[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100545373":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":34,"locations":40,"responsibleParty":63,"collaborators":65,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":27,"enrollmentInfo":82,"targetDuration":27,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":43,"whyStopped":27,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Centre Hospitalier Universitaire, Amiens","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Ketoprofen","EXPERIMENTAL","Ketoprofen 100 mg twice a day, during 48 after surgery, intravenous administration",[13,14],"Drug: pain management","Drug: ketoprofen",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo","PLACEBO_COMPARATOR","Placebo twice a day, during 48 h after surgery, intravenous administration",[13,20],"Drug: PLacebo",[22,28,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","pain management","o Pain management in both arms Intraoperative time: intravenous ketamine 0.5 mg kg-1, intravenous dexamethasone 8 mg Postoperative time: paracetamol 1 g every 6 hours a day, nefopam 20 every 8 hours a day, patient control analgesia with morphine or oxycontin",[9,16],null,{"type":23,"name":29,"description":11,"armGroupLabels":30,"otherNames":27},"ketoprofen",[9],{"type":23,"name":32,"description":18,"armGroupLabels":33,"otherNames":27},"PLacebo",[16],[35],{"name":36,"role":37,"phone":38,"phoneExt":27,"email":39},"Osama ABOU ARAB, Pr","CONTACT","03 22 08 78 36","abouarab.osama@chu-amiens.fr",[41],{"facility":42,"status":43,"city":44,"state":27,"zip":27,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"CHU Amiens Picardie","RECRUITING","Amiens","France","FR",{"type":48,"coordinates":49},"Point",[50,51],2.3,49.9,{"lat":51,"lon":50},[54,56,59,61],{"name":55,"role":37,"phone":27,"phoneExt":27,"email":39},"Osama ABOU ARAB",{"name":57,"role":58,"phone":27,"phoneExt":27,"email":27},"Emmanuel BESNIER, MD","PRINCIPAL_INVESTIGATOR",{"name":60,"role":58,"phone":27,"phoneExt":27,"email":27},"Mouhamed MOUSSA, MD",{"name":62,"role":58,"phone":27,"phoneExt":27,"email":27},"Richard Descamps, MD",{"type":64,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR",[66,68,70],{"name":67,"class":6},"University Hospital, Rouen",{"name":69,"class":6},"University Hospital, Lille",{"name":71,"class":6},"University Hospital, Caen","100545373","phase-3-non-steroidal-anti-inflammatory-in-cardiac-surgery-100545373",false,"NCT06381063","Non-steroidal Anti-inflammatory in Cardiac Surgery","Effect of Non-steroidal Anti-inflammatory Drugs in Pain Management After Cardiac Surgery","KETOPAIN","Inclusion Criteria:\n\n* scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)\n* under cardiopulmonary bypass\n* Affiliation to the French national healthcare system\n* Written consent obtained\n\nExclusion Criteria:\n\n* age\\\u003C18\n* weight\\\u003C50 kg\n* chronic use of NSAID\n* mini-invasive surgery\n* NSAID contraindication\n* NSAID allergy\n* Nefopam contraindication\n* Paracetamol contraindication\n* Tramadol contraindication\n* Urgent surgery\n* Endocarditis\n* Immunosuppressive drug\n* HIV infection with CD4\\\u003C200 mm3\n* Organ transplantation\n* Stage 4 or 5 chronic kidney disease\n* Gastro duodenal ulcer\n* Pregnancy\n* Depression\n* Auto immune disease","ALL","18 Years",{"count":83,"type":84},238,"ESTIMATED","INTERVENTIONAL",[87],"PHASE3","Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.",[90,91,92,93,94],"Acute Postoperative Pain","Non-steroidal Anti-inflammatory Drugs","Cardiac Surgery","Pain Intensity","Multimodal Pain Management",[90,96,97,98,99],"non-steroidal anti-inflammatory drugs","cardiac surgery","pain intensity","multimodal pain management","2025-07-18",{"date":102,"type":103},"2025-07-23","ACTUAL",{"date":105,"type":103},"2024-03-27",{"date":107,"type":84},"2027-07",{"name":5,"class":6},1]