[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100379157":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":55,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":38,"whyStopped":25,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Children's Hospital Medical Center, Cincinnati","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nitric Oxide","EXPERIMENTAL","Intraoperative NO entrained at 20 ppm into the oxygenator of the CPB circuit with standard care",[13],"Drug: Nitric Oxide",{"label":15,"type":16,"description":17,"interventionNames":18},"Oxygen","PLACEBO_COMPARATOR","Standard CPB without NO administered at any point intraoperatively",[19],"Drug: Oxygen",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","gNO will be entrained at 20 ppm into the oxygenator of the CPB circuit",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Oxygen alone will be entrained for placebo arm",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"David S Cooepr, MD","CONTACT","5138035448","David.Cooper@cchmc.org",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Cincinnati Children's Hospital Medical Center","RECRUITING","Cincinnati","Ohio","45229","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-84.51439,39.12711,{"lat":48,"lon":47},[51],{"name":52,"role":32,"phone":33,"phoneExt":25,"email":34},"David S. Cooper, MD",{"type":54,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[56,59],{"name":57,"class":58},"Mallinckrodt","INDUSTRY",{"name":60,"class":6},"Indiana University","100379157","phase-3-no-during-cpb-in-neonates-to-reduce-risk-of-aki-100379157",false,"NCT04216927","NO During CPB in Neonates to Reduce Risk of AKI","Efficacy of Nitric Oxide Administration During Cardiopulmonary Bypass in Neonates at Reducing the Risk of Acute Kidney Injury","Inclusion Criteria:\n\n* All neonates (≤31 days) undergoing cardiac surgery with CPB for CHD will be deemed eligible for enrollment.\n\nExclusion Criteria:\n\n1. Failure to obtain informed consent from parent\u002Fguardian\n2. Clinical signs of preoperative persistent elevated pulmonary vascular resistance,\n3. Emergency surgery,\n4. Episode of cardiac arrest within 1 week before surgery,\n5. Recent treatment with steroids and\u002For a condition that may require treatment with steroids (excluding steroid administration specifically for CPB),\n6. Use of inhaled NO (iNO) immediately prior to surgery,\n7. Structural renal abnormalities by ultrasound,\n8. Preoperative AKI,\n9. Use of other investigational drugs,\n10. Weight less than \\\u003C2 kg,\n11. Gestational age \\\u003C36 weeks,\n12. Major extracardiac congenital anomalies,\n13. Non-English speakers.","ALL","1 Day","31 Days",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"PHASE3","Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality. Despite effort, to date, no successful therapeutic agent has gained widespread success in preventing this postoperative decline in renal function. Nitric oxide is an intricate regulator of acute inflammation and coagulation and is a potent vasodilator. The investigators hypothesize that nitric oxide, administered during cardiopulmonary bypass (CPB), may reduce the incidence of AKI.",[79,80,81],"AKI","CHD - Congenital Heart Disease","Surgery","2025-07-21",{"date":84,"type":85},"2025-07-24","ACTUAL",{"date":87,"type":85},"2023-01-10",{"date":89,"type":73},"2026-06-30",{"name":5,"class":6},1]