[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548332":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":43,"locations":53,"responsibleParty":869,"collaborators":27,"id":871,"slug":872,"hasResults":873,"nctId":874,"briefTitle":875,"officialTitle":876,"acronym":27,"eligibilityCriteria":877,"healthyVolunteers":873,"sex":878,"minAge":879,"maxAge":880,"enrollmentInfo":881,"targetDuration":27,"studyType":884,"phases":885,"briefSummary":887,"conditions":888,"keywords":27,"overallStatus":56,"whyStopped":27,"lastUpdateSubmitDate":890,"lastUpdatePostDateStruct":891,"startDateStruct":894,"completionDateStruct":896,"leadSponsor":898,"locationsCount":899},{"fullName":5,"class":6},"Biotheus Inc.","INDUSTRY",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"PM8002 Plus Nab-Paclitaxel","EXPERIMENTAL","Patients will receive both PM8002 and Nab-Paclitaxel.",[13,14],"Drug: PM8002","Drug: Nab-Paclitaxel",{"label":16,"type":17,"description":18,"interventionNames":19},"Placebo Plus Nab-Paclitaxel","PLACEBO_COMPARATOR","Patients will receive both Placebo and Nab-Paclitaxel.",[14,20],"Drug: Placebo",[22,28,32],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DRUG","PM8002","PM8002 20 mg\u002Fkg via intravenous (IV) infusion on Days 1 and 15 of each 28-day cycle",[9],null,{"type":23,"name":29,"description":30,"armGroupLabels":31,"otherNames":27},"Nab-Paclitaxel","Nab-Paclitaxel 100mg\u002Fm2 via IV infusion on Days 1, 8, and 15 of each 28-day cycle",[9,16],{"type":23,"name":33,"description":34,"armGroupLabels":35,"otherNames":27},"Placebo","Placebo 20 mg\u002Fkg via IV infusion on Days 1 and 15 of each 28-day cycle",[16],[37,41],{"name":38,"affiliation":39,"role":40},"Jiong Wu, professor","Fudan University","STUDY_CHAIR",{"name":42,"affiliation":39,"role":40},"Jian Zhang, professor",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":27,"email":48},"Yanqing Cao","CONTACT","+86 13810452270","cao.yq@biotheus.com",{"name":50,"role":46,"phone":51,"phoneExt":27,"email":52},"Linlin Fan","+86 18612186005","fan.ll@biotheus.com",[54,72,84,97,106,119,128,137,150,163,176,188,199,208,220,233,242,255,267,280,293,305,317,329,341,350,363,372,381,394,406,418,430,444,456,468,480,492,505,518,527,540,549,561,570,578,591,600,613,625,637,649,661,676,685,694,707,718,731,740,752,764,776,785,797,810,823,836,845,857],{"facility":55,"status":56,"city":57,"state":58,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":61,"geoPoint":66,"contacts":67},"The first affiliated hospital of bengbu medical University","RECRUITING","Bengbu","Anhui","China","CN",{"type":62,"coordinates":63},"Point",[64,65],117.36083,32.94083,{"lat":65,"lon":64},[68,70],{"name":69,"role":46,"phone":27,"phoneExt":27,"email":27},"Gongsheng Jin",{"name":69,"role":71,"phone":27,"phoneExt":27,"email":27},"PRINCIPAL_INVESTIGATOR",{"facility":73,"status":56,"city":74,"state":58,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":75,"geoPoint":79,"contacts":80},"The First Affiliated Hospital of Anhui Medical University","Hefei",{"type":62,"coordinates":76},[77,78],117.28083,31.86389,{"lat":78,"lon":77},[81,83],{"name":82,"role":46,"phone":27,"phoneExt":27,"email":27},"Yingying Du",{"name":82,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":85,"status":56,"city":86,"state":87,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":88,"geoPoint":92,"contacts":93},"Cancer Hospital Chinese Academy of Medical Sciences","Beijing","Beijing Municipality",{"type":62,"coordinates":89},[90,91],116.39723,39.9075,{"lat":91,"lon":90},[94,96],{"name":95,"role":46,"phone":27,"phoneExt":27,"email":27},"Peng Yuan",{"name":95,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":98,"status":56,"city":86,"state":87,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":99,"geoPoint":101,"contacts":102},"Fifth Medical Center of Chinese PLA General Hospital",{"type":62,"coordinates":100},[90,91],{"lat":91,"lon":90},[103,105],{"name":104,"role":46,"phone":27,"phoneExt":27,"email":27},"Tao Wang",{"name":104,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":107,"status":56,"city":108,"state":109,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Chongqing University Cancer Hospital","Chongqing","Chongqing Municipality",{"type":62,"coordinates":111},[112,113],106.55771,29.56026,{"lat":113,"lon":112},[116,118],{"name":117,"role":46,"phone":27,"phoneExt":27,"email":27},"Xiaohua Zeng",{"name":117,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":120,"status":56,"city":108,"state":109,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":121,"geoPoint":123,"contacts":124},"The First Affiliated Hospital of Chongqing Medical University",{"type":62,"coordinates":122},[112,113],{"lat":113,"lon":112},[125,127],{"name":126,"role":46,"phone":27,"phoneExt":27,"email":27},"Lu Gan",{"name":126,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":129,"status":56,"city":108,"state":109,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":130,"geoPoint":132,"contacts":133},"The Southwest Hospital of Army Medical University",{"type":62,"coordinates":131},[112,113],{"lat":113,"lon":112},[134,136],{"name":135,"role":46,"phone":27,"phoneExt":27,"email":27},"Yi Zhang",{"name":135,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":138,"status":56,"city":139,"state":140,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Fujian Provincial Cancer Hospital","Fuzhou","Fujian",{"type":62,"coordinates":142},[143,144],119.30611,26.06139,{"lat":144,"lon":143},[147,149],{"name":148,"role":46,"phone":27,"phoneExt":27,"email":27},"Fan Wu",{"name":148,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":151,"status":56,"city":152,"state":153,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":154,"geoPoint":158,"contacts":159},"Lanzhou University First Hospital","Lanzhou","Gansu",{"type":62,"coordinates":155},[156,157],103.83987,36.05701,{"lat":157,"lon":156},[160,162],{"name":161,"role":46,"phone":27,"phoneExt":27,"email":27},"Xiaoling Ling",{"name":161,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":164,"status":56,"city":165,"state":166,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"The First People's Hospital of Foshan","Foshan","Guangdong",{"type":62,"coordinates":168},[169,170],113.13148,23.02677,{"lat":170,"lon":169},[173,175],{"name":174,"role":46,"phone":27,"phoneExt":27,"email":27},"Qian Hu",{"name":174,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":177,"status":56,"city":178,"state":166,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":179,"geoPoint":183,"contacts":184},"Affillated Cancer Hospital and Institute of Guangzhou Medical University","Guangzhou",{"type":62,"coordinates":180},[181,182],113.25,23.11667,{"lat":182,"lon":181},[185,187],{"name":186,"role":46,"phone":27,"phoneExt":27,"email":27},"Hongsheng Li",{"name":186,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":189,"status":56,"city":178,"state":166,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":190,"geoPoint":192,"contacts":193},"Sun Yat-sen Memorial Hospital Affiliated to Sun Yat-sen University",{"type":62,"coordinates":191},[181,182],{"lat":182,"lon":181},[194,196,197],{"name":195,"role":46,"phone":27,"phoneExt":27,"email":27},"Ying Wang",{"name":195,"role":71,"phone":27,"phoneExt":27,"email":27},{"name":198,"role":71,"phone":27,"phoneExt":27,"email":27},"Yaping Yang",{"facility":200,"status":56,"city":178,"state":166,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":201,"geoPoint":203,"contacts":204},"Sun Yat-sen University Cancer Center",{"type":62,"coordinates":202},[181,182],{"lat":182,"lon":181},[205,207],{"name":206,"role":46,"phone":27,"phoneExt":27,"email":27},"Shusen Wang",{"name":206,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":209,"status":56,"city":210,"state":166,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":211,"geoPoint":215,"contacts":216},"Yuebei People's Hospital","Shaoguan",{"type":62,"coordinates":212},[213,214],113.58333,24.8,{"lat":214,"lon":213},[217,219],{"name":218,"role":46,"phone":27,"phoneExt":27,"email":27},"Ruiwen Lei",{"name":218,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":221,"status":56,"city":222,"state":223,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Guangxi Medical University Cancer Hospital","Nanning","Guangxi",{"type":62,"coordinates":225},[226,227],108.31667,22.81667,{"lat":227,"lon":226},[230,232],{"name":231,"role":46,"phone":27,"phoneExt":27,"email":27},"Weimin Xie",{"name":231,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":234,"status":56,"city":222,"state":223,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":235,"geoPoint":237,"contacts":238},"The First Affiliated Hospital of Guangxi Medical University",{"type":62,"coordinates":236},[226,227],{"lat":227,"lon":226},[239,241],{"name":240,"role":46,"phone":27,"phoneExt":27,"email":27},"Yang Li",{"name":240,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":243,"status":56,"city":244,"state":245,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":246,"geoPoint":250,"contacts":251},"Affiliated Hospital of Hebei University","Baoding","Hebei",{"type":62,"coordinates":247},[248,249],115.46246,38.87288,{"lat":249,"lon":248},[252,254],{"name":253,"role":46,"phone":27,"phoneExt":27,"email":27},"Hua Yang",{"name":253,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":256,"status":56,"city":257,"state":245,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":258,"geoPoint":262,"contacts":263},"The Fourth Hospital of Hebei Medical University","Shijiazhuang",{"type":62,"coordinates":259},[260,261],114.47861,38.04139,{"lat":261,"lon":260},[264,266],{"name":265,"role":46,"phone":27,"phoneExt":27,"email":27},"Cuizhi Geng",{"name":265,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":268,"status":56,"city":269,"state":270,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Harbin Medical University Cancer Hospital","Harbin","Heilongjiang",{"type":62,"coordinates":272},[273,274],126.65,45.75,{"lat":274,"lon":273},[277,279],{"name":278,"role":46,"phone":27,"phoneExt":27,"email":27},"Qingyuan Zhang",{"name":278,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":281,"status":56,"city":282,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"The Affiliated Anyang Tumor Hospital of Henan University of Science and Technology","Anyang","Henan",{"type":62,"coordinates":285},[286,287],114.38278,36.096,{"lat":287,"lon":286},[290,292],{"name":291,"role":46,"phone":27,"phoneExt":27,"email":27},"Junlan Guo",{"name":291,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":294,"status":56,"city":295,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"The First Affiliated Hospital of Henan University of Science and Technology","Luoyang",{"type":62,"coordinates":297},[298,299],112.43684,34.67345,{"lat":299,"lon":298},[302,304],{"name":303,"role":46,"phone":27,"phoneExt":27,"email":27},"Xinshuai Wang",{"name":303,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":306,"status":56,"city":307,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Nanyang Central Hospital","Nanyang",{"type":62,"coordinates":309},[310,311],112.54659,33.00524,{"lat":311,"lon":310},[314,316],{"name":315,"role":46,"phone":27,"phoneExt":27,"email":27},"Hao Zhang",{"name":315,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":318,"status":56,"city":319,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"The First Affiliated Hospital of Xinxiang Medical University","Xinxiang",{"type":62,"coordinates":321},[322,323],113.80151,35.19033,{"lat":323,"lon":322},[326,328],{"name":327,"role":46,"phone":27,"phoneExt":27,"email":27},"Yinghua Ji",{"name":327,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":330,"status":56,"city":331,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":332,"geoPoint":336,"contacts":337},"Henan Cancer Hospital","Zhengzhou",{"type":62,"coordinates":333},[334,335],113.64861,34.75778,{"lat":335,"lon":334},[338,340],{"name":339,"role":46,"phone":27,"phoneExt":27,"email":27},"Min Yan",{"name":339,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":342,"status":56,"city":331,"state":283,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":343,"geoPoint":345,"contacts":346},"The First Affiliated Hospital of Zhengzhou University",{"type":62,"coordinates":344},[334,335],{"lat":335,"lon":334},[347,349],{"name":348,"role":46,"phone":27,"phoneExt":27,"email":27},"Hong Zong",{"name":348,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":351,"status":56,"city":352,"state":353,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":354,"geoPoint":358,"contacts":359},"Hubei Cancer Hospital","Wuhan","Hubei",{"type":62,"coordinates":355},[356,357],114.26667,30.58333,{"lat":357,"lon":356},[360,362],{"name":361,"role":46,"phone":27,"phoneExt":27,"email":27},"Xinhong Wu",{"name":361,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":364,"status":56,"city":352,"state":353,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":365,"geoPoint":367,"contacts":368},"Union Hospital Tongji Medical College of Hust",{"type":62,"coordinates":366},[356,357],{"lat":357,"lon":356},[369,371],{"name":370,"role":46,"phone":27,"phoneExt":27,"email":27},"Jing Yao",{"name":370,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":373,"status":56,"city":352,"state":353,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":374,"geoPoint":376,"contacts":377},"Zhongnan Hospital of Wuhan University",{"type":62,"coordinates":375},[356,357],{"lat":357,"lon":356},[378,380],{"name":379,"role":46,"phone":27,"phoneExt":27,"email":27},"Haijun Yu",{"name":379,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":382,"status":56,"city":383,"state":384,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":385,"geoPoint":389,"contacts":390},"The First People's Hospital of Changde City","Changde","Hunan",{"type":62,"coordinates":386},[387,388],111.69844,29.03205,{"lat":388,"lon":387},[391,393],{"name":392,"role":46,"phone":27,"phoneExt":27,"email":27},"Tao Wu",{"name":392,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":395,"status":56,"city":396,"state":384,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":397,"geoPoint":401,"contacts":402},"Hunan Cancer Hospital","Changsha",{"type":62,"coordinates":398},[399,400],112.97087,28.19874,{"lat":400,"lon":399},[403,405],{"name":404,"role":46,"phone":27,"phoneExt":27,"email":27},"Quchang Ouyang",{"name":404,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":407,"status":56,"city":408,"state":384,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":409,"geoPoint":413,"contacts":414},"Xiangyang Cancer Hospital","Xiangyang",{"type":62,"coordinates":410},[411,412],110.2525,29.22833,{"lat":412,"lon":411},[415,417],{"name":416,"role":46,"phone":27,"phoneExt":27,"email":27},"Yuehua Wang",{"name":416,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":419,"status":56,"city":420,"state":384,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":421,"geoPoint":425,"contacts":426},"The Central Hospital of Yongzhou","Yongzhou",{"type":62,"coordinates":422},[423,424],111.61306,26.42389,{"lat":424,"lon":423},[427,429],{"name":428,"role":46,"phone":27,"phoneExt":27,"email":27},"Sijuan Ding",{"name":428,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":431,"status":432,"city":433,"state":434,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":435,"geoPoint":439,"contacts":440},"Jiangsu Province Hospital","NOT_YET_RECRUITING","Nanjing","Jiangsu",{"type":62,"coordinates":436},[437,438],118.77778,32.06167,{"lat":438,"lon":437},[441,443],{"name":442,"role":46,"phone":27,"phoneExt":27,"email":27},"Yongmei Yin",{"name":442,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":445,"status":56,"city":446,"state":434,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":447,"geoPoint":451,"contacts":452},"The Affiliated Hospital of Nantong University","Nantong",{"type":62,"coordinates":448},[449,450],120.87472,32.03028,{"lat":450,"lon":449},[453,455],{"name":454,"role":46,"phone":27,"phoneExt":27,"email":27},"Sujie Ni",{"name":454,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":457,"status":56,"city":458,"state":434,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":459,"geoPoint":463,"contacts":464},"The Second Affiliated Hospital of Suzhou University","Suzhou",{"type":62,"coordinates":460},[461,462],120.59538,31.30408,{"lat":462,"lon":461},[465,467],{"name":466,"role":46,"phone":27,"phoneExt":27,"email":27},"Zhixiang Zhuang",{"name":466,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":469,"status":56,"city":470,"state":434,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":471,"geoPoint":475,"contacts":476},"Xuzhou Central Hospital","Xuzhou",{"type":62,"coordinates":472},[473,474],117.28386,34.20442,{"lat":474,"lon":473},[477,479],{"name":478,"role":46,"phone":27,"phoneExt":27,"email":27},"Yanhua Liu",{"name":478,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":481,"status":56,"city":482,"state":434,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":483,"geoPoint":487,"contacts":488},"Northern Jiangsu People's Hospital","Yangzhou",{"type":62,"coordinates":484},[485,486],119.43583,32.39722,{"lat":486,"lon":485},[489,491],{"name":490,"role":46,"phone":27,"phoneExt":27,"email":27},"Deyuan Fu",{"name":490,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":493,"status":56,"city":494,"state":495,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":496,"geoPoint":500,"contacts":501},"Jiangxi Cancer Hospital","Nanchang","Jiangxi",{"type":62,"coordinates":497},[498,499],115.85306,28.68396,{"lat":499,"lon":498},[502,504],{"name":503,"role":46,"phone":27,"phoneExt":27,"email":27},"Zhengkui Sun",{"name":503,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":506,"status":56,"city":507,"state":508,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":509,"geoPoint":513,"contacts":514},"Jilin Cancer Hospital","Changchun","Jilin",{"type":62,"coordinates":510},[511,512],125.32278,43.88,{"lat":512,"lon":511},[515,517],{"name":516,"role":46,"phone":27,"phoneExt":27,"email":27},"Chunjiao Wu",{"name":516,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":519,"status":56,"city":507,"state":508,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":520,"geoPoint":522,"contacts":523},"The First Hospital of Jilin University",{"type":62,"coordinates":521},[511,512],{"lat":512,"lon":511},[524,525],{"name":45,"role":46,"phone":27,"phoneExt":27,"email":27},{"name":526,"role":71,"phone":27,"phoneExt":27,"email":27},"Jiuwei Cui",{"facility":528,"status":56,"city":529,"state":530,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":531,"geoPoint":535,"contacts":536},"Affiliated Zhongshan Hospital of Dalian University","Dalian","Liaoning",{"type":62,"coordinates":532},[533,534],121.60222,38.91222,{"lat":534,"lon":533},[537,539],{"name":538,"role":46,"phone":27,"phoneExt":27,"email":27},"Xuening Ji",{"name":538,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":541,"status":56,"city":529,"state":530,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":542,"geoPoint":544,"contacts":545},"The Second Hospital Of Dalian Medical University",{"type":62,"coordinates":543},[533,534],{"lat":534,"lon":533},[546,548],{"name":547,"role":46,"phone":27,"phoneExt":27,"email":27},"Man Li",{"name":547,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":550,"status":56,"city":551,"state":530,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":552,"geoPoint":556,"contacts":557},"Liaoning Cancer Hospital","Shenyang",{"type":62,"coordinates":553},[554,555],123.43278,41.79222,{"lat":555,"lon":554},[558,560],{"name":559,"role":46,"phone":27,"phoneExt":27,"email":27},"Jianyi Li",{"name":559,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":562,"status":56,"city":551,"state":530,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":563,"geoPoint":565,"contacts":566},"Shengjing Hospital of China Medical University",{"type":62,"coordinates":564},[554,555],{"lat":555,"lon":554},[567,569],{"name":568,"role":46,"phone":27,"phoneExt":27,"email":27},"Caigang Liu",{"name":568,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":571,"status":56,"city":551,"state":530,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":572,"geoPoint":574,"contacts":575},"The First Hospital of China Medical University",{"type":62,"coordinates":573},[554,555],{"lat":555,"lon":554},[576],{"name":577,"role":46,"phone":27,"phoneExt":27,"email":27},"Yuee Teng",{"facility":579,"status":56,"city":580,"state":581,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":582,"geoPoint":586,"contacts":587},"The First Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi",{"type":62,"coordinates":583},[584,585],108.92861,34.25833,{"lat":585,"lon":584},[588,590],{"name":589,"role":46,"phone":27,"phoneExt":27,"email":27},"Jin Yang",{"name":589,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":592,"status":56,"city":580,"state":581,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":593,"geoPoint":595,"contacts":596},"The Second Affiliated Hospital of Xi'an Jiaotong University",{"type":62,"coordinates":594},[584,585],{"lat":585,"lon":584},[597,599],{"name":598,"role":46,"phone":27,"phoneExt":27,"email":27},"Shuqun Zhang",{"name":598,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":601,"status":56,"city":602,"state":603,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":604,"geoPoint":608,"contacts":609},"Shandong Cancer Hospital","Jinan","Shandong",{"type":62,"coordinates":605},[606,607],116.99722,36.66833,{"lat":607,"lon":606},[610,612],{"name":611,"role":46,"phone":27,"phoneExt":27,"email":27},"Huihui Li",{"name":611,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":614,"status":56,"city":615,"state":603,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":616,"geoPoint":620,"contacts":621},"Affiliated hospital of Jining Medical University","Jining",{"type":62,"coordinates":617},[618,619],116.58139,35.405,{"lat":619,"lon":618},[622,624],{"name":623,"role":46,"phone":27,"phoneExt":27,"email":27},"Zhongsheng Xia",{"name":623,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":626,"status":56,"city":627,"state":603,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":628,"geoPoint":632,"contacts":633},"Linyi Cancer Hospital","Linyi",{"type":62,"coordinates":629},[630,631],118.34278,35.06306,{"lat":631,"lon":630},[634,636],{"name":635,"role":46,"phone":27,"phoneExt":27,"email":27},"Jingfen Wang",{"name":635,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":638,"status":56,"city":639,"state":603,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":640,"geoPoint":644,"contacts":645},"The Affiliated Hospital of Qingdao University","Qingdao",{"type":62,"coordinates":641},[642,643],120.38042,36.06488,{"lat":643,"lon":642},[646,648],{"name":647,"role":46,"phone":27,"phoneExt":27,"email":27},"Haibo Wang",{"name":647,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":650,"status":56,"city":651,"state":603,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":652,"geoPoint":656,"contacts":657},"Weifang People's Hospital","Weifang",{"type":62,"coordinates":653},[654,655],119.10194,36.71,{"lat":655,"lon":654},[658,660],{"name":659,"role":46,"phone":27,"phoneExt":27,"email":27},"Wenhui Wang",{"name":659,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":662,"status":56,"city":663,"state":664,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":665,"geoPoint":669,"contacts":670},"Fudan University Shanghai Cancer Center","Shanghai","Shanghai Municipality",{"type":62,"coordinates":666},[667,668],121.45806,31.22222,{"lat":668,"lon":667},[671,673,675],{"name":672,"role":46,"phone":27,"phoneExt":27,"email":27},"Jian Zhang",{"name":674,"role":71,"phone":27,"phoneExt":27,"email":27},"Jiong Wu",{"name":672,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":677,"status":56,"city":663,"state":664,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":678,"geoPoint":680,"contacts":681},"Obstetrics and Gynecology Hospital of Fudan University",{"type":62,"coordinates":679},[667,668],{"lat":668,"lon":667},[682,684],{"name":683,"role":46,"phone":27,"phoneExt":27,"email":27},"Kejin Wu",{"name":683,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":686,"status":56,"city":663,"state":664,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":687,"geoPoint":689,"contacts":690},"Ruijin hospital of Shanghai Jiao Tong university School of Medicine",{"type":62,"coordinates":688},[667,668],{"lat":668,"lon":667},[691,693],{"name":692,"role":46,"phone":27,"phoneExt":27,"email":27},"Kunwei Shen",{"name":692,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":695,"status":56,"city":696,"state":697,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":698,"geoPoint":702,"contacts":703},"Shanxi cancer hospital","Taiyuan","Shanxi",{"type":62,"coordinates":699},[700,701],112.56028,37.86944,{"lat":701,"lon":700},[704,706],{"name":705,"role":46,"phone":27,"phoneExt":27,"email":27},"Fuguo Tian",{"name":705,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":708,"status":56,"city":709,"state":697,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":710,"geoPoint":714,"contacts":715},"Runcheng City Center Hospital","Yuncheng",{"type":62,"coordinates":711},[712,713],110.99278,35.02306,{"lat":713,"lon":712},[716],{"name":717,"role":46,"phone":27,"phoneExt":27,"email":27},"Xiaoke Hou",{"facility":719,"status":56,"city":720,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":722,"geoPoint":726,"contacts":727},"Sichuan Cancer Hospital","Chengdu","Sichuan",{"type":62,"coordinates":723},[724,725],104.06667,30.66667,{"lat":725,"lon":724},[728,730],{"name":729,"role":46,"phone":27,"phoneExt":27,"email":27},"Junjie Li",{"name":729,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":732,"status":56,"city":720,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":733,"geoPoint":735,"contacts":736},"Sichuan Provincial People's Hospital",{"type":62,"coordinates":734},[724,725],{"lat":725,"lon":724},[737,739],{"name":738,"role":46,"phone":27,"phoneExt":27,"email":27},"Jing Luo",{"name":738,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":741,"status":56,"city":742,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":743,"geoPoint":747,"contacts":748},"Mianyang Central Hospital","Mianyang",{"type":62,"coordinates":744},[745,746],104.68168,31.46784,{"lat":746,"lon":745},[749,751],{"name":750,"role":46,"phone":27,"phoneExt":27,"email":27},"Xiaobo Du",{"name":750,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":753,"status":56,"city":754,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":755,"geoPoint":759,"contacts":760},"Nanchong Central Hospital of Sichuan Province","Nanchong",{"type":62,"coordinates":756},[757,758],106.08473,30.79508,{"lat":758,"lon":757},[761,763],{"name":762,"role":46,"phone":27,"phoneExt":27,"email":27},"Xin Hu",{"name":762,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":765,"status":56,"city":766,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":767,"geoPoint":771,"contacts":772},"The First People's Hospital of Neijiang","Neijiang",{"type":62,"coordinates":768},[769,770],105.06216,29.58354,{"lat":770,"lon":769},[773,775],{"name":774,"role":46,"phone":27,"phoneExt":27,"email":27},"Shubin Tang",{"name":774,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":777,"status":56,"city":766,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":778,"geoPoint":780,"contacts":781},"The Second People's Hospital Of Neijiang",{"type":62,"coordinates":779},[769,770],{"lat":770,"lon":769},[782,784],{"name":783,"role":46,"phone":27,"phoneExt":27,"email":27},"Xujiang Wang",{"name":783,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":786,"status":56,"city":787,"state":721,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":788,"geoPoint":792,"contacts":793},"Suining Central Hospital","Suining",{"type":62,"coordinates":789},[790,791],105.57332,30.50802,{"lat":791,"lon":790},[794,796],{"name":795,"role":46,"phone":27,"phoneExt":27,"email":27},"Hongwei Yang",{"name":795,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":798,"status":56,"city":799,"state":800,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":801,"geoPoint":805,"contacts":806},"Tian Jin Medicial University Cancer Institute&Hospital","Tianjin","Tianjin Municipality",{"type":62,"coordinates":802},[803,804],117.17667,39.14222,{"lat":804,"lon":803},[807,809],{"name":808,"role":46,"phone":27,"phoneExt":27,"email":27},"Zhongsheng Tong",{"name":808,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":811,"status":56,"city":812,"state":813,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":814,"geoPoint":818,"contacts":819},"Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University)","Kunming","Yunnan",{"type":62,"coordinates":815},[816,817],102.71833,25.03889,{"lat":817,"lon":816},[820,822],{"name":821,"role":46,"phone":27,"phoneExt":27,"email":27},"Jianyun Nie",{"name":821,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":824,"status":56,"city":825,"state":826,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":827,"geoPoint":831,"contacts":832},"The Second Affiliated Hospital Zhejiang University School Of Medicine","Hangzhou","Zhejiang",{"type":62,"coordinates":828},[829,830],120.16142,30.29365,{"lat":830,"lon":829},[833,835],{"name":834,"role":46,"phone":27,"phoneExt":27,"email":27},"Yiding Chen",{"name":834,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":837,"status":56,"city":825,"state":826,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":838,"geoPoint":840,"contacts":841},"Zhejiang Cancer Hospital",{"type":62,"coordinates":839},[829,830],{"lat":830,"lon":829},[842,844],{"name":843,"role":46,"phone":27,"phoneExt":27,"email":27},"Hai Hu",{"name":843,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":846,"status":56,"city":847,"state":826,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":848,"geoPoint":852,"contacts":853},"Taizhou Hospital of Zhejiang Province","Taizhou",{"type":62,"coordinates":849},[850,851],121.43312,28.66266,{"lat":851,"lon":850},[854,856],{"name":855,"role":46,"phone":27,"phoneExt":27,"email":27},"Bojian Xie",{"name":855,"role":71,"phone":27,"phoneExt":27,"email":27},{"facility":858,"status":56,"city":859,"state":826,"zip":27,"country":59,"countryCode":60,"cosmosGeoPoint":860,"geoPoint":864,"contacts":865},"The First Affiliated Hospital of Wenzhou Medical University","Wenzhou",{"type":62,"coordinates":861},[862,863],120.66682,27.99942,{"lat":863,"lon":862},[866,868],{"name":867,"role":46,"phone":27,"phoneExt":27,"email":27},"Zhenchen Wang",{"name":867,"role":71,"phone":27,"phoneExt":27,"email":27},{"type":870,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100548332","phase-3-pm8002-or-placebo-plus-nab-paclitaxel-as-first-line-treatment-in-inoperable-locally-advancedmetastatic-tnbc-100548332",false,"NCT06419621","PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced\u002FMetastatic TNBC","A Multicenter, Randomized, Double-blind Phase III Study of PM8002 or Placebo in Combination With Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced\u002FMetastatic Triple-negative Breast Cancer(TNBC)","Inclusion Criteria:\n\n* Ability to understand and willing to provide written informed consent and to comply with scheduled visits and study procedures;\n* Female, aged 18 to 70 years (inclusive);\n* Histologically confirmed unresectable locally advanced or metastatic breast cancer with negative status for ER, PR, and HER-2. Testing results for all three markers conducted within 24 months prior to the initiation of the study by a local facility accredited by clinical research center are acceptable. If deemed necessary by the investigator during screening, subjects may provide additional biopsy to confirm the latest pathological;\n* Subjects who have not received prior systemic treatment（except endocrine therapy） for advanced breast cancer are eligible for the study. Subjects who have received Taxane-based chemotherapy during the neoadjuvant and\u002For adjuvant treatment phase are eligible, as long as the occurrence of relapse or metastasis is at least 12 months after the end of treatment;\n* Performance status as assessed by the Eastern Cooperative Oncology Group (ECOG) is 0-1;\n* Life expectancy of 12 weeks or more;\n* According to RECIST 1.1, the subject has at least 1 measurable lesion as the targeted lesion (the only bone metastasis or the only central nervous system metastasis should not be considered as a measurable lesion. A measurable lesion located at the previously irradiated radiation field or other local treatment area should not be selected as targeted lesion, unless the lesion shows unequivocal radiographic progression).\n\nExclusion Criteria:\n\n* Previous treatment with immune checkpoint agonists (such as CD137 agonists) or immune checkpoint inhibitors (such as CTLA-4, PD-1, PD-L1, LAG3 monoclonal antibody, etc.) or anti-vascular endothelial growth factor (VEGF) target drugs;\n* Has uncontrolled or symptomatic brain or spine cord metastases;\n* Those who have had other active malignant tumors within 5 years prior to the study treatment, except for those that can be treated locally and have been cured ;\n* Poorly controlled hypertension (systolic blood pressure ≥ 140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg);\n* With a history of hypertensive crisis or hypertensive encephalopathy;\n* With a history of abdominal fistula, tracheoesophageal fistula, gastrointestinal perforation, or intra-abdominal abscess within the last 6 months prior to the start of the study treatment;\n* Adverse events resulting from prior anti-tumor therapies should be assessed and graded according to the CTCAE 5.0 criteria, subjects whose AEs have not returned to Grade 1 or below;\n* Has uncontrollable pleural, pericardial, or abdominal effusions;\n* Has received allogeneic hematopoietic stem cell transplantation or organ transplantation.","FEMALE","18 Years","70 Years",{"count":882,"type":883},360,"ESTIMATED","INTERVENTIONAL",[886],"PHASE3","This multicenter, randomized, double-blind study will evaluate the safety and efficacy of PM8002 in combination with Nab-Paclitaxel compared with placebo combined with Nab-Paclitaxel as first-line treatment in inoperable locally advanced\u002Fmetastatic triple-negative breast cancer(TNBC)",[889],"Triple Negative Breast Cancer(TNBC)","2025-03-09",{"date":892,"type":893},"2025-03-12","ACTUAL",{"date":895,"type":893},"2024-06-11",{"date":897,"type":883},"2028-07",{"name":5,"class":6},70]