[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100423118":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":36,"centralContacts":40,"locations":49,"responsibleParty":69,"collaborators":72,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":83,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":12,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":105,"overallStatus":52,"whyStopped":12,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Charles University, Czech Republic","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"A","NO_INTERVENTION","Patients will be provided with a basic information and standard of care support.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"B","EXPERIMENTAL","Active prehabilitation will be provided, composed of i) three physical activity-related interventions provided by a physical and rehabilitation medicine (PRM) specialist; iii) three 30 min consultations regarding nutritional status with physician or nutrition specialist; ii) three sessions with psychologist.",[18,19,20],"Other: Physiological intervention","Behavioral: Psychological intervention","Dietary Supplement: Nutritional intervention",[22,26,31],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":12},"Physiological intervention","* Rehabilitation specialist consultation (3x)\n* Individualized home-based exercise plan\n* Functional capacity measuring",[14],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":12},"BEHAVIORAL","Psychological intervention","* Clinical psychologist consultation (3x)\n* Anxiety and depression scoring\n* Psychological support",[14],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":12},"DIETARY_SUPPLEMENT","Nutritional intervention","* Nutritional specialist consultation (3x)\n* Malnutrition scoring\n* Dietary supplementation",[14],[37],{"name":38,"affiliation":5,"role":39},"David Cibula, prof.","PRINCIPAL_INVESTIGATOR",[41,46],{"name":42,"role":43,"phone":44,"phoneExt":12,"email":45},"Jana Stribrna","CONTACT","+420 224 967 432","jana.stribrna@vfn.cz",{"name":47,"role":43,"phone":12,"phoneExt":12,"email":48},"Stefan Lednicky, MD.","stefan.lednicky@vfn.cz",[50],{"facility":51,"status":52,"city":53,"state":12,"zip":54,"country":55,"countryCode":12,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Gynecologic Oncology Center in Prague","RECRUITING","Prague","12000","Czechia",{"type":57,"coordinates":58},"Point",[59,60],14.42076,50.08804,{"lat":60,"lon":59},[63,67],{"name":64,"role":43,"phone":65,"phoneExt":12,"email":66},"David Cibula, M.D.","+420603547055","dc@davidcibula.cz",{"name":42,"role":43,"phone":68,"phoneExt":12,"email":45},"+420224967432",{"type":39,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"David Cibula","professor",[73,75,77,79],{"name":74,"class":6},"University Hospital Ostrava",{"name":76,"class":6},"University Hospital Olomouc",{"name":78,"class":6},"University Hospital Pilsen",{"name":80,"class":6},"The Faculty Hospital Na Bulovce","100423118","phase-3-prehabilitation-in-gynaecological-cancer-patients-100423118",false,"NCT04789694","Prehabilitation in Gynaecological Cancer Patients","Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management: A Prospective Randomised Trial.","PHOCUS","Inclusion criteria\n\nTwo groups of patients will be eligible for the trial:\n\ni) Epithelial ovarian cancer patients referred for NACT: a) FIGO stage III or IV disease; b) Patient is not a candidate for primary debulking surgery; c) Patient is a suitable candidate for standard of care combined chemotherapy; d) Patient is a candidate for interval.debulking surgery\n\nii) Stage I or II endometrial cancer patients classifying as frail according to the validated modified Frailty Index: a) FIGO stage I or II; b) Patient is classified as frail; c) Patient is suitable candidate for hormonal therapy.\n\nExclusion criteria\n\n1. Second malignant tumour (under the treatment)\n2. Patient is not suitable for any surgery delay\n3. Patient is not physically able to meet the prehabilitation intervention plan or is unable to walk","FEMALE","18 Years","85 Years",{"count":93,"type":94},64,"ESTIMATED","INTERVENTIONAL",[97],"PHASE3","Prehabilitation refers to interventions aiming to improve patients' resilience and functional capacity before a known stressful event, e.g., scheduled surgery. These interventions usually consist of physical activity and psychological and nutritional support. There is substantial evidence of the positive effect of multimodal prehabilitation among patients treated surgically for non-gynaecological cancers; however, no prospective data are available in gynaecological cancer patients.\n\nPHOCUS trial is a prospective randomised trial aiming to evaluate the role of multimodal prehabilitation in patients with gynaecological cancer. Sixty-four patients will be randomised in single institution within 36 months with a 1:1 ratio into ARM A: control arm which will be provided with a basic information and standard of care support; ARM B: active arm undergoing multimodal prehabilitation composed of physical activity and psychological and nutritional support. All patients will be assessed at standard intervals (three times during the trial) by a spectrum of non-invasive tests, evaluating physical functional capacity, postoperative morbidity, nutritional status, level of stress and anxiety, and quality of life.",[100,101,102,103,104],"Ovarian Cancer","Ovarian Cancer Stage III","Ovarian Cancer Stage IV","Endometrial Cancer","Frailty",[106,107,108,109,110,104,111],"Prehabilitation","Epitelial ovarian cancer","Functional capacity","Quality of life","Multimodal prehabilitation","Endometrial cancer","2026-03-18",{"date":114,"type":115},"2026-03-19","ACTUAL",{"date":117,"type":115},"2021-01-25",{"date":119,"type":94},"2026-06-30",{"name":5,"class":6},1]