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Clinic","Kasuga-shi","Fukuoka","816-0802","Japan","JP",{"facility":1750,"status":56,"city":1744,"state":1745,"zip":1751,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Ikeda Neurosurgical Clinic","816-0824",{"facility":1753,"status":56,"city":1754,"state":1755,"zip":1756,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Hikita Pediatric Clinic","Kiryu-shi","Gunma","3760035",{"facility":1758,"status":56,"city":1759,"state":1760,"zip":1761,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Konan Medical Center","Higashinada-ku Kobe-shi","Hyōgo","658-0064",{"facility":1763,"status":56,"city":1764,"state":1760,"zip":1765,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Yamaguchi Clinic","Nishinomiya-shi","663-8204",{"facility":1767,"status":56,"city":1768,"state":1769,"zip":1770,"country":1747,"countryCode":1748,"cosmosGeoPoint":1771,"geoPoint":1775,"contacts":25},"Mito Kyodo General Hospital","Mito","Ibaraki","310-0015",{"type":49,"coordinates":1772},[1773,1774],140.45,36.35,{"lat":1774,"lon":1773},{"facility":1777,"status":56,"city":1778,"state":1779,"zip":1780,"country":1747,"countryCode":1748,"cosmosGeoPoint":1781,"geoPoint":1785,"contacts":25},"Tanaka Neurosurgery & Headache Clinic","Kagoshima","Kagoshima-ken","890-0052",{"type":49,"coordinates":1782},[1783,1784],130.55,31.56667,{"lat":1784,"lon":1783},{"facility":1787,"status":56,"city":1788,"state":1789,"zip":1790,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Sendai Headache and Neurology Clinic","Taihaku-ku Sendai-shi","Miyagi","982-0014",{"facility":1792,"status":56,"city":1793,"state":1794,"zip":1795,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Tennoji Dai Brain Clinic","Abeno-ku Osaka-shi","Osaka","545-0053",{"facility":1797,"status":56,"city":1798,"state":1794,"zip":1799,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Tominaga Clinic","Naniwa-ku","556-0015",{"facility":1801,"status":56,"city":1802,"state":1803,"zip":1804,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Tokyo Headache Clinic","Shibuya-ku","Tokyo","151-0051",{"facility":1806,"status":162,"city":1807,"state":1803,"zip":1808,"country":1747,"countryCode":1748,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Tokyo Medical University Hospital","Shinjuku-ku","160-0023",{"facility":1810,"status":42,"city":1811,"state":25,"zip":1812,"country":1747,"countryCode":1748,"cosmosGeoPoint":1813,"geoPoint":1817,"contacts":25},"Local lndependent Administrative Corporation Hiroshima City Hospital Organization Hiroshima City","Hiroshima","730-8518",{"type":49,"coordinates":1814},[1815,1816],132.45,34.4,{"lat":1816,"lon":1815},{"facility":1819,"status":56,"city":1820,"state":1821,"zip":1822,"country":1823,"countryCode":1824,"cosmosGeoPoint":25,"geoPoint":25,"contacts":25},"Clinstile S.A. de C.V.","Col. Roma Norte","Mexico City","C.P. 06700.","Mexico","MX",{"facility":1826,"status":42,"city":1827,"state":1828,"zip":1829,"country":1823,"countryCode":1824,"cosmosGeoPoint":1830,"geoPoint":1834,"contacts":25},"Neurociencias Estudios Clinicos S.C.","Culiacán","Sinaloa","800200",{"type":49,"coordinates":1831},[1832,1833],-107.39421,24.80209,{"lat":1833,"lon":1832},{"facility":1836,"status":56,"city":1837,"state":1838,"zip":1839,"country":1823,"countryCode":1824,"cosmosGeoPoint":1840,"geoPoint":1844,"contacts":25},"Clinical Reseach Institute, S.C.","Tlalnepantla","State of Mexico","C.P. 54055",{"type":49,"coordinates":1841},[1842,1843],-99.19538,19.54005,{"lat":1843,"lon":1842},{"facility":1846,"status":56,"city":1847,"state":25,"zip":1848,"country":1823,"countryCode":1824,"cosmosGeoPoint":1849,"geoPoint":1853,"contacts":25},"Unidad de Investigacion en Salud de Chihuahua S.C.","Chihuahua City","31203",{"type":49,"coordinates":1850},[1851,1852],-106.08889,28.63528,{"lat":1852,"lon":1851},{"facility":1855,"status":56,"city":1856,"state":1857,"zip":1858,"country":1859,"countryCode":1860,"cosmosGeoPoint":1861,"geoPoint":1865,"contacts":25},"MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak","Wroclaw","Lower Silesian Voivodeship","52-210","Poland","PL",{"type":49,"coordinates":1862},[1863,1864],17.03006,51.10286,{"lat":1864,"lon":1863},{"facility":1867,"status":42,"city":1868,"state":25,"zip":1869,"country":1859,"countryCode":1860,"cosmosGeoPoint":1870,"geoPoint":1874,"contacts":25},"NZOZ Wielospecjalistyczna Poradnia Lekarska SYNAPSIS, Lech Szczechowski","Katowice","40-123",{"type":49,"coordinates":1871},[1872,1873],19.02173,50.2597,{"lat":1873,"lon":1872},{"facility":1876,"status":56,"city":1877,"state":25,"zip":1878,"country":1859,"countryCode":1860,"cosmosGeoPoint":1879,"geoPoint":1883,"contacts":25},"Centrum Medyczne Plejady","Krakow","30-363",{"type":49,"coordinates":1880},[1881,1882],19.93658,50.06143,{"lat":1882,"lon":1881},{"facility":1885,"status":56,"city":1877,"state":25,"zip":1886,"country":1859,"countryCode":1860,"cosmosGeoPoint":1887,"geoPoint":1889,"contacts":25},"Oddzial Kliniczny Dzieci Starszych z Pododdzialami: Neurologicznym, Reumatologicznym","31-503",{"type":49,"coordinates":1888},[1881,1882],{"lat":1882,"lon":1881},{"facility":1891,"status":56,"city":1877,"state":25,"zip":1886,"country":1859,"countryCode":1860,"cosmosGeoPoint":1892,"geoPoint":1894,"contacts":25},"Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie, Apteka Szpitalna",{"type":49,"coordinates":1893},[1881,1882],{"lat":1882,"lon":1881},{"facility":1896,"status":56,"city":1877,"state":25,"zip":1886,"country":1859,"countryCode":1860,"cosmosGeoPoint":1897,"geoPoint":1899,"contacts":25},"Wojewódzki Specjalistyczny Szpital Dzieciecy im. Sw. Ludwika w Krakowie",{"type":49,"coordinates":1898},[1881,1882],{"lat":1882,"lon":1881},{"facility":1901,"status":56,"city":1902,"state":25,"zip":1903,"country":1859,"countryCode":1860,"cosmosGeoPoint":1904,"geoPoint":1908,"contacts":25},"Clinical Research Center Sp. z.o.o. Medic-R Spolka komandytowa","Poznan","61-731",{"type":49,"coordinates":1905},[1906,1907],16.92993,52.40692,{"lat":1907,"lon":1906},{"facility":1910,"status":42,"city":1911,"state":25,"zip":1912,"country":1859,"countryCode":1860,"cosmosGeoPoint":1913,"geoPoint":1917,"contacts":25},"Euromedis Sp. z o. o.","Szczecin","70-111",{"type":49,"coordinates":1914},[1915,1916],14.55302,53.42894,{"lat":1916,"lon":1915},{"facility":1919,"status":42,"city":1920,"state":1921,"zip":1922,"country":1923,"countryCode":1924,"cosmosGeoPoint":1925,"geoPoint":1929,"contacts":25},"Hospital Universitario Marqués de Valdecilla","Santander","Cantabria","39008","Spain","ES",{"type":49,"coordinates":1926},[1927,1928],-3.80493,43.46589,{"lat":1928,"lon":1927},{"facility":1931,"status":56,"city":1932,"state":25,"zip":1933,"country":1923,"countryCode":1924,"cosmosGeoPoint":1934,"geoPoint":1938,"contacts":25},"Hospital Universitario Vall d'Hebron","Barcelona","08035",{"type":49,"coordinates":1935},[1936,1937],2.15899,41.38879,{"lat":1937,"lon":1936},{"facility":1940,"status":42,"city":1932,"state":25,"zip":1941,"country":1923,"countryCode":1924,"cosmosGeoPoint":1942,"geoPoint":1944,"contacts":25},"Centre d'Atencio Primaria Balenya","08550",{"type":49,"coordinates":1943},[1936,1937],{"lat":1937,"lon":1936},{"facility":1946,"status":42,"city":1947,"state":25,"zip":1948,"country":1923,"countryCode":1924,"cosmosGeoPoint":1949,"geoPoint":1953,"contacts":25},"Instituto de Investigaciones del Sueno","Madrid","28036",{"type":49,"coordinates":1950},[1951,1952],-3.70256,40.4165,{"lat":1952,"lon":1951},{"facility":1955,"status":56,"city":1956,"state":25,"zip":1957,"country":1923,"countryCode":1924,"cosmosGeoPoint":1958,"geoPoint":1962,"contacts":25},"Hospital Universitario Virgen del Rocío","Seville","41013",{"type":49,"coordinates":1959},[1960,1961],-5.97317,37.38283,{"lat":1961,"lon":1960},{"facility":1964,"status":56,"city":1965,"state":25,"zip":1966,"country":1923,"countryCode":1924,"cosmosGeoPoint":1967,"geoPoint":1971,"contacts":25},"Hospital Clinico Universitario de Valladolid","Valladolid","47005",{"type":49,"coordinates":1968},[1969,1970],-4.72353,41.65541,{"lat":1970,"lon":1969},{"facility":1973,"status":56,"city":1974,"state":1975,"zip":1976,"country":1977,"countryCode":1978,"cosmosGeoPoint":1979,"geoPoint":1983,"contacts":25},"ProbarE i Lund AB","Lund","Skåne LÄN [se-12]","22222","Sweden","SE",{"type":49,"coordinates":1980},[1981,1982],13.19321,55.70584,{"lat":1982,"lon":1981},{"facility":1985,"status":42,"city":1986,"state":25,"zip":1987,"country":1977,"countryCode":1978,"cosmosGeoPoint":1988,"geoPoint":1992,"contacts":25},"Avdelningen för kliniska Prövningar, Universitetssjukhuset Örebro","Örebro","703 62",{"type":49,"coordinates":1989},[1990,1991],15.2066,59.27412,{"lat":1991,"lon":1990},{"facility":1994,"status":56,"city":1995,"state":25,"zip":1996,"country":1977,"countryCode":1978,"cosmosGeoPoint":1997,"geoPoint":2001,"contacts":25},"ProbarE i Stockholm AB","Stockholm","113 29",{"type":49,"coordinates":1998},[1999,2000],18.06871,59.32938,{"lat":2000,"lon":1999},{"facility":2003,"status":42,"city":2004,"state":25,"zip":2005,"country":2006,"countryCode":2007,"cosmosGeoPoint":2008,"geoPoint":2012,"contacts":25},"Leicester Royal Infirmary","Leicester","LE1 5WW","United Kingdom","UK",{"type":49,"coordinates":2009},[2010,2011],-1.13169,52.6386,{"lat":2011,"lon":2010},{"facility":2014,"status":56,"city":2015,"state":25,"zip":2016,"country":2006,"countryCode":2007,"cosmosGeoPoint":2017,"geoPoint":2021,"contacts":25},"Re:Cognition Health Limited","London","W1G 9JF",{"type":49,"coordinates":2018},[2019,2020],-0.12574,51.50853,{"lat":2020,"lon":2019},{"facility":2023,"status":56,"city":2015,"state":25,"zip":2024,"country":2006,"countryCode":2007,"cosmosGeoPoint":2025,"geoPoint":2027,"contacts":25},"Great Ormond Street Hospital for Children NHS Foundation Trust","WC1N 3JH",{"type":49,"coordinates":2026},[2019,2020],{"lat":2020,"lon":2019},{"type":2029,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100412337","phase-3-randomized-study-in-children-and-adolescents-with-migraine-acute-treatment-100412337",false,"NCT04649242","Randomized Study in Children and Adolescents With Migraine: Acute Treatment","Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to \u003C 18 Years of Age","Inclusion Criteria:\n\n1. History of migraine (with or without aura) for \\> 6 months before Screening according to the IHS Classification ICHD-319 specifications for pediatric migraine. History may be verified using both medical records and recall by the participant and\u002For participant's parent(s)\u002Flegal representative(s).\n2. History of 1 to 8 moderate or severe attacks per month during the 2 months prior to enrollment, with attacks lasting \\> 3 hours without treatment, and attacks occurring at intervals \\> 24 hours.\n3. Prophylactic migraine medication are permitted if the dose has been stable for at least 12 weeks prior to the Baseline Visit, and the dose is not expected to change during the course of the study.\n\n   1. Participants may remain on one (1) medication with possible migraine prophylactic effects, excluding CGRP antagonists \\[biologic or small molecule\\], during the treatment phases.\n   2. Concomitant use of a CGRP antagonist, such as erenumab or fremanezumab, is prohibited.\n   3. Previously discontinued prophylactic migraine medication must have done so at least 90 days prior to the Screening Visit.\n4. Verbally distinguish between migraine and other types of headaches.\n5. Participants must have a weight \\> 40 kg at the Screening Visit.\n6. Adequate venous access for blood sampling.\n7. Male and female participants ≥ 6 to \\\u003C 18 years of age (participants must not reach their 18th birthday during the study).\n\nExclusion Criteria:\n\n1. History of cluster headache or hemiplegic migraine headache.\n2. Confounding and clinically significant pain syndrome that may interfere with the participant's ability to participate in this study.\n3. Current psychiatric condition that is uncontrolled and\u002For untreated for a minimum of 6 months prior to the Screening Visit. Participants with a lifetime history of psychosis and\u002For mania.\n4. History of suicidal behavior or major psychiatric disorder.\n5. Current diagnosis or history of substance abuse; positive drug test at Screening.\n6. History of moderate or severe head trauma or other neurological disorder (including seizure disorder) or systemic medical disease that is likely to affect central nervous system functioning.\n7. Recent or planned surgery, requiring general anesthesia, \\\u003C8 weeks prior to the Screening Visit.\n8. Participant has had gastrointestinal surgery that interferes with physiological absorption and motility (i.e., gastric bypass, duodenectomy, or gastric banding).\n9. Current diagnosis of viral hepatitis or a history of liver disease.\n10. Conditions considered clinically relevant in the context of the study such as uncontrolled hypertension (high blood pressure), diabetes, a life-threatening allergy","ALL","6 Years","17 Years",{"count":2041,"type":2042},2100,"ESTIMATED","INTERVENTIONAL",[2045],"PHASE3","The purpose of this study is to test the safety and efficacy of BHV-3000 versus placebo in the acute treatment of moderate or severe migraine in children and adolescents.",[2048],"Pediatric Migraine",[2050,2051,2052,2053,2054,2055,2056,2057,2048],"Migraine","Acute treatment","Phonophobia","Photophobia","Nausea","Pediatric","Children","Adolescent","2026-06-29",{"date":2060,"type":2061},"2026-07-01","ACTUAL",{"date":2063,"type":2061},"2021-01-15",{"date":2065,"type":2042},"2029-01-09",{"name":5,"class":6},246]