalud.es",{"name":755,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":759,"status":75,"city":760,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":761,"geoPoint":765,"contacts":766},"Complejo Hospitalario Santiago (CHUS)","Santiago de Compostela",{"type":81,"coordinates":762},[763,764],-8.54569,42.88052,{"lat":764,"lon":763},[767,770],{"name":768,"role":65,"phone":32,"phoneExt":32,"email":769},"Marta Sonia González Pérez","marta.sonia.gonzalez.perez@sergas.es",{"name":768,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":772,"status":75,"city":773,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":774,"geoPoint":778,"contacts":779},"Hospital General de Segovia","Segovia",{"type":81,"coordinates":775},[776,777],-4.11839,40.94808,{"lat":777,"lon":776},[780,784],{"name":781,"role":65,"phone":782,"phoneExt":32,"email":783},"Aránzazu García Mateo, Dr","+ 34 921 41 91 00","aranzazugarciamateo@hotmail.com",{"name":785,"role":92,"phone":32,"phoneExt":32,"email":32},"Aránzazu García Mateo",{"facility":787,"status":75,"city":788,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":789,"geoPoint":793,"contacts":794},"Complejo Hospitalario Regional Virgen Del Rocío","Seville",{"type":81,"coordinates":790},[791,792],-5.97317,37.38283,{"lat":792,"lon":791},[795,798],{"name":796,"role":65,"phone":32,"phoneExt":32,"email":797},"Estrella Carrillo Cruz, Dr","estrellacarrillocruz@gmail.com",{"name":799,"role":92,"phone":32,"phoneExt":32,"email":32},"Estrella Carrillo Cruz",{"facility":801,"status":75,"city":788,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":802,"geoPoint":804,"contacts":805},"H. Universitario de Valme",{"type":81,"coordinates":803},[791,792],{"lat":792,"lon":791},[806,809],{"name":807,"role":65,"phone":32,"phoneExt":32,"email":808},"María del Carmen Couto Caro","mariac.couto.sspa@juntadeandalucia.es",{"name":807,"role":92,"phone":32,"phoneExt":32,"email":32},{"facility":811,"status":75,"city":788,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":812,"geoPoint":814,"contacts":815},"Hospital Universitario Reina Sofía",{"type":81,"coordinates":813},[791,792],{"lat":792,"lon":791},[816,819],{"name":817,"role":65,"phone":32,"phoneExt":32,"email":818},"Miguel Ángel Álvarez Rivas, Dr","mangel.alvarez.sspa@juntadeandalucia.es",{"name":820,"role":92,"phone":32,"phoneExt":32,"email":32},"Miguel Ángel Álvarez Rivas",{"facility":822,"status":75,"city":823,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":824,"geoPoint":828,"contacts":829},"Hospital Universitari de Tarragona Joan XXIII","Tarragona",{"type":81,"coordinates":825},[826,827],1.24544,41.11905,{"lat":827,"lon":826},[830,833],{"name":831,"role":65,"phone":32,"phoneExt":32,"email":832},"Josep Sarrà Escarré","jsarra@iconcologia.net",{"name":834,"role":92,"phone":32,"phoneExt":32,"email":32},"Josep Sarrà Escarré, Dr",{"facility":836,"status":75,"city":837,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":838,"geoPoint":842,"contacts":843},"Hospital Universitari Mutua Terrassa","Terrassa",{"type":81,"coordinates":839},[840,841],2.01667,41.56667,{"lat":841,"lon":840},[844,848],{"name":845,"role":65,"phone":846,"phoneExt":32,"email":847},"Josep Mª Martí Tutusaus, Dr","+ 34 93 736 50 50","jmarti@mutuaterrassa.es",{"name":849,"role":92,"phone":32,"phoneExt":32,"email":32},"Josep Mª Martí Tutusaus",{"facility":851,"status":75,"city":852,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":853,"geoPoint":857,"contacts":858},"Complejo Hospitalario de Toledo (Virgen de la Salud)","Toledo",{"type":81,"coordinates":854},[855,856],-4.02263,39.8581,{"lat":856,"lon":855},[859,863],{"name":860,"role":65,"phone":861,"phoneExt":32,"email":862},"Felipe Casado Montero, Dr","925 269243","lfcasadom@telefonica.net",{"name":864,"role":92,"phone":32,"phoneExt":32,"email":32},"Felipe Casado Montero",{"facility":866,"status":75,"city":867,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":868,"geoPoint":872,"contacts":873},"Hospital Clínico Universitario de Valencia","Valencia",{"type":81,"coordinates":869},[870,871],-0.37966,39.47391,{"lat":871,"lon":870},[874,878],{"name":875,"role":65,"phone":876,"phoneExt":32,"email":877},"Ana Isabel Teruel Casasus, Dr","961 973838","ateruelc@hotmail.com",{"name":879,"role":92,"phone":32,"phoneExt":32,"email":32},"Ana Isabel Teruel Casasus",{"facility":881,"status":75,"city":867,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":882,"geoPoint":884,"contacts":885},"Hospital Universitari i Politecnic la Fe",{"type":81,"coordinates":883},[870,871],{"lat":871,"lon":870},[886,890],{"name":887,"role":65,"phone":888,"phoneExt":32,"email":889},"Mario Arnao Herraiz, Dr","96 1244192","arnao_mar@gva.es",{"name":891,"role":92,"phone":32,"phoneExt":32,"email":32},"Mario Arnao Herraiz",{"facility":893,"status":75,"city":867,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":894,"geoPoint":896,"contacts":897},"Hospital Universitario Dr. Peset Aleixandre",{"type":81,"coordinates":895},[870,871],{"lat":871,"lon":870},[898,902],{"name":899,"role":65,"phone":900,"phoneExt":32,"email":901},"Paz Ribas García, Dr","963 862500","ribas_paz@gva.es",{"name":903,"role":92,"phone":32,"phoneExt":32,"email":32},"Paz Ribas García",{"facility":905,"status":75,"city":906,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":907,"geoPoint":911,"contacts":912},"H. U. Txagorritxu","Vitoria-Gasteiz",{"type":81,"coordinates":908},[909,910],-2.67268,42.84998,{"lat":910,"lon":909},[913,916],{"name":914,"role":65,"phone":32,"phoneExt":32,"email":915},"Xabier Gutierrez López de Ocariz, Dr","XABIER.GUTIERREZLOPEZDEOCARIZ@osakidetza.eus",{"name":917,"role":92,"phone":32,"phoneExt":32,"email":32},"Xabier Gutierrez López de Ocariz",{"facility":919,"status":75,"city":920,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":921,"geoPoint":925,"contacts":926},"Hospital Clinico Universitario Lozano Blesa","Zaragoza",{"type":81,"coordinates":922},[923,924],-0.87734,41.65606,{"lat":924,"lon":923},[927,931],{"name":928,"role":65,"phone":929,"phoneExt":32,"email":930},"Luis Ramón Palomera Bernal, Dr","34 976 556 400","lpalomera@salud.aragon.es",{"name":932,"role":92,"phone":32,"phoneExt":32,"email":32},"Luis Ramón Palomera Bernal",{"facility":934,"status":75,"city":920,"state":32,"zip":32,"country":78,"countryCode":79,"cosmosGeoPoint":935,"geoPoint":937,"contacts":938},"Hospital Universitario Miguel Servet",{"type":81,"coordinates":936},[923,924],{"lat":924,"lon":923},[939,942],{"name":940,"role":65,"phone":32,"phoneExt":32,"email":941},"Ana Cristina Godoy Molias","anagodoy1006@hotmail.com",{"name":940,"role":92,"phone":32,"phoneExt":32,"email":32},{"type":944,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[946,949,951],{"name":947,"class":948},"Bristol-Myers Squibb","INDUSTRY",{"name":950,"class":948},"Sanofi",{"name":952,"class":948},"Adknoma Health Research","100482153","phase-3-ndmm-patients-candidates-for-asct-comparing-extended-vrd-plus-vs-isa-vrd-vs-isa-v-iberdomide-100482153",false,"NCT05558319","NDMM Patients Candidates for ASCT Comparing Extended VRD Plus vs. Isa-VRD vs. Isa-V-Iberdomide","GEM21menos65. A Phase III Trial for NDMM Patients Who Are Candidates for ASCT Comparing Extended VRD Plus Early Rescue Intervention vs Isatuximab-VRD vs Isatuximab-V-Iberdomide-D","GEM21menos65","Inclusion Criteria:\n\n1. Patient is, in the investigator's opinion, willing and able to comply with the protocol requirements.\n2. Patient must be able to understand the study procedures.\n3. Patient has given voluntary written informed consent before performance of any studyrelated procedure non part of normal medical care, with the understanding that consent may be withdrawn by the patient at any time without prejudice to their future medical care.\n4. Newly diagnosed multiple myeloma patient who requires start active treatment according to the 2014 IMWG criteria, namely clonal bone marrow plasma cells ≥10% or biopsy-proven bony or extramedullary plasmacytoma and any one or more of the following myeloma defining events: evidence of end organ damage that can be attributed to the underlying plasma cell proliferative disorder, specifically: Hypercalcaemia, Anaemia, Renal Insufficiency, or Bone lesions (one or more osteolytic lesions on skeletal radiography, CT, or PET-CT), and any one or more of the following biomarkers: clonal BMPC% ≥60%, i\u002Fu free light ratio ≥100 or \\> 1 focal lesions on MRI or PET\u002FCT) \\[Lancet Oncol. 2014;15(12): e538-e548\\].\n5. Patient must have a measurable secretory disease defined as either serum monoclonal protein of ≥ 0,5 g\u002Fdl or urine monoclonal (light chain) protein ≥ 200 mg\u002F24 h. For patients whose disease is only measurable by serum FLC, the involved FLC should be ≥ 10mg\u002FdL (100 mg\u002FL), with an abnormal serum FLC ratio.\n6. Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2.\n7. Patient must be ≤ 65 years of age.\n8. Patient must have adequate organ function, defined as follows:\n\n   * Absolute neutrophil count (ANC) ≥1.0 X 109\u002FL without G-CSF use in the prior 7 days\n   * Hemoglobin ≥8.0 g\u002FdL (prior red blood cell (RBC) transfusion or recombinant human erythropoietin use is permitted)\n   * Platelets ≥ 75 x 109\u002FL in participants in whom \\\u003C50% of bone marrow nucleated cells are plasma cells and ≥ 50×109\u002FL in participants in whom ≥50% of bone marrow nucleated cells are plasma cells (without transfusion support or thrombopoietin receptor agonist within 7 days before the laboratory test).\n   * Calcium Corrected serum calcium ≤13.5 mg\u002FdL (≤3.4 mmol\u002FL); or free ionized calcium ≤6.5 mg\u002FdL (≤1.6 mmol\u002FL).\n   * Total bilirubin ≤2 X ULN\n   * ALT ≤2.5 X ULN\n   * AST ≤2.5 X ULN\n   * Renal: eGFRa: ≥40 mL\u002Fmin\u002F 1.73 m2\n   * Cardiac: LVEF (echo) ≥ 50%\n9. Female patient: contraceptive use should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. A female patient is eligible to participate if she is not pregnant or breastfeeding, and at least one of the following conditions applies:\n\n   * Is not a woman of childbearing potential (WOCBP), i.e., fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilization methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy OR\n   * Is a WOCBP and\n\n     * She understands the potential teratogenic risk to the unborn child\n     * She understands the need for effective contraception as stated in the protocol, without interruption, 28 days before starting study treatment, throughout the entire duration of study treatment, during dose interruptions and for at least 28 days after the last dose of study treatment.\n     * She understands and agrees to inform the Investigator if a change or stop of method of contraception is needed.\n     * She must be capable of complying with effective contraceptive measures.\n     * She is informed and understands the potential consequences of pregnancy and the need to notify her study doctor immediately if there is a risk of pregnancy.\n     * She understands the need to commence study treatment as soon as it is dispensed following a negative pregnancy test.\n     * She understands and accepts the need to undergo pregnancy testing based on the frequency outlined in this plan and in the Informed Consent.\n     * She acknowledges she understands the hazards iberdomide or lenalidomide can cause to an unborn fetus and the necessary precautions associated with the use of study drugs.\n\n   The Investigator must ensure that a WOCBP: i) Complies with the conditions of the pregnancy prevention plan, including confirmation that she has an adequate level of understanding. ii) Acknowledges the aforementioned requirements.\n\n   A WOCBP must have a negative highly sensitive serum pregnancy test (as required by local regulations) within 72 hours before the first dose of study drug.\n\n   Nonchildbearing potential is defined as follows (by other than medical reasons):\n   * Has not achieved menarche at some point.\n   * Has undergone a hysterectomy or bilateral oophorectomy.\n   * Has been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (ie, has had menses at any time in the preceding 24 consecutive months).\n10. Male patient: contraceptive use should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.\n\n    Male patient is eligible to participate if he agrees to the following from the time of first dose of study until 6 months after the last dose of iberdomide or lenalidomide to allow for clearance of any altered sperm:\n    * Understand the potential teratogenic risk if engaged in sexual activity with a pregnant female or a WOCBP.\n    * Understand the need for the use of a condom even if he has had a vasectomy, if engaged in sexual activity with a pregnant female or a FCBP\n    * Understand the potential teratogenic risk, so the subject should not donate semen or sperm.. Understand that the effects on fertility are currently unknown, therefore all family planning options and\u002For alternatives should be thoroughly discussed with the study doctor prior to receiving iberdomide.\n11. All prior treatment-related toxicities (defined by National Cancer Institute- Common Toxicity Criteria for Adverse Events (NCI-CTCAE), version 5.0 must be ≤ Grade 1 at the time of enrolment except for alopecia.\n\nExclusion Criteria:\n\n1. Patient has a diagnosis of primary amyloidosis, monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), plasma cell leukemia or active POEMS syndrome at the time of screening.\n2. Patient has had clinical evidence of central nervous system (CNS) or pulmonary leukostasis, disseminated intravascular coagulation, or CNS multiple myeloma.\n3. Prior history of malignancies, other than multiple myeloma (except for basal or squamous cell carcinoma of the skin, carcinoma in situ of the cervix or the breast), unless the patient has been free of the disease for ≥ 5 years.\n4. Any serious medical condition that places the subject at an unacceptable risk if he or she participates in this study; subjects with conditions requiring chronic steroid or immunosuppressive treatment, such as rheumatoid arthritis, multiple sclerosis and\u002For lupus, that likely need additional steroid or immunosuppressive treatments in addition to the study treatment.\n5. Pregnant or breastfeeding females.\n6. Men and women of reproductive potential who are not using effective contraceptive methods (double barrier method, intrauterine device, oral contraception).\n7. Patient is simultaneously enrolled in other interventional clinical trial.\n8. Patient has used an investigational drug within 28 days or five half-lives, whichever is longer, preceding the first dose of study drug.\n9. Patient must not have received prior radiotherapy (except localized palliative radiotherapy for pain, palliation or fracture) within 2 weeks of start of study therapy. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis.\n10. Major surgery (except kyphoplasty) ≤ 4 weeks prior to initiating protocol therapy.\n11. Patient has peripheral neuropathy or neuropathic pain grade 1 with pain or ≥2, as defined by the National Cancer Institute Terminology Criteria for Adverse Events (NCI CTCAE) Version 5.0.\n12. Patient evidence of cardiovascular risk including any of the following:\n\n    * Myocardial infarction within 6 months before randomization, or an unstable or uncontrolled disease\u002Fcondition related to or affecting cardiac function (eg, unstable angina, congestive heart failure, New York Heart Association Class III-IV).\n    * Uncontrolled cardiac arrhythmia.\n    * Screening 12-lead ECG showing a baseline interval QTcF\\> 470 msec (exception: subjects with pacemaker).\n    * Patients with uncontrolled hypertension.\n13. Patients who have current unstable liver or biliary disease defined by the presence of ascites, encephalopathy, coagulopathy, hypoalbuminemia, esophageal or gastric varices, persistent jaundice, or cirrhosis. Note: Stable chronic liver disease (including Gilbert's syndrome or asymptomatic gallstones) or hepatobiliary involvement of malignancy is acceptable if otherwise meets entry criteria.\n14. Presence of active renal condition (infection, requirement for dialysis or any other condition that could affect patient's safety). Participants with isolated proteinuria resulting from MM are eligible, provided they fulfil inclusion criteria.\n15. Evidence of active mucosal or internal bleeding.\n16. Any serious medical condition or psychiatric illness that would interfere in understanding of the informed consent form.\n17. Uncontrolled endocrine diseases (i.e. diabetes mellitus, hypothyroidism or hyperthyroidism) (i.e. requiring relevant changes in medication within the last month, or hospital admission within the last 3 months).\n18. Patient with acute diffuse infiltrative pulmonary disease and\u002For pericardial disease.\n19. Patient with severe chronic obstructive pulmonary disease (COPD) or asthma with forced expiratory volume in the first minute (FEV1) less than 50%.\n20. History of interstitial lung disease or ongoing interstitial lung disease.\n21. Subject has gastrointestinal disease that may significantly alter the absorption of iberdomide and\u002For other oral study treatment.\n22. Patient has an active infection requiring systemic antibiotic, antiviral, or antifungal treatment at the time of starting treatment.\n23. Patient has known HIV infection.\n24. Patient has positive hepatitis B surface antigen (HBsAg), or hepatitis B core antibody (HBcAb) at screening or within 3 months prior to first dose of study treatment.\n25. Patient has positive hepatitis C antibody test result or positive hepatitis C RNA test result at screening or within 3 months prior to first dose of study treatment. Note: Participants with positive Hepatitis C antibody due to prior resolved disease can be enrolled, only if a confirmatory negative Hepatitis C RNA test is obtained. Note: Hepatitis RNA testing is optional and participants with negative Hepatitis C antibody test are not required.\n26. Patient require concurrent administration of a strong inhibitor or inducer of cytochrome P450 (CYP3A4\u002F5) (including within 14 days of initiating study treatment).\n27. Patient has a known immediate or delayed hypersensitivity reaction or idiosyncratic reactions to iberdomide or drugs chemically related to iberdomide.\n28. Patient has a known immediate or delayed hypersensitivity reaction or idiosyncratic reactions to isatuximab or drugs chemically related to isatuximab, hypersensitivity reactions, or idiosyncratic reactions to other molecular antibodies.\n29. Patient has a known immediate or delayed hypersensitivity reaction or idiosyncratic reactions to lenalidomide or dexamethasone or drugs chemically related to lenalidomide or dexamethasone.","ALL","18 Years","65 Years",{"count":965,"type":966},480,"ESTIMATED","INTERVENTIONAL",[969],"PHASE3","This is a Phase III open-label, 3-arm, parallel, randomized, controlled trial. The allocation ratio 1:1:1 and outcome assessment are blind to group allocation. Patients will be randomized from 3 arms. Patients will receive VRD extended + ASCT plus ERI or Isatuximab-VRD + ASCT or Isatuximab-VID + ASCT.",[972],"Newly Diagnosed Multiple Myeloma","2026-06-23",{"date":975,"type":976},"2026-06-25","ACTUAL",{"date":978,"type":976},"2022-11-10",{"date":980,"type":966},"2029-04",{"name":5,"class":6},68]