[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616911":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":45,"responsibleParty":258,"collaborators":261,"id":286,"slug":287,"hasResults":288,"nctId":289,"briefTitle":290,"officialTitle":291,"acronym":26,"eligibilityCriteria":292,"healthyVolunteers":288,"sex":293,"minAge":294,"maxAge":295,"enrollmentInfo":296,"targetDuration":26,"studyType":299,"phases":300,"briefSummary":302,"conditions":303,"keywords":306,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":317},{"fullName":5,"class":6},"Sun Yat-sen University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Houyanqing Oral Liquid combined with Conventional Treatment","EXPERIMENTAL","This arm involves Houyanqing Oral Liquid combined with conventional treatment for preventing radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients receiving radical radiotherapy. Specific interventions include: 1) Houyanqing Oral Liquid administration before and during radiotherapy; 2) Conventional treatment (same as the control arm): oral hygiene management, epithelial repair promotion, and symptomatic support therapy; 3) Radical radiotherapy (conventional fractionation). The aim is to evaluate the effect of this combined regimen on reducing RIOM severity.",[13,14],"Drug: Houyanqing Oral Liquid","Other: Conventional Treatment for Radiation-Induced Oral Mucositis",{"label":16,"type":17,"description":18,"interventionNames":19},"Conventional Treatment","ACTIVE_COMPARATOR","This arm consists of conventional treatment for preventing radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients undergoing radical radiotherapy. Specific interventions include: 1) Oral hygiene management; 2) Epithelial repair promotion; 3) Symptomatic support . Patients in this arm will receive radical radiotherapy (conventional fractionation) but will not be administered Houyanqing Oral Liquid.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Houyanqing Oral Liquid","Houyanqing Oral Liquid is a Chinese herbal preparation formulated with Achyranthes aspera L., Kalimeris indica (L.) Sch.-Bip., Plantago asiatica L., and Carpesium abrotanoides L.. For this study, it is used in nasopharyngeal carcinoma patients receiving radical radiotherapy: the dosage is 10mL per administration, 4 times daily. The medication is initiated prior to radiotherapy and continued until the completion of radiotherapy, with the purpose of preventing and treating radiation-induced oral mucositis.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Treatment for Radiation-Induced Oral Mucositis","This intervention refers to the conventional management measures for radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma patients undergoing radical radiotherapy, including three modules: 1) Oral hygiene management; 2) Epithelial repair promotion; 3) Symptomatic support. These measures are implemented throughout the radiotherapy period to alleviate RIOM-related symptoms.",[16,9],[32],{"name":33,"affiliation":34,"role":35},"Ming-Yuan Chen, MD, PhD","Fifth Affiliated Hospital of Sun Yat-sen University","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","86-13903052650","chmingy@mail.sysu.edu.cn",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Yan-Rou Xie, MD","86-13751762936","292352606@qq.com",[46,65,79,93,103,116,127,141,154,168,178,192,206,220,234,244],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Cancer Hospital Chinese Academy of Medical Science","RECRUITING","Beijing","Beijing Municipality","100021","China","CN",{"type":55,"coordinates":56},"Point",[57,58],116.39723,39.9075,{"lat":58,"lon":57},[61],{"name":62,"role":38,"phone":63,"phoneExt":26,"email":64},"Jun-Ling Yi, PhD.","+86 13661217998","yijunlin1969@163.com",{"facility":66,"status":48,"city":67,"state":68,"zip":69,"country":52,"countryCode":53,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Fujian Medical University Cancer Hospital","Fuzhou","Fujian","350014",{"type":55,"coordinates":71},[72,73],119.30611,26.06139,{"lat":73,"lon":72},[76],{"name":77,"role":38,"phone":78,"phoneExt":26,"email":26},"Sufang Qiu","86-13609589163",{"facility":80,"status":48,"city":81,"state":82,"zip":83,"country":52,"countryCode":53,"cosmosGeoPoint":84,"geoPoint":88,"contacts":89},"Sun Yat-sen University Cancer Center","Guangzhou","Guangdong","510060",{"type":55,"coordinates":85},[86,87],113.25,23.11667,{"lat":87,"lon":86},[90],{"name":91,"role":38,"phone":92,"phoneExt":26,"email":26},"Pei-Yu Huang, MD","86-18928013516",{"facility":94,"status":48,"city":81,"state":82,"zip":95,"country":52,"countryCode":53,"cosmosGeoPoint":96,"geoPoint":98,"contacts":99},"Affiliated Cancer Hospital & Institute of Guangzhou Medical University","510095",{"type":55,"coordinates":97},[86,87],{"lat":87,"lon":86},[100],{"name":101,"role":38,"phone":102,"phoneExt":26,"email":26},"Bin Qi","86-13580580985",{"facility":104,"status":48,"city":105,"state":82,"zip":106,"country":52,"countryCode":53,"cosmosGeoPoint":107,"geoPoint":111,"contacts":112},"Cancer Hospital of Shantou University Medical College","Shantou","515041",{"type":55,"coordinates":108},[109,110],116.67876,23.35489,{"lat":110,"lon":109},[113],{"name":114,"role":38,"phone":115,"phoneExt":26,"email":26},"Kai Chen","86-13005222990",{"facility":34,"status":48,"city":117,"state":82,"zip":118,"country":52,"countryCode":53,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Zhuhai","519000",{"type":55,"coordinates":120},[121,122],113.56778,22.27694,{"lat":122,"lon":121},[125],{"name":126,"role":38,"phone":39,"phoneExt":26,"email":40},"Ming-Yuan Chen, PhD.",{"facility":128,"status":48,"city":129,"state":130,"zip":131,"country":52,"countryCode":53,"cosmosGeoPoint":132,"geoPoint":136,"contacts":137},"Cancer Hospital of Guangxi Medical University","Nanning","Guangxi","530021",{"type":55,"coordinates":133},[134,135],108.31667,22.81667,{"lat":135,"lon":134},[138],{"name":139,"role":38,"phone":140,"phoneExt":26,"email":26},"Song Qu","86-13607887386",{"facility":142,"status":48,"city":143,"state":130,"zip":144,"country":52,"countryCode":53,"cosmosGeoPoint":145,"geoPoint":149,"contacts":150},"Wuzhou Red Cross Hospital","Wuzhou","543002",{"type":55,"coordinates":146},[147,148],111.28848,23.48054,{"lat":148,"lon":147},[151],{"name":152,"role":38,"phone":153,"phoneExt":26,"email":26},"Jin-Hui Liang","86-13878480806",{"facility":155,"status":48,"city":156,"state":157,"zip":158,"country":52,"countryCode":53,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Xiangya Hospital of Central South University","Changsha","Hunan","410008",{"type":55,"coordinates":160},[161,162],112.97087,28.19874,{"lat":162,"lon":161},[165],{"name":166,"role":38,"phone":167,"phoneExt":26,"email":26},"Yu-Xiang He","86-13786112914",{"facility":169,"status":48,"city":156,"state":157,"zip":170,"country":52,"countryCode":53,"cosmosGeoPoint":171,"geoPoint":173,"contacts":174},"Hunan Cancer Hospital","410013",{"type":55,"coordinates":172},[161,162],{"lat":162,"lon":161},[175],{"name":176,"role":38,"phone":177,"phoneExt":26,"email":26},"Ya-Qian Han","86-18673176667",{"facility":179,"status":48,"city":180,"state":181,"zip":182,"country":52,"countryCode":53,"cosmosGeoPoint":183,"geoPoint":187,"contacts":188},"The First People's Hospital of Changzhou","Changzhou","Jiangsu","213003",{"type":55,"coordinates":184},[185,186],119.95401,31.77359,{"lat":186,"lon":185},[189],{"name":190,"role":38,"phone":191,"phoneExt":26,"email":26},"Wen-Dong Gu","86-13861220022",{"facility":193,"status":48,"city":194,"state":195,"zip":196,"country":52,"countryCode":53,"cosmosGeoPoint":197,"geoPoint":201,"contacts":202},"Eye & ENT Hospital of Fudan University","Shanghai","Shanghai Municipality","200031",{"type":55,"coordinates":198},[199,200],121.45806,31.22222,{"lat":200,"lon":199},[203],{"name":204,"role":38,"phone":205,"phoneExt":26,"email":26},"Xiao-Shen Wang","86-18917785187",{"facility":207,"status":48,"city":208,"state":209,"zip":210,"country":52,"countryCode":53,"cosmosGeoPoint":211,"geoPoint":215,"contacts":216},"West China Hospital of Sichuan University","Chengdu","Sichuan","610041",{"type":55,"coordinates":212},[213,214],104.06667,30.66667,{"lat":214,"lon":213},[217],{"name":218,"role":38,"phone":219,"phoneExt":26,"email":26},"Lei Liu","86-18980606231",{"facility":221,"status":48,"city":222,"state":223,"zip":224,"country":52,"countryCode":53,"cosmosGeoPoint":225,"geoPoint":229,"contacts":230},"The First Affiliated Hospital of Kunming Medical University","Kunming","Yunnan","650032",{"type":55,"coordinates":226},[227,228],102.71833,25.03889,{"lat":228,"lon":227},[231],{"name":232,"role":38,"phone":233,"phoneExt":26,"email":26},"Zhi-Qiang Wang","86-15887085161",{"facility":235,"status":48,"city":222,"state":223,"zip":236,"country":52,"countryCode":53,"cosmosGeoPoint":237,"geoPoint":239,"contacts":240},"Yunnan Cancer Hospital","650118",{"type":55,"coordinates":238},[227,228],{"lat":228,"lon":227},[241],{"name":242,"role":38,"phone":243,"phoneExt":26,"email":26},"Ji-Yong Qin","86-13808757779",{"facility":245,"status":48,"city":246,"state":247,"zip":248,"country":52,"countryCode":53,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"Zhejiang Cancer Hospital","Hangzhou","Zhengjiang","310022",{"type":55,"coordinates":250},[251,252],120.16142,30.29365,{"lat":252,"lon":251},[255],{"name":256,"role":38,"phone":257,"phoneExt":26,"email":26},"Feng Jiang","86-13858065192",{"type":35,"investigatorFullName":259,"investigatorTitle":260,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Ming-Yuan Chen","Professor",[262,265,266,267,269,270,272,273,274,276,277,278,279,280,282,284],{"name":263,"class":264},"Fujian Cancer Hospital","OTHER_GOV",{"name":193,"class":6},{"name":245,"class":6},{"name":268,"class":6},"West China Hospital",{"name":235,"class":6},{"name":271,"class":6},"First Affiliated Hospital of Kunming Medical University",{"name":179,"class":6},{"name":155,"class":6},{"name":275,"class":6},"Affiliated Cancer Hospital of Shantou University Medical College",{"name":142,"class":6},{"name":169,"class":6},{"name":128,"class":6},{"name":94,"class":6},{"name":281,"class":6},"Sun Yat-Sen University Cancer Center",{"name":47,"class":283},"UNKNOWN",{"name":285,"class":283},"The Fifth Affiliated Hospital, Sun Yat-sen University","100616911","phase-3-prevention-and-treatment-of-radiation-induced-oral-mucositis-in-npc-with-houyanqing-oral-liquid-100616911",false,"NCT07311772","Prevention and Treatment of Radiation-Induced Oral Mucositis in NPC With Houyanqing Oral Liquid","A Randomized Controlled Study of Houyanqing Oral Liquid Combined With Conventional Treatment Versus Conventional Treatment Alone for Preventing and Treating Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma","Inclusion Criteria:\n\n1. Staged as Stage I-IV according to the 9th edition of the TNM Classification of Malignant Tumors formulated by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC);\n2. Age: 18 to 75 years old;\n3. Karnofsky Performance Status (KPS) score ≥ 80 before treatment;\n4. No oral diseases (such as oral mucositis or salivary gland damage) before radiotherapy;\n5. Requiring radical radiotherapy;\n6. The patient has signed the informed consent form and is willing and able to comply with the study's follow-up visits, treatment plan, laboratory tests, and other research procedures.\n\nExclusion Criteria:\n\n1. Patients with confirmed tumor recurrence, distant tumor metastasis, or who have received other anti-tumor treatments;\n2. Previous history of head and neck radiotherapy;\n3. Known allergy to the drugs used in this study (Houyanqing Oral Liquid, any conventional treatment drugs);\n4. Local use of Houyanqing Oral Liquid, Recombinant Human Epidermal Growth Factor (rhEGF) Topical Solution, Vitamin B12 Solution, or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) mouthwash in the oral cavity within one month before enrollment;\n5. Comorbidities requiring long-term treatment with immunosuppressive drugs, or systemic\u002Flocal use of corticosteroids at immunosuppressive doses before enrollment;\n6. HIV-positive patients;\n7. Pregnant women or lactating women;\n8. Patients with severe mental illnesses;\n9. Patients with severe cardio-cerebrovascular diseases, endocrine disorders, infectious diseases, or other tumors.","ALL","18 Years","75 Years",{"count":297,"type":298},386,"ESTIMATED","INTERVENTIONAL",[301],"PHASE3","To explore the efficacy of Houyanqing Oral Liquid combined with conventional treatment in preventing and treating radiation-induced oral mucositis, so as to improve the quality of life of nasopharyngeal carcinoma patients received radiotherapy.",[304,305],"Nasopharyngeal Cancinoma (NPC)","Radiation-induced Oral Mucositis",[307,305,23],"Nasopharyngeal Cancinoma","2026-05-06",{"date":310,"type":311},"2026-05-07","ACTUAL",{"date":313,"type":311},"2025-12-16",{"date":315,"type":298},"2027-08-15",{"name":5,"class":6},16]