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Faculty","06620",{"type":70,"coordinates":1733},[1726,1727],{"lat":1727,"lon":1726},{"facility":1736,"status":63,"city":1721,"state":45,"zip":1737,"country":1723,"countryCode":45,"cosmosGeoPoint":1738,"geoPoint":1740,"contacts":45},"Ankara Bilkent Sehir Hastanesi","06800",{"type":70,"coordinates":1739},[1726,1727],{"lat":1727,"lon":1726},{"facility":1742,"status":63,"city":1743,"state":45,"zip":1744,"country":1723,"countryCode":45,"cosmosGeoPoint":1745,"geoPoint":1749,"contacts":45},"Uludag Universitesi Tıp Fakultesi Hastanesi","Bursa","16059",{"type":70,"coordinates":1746},[1747,1748],29.06013,40.19559,{"lat":1748,"lon":1747},{"facility":1751,"status":77,"city":1743,"state":45,"zip":1752,"country":1723,"countryCode":45,"cosmosGeoPoint":1753,"geoPoint":1755,"contacts":45},"Bursa High Speciality Training and Research Dortcelik Mental Hospital","16285",{"type":70,"coordinates":1754},[1747,1748],{"lat":1748,"lon":1747},{"facility":1757,"status":63,"city":1758,"state":45,"zip":1759,"country":1723,"countryCode":45,"cosmosGeoPoint":1760,"geoPoint":1764,"contacts":45},"Gaziantep Universitesi Tip Fakultesi","Gaziantep","27580",{"type":70,"coordinates":1761},[1762,1763],37.3825,37.05944,{"lat":1763,"lon":1762},{"facility":1766,"status":77,"city":1767,"state":45,"zip":1768,"country":1723,"countryCode":45,"cosmosGeoPoint":1769,"geoPoint":1773,"contacts":45},"Erenkoy Mental Hospital","Istanbul","34736",{"type":70,"coordinates":1770},[1771,1772],28.94966,41.01384,{"lat":1772,"lon":1771},{"facility":1775,"status":63,"city":1776,"state":45,"zip":1777,"country":1723,"countryCode":45,"cosmosGeoPoint":1778,"geoPoint":1782,"contacts":45},"Kocaeli University Medical Faculty","Kocaeli","41001",{"type":70,"coordinates":1779},[1780,1781],27.51145,39.62497,{"lat":1781,"lon":1780},{"facility":1784,"status":63,"city":1785,"state":45,"zip":1786,"country":1723,"countryCode":45,"cosmosGeoPoint":1787,"geoPoint":1791,"contacts":45},"Liv Hospital","Samsun","55020",{"type":70,"coordinates":1788},[1789,1790],36.3361,41.27976,{"lat":1790,"lon":1789},{"facility":1793,"status":77,"city":1794,"state":45,"zip":1795,"country":1723,"countryCode":45,"cosmosGeoPoint":1796,"geoPoint":1800,"contacts":45},"Karadeniz Teknik University Medical Faculty","Trabzon","61080",{"type":70,"coordinates":1797},[1798,1799],39.72694,41.005,{"lat":1799,"lon":1798},{"type":1802,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR","100559067","phase-3-phase-3-study-of-adjunctive-treatment-with-seltorexant-in-adult-and-elderly-participants-with-major-depressive-disorder-and-insomnia-symptoms-100559067",false,"NCT06559306","Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms","A Two-Part Multicenter, Double-Blind, Randomized Placebo-Controlled Study to Evaluate Efficacy and Safety and the Maintenance of Effect of 20-(Milligram) mg Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients With Major Depressive Disorder With Insomnia Symptoms","Inclusion Criteria:\n\nParticipants in part 1 and direct enrollers to part 2:\n\n* Meet DSM-5 MDD, without psychotic features based upon clinical assessment and confirmed by the structured clinical interview for DSM-5 Axis I disorders-clinical trials version (SCID-CT) diagnosed with first depressive episode prior to age 60\n* Have had an inadequate response to at least 1 but no more than 2 antidepressants, administered at an adequate dose and duration in the current episode of depression. An inadequate response is defined as less than (\\\u003C) 50% reduction but with some improvement (that is, improvement greater than \\[\\>\\] 0%) in depressive symptom severity with residual symptoms other than insomnia present, and overall good tolerability, as assessed by the MGH-ATRQ, and this must include the participant's current antidepressant treatment\n* Is receiving and tolerating well any one of the following SSRI or SNRI for depressive symptoms at screening, in any formulation and available in the participating country: citalopram, duloxetine, escitalopram, fluvoxamine, fluoxetine, milnacipran, levomilnacipran, paroxetine, sertraline, venlafaxine, desvenlafaxine, vilazodone, or vortioxetine at a stable dose (at therapeutic dose level) for at least 6 weeks\n* Having a major depressive episode of at least moderate severity, as assessed with 17-item Hamilton Depression Rating Scale, implemented through the Structured Interview Guide (SIGH-D) in a blinded manner at screening and must not demonstrate a clinically significant improvement from the beginning to end of screening.\n\nParticipants entering after completing part 1:\n\n* Must have completed Part 1 DB treatment phase\n* Can consistently tolerate study drug (at the end of Part 1), and there is no additional safety risk for the participant if they proceed to Part 2\n* Was able to consistently follow the study procedures in Part 1 as judged by the investigator.\n* Must be medically stable based on clinical laboratory tests\n\nExclusion Criteria:\n\n* Has a recent (last 3 months) history of, or current signs and symptoms of, severe renal insufficiency clinically significant or unstable cardiovascular, respiratory, gastrointestinal, neurologic, hematologic, rheumatologic, immunologic or endocrine disorders and uncontrolled Type 1 or Type 2 diabetes mellitus\n* Has a history of narcolepsy and seizures\n* Has current signs\u002Fsymptoms of hypothyroidism or hyperthyroidism\n* Participants taking thyroid supplementation for antidepressant purposes\n* Has Cushing's disease, Addison's disease, primary amenorrhea, or other evidence of significant medical disorders of the HPA axis","ALL","18 Years","74 Years",{"count":1814,"type":1815},752,"ESTIMATED","INTERVENTIONAL",[1818],"PHASE3","The purpose of this study is to know how well seltorexant works, and also to evaluate safety and maintenance effect of seltorexant compared with placebo as an adjunctive therapy to an antidepressant in improving depressive symptoms in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).",[1821],"Depressive Disorder, Major","2026-06-04",{"date":1824,"type":1825},"2026-06-05","ACTUAL",{"date":1827,"type":1825},"2024-07-25",{"date":1829,"type":1815},"2026-12-30",{"name":5,"class":6},205]