[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556548":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":85,"collaborators":87,"id":94,"slug":95,"hasResults":96,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":102,"sex":103,"minAge":19,"maxAge":19,"enrollmentInfo":104,"targetDuration":19,"studyType":107,"phases":108,"briefSummary":110,"conditions":111,"keywords":117,"overallStatus":59,"whyStopped":19,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},{"fullName":5,"class":6},"Australian and New Zealand Intensive Care Research Centre","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Participant Group\u002FArm","RBC Transfusion Domain:\n\nPatients on ECMO in ICU enrolled in the RBC Transfusion Domain of RECOMMEND. Patients receive one of two RBC transfusion strategies (restrictive or liberal)",[12,13],"Other: Liberal RBC Transfusion","Other: Restrictive RBC Transfusion",[15,20],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Liberal RBC Transfusion","Liberal transfusion trigger group (patient receives RBC transfusion if Hb \\\u003C90g\u002FL).",[9],null,{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":19},"Restrictive RBC Transfusion","Restrictive transfusion trigger group (patient receives RBC transfusion if Hb \\\u003C70g\u002FL).",[9],[25],{"name":26,"affiliation":27,"role":28},"Carol Hodgson, PhD FACP FAHMS","Monash University","STUDY_CHAIR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":19,"email":34},"Curtis Hopkins, B.BioMed, MPH, MHA","CONTACT","+61 3 9903 0343","curtis.hopkins@monash.edu",{"name":26,"role":32,"phone":36,"phoneExt":19,"email":37},"+61 3 9903 0598","carol.hodgson@monash.edu",[39,57,71],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Royal Prince Alfred Hospital","NOT_YET_RECRUITING","Camperdown","New South Wales","2050","Australia","AU",{"type":48,"coordinates":49},"Point",[50,51],151.17642,-33.88965,{"lat":51,"lon":50},[54],{"name":55,"role":32,"phone":19,"phoneExt":19,"email":56},"Heidi Buhr","heidi.buhr@health.nsw.gov.au",{"facility":58,"status":59,"city":60,"state":43,"zip":61,"country":45,"countryCode":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"St. Vincent's Hospital Sydney","RECRUITING","Sydney","2010",{"type":48,"coordinates":63},[64,65],151.20732,-33.86785,{"lat":65,"lon":64},[68],{"name":69,"role":32,"phone":19,"phoneExt":19,"email":70},"Hergen Buscher, MBBS","hergen.buscher@svhs.org.au",{"facility":72,"status":41,"city":73,"state":74,"zip":75,"country":45,"countryCode":46,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"The Alfred Hospital","Melbourne","Victoria","3004",{"type":48,"coordinates":77},[78,79],144.96332,-37.814,{"lat":79,"lon":78},[82],{"name":83,"role":32,"phone":19,"phoneExt":19,"email":84},"Aidan Burrell, MD","Aidanburrell@gmail.com",{"type":86,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[88,89,91],{"name":27,"class":6},{"name":90,"class":6},"Berry Consultants",{"name":92,"class":93},"Research Path","UNKNOWN","100556548","phase-3-recommend-platform-trial-100556548",false,"NCT06526533","RECOMMEND Platform Trial","Generating New Evidence to Reduce Major Complications to Improve the Safety and Efficacy of ECMO in Severe Cardiac and Respiratory Failure (RECOMMEND)","RECOMMEND","PLATFORM INCLUSION CRITERIA:\n\n* Patients receiving ECMO\n* Patients enrolled in the EXCEL Registry - NCT03793257\n\nPLATFORM EXCLUSION CRITERIA:\n\n* Treating clinician regards death as imminent and inevitable\n* Treating clinician determines it is not in the patient's best interests\n\nRBC TRANSFUSION DOMAIN INCLUSION CRITERIA:\n\n• Aged 18 years or older\n\nRBC TRANSFUSION DOMAIN EXCLUSION CRITERIA:\n\n* Contraindication to RBC transfusion (including known patient preference)\n* Limitations of care put in place either through patient wishes or the treating medical teams.\n* Participant has already received ECMO \\>12 hours. The start of ECMO is defined as the time of initiation of extracorporeal blood flow unless ECMO was initiated during a surgical intervention in which case the start of ECMO is defined as the arrival time into the initial ICU (post-surgery)\n* The treating physician anticipates that ECMO treatment will cease before the end of tomorrow\n* The treating physician deems the study is not in the patient's best interest\n* The treating physician has concern regarding patient ability to tolerate restrictive or liberal transfusion trigger thresholds\n* Actively listed for a solid organ transplant and has not yet received one\n* Suspected or confirmed to be pregnant\n* Previous ECMO treatment during the same hospital admission",true,"ALL",{"count":105,"type":106},600,"ESTIMATED","INTERVENTIONAL",[109],"PHASE3","The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO)\n\nThe main question the platform trial aims to address is to determine the effect of a range of interventions on survival, organ support and resource utilisation to day 28 for hospitalised patients receiving ECMO.\n\nResearchers will compare various interventions within multiple platform trial domains to see if the interventions have effects on survival, organ support and resource utilisation for the patient cohort.\n\nParticipants will be enrolled in accordance with the platform trial's domain structure to answer the research questions.",[112,113,114,115,116],"Extracorporeal Membrane Oxygenation Complication","ARDS (Acute Respiratory Distress Syndrome)","Intensive Care Medicine","Cardiac Arrest (CA)","Critical Illness",[118,119,120,45,121,122,123,124,125,126],"ECMO","ICU","Platform Trial","Cardiac","Respiratory","VA","VV","eCPR","Adaptive","2026-05-11",{"date":129,"type":130},"2026-05-13","ACTUAL",{"date":132,"type":130},"2026-03-23",{"date":134,"type":106},"2029-06",{"name":5,"class":6},3]