[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100484674":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":36,"locations":46,"responsibleParty":628,"collaborators":630,"id":634,"slug":635,"hasResults":636,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":636,"sex":641,"minAge":642,"maxAge":26,"enrollmentInfo":643,"targetDuration":26,"studyType":646,"phases":647,"briefSummary":649,"conditions":650,"keywords":652,"overallStatus":49,"whyStopped":26,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":658,"completionDateStruct":660,"leadSponsor":662,"locationsCount":663},{"fullName":5,"class":6},"NYU Langone Health","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Catheter-Directed Therapy (CDT) plus Anticoagulation","EXPERIMENTAL","Participants will receive CDT consisting of mechanical thrombectomy (MT) or intrathrombus catheter-directed thrombolysis (CDL) using FDA-cleared devices for pulmonary embolism (PE). The exact technique and devices used will be at the discretion of the endovascular physician, within parameters defined by the PE-TRACT Manual of Operations (MOP) and accepted standard care. Before and after CDT, patients will receive standard PE therapy as in the no-CDT Arm.",[13,14],"Drug: Anticoagulant Therapy","Device: Catheter-Directed Therapy",{"label":16,"type":17,"description":18,"interventionNames":19},"No Catheter-Directed Therapy (No-CDT)","ACTIVE_COMPARATOR","Standard anticoagulant therapy (FDA-approved regimen) for the treatment of PE.",[13],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Anticoagulant Therapy","All subjects will receive anticoagulation for a minimum of 3 months.",[9,16],null,{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":26},"DEVICE","Catheter-Directed Therapy","The endovascular physician can choose to use either mechanical thrombectomy (MT) using a device cleared by the FDA to treat PE or catheter-directed thrombolysis (CDL) using an infusion catheter cleared by the FDA to administer thrombolytic drugs for the treatment of PE",[9],[33],{"name":34,"affiliation":5,"role":35},"Sunil Rao, MD","PRINCIPAL_INVESTIGATOR",[37,42],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Sunil Rao","CONTACT","212-263-0456","Sunil.rao@nyulangone.org",{"name":43,"role":39,"phone":44,"phoneExt":26,"email":45},"Lei Lei","212-263-4189","Lei.lei@nyulangone.org",[47,66,81,95,109,123,139,154,170,184,200,215,230,244,258,273,288,304,316,331,345,360,374,389,403,414,425,440,454,469,480,494,508,523,538,553,568,582,597,613],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"The University of Alabama At Birmingham","RECRUITING","Birmingham","Alabama","35233","United States","US",{"type":56,"coordinates":57},"Point",[58,59],-86.80249,33.52066,{"lat":59,"lon":58},[62],{"name":63,"role":39,"phone":64,"phoneExt":26,"email":65},"Samuel McElwee, MD","205-975-7123","skmcelwee@uabmc.edu",{"facility":67,"status":49,"city":68,"state":69,"zip":70,"country":53,"countryCode":54,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Stanford Medicine","Palo Alto","California","94304",{"type":56,"coordinates":72},[73,74],-122.14302,37.44188,{"lat":74,"lon":73},[77],{"name":78,"role":39,"phone":79,"phoneExt":26,"email":80},"Andrew Kesselman, MD","650-723-6855","ajk266@stanford.edu",{"facility":82,"status":49,"city":83,"state":69,"zip":84,"country":53,"countryCode":54,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"UC Davis Health","Sacramento","95817",{"type":56,"coordinates":86},[87,88],-121.4944,38.58157,{"lat":88,"lon":87},[91],{"name":92,"role":39,"phone":93,"phoneExt":26,"email":94},"Roger Goldman","916-734-8462","regoldman@ucdavis.edu",{"facility":96,"status":49,"city":97,"state":69,"zip":98,"country":53,"countryCode":54,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Scripps Memorial Hospital, La Jolla","San Diego","92121",{"type":56,"coordinates":100},[101,102],-117.16472,32.71571,{"lat":102,"lon":101},[105],{"name":106,"role":39,"phone":107,"phoneExt":26,"email":108},"Daniel S. Jones, MD","215-908-5726","Jones.Daniel@scrippshealth.org",{"facility":110,"status":49,"city":111,"state":69,"zip":112,"country":53,"countryCode":54,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"The Lundquist Institute","Torrance","90502",{"type":56,"coordinates":114},[115,116],-118.34063,33.83585,{"lat":116,"lon":115},[119],{"name":120,"role":39,"phone":121,"phoneExt":26,"email":122},"Janine Vintch, MD","310-222-8200","jvintch@dhs.lacounty.gov",{"facility":124,"status":49,"city":125,"state":126,"zip":127,"country":53,"countryCode":54,"cosmosGeoPoint":128,"geoPoint":132,"contacts":133},"Christiana Care","Newark","Delaware","19718",{"type":56,"coordinates":129},[130,131],-75.74966,39.68372,{"lat":131,"lon":130},[134,138],{"name":135,"role":39,"phone":136,"phoneExt":26,"email":137},"George Kimbiris, MD","302-733-5625","gkimbiris@christianacare.org",{"name":135,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":140,"status":49,"city":141,"state":142,"zip":143,"country":53,"countryCode":54,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"MedStar Health Research Institute","Washington D.C.","District of Columbia","20010",{"type":56,"coordinates":145},[146,147],-77.03637,38.89511,{"lat":147,"lon":146},[150],{"name":151,"role":39,"phone":152,"phoneExt":26,"email":153},"Saher Sabri, MD","202-877-3657","saher.s.sabri@medstar.net",{"facility":155,"status":49,"city":156,"state":157,"zip":158,"country":53,"countryCode":54,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Baptist Health Miami Cardiac & Vascular Institute","Miami","Florida","33176",{"type":56,"coordinates":160},[161,162],-80.19366,25.77427,{"lat":162,"lon":161},[165,169],{"name":166,"role":39,"phone":167,"phoneExt":26,"email":168},"Ripal Gandhi, MD","786-596-5990","gandhi@baptisthealth.net",{"name":166,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":171,"status":49,"city":172,"state":157,"zip":173,"country":53,"countryCode":54,"cosmosGeoPoint":174,"geoPoint":178,"contacts":179},"University of South Florida\u002F Tampa General Hospital","Tampa","33606",{"type":56,"coordinates":175},[176,177],-82.45843,27.94752,{"lat":177,"lon":176},[180],{"name":181,"role":39,"phone":182,"phoneExt":26,"email":183},"Glenn Hoots, MD","813-844-4570","hoots@usf.edu",{"facility":185,"status":49,"city":186,"state":187,"zip":188,"country":53,"countryCode":54,"cosmosGeoPoint":189,"geoPoint":193,"contacts":194},"Emory University School of Medicine","Atlanta","Georgia","30308",{"type":56,"coordinates":190},[191,192],-84.38798,33.749,{"lat":192,"lon":191},[195,199],{"name":196,"role":39,"phone":197,"phoneExt":26,"email":198},"Wissam Jabar, MD","404-686-7568","wissam.jaber@emory.edu",{"name":196,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":201,"status":49,"city":202,"state":203,"zip":204,"country":53,"countryCode":54,"cosmosGeoPoint":205,"geoPoint":209,"contacts":210},"University of Chicago Medical Center","Chicago","Illinois","60637",{"type":56,"coordinates":206},[207,208],-87.65005,41.85003,{"lat":208,"lon":207},[211],{"name":212,"role":39,"phone":213,"phoneExt":26,"email":214},"Jonathan D. Paul, MD","773-834-1497","jpaul@medicine.bsd.uchicago.edu",{"facility":216,"status":49,"city":217,"state":203,"zip":218,"country":53,"countryCode":54,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Advocate Good Samaritan Hospital","Downers Grove","60515",{"type":56,"coordinates":220},[221,222],-88.01117,41.80892,{"lat":222,"lon":221},[225,229],{"name":226,"role":39,"phone":227,"phoneExt":26,"email":228},"Mahesh Raju, MD","630-719-4799","Mahesh.raju@aah.org",{"name":226,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":231,"status":49,"city":232,"state":203,"zip":233,"country":53,"countryCode":54,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"Loyola University Chicago","Maywood","60153",{"type":56,"coordinates":235},[236,237],-87.84312,41.8792,{"lat":237,"lon":236},[240],{"name":241,"role":39,"phone":242,"phoneExt":26,"email":243},"Amir Darki, MD","708-216-4466","adarki@lumc.edu",{"facility":245,"status":49,"city":246,"state":203,"zip":247,"country":53,"countryCode":54,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"Southern Illinois University School of Medicine","Springfield","62781",{"type":56,"coordinates":249},[250,251],-89.64371,39.80172,{"lat":251,"lon":250},[254],{"name":255,"role":39,"phone":256,"phoneExt":26,"email":257},"Abdul Moiz Hafiz","217-545-8000","ahafiz96@siumed.edu",{"facility":259,"status":49,"city":260,"state":261,"zip":262,"country":53,"countryCode":54,"cosmosGeoPoint":263,"geoPoint":267,"contacts":268},"University of Iowa","Iowa City","Iowa","52242",{"type":56,"coordinates":264},[265,266],-91.53017,41.66113,{"lat":266,"lon":265},[269],{"name":270,"role":39,"phone":271,"phoneExt":26,"email":272},"Kevin Doerschug","319-356-1445","kevin-doerschug@uiowa.edu",{"facility":274,"status":49,"city":275,"state":276,"zip":277,"country":53,"countryCode":54,"cosmosGeoPoint":278,"geoPoint":282,"contacts":283},"MaineHealth","Portland","Maine","04102",{"type":56,"coordinates":279},[280,281],-70.2589,43.65737,{"lat":281,"lon":280},[284],{"name":285,"role":39,"phone":286,"phoneExt":26,"email":287},"Paul Kim, MD","207-956-6650","kimp9@spectrummg.com",{"facility":289,"status":49,"city":290,"state":291,"zip":292,"country":53,"countryCode":54,"cosmosGeoPoint":293,"geoPoint":297,"contacts":298},"Boston Medical Center","Boston","Massachusetts","02118",{"type":56,"coordinates":294},[295,296],-71.05977,42.35843,{"lat":296,"lon":295},[299,303],{"name":300,"role":39,"phone":301,"phoneExt":26,"email":302},"Ashvin Pande, MD","617-638-8703","Ashvin.pande@bmc.org",{"name":300,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":305,"status":49,"city":290,"state":291,"zip":306,"country":53,"countryCode":54,"cosmosGeoPoint":307,"geoPoint":309,"contacts":310},"Beth Israel Deaconess Medical Center","02215",{"type":56,"coordinates":308},[295,296],{"lat":296,"lon":295},[311,315],{"name":312,"role":39,"phone":313,"phoneExt":26,"email":314},"Brett Carroll, MD","617-667-8800","bcarrol2@bidmc.harvard.edu",{"name":312,"role":35,"phone":26,"phoneExt":26,"email":26},{"facility":317,"status":49,"city":318,"state":319,"zip":320,"country":53,"countryCode":54,"cosmosGeoPoint":321,"geoPoint":325,"contacts":326},"University of Michigan","Ann Arbor","Michigan","48109",{"type":56,"coordinates":322},[323,324],-83.74088,42.27756,{"lat":324,"lon":323},[327],{"name":328,"role":39,"phone":329,"phoneExt":26,"email":330},"Minhajuddin Khaja, MD, MBA","734-936-4478","mkhaja@med.umich.edu",{"facility":332,"status":49,"city":333,"state":319,"zip":334,"country":53,"countryCode":54,"cosmosGeoPoint":335,"geoPoint":339,"contacts":340},"Trinity Health - Ann Arbor Hospital","Ypsilanti","48197",{"type":56,"coordinates":336},[337,338],-83.61299,42.24115,{"lat":338,"lon":337},[341],{"name":342,"role":39,"phone":343,"phoneExt":26,"email":344},"Hriday Shah, MD","734-712-8350","hriday.shah@aiarad.com",{"facility":346,"status":49,"city":347,"state":348,"zip":349,"country":53,"countryCode":54,"cosmosGeoPoint":350,"geoPoint":354,"contacts":355},"Washington University in St. Louis","St Louis","Missouri","63110",{"type":56,"coordinates":351},[352,353],-90.19789,38.62727,{"lat":353,"lon":352},[356],{"name":357,"role":39,"phone":358,"phoneExt":26,"email":359},"Pavan Kavali, MD","314-362-2900","pavan.kavali@wustl.edu",{"facility":361,"status":49,"city":125,"state":362,"zip":363,"country":53,"countryCode":54,"cosmosGeoPoint":364,"geoPoint":368,"contacts":369},"Rutgers New Jersey Medical School","New Jersey","07103",{"type":56,"coordinates":365},[366,367],-74.17237,40.73566,{"lat":367,"lon":366},[370],{"name":371,"role":39,"phone":372,"phoneExt":26,"email":373},"Abhishek Kumar, M.D.","973-972-5188","kumarab@njms.rutgers.edu",{"facility":375,"status":49,"city":376,"state":377,"zip":378,"country":53,"countryCode":54,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"University of New Mexico Health Sciences Center","Albuquerque","New Mexico","87131",{"type":56,"coordinates":380},[381,382],-106.65114,35.08449,{"lat":382,"lon":381},[385],{"name":386,"role":39,"phone":387,"phoneExt":26,"email":388},"Carolina Ponce Orellana, MD","505-272-6020","CPonceOr@salud.unm.edu",{"facility":390,"status":49,"city":391,"state":391,"zip":392,"country":53,"countryCode":54,"cosmosGeoPoint":393,"geoPoint":397,"contacts":398},"NYU Langone Health - Tisch Hospital","New York","10016",{"type":56,"coordinates":394},[395,396],-74.00597,40.71427,{"lat":396,"lon":395},[399],{"name":400,"role":39,"phone":401,"phoneExt":26,"email":402},"Bedros Taslakian, MD, EBIR, FCIRSE","332-237-9866","bedros.taslakian@nyulangone.org",{"facility":404,"status":49,"city":391,"state":391,"zip":405,"country":53,"countryCode":54,"cosmosGeoPoint":406,"geoPoint":408,"contacts":409},"Icahn School of Medicine at Mount Sinai","10029",{"type":56,"coordinates":407},[395,396],{"lat":396,"lon":395},[410],{"name":411,"role":39,"phone":412,"phoneExt":26,"email":413},"Hooman Poor, MD","212-241-5656","hooman.poor@mountsinai.org",{"facility":415,"status":49,"city":391,"state":391,"zip":416,"country":53,"countryCode":54,"cosmosGeoPoint":417,"geoPoint":419,"contacts":420},"Weill Cornell Medicine","10065",{"type":56,"coordinates":418},[395,396],{"lat":396,"lon":395},[421],{"name":422,"role":39,"phone":423,"phoneExt":26,"email":424},"Christopher M. Harnain, MD, MBA, RPVI","212.746.4635","cmh9017@med.cornell.edu",{"facility":426,"status":49,"city":427,"state":428,"zip":429,"country":53,"countryCode":54,"cosmosGeoPoint":430,"geoPoint":434,"contacts":435},"Promedica","Toledo","Ohio","43606",{"type":56,"coordinates":431},[432,433],-83.55521,41.66394,{"lat":433,"lon":432},[436],{"name":437,"role":39,"phone":438,"phoneExt":26,"email":439},"Zakaria Assi, MD","419-291-4438","zassi@buckeye-express.com",{"facility":441,"status":49,"city":275,"state":442,"zip":443,"country":53,"countryCode":54,"cosmosGeoPoint":444,"geoPoint":448,"contacts":449},"Oregon Health & Science University","Oregon","97239",{"type":56,"coordinates":445},[446,447],-122.67621,45.52345,{"lat":447,"lon":446},[450],{"name":451,"role":39,"phone":452,"phoneExt":26,"email":453},"Khashayar Farsad, MD, PhD","503-494-7226","farsad@ohsu.edu",{"facility":455,"status":49,"city":456,"state":457,"zip":458,"country":53,"countryCode":54,"cosmosGeoPoint":459,"geoPoint":463,"contacts":464},"University of Pennsylvania","Philadelphia","Pennsylvania","19104",{"type":56,"coordinates":460},[461,462],-75.16362,39.95238,{"lat":462,"lon":461},[465],{"name":466,"role":39,"phone":467,"phoneExt":26,"email":468},"Steven Pugliese, MD","215-614-1527","Steven.Pugliese@pennmedicine.upenn.edu",{"facility":470,"status":49,"city":456,"state":457,"zip":471,"country":53,"countryCode":54,"cosmosGeoPoint":472,"geoPoint":474,"contacts":475},"Thomas Jefferson University","19107",{"type":56,"coordinates":473},[461,462],{"lat":462,"lon":461},[476],{"name":477,"role":39,"phone":478,"phoneExt":26,"email":479},"Carin Gonsalves, MD","215-955-6609","Carin.Gonsalves@jefferson.edu",{"facility":481,"status":49,"city":482,"state":457,"zip":483,"country":53,"countryCode":54,"cosmosGeoPoint":484,"geoPoint":488,"contacts":489},"University of Pittsburgh Medical Center","Pittsburgh","15232",{"type":56,"coordinates":485},[486,487],-79.99589,40.44062,{"lat":487,"lon":486},[490],{"name":491,"role":39,"phone":492,"phoneExt":26,"email":493},"Rabih A. Chaer, MD","412-802-3025","chaerra@upmc.edu",{"facility":495,"status":49,"city":496,"state":457,"zip":497,"country":53,"countryCode":54,"cosmosGeoPoint":498,"geoPoint":502,"contacts":503},"Main Line Healh","Wynnewood","19096",{"type":56,"coordinates":499},[500,501],-75.27074,40.00289,{"lat":501,"lon":500},[504],{"name":505,"role":39,"phone":506,"phoneExt":26,"email":507},"Lee Greenspon, MD","610-642-3796","GreensponL@MLHS.ORG",{"facility":509,"status":49,"city":510,"state":511,"zip":512,"country":53,"countryCode":54,"cosmosGeoPoint":513,"geoPoint":517,"contacts":518},"Lifespan","Providence","Rhode Island","02903",{"type":56,"coordinates":514},[515,516],-71.41283,41.82399,{"lat":516,"lon":515},[519],{"name":520,"role":39,"phone":521,"phoneExt":26,"email":522},"DaeHee Kim, MD","401-444-5184","daehee_kim@brown.edu",{"facility":524,"status":49,"city":525,"state":526,"zip":527,"country":53,"countryCode":54,"cosmosGeoPoint":528,"geoPoint":532,"contacts":533},"Medical University of South Carolina","Charleston","South Carolina","29425",{"type":56,"coordinates":529},[530,531],-79.93275,32.77632,{"lat":531,"lon":530},[534],{"name":535,"role":39,"phone":536,"phoneExt":26,"email":537},"Kevin W. Dickey","843-792-5069","dickeyke@musc.edu",{"facility":539,"status":49,"city":540,"state":541,"zip":542,"country":53,"countryCode":54,"cosmosGeoPoint":543,"geoPoint":547,"contacts":548},"The University of Texas Health Science Center at Houston","Houston","Texas","77030",{"type":56,"coordinates":544},[545,546],-95.36327,29.76328,{"lat":546,"lon":545},[549],{"name":550,"role":39,"phone":551,"phoneExt":26,"email":552},"Bela Patel, MD","713-500-6831","Bela.patel@uth.tmc.edu",{"facility":554,"status":49,"city":555,"state":556,"zip":557,"country":53,"countryCode":54,"cosmosGeoPoint":558,"geoPoint":562,"contacts":563},"Intermountain Health","Murray","Utah","84107",{"type":56,"coordinates":559},[560,561],-111.88799,40.66689,{"lat":561,"lon":560},[564],{"name":565,"role":39,"phone":566,"phoneExt":26,"email":567},"Mark Dodson, MD","801-507-4603","Mark.Dodson@imail.org",{"facility":569,"status":49,"city":570,"state":556,"zip":571,"country":53,"countryCode":54,"cosmosGeoPoint":572,"geoPoint":576,"contacts":577},"University of Utah Health","Salt Lake City","84108",{"type":56,"coordinates":573},[574,575],-111.89105,40.76078,{"lat":575,"lon":574},[578],{"name":579,"role":39,"phone":580,"phoneExt":26,"email":581},"Nathan Hatton, MD","801-581-5811","nathan.hatton@hsc.utah.edu",{"facility":583,"status":49,"city":584,"state":585,"zip":586,"country":53,"countryCode":54,"cosmosGeoPoint":587,"geoPoint":591,"contacts":592},"Sentara Health Research Center","Norfolk","Virginia","23507",{"type":56,"coordinates":588},[589,590],-76.28522,36.84681,{"lat":590,"lon":589},[593],{"name":594,"role":39,"phone":595,"phoneExt":26,"email":596},"David Dexter, MD","757-388-5480","djdexte1@sentara.com",{"facility":598,"status":49,"city":599,"state":585,"zip":600,"country":53,"countryCode":54,"cosmosGeoPoint":601,"geoPoint":605,"contacts":606},"Carilion Clinic","Roanoke","24014",{"type":56,"coordinates":602},[603,604],-79.94143,37.27097,{"lat":604,"lon":603},[607,611],{"name":608,"role":39,"phone":609,"phoneExt":26,"email":610},"Joseph A. Hughes, M.D","540-981-7083","jahughes1@carilionclinic.org",{"name":612,"role":35,"phone":26,"phoneExt":26,"email":26},"Joseph Hughes, MD",{"facility":614,"status":49,"city":615,"state":616,"zip":617,"country":53,"countryCode":54,"cosmosGeoPoint":618,"geoPoint":622,"contacts":623},"Medical College of Wisconsin","Milwaukee","Wisconsin","53226",{"type":56,"coordinates":619},[620,621],-87.90647,43.0389,{"lat":621,"lon":620},[624],{"name":625,"role":39,"phone":626,"phoneExt":26,"email":627},"Matthew J. Scheidt, MD","414-805-3125","mscheidt@mcw.edu",{"type":629,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[631],{"name":632,"class":633},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100484674","phase-3-pulmonary-embolism---thrombus-removal-with-catheter-directed-therapy-100484674",false,"NCT05591118","Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy","PE-TRACT","Inclusion Criteria:\n\n1. Symptomatic PE diagnosed by contrast-enhanced CT angiography with involvement of a main or lobar pulmonary artery branch; and\n2. Right ventricular (RV) dilation as defined by the presence of an RV\u002FLeft ventricular ratio \\> 1 on CT angiography\n\nExclusion Criteria:\n\n1. Age \\\u003C 18 years\n2. Systolic blood pressure \\\u003C 90 mmHg for \\>15 consecutive minutes or \\> 40 mmHg drop from baseline, or vasopressor requirement for blood pressure support (i.e., massive PE), occurring within 1 hour prior to eligibility assessment.\n3. Symptom duration \\> 14 days for the current PE episode\n4. Irreversible INR \\> 3\n5. Irreversible Thrombocytopenia (Platelets \\\u003C 50,000\u002Fmicroliter)\n6. Creatinine \\> 2.0 mg\u002Fdl\n7. Hemoglobin \\\u003C 7.0 g\u002Fdl\n8. Pregnancy (positive urine or blood pregnancy test (a pregnancy test must be obtained within 7 days prior to randomization in people of childbearing potential))\n9. Allergy or hypersensitivity to Recombinant Tissue Plasminogen Activator (rt-PA), or iodinated contrast, except for mild-moderate contrast allergies for which steroid pre-medication can be used\n10. Life expectancy \\\u003C 1 year\n11. Chronic inability to independently walk prior to the current PE episode (e.g. wheelchair dependent, walker or cane dependent, paraplegic, and\u002For bed-bound)\n12. Allergy to heparin or history of Heparin-Induced Thrombocytopenia (HIT)\n13. Unable or unwilling to provide informed consent\n14. Major contraindication or unsuitability for all CDT methods available at the Clinical Center","ALL","18 Years",{"count":644,"type":645},500,"ESTIMATED","INTERVENTIONAL",[648],"PHASE3","PE-TRACT is an open-label, assessor-blinded, randomized trial, aiming to compare catheter-directed therapy (CDT) and anticoagulation (CDT group) with anticoagulation alone (No-CDT) in 500 patients with submassive PE, proximal pulmonary artery thrombus and right ventricular dilation.",[651],"Pulmonary Embolism",[653],"Catheter-Directed Therapy (CDT)","2026-05-15",{"date":656,"type":657},"2026-05-18","ACTUAL",{"date":659,"type":657},"2023-07-17",{"date":661,"type":645},"2027-08-04",{"name":5,"class":6},40]