[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565639":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":61,"collaborators":26,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":26,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Shandong University of Traditional Chinese Medicine","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"P4mNC group","EXPERIMENTAL","On days 8-12 of the menstrual cycle (MC), depending on the length of the patient's MC, transvaginal ultrasound is used to monitor follicular development and endometrial growth. Vaginal micronized progesterone (Utrogestan, Besins, Belgium) is started at 200 mg in the afternoon and 200 mg in the evening when the dominant follicle reached ≥16 mm and the endometrial thickness is at least 7 mm. A blastocyst is transferred on day 5 after the addition of progesterone. On day 14 after blastocyst transfer, serum β-hCG levels are measured. Upon positive serum pregnancy testing, progesterone support will continue until 8-10 weeks of gestation. However, afternoon progesterone use is eliminated for 30 days after embryo transfer.",[13],"Drug: Progesterone-modified natural cycle preparation for frozen embryo transfer",{"label":15,"type":16,"description":17,"interventionNames":18},"HRT group","ACTIVE_COMPARATOR","Endometrial preparation will begin on the second day of the menstrual cycle with oral estradiol (E2) valerate at a dose of 2 mg twice daily. When the patient's endometrial thickness is ≥7 mm, vaginal progesterone administration will be initiated at a dose of 200 mg 3 times daily. On day 5 of the progesterone administration, blastocysts are thawed and transferred. For patients with endometrial thickness \\\u003C7 mm, patients continued oral E2 until the endometrium is ≥7 mm. On day 14 after blastocyst transfer, serum β-hCG levels are measured. Upon positive serum pregnancy testing, E2 and progesterone supplementation is continued for 8-10 weeks of gestation.",[19],"Drug: Hormone replacement therapy cycle preparation for frozen embryo transfer",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Progesterone-modified natural cycle preparation for frozen embryo transfer","A novel endometrial preparation protocol that optimizes the natural cycle, whereby as long as the thickness of the endometrium is suitable for embryo transfer, vaginal progesterone can be used to transform the endometrium before ovulation and subsequently FET.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Hormone replacement therapy cycle preparation for frozen embryo transfer","A traditional endometrial preparation protocol is used for FET, which involves using fixed or flexible exogenous estradiol for artificial cycles. This protocol typically involves starting exogenous estradiol on day 3 or 4 of the cycle, continuing for 7-10 days, and then discontinuing. Upon determining that the endometrial thickness meets the standard, progesterone conversion of the endometrium can be performed.",[15],[32],{"name":33,"affiliation":34,"role":35},"Zhen-Gao Sun, MD","Affiliated Hospital of Shandong University of Traditional Chinese Medicine","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Xian-Ling Cao, MD","CONTACT","0531-68901236","caoxianlingling@163.com",[43],{"facility":34,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Jinan","Shandong","250014","China","CN",{"type":51,"coordinates":52},"Point",[53,54],116.99722,36.66833,{"lat":54,"lon":53},[57],{"name":58,"role":39,"phone":59,"phoneExt":26,"email":60},"Jing-Yan Song, MD","18765800113","songjingyan@sdutcm.edu.cn",{"type":35,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Jing-Yan Song","Prof.","100565639","phase-3-progesterone-modified-natural-cycle-for-fet-100565639",false,"NCT06644794","Progesterone-modified Natural Cycle for FET","Comparison of Progesterone-modified Natural Cycle and Hormone Replacement Therapy Cycle for Endometrial Preparation in Single Frozen Blastocyst Transfer","COMPROSET","Inclusion Criteria:\n\n* Patients aged 21 to 44 years undergoing FBT\n* Body mass index (BMI) 18-35 kg\u002Fm2\n* Having regular ovulatory cycles\n\nExclusion Criteria:\n\n* Untreated uterine adhesions\n* Medical contraindications to estrogen and progesterone therapy\n* Illnesses contraindicating assisted reproductive technology or pregnancy\n* History of recurrent implantation failures (\\> 2 embryo transfer failures)","FEMALE","21 Years","44 Years",{"count":76,"type":77},336,"ESTIMATED","INTERVENTIONAL",[80],"PHASE3","Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.",[83],"Infertility, Female",[85,86,87],"Progesterone-modified natural cycle","Hormone replacement therapy","Frozen-thawed embryo transfer","2026-04-23",{"date":90,"type":91},"2026-04-29","ACTUAL",{"date":93,"type":91},"2025-03-05",{"date":95,"type":77},"2028-12-01",{"name":5,"class":6},1]