[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100466807":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":35,"centralContacts":40,"locations":49,"responsibleParty":68,"collaborators":45,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":73,"sex":78,"minAge":79,"maxAge":45,"enrollmentInfo":80,"targetDuration":45,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":52,"whyStopped":45,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"University of Texas Southwestern Medical Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2)","EXPERIMENTAL","This a prospective double blind randomized controlled clinical trial. The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital endoscopy lab.",[13],"Drug: Admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2)",{"label":15,"type":10,"description":11,"interventionNames":16},"Admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7)",[17],"Drug: Admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7)",[19,29],{"type":20,"name":9,"description":21,"armGroupLabels":22,"otherNames":23},"DRUG","The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).\n\nThe objectives are to compare the treatment arms, P2E7 and P7E2, in a randomized controlled double-blind trial for anesthesia for endoscopic procedures. Comparison between an admixture of Propofol\u002FEtomidate 75%\u002F25% versus 25%\u002F75% being utilized as principal anesthetic for endoscopic procedures at CUH endoscopy lab.",[9],[24,25,26,27,28],"propofol","etomidate","P7E2","propofol 75% by volume","etomidate 25% by volume",{"type":20,"name":15,"description":21,"armGroupLabels":30,"otherNames":31},[15],[24,25,32,33,34],"P2E7","propofol 25% by volume","etomidate 75% by volume",[36],{"name":37,"affiliation":38,"role":39},"Kapil Anand","University of Texas","STUDY_DIRECTOR",[41,47],{"name":42,"role":43,"phone":44,"phoneExt":45,"email":46},"Christopher Choi","CONTACT","2146486400",null,"christopher.choi@utsouthwestern.edu",{"name":37,"role":43,"phone":44,"phoneExt":45,"email":48},"kapil.anand@utsouthwestern.edu",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Clements University Hospital","RECRUITING","Dallas","Texas","75390","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-96.80667,32.78306,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":67,"phoneExt":45,"email":45},"Joseph M Hendrix, MD","8172667987",{"type":69,"investigatorFullName":42,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"PRINCIPAL_INVESTIGATOR","Assistant Professor of Anesthesiology and Pain Management","100466807","phase-3-propofol-and-etomidate-admixtures-comparisons-trial-peac-trial-100466807",false,"NCT05358535","Propofol and Etomidate Admixtures Comparisons Trial (PEAC Trial)","PEAC","Inclusion Criteria:\n\n1. Adult patients (age ≥18 years old)\n2. Having endoscopic procedure at CUH with anesthesia\n3. ASA 3 or above\n4. Ejection Fraction test result available\n\nExclusion Criteria:\n\n1. Known allergies or adverse reactions to study drugs or study drug components or preservatives\n2. Patient refusal\n3. Clinician refusal\n4. Documented cognitive impairments precluding subject ability to consent for themselves unless a surrogate documented legally acceptable decision maker consents for patient participation\n5. Prisoner or incarcerated or patients held by law enforcement officials in custody\n6. Pregnancy or patient refusal for pregnancy testing or screening (standard UTSW policy and protocol requires pregnancy testing for appropriate patients prior to anesthesia)","ALL","18 Years",{"count":81,"type":82},200,"ESTIMATED","INTERVENTIONAL",[85],"PHASE3","The purpose of this study is to evaluate the hemodynamics and adverse event profile in comparison between two treatment arms, one using an admixture of propofol and etomidate at a ratio by volume of 25%\u002F75% (P2E7), and one using an admixture of propofol and etomidate at a ratio by volume of 75%\u002F25% (P7E2), for anesthesia during endoscopic procedures at the Clements University Hospital (CUH) endoscopy lab (Endo).",[88,89,90,91,92,93],"Anesthesia","Propofol Adverse Reaction","Etomidate Adverse Reaction","Anesthesia Complication","Anesthesia; Adverse Effect","Anesthesia; Reaction",[95,96,97,98,99,100,101],"anesthesia","anesthesiology","adverse drug reaction","drug side effect","sedation","cardiopulmonary","hemodynamics","2026-01-16",{"date":104,"type":105},"2026-01-20","ACTUAL",{"date":107,"type":105},"2022-09-19",{"date":109,"type":82},"2027-03",{"name":5,"class":6},1]