[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470939":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":33,"locations":39,"responsibleParty":56,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":32,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":32,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":42,"whyStopped":32,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Hospital for Special Surgery, New York","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control Arm","PLACEBO_COMPARATOR","The control arm will receive a pre-op placebo injection of saline, and ACLR surgery with intra-op placebo injection",[13],"Procedure: placebo saline injection",{"label":15,"type":16,"description":17,"interventionNames":18},"Investigational Arm","EXPERIMENTAL","The investigational arm will receive a pre-op PRP injection, and ACLR surgery with PRP injection",[19],"Procedure: platelet rich plasma (PRP) injection",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","platelet rich plasma (PRP) injection","We aim to evaluate early catabolic and inflammatory changes in knee joints in patients receiving PRP injections following ACL injury, as these patients are at higher risk of developing PTOA. We also aim to establish correlations between markers of biologic activity of PRP and clinical outcomes (including both patient-reported outcomes and clinical functional outcomes), with emphasis on cellular and molecular inflammatory parameters modulated by PRP.",[15],[27],"Autologous Conditioned Plasma (ACP)",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"placebo saline injection","Patients randomized into the control arm will receive the placebo or saline injection",[9],null,[34],{"name":35,"role":36,"phone":37,"phoneExt":32,"email":38},"Jessica Andres-Bergos, PhD","CONTACT","(917) 260-4694","andresbergosj@hss.edu",[40],{"facility":41,"status":42,"city":43,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hospital for Special Surgery","RECRUITING","New York","10021","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-74.00597,40.71427,{"lat":51,"lon":50},[54],{"name":35,"role":36,"phone":55,"phoneExt":32,"email":38},"9172604694",{"type":57,"investigatorFullName":32,"investigatorTitle":32,"investigatorAffiliation":32,"oldNameTitle":32,"oldOrganization":32},"SPONSOR",[59],{"name":60,"class":6},"Orthopedic Research and Education Foundation","100470939","phase-3-prp-in-aclr-to-prevent-ptoa-100470939",false,"NCT05412381","PRP in ACLR to Prevent PTOA","Platelet Rich Plasma (PRP) Treatment of the Anterior Cruciate Ligament Injured Knee to Decrease the Risk of Post-traumatic Osteoarthritis (PTOA): a Randomized Double-blind Controlled Trial","Inclusion Criteria:\n\n* Acute ACL injury within 6 weeks of presentation\n* Age 14-50\n* Male or female\n* Meniscus injury that can be treated with meniscectomy or repair (the lack of meniscus injury will not exclude patients)\n\nExclusion Criteria:\n\n* Prior ACL reconstruction\n* Prior cartilage repair procedure\n* Prior meniscus surgery within 12 months\n* Prior steroid, hyaluronic acid, or PRP injection within 6 months\n* Other ligament injury requiring repair\n* Any cartilage lesion requiring repair\n* Any cartilage lesion greater than grade 2 (partial thickness injury)\n* History of inflammatory arthritis or joint sepsis\n* Non English speakers","ALL","14 Years","50 Years",{"count":72,"type":73},56,"ESTIMATED","INTERVENTIONAL",[76],"PHASE3","The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.",[79,80,81],"Anterior Cruciate Ligament Injuries","Post-traumatic Osteoarthritis","PRP",[83,84,85,86],"platelet-rich plasma","regenerative medicine","anterior cruciate ligament reconstruction","post-traumatic osteoarthritis","2026-02-11",{"date":89,"type":90},"2026-02-13","ACTUAL",{"date":92,"type":90},"2022-06-27",{"date":94,"type":73},"2026-12-31",{"name":5,"class":6},1]