[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100543080":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":63,"collaborators":26,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":26,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":26,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":91,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Keck School of Medicine of USC","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","PLACEBO_COMPARATOR","placebo sugar pill and standard intraoperative pain control using short-acting opioids, with drug choice and dosing at the practitioner's discretion",[13],"Drug: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Interventional","EXPERIMENTAL","5mg PO methadone for participants \\\u003C50kg or 10mg PO methadone for participants \\>50kg",[19],"Drug: Methadone group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Methadone group","5mg PO methadone for participants \\<50kg or 10mg PO methadone for participants \\>50kg",[15],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","sugar pill that is identical look-alike to study drug",[9],[32],{"name":33,"affiliation":5,"role":34},"Alexander Chen, M.D.","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","323-442-7400","painmed@usc.edu",[41],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"USC Healthcare Consultation 3","Los Angeles","California","90033","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-118.24368,34.05223,{"lat":52,"lon":51},[55,56,59,61],{"name":33,"role":37,"phone":38,"phoneExt":26,"email":39},{"name":57,"role":58,"phone":26,"phoneExt":26,"email":26},"Abigail Song, B.S.","SUB_INVESTIGATOR",{"name":60,"role":58,"phone":26,"phoneExt":26,"email":26},"Benjamin Liu, M.D.",{"name":62,"role":58,"phone":26,"phoneExt":26,"email":26},"Paul Lee, M.D., M.S.",{"type":34,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Abigail Song","Co-Investigator","100543080","phase-3-po-methadone-ortho-outpatient-100543080",false,"NCT06351215","PO Methadone Ortho Outpatient","Use of Single-Dose Oral Methadone for Pain Management in Outpatient Arthroscopic Hip and Knee Procedures","Inclusion Criteria:\n\n* medically optimized participants who will undergo elective arthroscopic knee or hip repair\n\nExclusion Criteria:\n\n* pregnant or breastfeeding, age under 18, history of respiratory compromise, allergy to opioids, recipient of pre-operative nerve block","ALL","18 Years",{"count":76,"type":77},100,"ESTIMATED","INTERVENTIONAL",[80],"PHASE3","The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are:\n\nDoes oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment?\n\nResearchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above.\n\nParticipants will:\n\nReceive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery",[83,84],"Arthroscopic Knee Repair","Arthroscopic Hip Repair",[86,87,88,89,90],"arthroscopic knee repair","arthroscopic hip repair","oral methadone","post-operative pain control","ambulatory surgery","NOT_YET_RECRUITING","2025-03-03",{"date":94,"type":95},"2025-03-05","ACTUAL",{"date":97,"type":77},"2025-05-01",{"date":99,"type":77},"2025-12-15",{"name":5,"class":6},1]