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Signed informed consent prior to participation in the extension study.\n2. Participants must have participated in the SIRIUS-LN core study and must have completed the entire treatment up to Week 144 on double-blind or open label study treatment.\n\nExclusion Criteria:\n\n1. Use of prohibited therapies\n2. Pregnant or nursing (lactating) women.","ALL","18 Years","100 Years",{"count":272,"type":273},315,"ESTIMATED","INTERVENTIONAL",[276],"PHASE3","The purpose of this 2-year extension study is the evaluation of the efficacy and safety\n\n1. after study treatment withdrawal in patients with lupus nephritis (LN) who achieved response (complete renal response \\[CRR\\] or partial renal response \\[PRR\\]) on double-blind treatment at the end of the SIRIUS-LN core study, and\n2. of open-label ianalumab 300 mg treatment in patients who, at the end of the SIRIUS-LN core study, were either already receiving ianalumab open-label treatment or did not meet CRR\u002FPRR criteria on double-blind treatment at the end of the SIRIUS-LN core study.",[279],"Lupus Nephritis",[281,282,283,26],"Lupus Nephritis (LN)","B cell depletion","ianalumab","2026-03-10",{"date":286,"type":287},"2026-03-11","ACTUAL",{"date":289,"type":287},"2025-05-19",{"date":291,"type":273},"2032-07-16",{"name":29,"class":6},25]