[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610534":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":35,"locations":41,"responsibleParty":1087,"collaborators":34,"id":1089,"slug":1090,"hasResults":1091,"nctId":1092,"briefTitle":1093,"officialTitle":1094,"acronym":1095,"eligibilityCriteria":1096,"healthyVolunteers":1091,"sex":1097,"minAge":1098,"maxAge":34,"enrollmentInfo":1099,"targetDuration":34,"studyType":1102,"phases":1103,"briefSummary":1105,"conditions":1106,"keywords":1108,"overallStatus":44,"whyStopped":34,"lastUpdateSubmitDate":1111,"lastUpdatePostDateStruct":1112,"startDateStruct":1115,"completionDateStruct":1117,"leadSponsor":1119,"locationsCount":1120},{"fullName":5,"class":6},"Summit Therapeutics","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm A: Ivonescimab in combination with mFOLFOX6","EXPERIMENTAL","Subjects will receive Ivonescimab Plus mFOLFOX6 via intravenous infusion (IV) Q2W, up to 8 cycles. Afterward, Ivonescimab plus Leucovorin and 5-FU will be used for maintenance treatment (administered on Day 1 of each cycle, Q2W) up to 2 years.",[13],"Drug: Drug: Ivonescimab Injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Arm B: Bevacizumab in combination with mFOLFOX6","ACTIVE_COMPARATOR","Subjects will receive bevacizumab Plus mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) via intravenous infusion (IV) Q2W, up to 8 cycles in treatment periods per the randomization schedule. Afterward, bevacizumab Plus 5-FU and Leucovorin will be used for maintenance treatment (administered on Day 1 of each cycle, Q2W) up to 2 years.",[19],"Drug: Drug: Bevacizumab Injection",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Drug: Ivonescimab Injection","Subjects will receive Ivonescimab Plus mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) via intravenous infusion (IV) Q2W, up to 8 cycles. Afterward, Ivonescimab plus Leucovorin and 5-Fluorouracil will be used for maintenance treatment (administered on Day 1 of each cycle, Q2W) for up to 2 years.",[9],[27,28,29],"Oxaliplatin","Leucovorin","5-Fluorouracil",{"type":22,"name":31,"description":17,"armGroupLabels":32,"otherNames":33},"Drug: Bevacizumab Injection",[15],[27,28,29],null,[36],{"name":37,"role":38,"phone":39,"phoneExt":34,"email":40},"Nindhana Paranthaman, MD","CONTACT","1-833-256-0522","medicalaffairs@summitplc.com",[42,56,65,74,79,87,95,103,111,119,127,132,140,145,150,158,166,174,182,190,198,207,215,223,232,241,249,257,265,273,281,289,298,303,311,320,328,336,345,353,362,371,380,389,398,407,416,425,434,443,452,459,467,475,484,492,500,505,513,518,526,535,543,551,556,564,573,582,591,600,605,613,622,631,639,648,656,665,674,684,692,700,708,719,728,737,746,754,764,772,780,788,796,804,812,822,830,840,848,856,859,867,875,883,886,894,899,907,915,923,931,936,944,952,963,971,981,991,999,1004,1012,1017,1025,1033,1041,1046,1051,1062,1070,1079],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":34},"Clinical Study Site","RECRUITING","Tuscaloosa","Alabama","35487","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-87.56917,33.20984,{"lat":54,"lon":53},{"facility":43,"status":44,"city":57,"state":58,"zip":59,"country":48,"countryCode":49,"cosmosGeoPoint":60,"geoPoint":64,"contacts":34},"Goodyear","Arizona","85338",{"type":51,"coordinates":61},[62,63],-112.35821,33.43532,{"lat":63,"lon":62},{"facility":43,"status":44,"city":66,"state":67,"zip":68,"country":48,"countryCode":49,"cosmosGeoPoint":69,"geoPoint":73,"contacts":34},"Beverly Hills","California","90211",{"type":51,"coordinates":70},[71,72],-118.40036,34.07362,{"lat":72,"lon":71},{"facility":43,"status":44,"city":66,"state":67,"zip":75,"country":48,"countryCode":49,"cosmosGeoPoint":76,"geoPoint":78,"contacts":34},"90212",{"type":51,"coordinates":77},[71,72],{"lat":72,"lon":71},{"facility":43,"status":44,"city":80,"state":67,"zip":81,"country":48,"countryCode":49,"cosmosGeoPoint":82,"geoPoint":86,"contacts":34},"Cerritos","90703",{"type":51,"coordinates":83},[84,85],-118.06479,33.85835,{"lat":85,"lon":84},{"facility":43,"status":44,"city":88,"state":67,"zip":89,"country":48,"countryCode":49,"cosmosGeoPoint":90,"geoPoint":94,"contacts":34},"Corona","92882",{"type":51,"coordinates":91},[92,93],-117.56644,33.87529,{"lat":93,"lon":92},{"facility":43,"status":44,"city":96,"state":67,"zip":97,"country":48,"countryCode":49,"cosmosGeoPoint":98,"geoPoint":102,"contacts":34},"Duarte","91010",{"type":51,"coordinates":99},[100,101],-117.97729,34.13945,{"lat":101,"lon":100},{"facility":43,"status":44,"city":104,"state":67,"zip":105,"country":48,"countryCode":49,"cosmosGeoPoint":106,"geoPoint":110,"contacts":34},"Fountain Valley","92708",{"type":51,"coordinates":107},[108,109],-117.95367,33.70918,{"lat":109,"lon":108},{"facility":43,"status":44,"city":112,"state":67,"zip":113,"country":48,"countryCode":49,"cosmosGeoPoint":114,"geoPoint":118,"contacts":34},"Huntington Beach","92648",{"type":51,"coordinates":115},[116,117],-117.99923,33.6603,{"lat":117,"lon":116},{"facility":43,"status":44,"city":120,"state":67,"zip":121,"country":48,"countryCode":49,"cosmosGeoPoint":122,"geoPoint":126,"contacts":34},"Irvine","92612",{"type":51,"coordinates":123},[124,125],-117.82311,33.66946,{"lat":125,"lon":124},{"facility":43,"status":44,"city":120,"state":67,"zip":128,"country":48,"countryCode":49,"cosmosGeoPoint":129,"geoPoint":131,"contacts":34},"92618",{"type":51,"coordinates":130},[124,125],{"lat":125,"lon":124},{"facility":43,"status":44,"city":133,"state":67,"zip":134,"country":48,"countryCode":49,"cosmosGeoPoint":135,"geoPoint":139,"contacts":34},"Los Angeles","90027",{"type":51,"coordinates":136},[137,138],-118.24368,34.05223,{"lat":138,"lon":137},{"facility":43,"status":44,"city":133,"state":67,"zip":141,"country":48,"countryCode":49,"cosmosGeoPoint":142,"geoPoint":144,"contacts":34},"90067",{"type":51,"coordinates":143},[137,138],{"lat":138,"lon":137},{"facility":43,"status":44,"city":133,"state":67,"zip":146,"country":48,"countryCode":49,"cosmosGeoPoint":147,"geoPoint":149,"contacts":34},"90404",{"type":51,"coordinates":148},[137,138],{"lat":138,"lon":137},{"facility":43,"status":44,"city":151,"state":67,"zip":152,"country":48,"countryCode":49,"cosmosGeoPoint":153,"geoPoint":157,"contacts":34},"Murrieta","92562",{"type":51,"coordinates":154},[155,156],-117.21392,33.55391,{"lat":156,"lon":155},{"facility":43,"status":44,"city":159,"state":67,"zip":160,"country":48,"countryCode":49,"cosmosGeoPoint":161,"geoPoint":165,"contacts":34},"Orange","92868",{"type":51,"coordinates":162},[163,164],-117.85311,33.78779,{"lat":164,"lon":163},{"facility":43,"status":44,"city":167,"state":67,"zip":168,"country":48,"countryCode":49,"cosmosGeoPoint":169,"geoPoint":173,"contacts":34},"Pasadena","91030",{"type":51,"coordinates":170},[171,172],-118.14452,34.14778,{"lat":172,"lon":171},{"facility":43,"status":44,"city":175,"state":67,"zip":176,"country":48,"countryCode":49,"cosmosGeoPoint":177,"geoPoint":181,"contacts":34},"Torrance","90503",{"type":51,"coordinates":178},[179,180],-118.34063,33.83585,{"lat":180,"lon":179},{"facility":43,"status":44,"city":183,"state":67,"zip":184,"country":48,"countryCode":49,"cosmosGeoPoint":185,"geoPoint":189,"contacts":34},"Upland","91786",{"type":51,"coordinates":186},[187,188],-117.64839,34.09751,{"lat":188,"lon":187},{"facility":43,"status":44,"city":191,"state":67,"zip":192,"country":48,"countryCode":49,"cosmosGeoPoint":193,"geoPoint":197,"contacts":34},"West Hollywood","90048",{"type":51,"coordinates":194},[195,196],-118.36174,34.09001,{"lat":196,"lon":195},{"facility":43,"status":44,"city":199,"state":200,"zip":201,"country":48,"countryCode":49,"cosmosGeoPoint":202,"geoPoint":206,"contacts":34},"Hartford","Connecticut","06106",{"type":51,"coordinates":203},[204,205],-72.68509,41.76371,{"lat":205,"lon":204},{"facility":43,"status":44,"city":208,"state":200,"zip":209,"country":48,"countryCode":49,"cosmosGeoPoint":210,"geoPoint":214,"contacts":34},"New Haven","06520-8028",{"type":51,"coordinates":211},[212,213],-72.92816,41.30815,{"lat":213,"lon":212},{"facility":43,"status":44,"city":216,"state":200,"zip":217,"country":48,"countryCode":49,"cosmosGeoPoint":218,"geoPoint":222,"contacts":34},"Norwich","06360",{"type":51,"coordinates":219},[220,221],-72.07591,41.52426,{"lat":221,"lon":220},{"facility":43,"status":44,"city":224,"state":225,"zip":226,"country":48,"countryCode":49,"cosmosGeoPoint":227,"geoPoint":231,"contacts":34},"Newark","Delaware","19713",{"type":51,"coordinates":228},[229,230],-75.74966,39.68372,{"lat":230,"lon":229},{"facility":43,"status":44,"city":233,"state":234,"zip":235,"country":48,"countryCode":49,"cosmosGeoPoint":236,"geoPoint":240,"contacts":34},"Hialeah","Florida","33013",{"type":51,"coordinates":237},[238,239],-80.27811,25.8576,{"lat":239,"lon":238},{"facility":43,"status":44,"city":242,"state":234,"zip":243,"country":48,"countryCode":49,"cosmosGeoPoint":244,"geoPoint":248,"contacts":34},"Miami","33176",{"type":51,"coordinates":245},[246,247],-80.19366,25.77427,{"lat":247,"lon":246},{"facility":43,"status":44,"city":250,"state":234,"zip":251,"country":48,"countryCode":49,"cosmosGeoPoint":252,"geoPoint":256,"contacts":34},"Orlando","32806",{"type":51,"coordinates":253},[254,255],-81.37924,28.53834,{"lat":255,"lon":254},{"facility":43,"status":44,"city":258,"state":234,"zip":259,"country":48,"countryCode":49,"cosmosGeoPoint":260,"geoPoint":264,"contacts":34},"Plantation","33322",{"type":51,"coordinates":261},[262,263],-80.23184,26.13421,{"lat":263,"lon":262},{"facility":43,"status":44,"city":266,"state":234,"zip":267,"country":48,"countryCode":49,"cosmosGeoPoint":268,"geoPoint":272,"contacts":34},"Port Saint Lucie","34952",{"type":51,"coordinates":269},[270,271],-80.35033,27.29393,{"lat":271,"lon":270},{"facility":43,"status":44,"city":274,"state":234,"zip":275,"country":48,"countryCode":49,"cosmosGeoPoint":276,"geoPoint":280,"contacts":34},"St. Petersburg","33705",{"type":51,"coordinates":277},[278,279],-82.67927,27.77086,{"lat":279,"lon":278},{"facility":43,"status":44,"city":282,"state":234,"zip":283,"country":48,"countryCode":49,"cosmosGeoPoint":284,"geoPoint":288,"contacts":34},"Tamarac","33321",{"type":51,"coordinates":285},[286,287],-80.24977,26.21286,{"lat":287,"lon":286},{"facility":43,"status":44,"city":290,"state":291,"zip":292,"country":48,"countryCode":49,"cosmosGeoPoint":293,"geoPoint":297,"contacts":34},"Atlanta","Georgia","30303",{"type":51,"coordinates":294},[295,296],-84.38798,33.749,{"lat":296,"lon":295},{"facility":43,"status":44,"city":290,"state":291,"zip":299,"country":48,"countryCode":49,"cosmosGeoPoint":300,"geoPoint":302,"contacts":34},"30322",{"type":51,"coordinates":301},[295,296],{"lat":296,"lon":295},{"facility":43,"status":44,"city":304,"state":291,"zip":305,"country":48,"countryCode":49,"cosmosGeoPoint":306,"geoPoint":310,"contacts":34},"Newnan","30265",{"type":51,"coordinates":307},[308,309],-84.79966,33.38067,{"lat":309,"lon":308},{"facility":43,"status":44,"city":312,"state":313,"zip":314,"country":48,"countryCode":49,"cosmosGeoPoint":315,"geoPoint":319,"contacts":34},"Chicago","Illinois","60611",{"type":51,"coordinates":316},[317,318],-87.65005,41.85003,{"lat":318,"lon":317},{"facility":43,"status":44,"city":321,"state":313,"zip":322,"country":48,"countryCode":49,"cosmosGeoPoint":323,"geoPoint":327,"contacts":34},"Elmhurst","60540",{"type":51,"coordinates":324},[325,326],-87.94034,41.89947,{"lat":326,"lon":325},{"facility":43,"status":44,"city":329,"state":313,"zip":330,"country":48,"countryCode":49,"cosmosGeoPoint":331,"geoPoint":335,"contacts":34},"O'Fallon","62269",{"type":51,"coordinates":332},[333,334],-89.91121,38.59227,{"lat":334,"lon":333},{"facility":43,"status":44,"city":337,"state":338,"zip":339,"country":48,"countryCode":49,"cosmosGeoPoint":340,"geoPoint":344,"contacts":34},"Fort Wayne","Indiana","46804",{"type":51,"coordinates":341},[342,343],-85.12886,41.1306,{"lat":343,"lon":342},{"facility":43,"status":44,"city":346,"state":338,"zip":347,"country":48,"countryCode":49,"cosmosGeoPoint":348,"geoPoint":352,"contacts":34},"Indianapolis","46202",{"type":51,"coordinates":349},[350,351],-86.15804,39.76838,{"lat":351,"lon":350},{"facility":43,"status":44,"city":354,"state":355,"zip":356,"country":48,"countryCode":49,"cosmosGeoPoint":357,"geoPoint":361,"contacts":34},"Westwood","Kansas","66205",{"type":51,"coordinates":358},[359,360],-94.6169,39.04056,{"lat":360,"lon":359},{"facility":43,"status":44,"city":363,"state":364,"zip":365,"country":48,"countryCode":49,"cosmosGeoPoint":366,"geoPoint":370,"contacts":34},"Edgewood","Kentucky","41017",{"type":51,"coordinates":367},[368,369],-84.58189,39.01867,{"lat":369,"lon":368},{"facility":43,"status":44,"city":372,"state":373,"zip":374,"country":48,"countryCode":49,"cosmosGeoPoint":375,"geoPoint":379,"contacts":34},"Baltimore","Maryland","21201",{"type":51,"coordinates":376},[377,378],-76.61219,39.29038,{"lat":378,"lon":377},{"facility":43,"status":44,"city":381,"state":382,"zip":383,"country":48,"countryCode":49,"cosmosGeoPoint":384,"geoPoint":388,"contacts":34},"Detroit","Michigan","48201",{"type":51,"coordinates":385},[386,387],-83.04575,42.33143,{"lat":387,"lon":386},{"facility":43,"status":44,"city":390,"state":391,"zip":392,"country":48,"countryCode":49,"cosmosGeoPoint":393,"geoPoint":397,"contacts":34},"Saint Louis Park","Minnesota","55426",{"type":51,"coordinates":394},[395,396],-93.34801,44.9483,{"lat":396,"lon":395},{"facility":43,"status":44,"city":399,"state":400,"zip":401,"country":48,"countryCode":49,"cosmosGeoPoint":402,"geoPoint":406,"contacts":34},"Springfield","Missouri","65804",{"type":51,"coordinates":403},[404,405],-93.29824,37.21533,{"lat":405,"lon":404},{"facility":43,"status":44,"city":408,"state":409,"zip":410,"country":48,"countryCode":49,"cosmosGeoPoint":411,"geoPoint":415,"contacts":34},"Billings","Montana","59102",{"type":51,"coordinates":412},[413,414],-108.50069,45.78329,{"lat":414,"lon":413},{"facility":43,"status":44,"city":417,"state":418,"zip":419,"country":48,"countryCode":49,"cosmosGeoPoint":420,"geoPoint":424,"contacts":34},"Lincoln","Nebraska","68506",{"type":51,"coordinates":421},[422,423],-96.66696,40.8,{"lat":423,"lon":422},{"facility":43,"status":44,"city":426,"state":427,"zip":428,"country":48,"countryCode":49,"cosmosGeoPoint":429,"geoPoint":433,"contacts":34},"Lebanon","New Hampshire","03766",{"type":51,"coordinates":430},[431,432],-72.25176,43.64229,{"lat":432,"lon":431},{"facility":43,"status":44,"city":435,"state":436,"zip":437,"country":48,"countryCode":49,"cosmosGeoPoint":438,"geoPoint":442,"contacts":34},"New Brunswick","New Jersey","08901",{"type":51,"coordinates":439},[440,441],-74.45182,40.48622,{"lat":441,"lon":440},{"facility":43,"status":44,"city":444,"state":445,"zip":446,"country":48,"countryCode":49,"cosmosGeoPoint":447,"geoPoint":451,"contacts":34},"Mineola","New York","11501",{"type":51,"coordinates":448},[449,450],-73.64068,40.74927,{"lat":450,"lon":449},{"facility":43,"status":44,"city":445,"state":445,"zip":453,"country":48,"countryCode":49,"cosmosGeoPoint":454,"geoPoint":458,"contacts":34},"10016",{"type":51,"coordinates":455},[456,457],-74.00597,40.71427,{"lat":457,"lon":456},{"facility":43,"status":44,"city":460,"state":445,"zip":461,"country":48,"countryCode":49,"cosmosGeoPoint":462,"geoPoint":466,"contacts":34},"The Bronx","10461",{"type":51,"coordinates":463},[464,465],-73.86641,40.84985,{"lat":465,"lon":464},{"facility":43,"status":44,"city":468,"state":445,"zip":469,"country":48,"countryCode":49,"cosmosGeoPoint":470,"geoPoint":474,"contacts":34},"White Plains","10601-5000",{"type":51,"coordinates":471},[472,473],-73.76291,41.03399,{"lat":473,"lon":472},{"facility":43,"status":44,"city":476,"state":477,"zip":478,"country":48,"countryCode":49,"cosmosGeoPoint":479,"geoPoint":483,"contacts":34},"Akron","Ohio","44032",{"type":51,"coordinates":480},[481,482],-81.51901,41.08144,{"lat":482,"lon":481},{"facility":43,"status":44,"city":485,"state":477,"zip":486,"country":48,"countryCode":49,"cosmosGeoPoint":487,"geoPoint":491,"contacts":34},"Canton","44703",{"type":51,"coordinates":488},[489,490],-81.37845,40.79895,{"lat":490,"lon":489},{"facility":43,"status":44,"city":493,"state":477,"zip":494,"country":48,"countryCode":49,"cosmosGeoPoint":495,"geoPoint":499,"contacts":34},"Cincinnati","45219",{"type":51,"coordinates":496},[497,498],-84.51439,39.12711,{"lat":498,"lon":497},{"facility":43,"status":44,"city":493,"state":477,"zip":501,"country":48,"countryCode":49,"cosmosGeoPoint":502,"geoPoint":504,"contacts":34},"45220",{"type":51,"coordinates":503},[497,498],{"lat":498,"lon":497},{"facility":43,"status":44,"city":506,"state":477,"zip":507,"country":48,"countryCode":49,"cosmosGeoPoint":508,"geoPoint":512,"contacts":34},"Cleveland","44111",{"type":51,"coordinates":509},[510,511],-81.69541,41.4995,{"lat":511,"lon":510},{"facility":43,"status":44,"city":506,"state":477,"zip":514,"country":48,"countryCode":49,"cosmosGeoPoint":515,"geoPoint":517,"contacts":34},"44195",{"type":51,"coordinates":516},[510,511],{"lat":511,"lon":510},{"facility":43,"status":44,"city":519,"state":477,"zip":520,"country":48,"countryCode":49,"cosmosGeoPoint":521,"geoPoint":525,"contacts":34},"Mayfield Heights","44124",{"type":51,"coordinates":522},[523,524],-81.4579,41.51922,{"lat":524,"lon":523},{"facility":43,"status":44,"city":527,"state":528,"zip":529,"country":48,"countryCode":49,"cosmosGeoPoint":530,"geoPoint":534,"contacts":34},"Oklahoma City","Oklahoma","73120",{"type":51,"coordinates":531},[532,533],-97.51643,35.46756,{"lat":533,"lon":532},{"facility":43,"status":44,"city":426,"state":536,"zip":537,"country":48,"countryCode":49,"cosmosGeoPoint":538,"geoPoint":542,"contacts":34},"Pennsylvania","17042",{"type":51,"coordinates":539},[540,541],-76.41135,40.34093,{"lat":541,"lon":540},{"facility":43,"status":44,"city":544,"state":536,"zip":545,"country":48,"countryCode":49,"cosmosGeoPoint":546,"geoPoint":550,"contacts":34},"Philadelphia","19111",{"type":51,"coordinates":547},[548,549],-75.16362,39.95238,{"lat":549,"lon":548},{"facility":43,"status":44,"city":544,"state":536,"zip":552,"country":48,"countryCode":49,"cosmosGeoPoint":553,"geoPoint":555,"contacts":34},"19140",{"type":51,"coordinates":554},[548,549],{"lat":549,"lon":548},{"facility":43,"status":44,"city":557,"state":536,"zip":558,"country":48,"countryCode":49,"cosmosGeoPoint":559,"geoPoint":563,"contacts":34},"Pittsburgh","15212",{"type":51,"coordinates":560},[561,562],-79.99589,40.44062,{"lat":562,"lon":561},{"facility":43,"status":44,"city":565,"state":566,"zip":567,"country":48,"countryCode":49,"cosmosGeoPoint":568,"geoPoint":572,"contacts":34},"Providence","Rhode Island","02903",{"type":51,"coordinates":569},[570,571],-71.41283,41.82399,{"lat":571,"lon":570},{"facility":43,"status":44,"city":574,"state":575,"zip":576,"country":48,"countryCode":49,"cosmosGeoPoint":577,"geoPoint":581,"contacts":34},"Greenville","South Carolina","29605",{"type":51,"coordinates":578},[579,580],-82.39401,34.85262,{"lat":580,"lon":579},{"facility":43,"status":44,"city":583,"state":584,"zip":585,"country":48,"countryCode":49,"cosmosGeoPoint":586,"geoPoint":590,"contacts":34},"Hermitage","Tennessee","37129",{"type":51,"coordinates":587},[588,589],-86.6225,36.19617,{"lat":589,"lon":588},{"facility":43,"status":44,"city":592,"state":593,"zip":594,"country":48,"countryCode":49,"cosmosGeoPoint":595,"geoPoint":599,"contacts":34},"Dallas","Texas","75235",{"type":51,"coordinates":596},[597,598],-96.80667,32.78306,{"lat":598,"lon":597},{"facility":43,"status":44,"city":592,"state":593,"zip":601,"country":48,"countryCode":49,"cosmosGeoPoint":602,"geoPoint":604,"contacts":34},"75390",{"type":51,"coordinates":603},[597,598],{"lat":598,"lon":597},{"facility":43,"status":44,"city":606,"state":593,"zip":607,"country":48,"countryCode":49,"cosmosGeoPoint":608,"geoPoint":612,"contacts":34},"Fort Worth","76104",{"type":51,"coordinates":609},[610,611],-97.32085,32.72541,{"lat":611,"lon":610},{"facility":43,"status":44,"city":614,"state":615,"zip":616,"country":48,"countryCode":49,"cosmosGeoPoint":617,"geoPoint":621,"contacts":34},"Salt Lake City","Utah","84106",{"type":51,"coordinates":618},[619,620],-111.89105,40.76078,{"lat":620,"lon":619},{"facility":43,"status":44,"city":623,"state":624,"zip":625,"country":48,"countryCode":49,"cosmosGeoPoint":626,"geoPoint":630,"contacts":34},"Charlottesville","Virginia","22908",{"type":51,"coordinates":627},[628,629],-78.47668,38.02931,{"lat":629,"lon":628},{"facility":43,"status":44,"city":632,"state":624,"zip":633,"country":48,"countryCode":49,"cosmosGeoPoint":634,"geoPoint":638,"contacts":34},"Fairfax","22031",{"type":51,"coordinates":635},[636,637],-77.30637,38.84622,{"lat":637,"lon":636},{"facility":43,"status":44,"city":640,"state":641,"zip":642,"country":48,"countryCode":49,"cosmosGeoPoint":643,"geoPoint":647,"contacts":34},"Spokane","Washington","99208",{"type":51,"coordinates":644},[645,646],-117.42908,47.65966,{"lat":646,"lon":645},{"facility":43,"status":44,"city":649,"state":641,"zip":650,"country":48,"countryCode":49,"cosmosGeoPoint":651,"geoPoint":655,"contacts":34},"Tacoma","98405",{"type":51,"coordinates":652},[653,654],-122.44429,47.25288,{"lat":654,"lon":653},{"facility":43,"status":44,"city":657,"state":658,"zip":659,"country":48,"countryCode":49,"cosmosGeoPoint":660,"geoPoint":664,"contacts":34},"Charleston","West Virginia","25304",{"type":51,"coordinates":661},[662,663],-81.63262,38.34982,{"lat":663,"lon":662},{"facility":43,"status":44,"city":666,"state":667,"zip":668,"country":48,"countryCode":49,"cosmosGeoPoint":669,"geoPoint":673,"contacts":34},"Madison","Wisconsin","53792",{"type":51,"coordinates":670},[671,672],-89.40123,43.07305,{"lat":672,"lon":671},{"facility":43,"status":44,"city":675,"state":34,"zip":676,"country":677,"countryCode":678,"cosmosGeoPoint":679,"geoPoint":683,"contacts":34},"Brussels","1000","Belgium","BE",{"type":51,"coordinates":680},[681,682],4.34878,50.85045,{"lat":682,"lon":681},{"facility":43,"status":44,"city":685,"state":34,"zip":686,"country":677,"countryCode":678,"cosmosGeoPoint":687,"geoPoint":691,"contacts":34},"Ghent","9000",{"type":51,"coordinates":688},[689,690],3.71667,51.05,{"lat":690,"lon":689},{"facility":43,"status":44,"city":693,"state":34,"zip":694,"country":677,"countryCode":678,"cosmosGeoPoint":695,"geoPoint":699,"contacts":34},"Haine-Saint-Paul","7100",{"type":51,"coordinates":696},[697,698],4.1885,50.45544,{"lat":698,"lon":697},{"facility":43,"status":44,"city":701,"state":34,"zip":702,"country":677,"countryCode":678,"cosmosGeoPoint":703,"geoPoint":707,"contacts":34},"Kortrijk","8500",{"type":51,"coordinates":704},[705,706],3.26487,50.82803,{"lat":706,"lon":705},{"facility":43,"status":44,"city":709,"state":710,"zip":711,"country":712,"countryCode":713,"cosmosGeoPoint":714,"geoPoint":718,"contacts":34},"Toronto","Ontario","M4N 3M5","Canada","CA",{"type":51,"coordinates":715},[716,717],-79.39864,43.70643,{"lat":717,"lon":716},{"facility":43,"status":44,"city":720,"state":721,"zip":722,"country":712,"countryCode":713,"cosmosGeoPoint":723,"geoPoint":727,"contacts":34},"Montreal","Quebec","H4A 3J1",{"type":51,"coordinates":724},[725,726],-73.58781,45.50884,{"lat":726,"lon":725},{"facility":43,"status":44,"city":729,"state":730,"zip":731,"country":712,"countryCode":713,"cosmosGeoPoint":732,"geoPoint":736,"contacts":34},"Regina","Saskatchewan","S4T7T1",{"type":51,"coordinates":733},[734,735],-104.6178,50.45008,{"lat":735,"lon":734},{"facility":43,"status":44,"city":738,"state":34,"zip":739,"country":740,"countryCode":34,"cosmosGeoPoint":741,"geoPoint":745,"contacts":34},"Hradec Králové","50005","Czechia",{"type":51,"coordinates":742},[743,744],15.83277,50.20923,{"lat":744,"lon":743},{"facility":43,"status":44,"city":747,"state":34,"zip":748,"country":740,"countryCode":34,"cosmosGeoPoint":749,"geoPoint":753,"contacts":34},"Prague","14059",{"type":51,"coordinates":750},[751,752],14.42076,50.08804,{"lat":752,"lon":751},{"facility":43,"status":44,"city":755,"state":34,"zip":756,"country":757,"countryCode":758,"cosmosGeoPoint":759,"geoPoint":763,"contacts":34},"Lyon","69374","France","FR",{"type":51,"coordinates":760},[761,762],4.84789,45.74906,{"lat":762,"lon":761},{"facility":43,"status":44,"city":765,"state":34,"zip":766,"country":757,"countryCode":758,"cosmosGeoPoint":767,"geoPoint":771,"contacts":34},"Montpellier","34298",{"type":51,"coordinates":768},[769,770],3.87635,43.61093,{"lat":770,"lon":769},{"facility":43,"status":44,"city":773,"state":34,"zip":774,"country":757,"countryCode":758,"cosmosGeoPoint":775,"geoPoint":779,"contacts":34},"Nantes","44000",{"type":51,"coordinates":776},[777,778],-1.55336,47.21725,{"lat":778,"lon":777},{"facility":43,"status":44,"city":781,"state":34,"zip":782,"country":757,"countryCode":758,"cosmosGeoPoint":783,"geoPoint":787,"contacts":34},"Paris","75015",{"type":51,"coordinates":784},[785,786],2.3488,48.85341,{"lat":786,"lon":785},{"facility":43,"status":44,"city":789,"state":34,"zip":790,"country":757,"countryCode":758,"cosmosGeoPoint":791,"geoPoint":795,"contacts":34},"Pierre-Bénite","69495",{"type":51,"coordinates":792},[793,794],4.82424,45.70359,{"lat":794,"lon":793},{"facility":43,"status":44,"city":797,"state":34,"zip":798,"country":757,"countryCode":758,"cosmosGeoPoint":799,"geoPoint":803,"contacts":34},"Poitiers","86000",{"type":51,"coordinates":800},[801,802],0.34348,46.58261,{"lat":802,"lon":801},{"facility":43,"status":44,"city":805,"state":34,"zip":806,"country":757,"countryCode":758,"cosmosGeoPoint":807,"geoPoint":811,"contacts":34},"Strasbourg","67033",{"type":51,"coordinates":808},[809,810],7.74553,48.58392,{"lat":810,"lon":809},{"facility":43,"status":44,"city":813,"state":34,"zip":814,"country":815,"countryCode":816,"cosmosGeoPoint":817,"geoPoint":821,"contacts":34},"Bonn","53113","Germany","DE",{"type":51,"coordinates":818},[819,820],7.09549,50.73438,{"lat":820,"lon":819},{"facility":43,"status":44,"city":823,"state":34,"zip":824,"country":815,"countryCode":816,"cosmosGeoPoint":825,"geoPoint":829,"contacts":34},"Hamburg","22763",{"type":51,"coordinates":826},[827,828],9.99302,53.55073,{"lat":828,"lon":827},{"facility":43,"status":44,"city":831,"state":710,"zip":832,"country":833,"countryCode":834,"cosmosGeoPoint":835,"geoPoint":839,"contacts":34},"Osaka","565-0871","Japan","JP",{"type":51,"coordinates":836},[837,838],135.50107,34.69379,{"lat":838,"lon":837},{"facility":43,"status":44,"city":841,"state":34,"zip":842,"country":833,"countryCode":834,"cosmosGeoPoint":843,"geoPoint":847,"contacts":34},"Aichi","464-8681",{"type":51,"coordinates":844},[845,846],130.62158,32.51879,{"lat":846,"lon":845},{"facility":43,"status":44,"city":849,"state":34,"zip":850,"country":833,"countryCode":834,"cosmosGeoPoint":851,"geoPoint":855,"contacts":34},"Chiba","260-8717",{"type":51,"coordinates":852},[853,854],140.11667,35.6,{"lat":854,"lon":853},{"facility":43,"status":44,"city":857,"state":34,"zip":858,"country":833,"countryCode":834,"cosmosGeoPoint":34,"geoPoint":34,"contacts":34},"Ehime","791-0280",{"facility":43,"status":44,"city":860,"state":34,"zip":861,"country":833,"countryCode":834,"cosmosGeoPoint":862,"geoPoint":866,"contacts":34},"Fukuoka","812-8582",{"type":51,"coordinates":863},[864,865],130.41667,33.6,{"lat":865,"lon":864},{"facility":43,"status":44,"city":868,"state":34,"zip":869,"country":833,"countryCode":834,"cosmosGeoPoint":870,"geoPoint":874,"contacts":34},"Gifu","501-1194",{"type":51,"coordinates":871},[872,873],136.76039,35.42291,{"lat":873,"lon":872},{"facility":43,"status":44,"city":876,"state":34,"zip":877,"country":833,"countryCode":834,"cosmosGeoPoint":878,"geoPoint":882,"contacts":34},"Hiroshima","734-8551",{"type":51,"coordinates":879},[880,881],132.45,34.4,{"lat":881,"lon":880},{"facility":43,"status":44,"city":884,"state":34,"zip":885,"country":833,"countryCode":834,"cosmosGeoPoint":34,"geoPoint":34,"contacts":34},"Hokkaido","060-8648",{"facility":43,"status":44,"city":887,"state":34,"zip":888,"country":833,"countryCode":834,"cosmosGeoPoint":889,"geoPoint":893,"contacts":34},"Kawasaki","216-8511",{"type":51,"coordinates":890},[891,892],139.71722,35.52056,{"lat":892,"lon":891},{"facility":43,"status":44,"city":831,"state":34,"zip":895,"country":833,"countryCode":834,"cosmosGeoPoint":896,"geoPoint":898,"contacts":34},"541-8567",{"type":51,"coordinates":897},[837,838],{"lat":838,"lon":837},{"facility":43,"status":44,"city":900,"state":34,"zip":901,"country":833,"countryCode":834,"cosmosGeoPoint":902,"geoPoint":906,"contacts":34},"Saitama","362-0806",{"type":51,"coordinates":903},[904,905],139.65657,35.90807,{"lat":905,"lon":904},{"facility":43,"status":44,"city":908,"state":34,"zip":909,"country":833,"countryCode":834,"cosmosGeoPoint":910,"geoPoint":914,"contacts":34},"Sendai","980-0872",{"type":51,"coordinates":911},[912,913],140.86667,38.26667,{"lat":913,"lon":912},{"facility":43,"status":44,"city":916,"state":34,"zip":917,"country":833,"countryCode":834,"cosmosGeoPoint":918,"geoPoint":922,"contacts":34},"Shizuoka","411-8777",{"type":51,"coordinates":919},[920,921],138.38333,34.98333,{"lat":921,"lon":920},{"facility":43,"status":44,"city":924,"state":34,"zip":925,"country":833,"countryCode":834,"cosmosGeoPoint":926,"geoPoint":930,"contacts":34},"Tokyo","104-0045",{"type":51,"coordinates":927},[928,929],139.69171,35.6895,{"lat":929,"lon":928},{"facility":43,"status":44,"city":924,"state":34,"zip":932,"country":833,"countryCode":834,"cosmosGeoPoint":933,"geoPoint":935,"contacts":34},"135-8550",{"type":51,"coordinates":934},[928,929],{"lat":929,"lon":928},{"facility":43,"status":44,"city":937,"state":34,"zip":938,"country":833,"countryCode":834,"cosmosGeoPoint":939,"geoPoint":943,"contacts":34},"Toyama","930-0194",{"type":51,"coordinates":940},[941,942],137.21667,36.7,{"lat":942,"lon":941},{"facility":43,"status":44,"city":945,"state":34,"zip":946,"country":833,"countryCode":834,"cosmosGeoPoint":947,"geoPoint":951,"contacts":34},"Yokohama","241-8515",{"type":51,"coordinates":948},[949,950],139.65,35.43333,{"lat":950,"lon":949},{"facility":43,"status":44,"city":953,"state":954,"zip":955,"country":956,"countryCode":957,"cosmosGeoPoint":958,"geoPoint":962,"contacts":34},"Rzeszów","Podkarpackie Voivodeship","35-021","Poland","PL",{"type":51,"coordinates":959},[960,961],21.99901,50.04132,{"lat":961,"lon":960},{"facility":43,"status":44,"city":964,"state":34,"zip":965,"country":956,"countryCode":957,"cosmosGeoPoint":966,"geoPoint":970,"contacts":34},"Warsaw","04-141",{"type":51,"coordinates":967},[968,969],21.01178,52.22977,{"lat":969,"lon":968},{"facility":43,"status":44,"city":972,"state":34,"zip":973,"country":974,"countryCode":975,"cosmosGeoPoint":976,"geoPoint":980,"contacts":34},"Rio Piedras","00935","Puerto Rico","PR",{"type":51,"coordinates":977},[978,979],-66.04989,18.39745,{"lat":979,"lon":978},{"facility":43,"status":44,"city":982,"state":34,"zip":983,"country":984,"countryCode":985,"cosmosGeoPoint":986,"geoPoint":990,"contacts":34},"A Coruña","15006","Spain","ES",{"type":51,"coordinates":987},[988,989],-8.396,43.37135,{"lat":989,"lon":988},{"facility":43,"status":44,"city":992,"state":34,"zip":993,"country":984,"countryCode":985,"cosmosGeoPoint":994,"geoPoint":998,"contacts":34},"Barcelona","08035",{"type":51,"coordinates":995},[996,997],2.15899,41.38879,{"lat":997,"lon":996},{"facility":43,"status":44,"city":992,"state":34,"zip":1000,"country":984,"countryCode":985,"cosmosGeoPoint":1001,"geoPoint":1003,"contacts":34},"08908",{"type":51,"coordinates":1002},[996,997],{"lat":997,"lon":996},{"facility":43,"status":44,"city":1005,"state":34,"zip":1006,"country":984,"countryCode":985,"cosmosGeoPoint":1007,"geoPoint":1011,"contacts":34},"Madrid","28009",{"type":51,"coordinates":1008},[1009,1010],-3.70256,40.4165,{"lat":1010,"lon":1009},{"facility":43,"status":44,"city":1005,"state":34,"zip":1013,"country":984,"countryCode":985,"cosmosGeoPoint":1014,"geoPoint":1016,"contacts":34},"28046",{"type":51,"coordinates":1015},[1009,1010],{"lat":1010,"lon":1009},{"facility":43,"status":44,"city":1018,"state":34,"zip":1019,"country":984,"countryCode":985,"cosmosGeoPoint":1020,"geoPoint":1024,"contacts":34},"Palma de Mallorca","07198",{"type":51,"coordinates":1021},[1022,1023],2.65024,39.56939,{"lat":1023,"lon":1022},{"facility":43,"status":44,"city":1026,"state":34,"zip":1027,"country":984,"countryCode":985,"cosmosGeoPoint":1028,"geoPoint":1032,"contacts":34},"Santander","39008",{"type":51,"coordinates":1029},[1030,1031],-3.80493,43.46589,{"lat":1031,"lon":1030},{"facility":43,"status":44,"city":1034,"state":34,"zip":1035,"country":984,"countryCode":985,"cosmosGeoPoint":1036,"geoPoint":1040,"contacts":34},"Valencia","46010",{"type":51,"coordinates":1037},[1038,1039],-0.37966,39.47391,{"lat":1039,"lon":1038},{"facility":43,"status":44,"city":1034,"state":34,"zip":1042,"country":984,"countryCode":985,"cosmosGeoPoint":1043,"geoPoint":1045,"contacts":34},"46014",{"type":51,"coordinates":1044},[1038,1039],{"lat":1039,"lon":1038},{"facility":43,"status":44,"city":1034,"state":34,"zip":1047,"country":984,"countryCode":985,"cosmosGeoPoint":1048,"geoPoint":1050,"contacts":34},"46026",{"type":51,"coordinates":1049},[1038,1039],{"lat":1039,"lon":1038},{"facility":43,"status":44,"city":1052,"state":1053,"zip":1054,"country":1055,"countryCode":1056,"cosmosGeoPoint":1057,"geoPoint":1061,"contacts":34},"Canterbury","England","CT13NS","United Kingdom","UK",{"type":51,"coordinates":1058},[1059,1060],1.07992,51.27904,{"lat":1060,"lon":1059},{"facility":43,"status":44,"city":1063,"state":1053,"zip":1064,"country":1055,"countryCode":1056,"cosmosGeoPoint":1065,"geoPoint":1069,"contacts":34},"London","EC1M 6BQ",{"type":51,"coordinates":1066},[1067,1068],-0.12574,51.50853,{"lat":1068,"lon":1067},{"facility":43,"status":44,"city":1071,"state":1072,"zip":1073,"country":1055,"countryCode":1056,"cosmosGeoPoint":1074,"geoPoint":1078,"contacts":34},"Aberdeen","Scotland","AB25 2ZN",{"type":51,"coordinates":1075},[1076,1077],-2.09814,57.14369,{"lat":1077,"lon":1076},{"facility":43,"status":44,"city":1080,"state":34,"zip":1081,"country":1055,"countryCode":1056,"cosmosGeoPoint":1082,"geoPoint":1086,"contacts":34},"Edinburgh","EH4 2XU",{"type":51,"coordinates":1083},[1084,1085],-3.19648,55.95206,{"lat":1085,"lon":1084},{"type":1088,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR","100610534","phase-3-phase-iii-study-of-ivonescimab-or-bevacizumab-combined-with-folfox-in-patients-with-metastatic-colorectal-cancer-100610534",false,"NCT07228832","Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer","A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination With FOLFOX Versus Bevacizumab in Combination With FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer","HARMONi-GI3","Inclusion Criteria:\n\n1. ECOG performance status score of 0 or 1\n2. Expected life expectancy ≥ 6 months\n3. Patients with histologically or cytologically confirmed metastatic CRC\n4. No prior systemic therapy for metastatic CRC\n5. At least 1 measurable noncerebral lesion\n\nExclusion Criteria:\n\n1. Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) disease\n2. Known BRAF V600E mutant status\n3. Current presence of significant radiographic or clinical manifestations of gastrointestinal (GI) obstruction\n4. Ascites requiring paracentesis within last 30 days\n5. Patients who have received prior immunotherapy or anti-angiogenic therapy for colorectal cancer\n6. Active or prior history of inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis, or chronic diarrhea)\n7. Resectable disease","ALL","18 Years",{"count":1100,"type":1101},600,"ESTIMATED","INTERVENTIONAL",[1104],"PHASE3","A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Treatment of Metastatic Colorectal Cancer(HARMONi-GI3)",[1107],"Metastatic Colorectal Cancer (CRC)",[1109,1110],"mCRC","Ivonescimab","2026-06-18",{"date":1113,"type":1114},"2026-06-23","ACTUAL",{"date":1116,"type":1114},"2025-11-18",{"date":1118,"type":1101},"2029-11-30",{"name":5,"class":6},130]