[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504608":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":36,"locations":42,"responsibleParty":74,"collaborators":76,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":40,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":40,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":105,"overallStatus":108,"whyStopped":40,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Rituximab","EXPERIMENTAL","Rituximab (375 mg\u002Fm2) will be given as a single intravenous infusion after remission. The prednisolone at a dose of 2 mg\u002Fkg per day (maximum 60 mg in single or divided doses) for 6 weeks, followed by 1.5 mg\u002Fkg (maximum 40 mg) as a single morning dose on alternate days for the next 6 weeks; therapy is then discontinued.",[13,14],"Drug: Rituximab","Drug: Corticosteroid",{"label":16,"type":6,"description":17,"interventionNames":18},"Routine Therapy","The prednisolone at a dose of 2 mg\u002Fkg per day (maximum 60 mg in single or divided doses) for 6 weeks, followed by 1.5 mg\u002Fkg (maximum 40 mg) as a single morning dose on alternate days for the next 6 weeks; therapy is then discontinued.",[14],[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DRUG","Rituximab 375 mg\u002Fm2 added to guideline-recommended corticosteroid therapy",[9],[25],"rituximab biosimilar (HANLIKANG®, Shanghai Henlius Biotech, Inc. China)",{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Corticosteroid","guideline-recommended corticosteroid therapy",[9,16],[31],"prednisolone\u002Fprednisone",[33],{"name":34,"affiliation":5,"role":35},"Qian Shen","STUDY_CHAIR",[37],{"name":34,"role":38,"phone":39,"phoneExt":40,"email":41},"CONTACT","+8602164932827",null,"shenqian@shmu.edu.cn",[43,58,66],{"facility":44,"status":40,"city":45,"state":46,"zip":40,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Children's hospital Affiliated to Shanghai Jiao Tong University School of Medicine","Shanghai","Shanghai Municipality","China","CN",{"type":50,"coordinates":51},"Point",[52,53],121.45806,31.22222,{"lat":53,"lon":52},[56],{"name":57,"role":38,"phone":40,"phoneExt":40,"email":40},"Yulin Kang",{"facility":59,"status":40,"city":45,"state":46,"zip":40,"country":47,"countryCode":48,"cosmosGeoPoint":60,"geoPoint":62,"contacts":63},"Shanghai's Children's Medical Center",{"type":50,"coordinates":61},[52,53],{"lat":53,"lon":52},[64],{"name":65,"role":38,"phone":40,"phoneExt":40,"email":40},"Lei Ying",{"facility":67,"status":40,"city":45,"state":46,"zip":40,"country":47,"countryCode":48,"cosmosGeoPoint":68,"geoPoint":70,"contacts":71},"Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine",{"type":50,"coordinates":69},[52,53],{"lat":53,"lon":52},[72],{"name":73,"role":38,"phone":40,"phoneExt":40,"email":40},"Yufeng Li",{"type":75,"investigatorFullName":40,"investigatorTitle":40,"investigatorAffiliation":40,"oldNameTitle":40,"oldOrganization":40},"SPONSOR",[77,79,81,83],{"name":78,"class":6},"Shanghai Shen Kang Hospital Development Center",{"name":80,"class":6},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine",{"name":82,"class":6},"Shanghai Children's Medical Center",{"name":84,"class":6},"Shanghai Children's Hospital","100504608","phase-3-rituximab-in-the-first-episode-of-paediatric-nephrotic-syndrome-100504608",false,"NCT05850546","Rituximab in the First Episode of Paediatric Nephrotic Syndrome","Efficacy and Safety of Single-dose Rituximab Biosimilar in the Initial Episode of Paediatric Steroid-sensitive Nephrotic Syndrome: A Multicenter, Open-Label, Noninferiority, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Children between 1 and 18 years with Steroid-Sensitive Nephrotic Syndrome (nephrotic-range proteinuria and either hypoalbuminemia or edema when albumin level is not available)\n2. Estimated glomerular filtration rate (eGFR) ≥90 ml\u002Fmin per 1.73 m2 at study entry\n3. Remission at study entry\n4. the cluster of differentiation antigen 20 (CD20) positive cells in peripheral blood ≥1% total lymphocytes\n5. No immunosuppressive agents have been used within 3 months of enrolment, except for the use of corticosteroid to treat nephrotic syndrome\n6. Provision of consent by a legal representative using a document approved by the institutional review board after receiving an adequate explanation of this clinical trial. For children ages 8-18, written assent is required using age-appropriate and background-appropriate documents\n\nExclusion Criteria:\n\n1. Diagnosis of secondary NS\n2. Patients showing one of the following abnormal clinical laboratories\n3. values: leukopenia (white blood cell count ≤3.0\\*109\u002FL); moderate and severe anemia (hemoglobin \\\u003C9.0g\u002FdL); thrombocytopenia (platelet count \\\u003C100\\*1012\u002F L); positivity of autoimmunity tests (ANA, Anti DNA antibody, ANCA) or reduced C3 levels; Alanine aminotransferase or aspartate aminotransferase \\> 2.5× upper limit of normal value\n4. Presence of severe or chronic infections within 6 months before assignment: tuberculosis or in whom tuberculosis is suspected; Epstein-Barr virus or cytomegalovirus; hepatitis B or hepatitis C or hepatitis B virus carrier, human immunodeficiency virus or other active viral infections\n5. Live vaccination within last month\n6. Patients with poorly controlled hypertension\n7. Patients with severe brain, heart, liver, and other important organs, as well as blood and endocrine system diseases\n8. Presence or history of autoimmune diseases, primary immunodeficiency, or tumor\n9. Patients with a known allergy to Rituximab and its excipients\n10. Assessed to be unfit for participation by the investigators (patients highly likely to be lost to follow-up or provide inaccurate data, for example, patients with alcohol or other substance misuse disorders, and patients with psychological disorders)",true,"ALL","1 Year","18 Years",{"count":97,"type":98},138,"ESTIMATED","INTERVENTIONAL",[101],"PHASE3","The study will be a randomized, open-label trial in children with the initial episode of SSNS and whose state of complete remission after received standard prednisolone, to determine whether rituximab (a single intravenous infusion of 375 mg\u002Fm2) would be noninferior to corticosteroid alone in maintaining complete disease remission during 12-month of follow-up.",[104],"Steroid-Sensitive Nephrotic Syndrome",[9,106,107],"Children","Relapse","NOT_YET_RECRUITING","2025-01-21",{"date":111,"type":112},"2025-01-22","ACTUAL",{"date":114,"type":98},"2025-03-01",{"date":116,"type":98},"2026-12-28",{"name":5,"class":6},3]