[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100531111":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":518,"collaborators":11,"id":520,"slug":521,"hasResults":522,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":526,"eligibilityCriteria":527,"healthyVolunteers":522,"sex":528,"minAge":529,"maxAge":11,"enrollmentInfo":530,"targetDuration":11,"studyType":533,"phases":534,"briefSummary":536,"conditions":537,"keywords":544,"overallStatus":59,"whyStopped":11,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":555,"completionDateStruct":557,"leadSponsor":559,"locationsCount":560},{"fullName":5,"class":6},"University Hospital, Angers","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Rivaroxaban arm","EXPERIMENTAL",null,[13],"Drug: Rivaroxaban 10 MG",{"label":15,"type":16,"description":17,"interventionNames":18},"Low-molecular-weight heparin arm","ACTIVE_COMPARATOR","Treatment with LMWH is the standard-of-care in this population of lower limb trauma patients at risk of thrombosis.\n\nThe control group is therefore the group of patients who receive prophylactic anticoagulant treatment with LMWH for the duration of immobilization (i.e. until full mobilization with weight-bearing).",[19],"Drug: Low Heparin Molecular Weight",[21,26],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":11},"DRUG","Rivaroxaban 10 MG","Administration of rivaroxaban 10 mg once daily to prevent venous thromboembolic events in patients with trauma to a lower limb.\n\nConsecutive patients with lower limb trauma and a TRiP(cast) score ≥ 7 are assessed for possible participation in the study. At the inclusion visit, if the patient meets the study's selection criteria, the investigator provides oral and written information (information letter written in a language the patient can understand) and answers any questions the patient may have. Depending on randomisation, the patient will receive either LMWH or rivaroxaban. The dose is rivaroxaban 10 mg orally once a day (no dosage adjustment).\n\nTreatment is started in the emergency department and continued at home for the duration of the immobilisation (i.e. until mobilisation with weight-bearing). The duration of treatment will be determined by the physician.",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"Low Heparin Molecular Weight","Administration of standard prophylactic anticoagulant treatment with LMWH for the duration of immobilisation (i.e. until full mobilisation with weight-bearing). Consecutive patients with lower limb trauma and a TRiP(cast) score ≥ 7 are assessed for possible participation in the study. At the inclusion visit, if the patient meets the study's selection criteria, the investigator provides oral and written information (information letter written in a language the patient can understand) and answers any questions the patient may have. Depending on randomisation, the patient will receive either LMWH or rivaroxaban. The dose of LMWH is free, given according to local practices and national recommendations.\n\nTreatment is started in the emergency department and continued at home for the duration of the immobilisation (i.e. until mobilisation with weight-bearing). The duration of treatment will be determined by the physician.",[15],[31],{"name":32,"affiliation":5,"role":33},"Delphine Douillet, Doctor","STUDY_DIRECTOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":11,"email":38},"CONTACT","0241353637","Delphine.Douillet@chu-angers.fr",{"name":40,"role":36,"phone":41,"phoneExt":11,"email":42},"Cindy Augereau, Mrs","0241354143","Cindy.Augereau@chu-angers.fr",[44,57,69,83,93,102,111,125,139,154,163,177,192,206,220,234,248,262,276,290,304,318,327,341,355,366,377,388,398,409,420,434,448,462,476,490,504],{"facility":45,"status":46,"city":47,"state":11,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":11},"Agen-Nerac Hospital, Emergency Department","ACTIVE_NOT_RECRUITING","Agen","47923","France","FR",{"type":52,"coordinates":53},"Point",[54,55],0.62055,44.20199,{"lat":55,"lon":54},{"facility":58,"status":59,"city":60,"state":11,"zip":61,"country":49,"countryCode":50,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Angers University Hospital, Emergency department","RECRUITING","Angers","49000",{"type":52,"coordinates":63},[64,65],-0.55202,47.47156,{"lat":65,"lon":64},[68],{"name":32,"role":36,"phone":37,"phoneExt":11,"email":38},{"facility":70,"status":59,"city":71,"state":11,"zip":72,"country":49,"countryCode":50,"cosmosGeoPoint":73,"geoPoint":77,"contacts":78},"Argenteuil hospital, Emergency department","Argenteuil","95100",{"type":52,"coordinates":74},[75,76],2.24744,48.94788,{"lat":76,"lon":75},[79],{"name":80,"role":36,"phone":81,"phoneExt":11,"email":82},"Catherine Le Gall, Doctor","0134232425","catherine.legall@ch-argenteuil.fr",{"facility":84,"status":85,"city":86,"state":11,"zip":87,"country":49,"countryCode":50,"cosmosGeoPoint":88,"geoPoint":92,"contacts":11},"Arpajon Hospital, Emergency Department","WITHDRAWN","Arpajon","91294",{"type":52,"coordinates":89},[90,91],2.24672,48.58875,{"lat":91,"lon":90},{"facility":94,"status":85,"city":95,"state":11,"zip":96,"country":49,"countryCode":50,"cosmosGeoPoint":97,"geoPoint":101,"contacts":11},"Caen University hospital, Emergency department","Caen","14000",{"type":52,"coordinates":98},[99,100],-0.35912,49.18585,{"lat":100,"lon":99},{"facility":103,"status":85,"city":104,"state":11,"zip":105,"country":49,"countryCode":50,"cosmosGeoPoint":106,"geoPoint":110,"contacts":11},"Tours University Hospital, Emergency department","Chambray-lès-Tours","37170",{"type":52,"coordinates":107},[108,109],0.70286,47.33537,{"lat":109,"lon":108},{"facility":112,"status":59,"city":113,"state":11,"zip":114,"country":49,"countryCode":50,"cosmosGeoPoint":115,"geoPoint":119,"contacts":120},"Cholet Hospital, Emergency department","Cholet","49300",{"type":52,"coordinates":116},[117,118],-0.87974,47.05893,{"lat":118,"lon":117},[121],{"name":122,"role":36,"phone":123,"phoneExt":11,"email":124},"Caroline Soulie, Doctor","0241496985","caroline.soulie-chavignon@ch-cholet.fr",{"facility":126,"status":59,"city":127,"state":11,"zip":128,"country":49,"countryCode":50,"cosmosGeoPoint":129,"geoPoint":133,"contacts":134},"Clermont-Ferrand University Hospital, Emergency department","Clermont-Ferrand","63000",{"type":52,"coordinates":130},[131,132],3.08682,45.77969,{"lat":132,"lon":131},[135],{"name":136,"role":36,"phone":137,"phoneExt":11,"email":138},"Romain Durif, Doctor","0473751940","rdurif@chu-clermontferrand.fr",{"facility":140,"status":59,"city":141,"state":11,"zip":142,"country":49,"countryCode":50,"cosmosGeoPoint":143,"geoPoint":147,"contacts":148},"Simone Veil Hospital, Emergency Department","Eaubonne","95600",{"type":52,"coordinates":144},[145,146],2.28249,48.99712,{"lat":146,"lon":145},[149],{"name":150,"role":36,"phone":151,"phoneExt":152,"email":153},"Hiba Boussaha, Doctor","01 34 06 61 15","+33","Hiba.boussaha@ch-simoneveil.fr",{"facility":155,"status":46,"city":156,"state":11,"zip":157,"country":49,"countryCode":50,"cosmosGeoPoint":158,"geoPoint":162,"contacts":11},"Eure-Seine Hospital, Emergency Departement","Évreux","27015",{"type":52,"coordinates":159},[160,161],1.15082,49.02414,{"lat":161,"lon":160},{"facility":164,"status":59,"city":165,"state":11,"zip":166,"country":49,"countryCode":50,"cosmosGeoPoint":167,"geoPoint":171,"contacts":172},"Grenoble University Hospital, Emergency Department","Grenoble","38000",{"type":52,"coordinates":168},[169,170],5.71479,45.17869,{"lat":170,"lon":169},[173],{"name":174,"role":36,"phone":175,"phoneExt":11,"email":176},"Damien Viglino, Professor","0476766784","dviglino@chu-grenoble.fr",{"facility":178,"status":179,"city":180,"state":11,"zip":181,"country":49,"countryCode":50,"cosmosGeoPoint":182,"geoPoint":186,"contacts":187},"La Roche sur Yon Hospital","NOT_YET_RECRUITING","La Roche-sur-Yon","85000",{"type":52,"coordinates":183},[184,185],-1.42757,46.66974,{"lat":185,"lon":184},[188],{"name":189,"role":36,"phone":190,"phoneExt":11,"email":191},"Iona MAITRE, Doctor","0251446205","iona.maitre@ght85.fr",{"facility":193,"status":59,"city":194,"state":11,"zip":195,"country":49,"countryCode":50,"cosmosGeoPoint":196,"geoPoint":200,"contacts":201},"La Rochelle Hospital, Adult emergency departement","La Rochelle","17000",{"type":52,"coordinates":197},[198,199],-1.15222,46.16308,{"lat":199,"lon":198},[202],{"name":203,"role":36,"phone":204,"phoneExt":11,"email":205},"Maxime Jonchier, Doctor","0546465050","maxime.jonchier@gmail.com",{"facility":207,"status":59,"city":208,"state":11,"zip":209,"country":49,"countryCode":50,"cosmosGeoPoint":210,"geoPoint":214,"contacts":215},"Le Mans Hospital, Emergency department","Le Mans","72000",{"type":52,"coordinates":211},[212,213],0.20251,48.0021,{"lat":213,"lon":212},[216],{"name":217,"role":36,"phone":218,"phoneExt":11,"email":219},"Cyrielle Houalard, Doctor","0243434343","cyrielle.houalard@gmail.com",{"facility":221,"status":59,"city":222,"state":11,"zip":223,"country":49,"countryCode":50,"cosmosGeoPoint":224,"geoPoint":228,"contacts":229},"Limoges University hospital, Emergency department","Limoges","87000",{"type":52,"coordinates":225},[226,227],1.24759,45.83362,{"lat":227,"lon":226},[230],{"name":231,"role":36,"phone":232,"phoneExt":11,"email":233},"Thomas Lafon, Doctor","0555056254","thomas.LAFON@chu-limoges.fr",{"facility":235,"status":59,"city":236,"state":11,"zip":237,"country":49,"countryCode":50,"cosmosGeoPoint":238,"geoPoint":242,"contacts":243},"Edouard Herriot University Hospital, Emergency Department","Lyon","69000",{"type":52,"coordinates":239},[240,241],4.84789,45.74906,{"lat":241,"lon":240},[244],{"name":245,"role":36,"phone":246,"phoneExt":11,"email":247},"Karim Tazarourte, Professor","0472110040","karim.tazarourte@chu-lyon.fr",{"facility":249,"status":59,"city":250,"state":11,"zip":251,"country":49,"countryCode":50,"cosmosGeoPoint":252,"geoPoint":256,"contacts":257},"Marseille University Hospital, Emergency department","Marseille","13005",{"type":52,"coordinates":253},[254,255],5.38107,43.29695,{"lat":255,"lon":254},[258],{"name":259,"role":36,"phone":260,"phoneExt":11,"email":261},"Thibault Markarian, Doctor","0413429700","thibault.markarian@ap-hm.fr",{"facility":263,"status":59,"city":264,"state":11,"zip":265,"country":49,"countryCode":50,"cosmosGeoPoint":266,"geoPoint":270,"contacts":271},"Melun Hospital, Emergency Department","Melun","77000",{"type":52,"coordinates":267},[268,269],2.65356,48.5457,{"lat":269,"lon":268},[272],{"name":273,"role":36,"phone":274,"phoneExt":11,"email":275},"Damien Herve du Penhoat, Doctor","+33164716000","damien.herve-du-penhoat@ghsif.fr",{"facility":277,"status":59,"city":278,"state":11,"zip":279,"country":49,"countryCode":50,"cosmosGeoPoint":280,"geoPoint":284,"contacts":285},"Montpellier University Hospital, emergency department","Montpellier","34000",{"type":52,"coordinates":281},[282,283],3.87635,43.61093,{"lat":283,"lon":282},[286],{"name":287,"role":36,"phone":288,"phoneExt":11,"email":289},"Mustapha Sebbane, Professor","0467337974","m-sebbane@chu-montpellier.fr",{"facility":291,"status":179,"city":292,"state":11,"zip":293,"country":49,"countryCode":50,"cosmosGeoPoint":294,"geoPoint":298,"contacts":299},"Nancy University Hospital, Emergency department","Nancy","54000",{"type":52,"coordinates":295},[296,297],6.18496,48.68439,{"lat":297,"lon":296},[300],{"name":301,"role":36,"phone":302,"phoneExt":11,"email":303},"Tahar CHOUIHED, Professor","0383851496","t.chouihed@chru-nancy.fr",{"facility":305,"status":59,"city":306,"state":11,"zip":307,"country":49,"countryCode":50,"cosmosGeoPoint":308,"geoPoint":312,"contacts":313},"Nantes University Hospital, Emergency department","Nantes","44000",{"type":52,"coordinates":309},[310,311],-1.55336,47.21725,{"lat":311,"lon":310},[314],{"name":315,"role":36,"phone":316,"phoneExt":11,"email":317},"François Javaudin, Doctor","0240083333","Francois.JAVAUDIN@chu-nantes.fr",{"facility":319,"status":85,"city":320,"state":11,"zip":321,"country":49,"countryCode":50,"cosmosGeoPoint":322,"geoPoint":326,"contacts":11},"Nice University Hospital, Emergency department","Nice","06000",{"type":52,"coordinates":323},[324,325],7.26608,43.70313,{"lat":325,"lon":324},{"facility":328,"status":59,"city":329,"state":11,"zip":330,"country":49,"countryCode":50,"cosmosGeoPoint":331,"geoPoint":335,"contacts":336},"Niort Hospital, Emergency Department","Niort","79000",{"type":52,"coordinates":332},[333,334],-0.45877,46.32313,{"lat":334,"lon":333},[337],{"name":338,"role":36,"phone":339,"phoneExt":11,"email":340},"Mathieu Violeau, Doctor","0549783015","mathieu.violeau@ch-niort.fr",{"facility":342,"status":179,"city":343,"state":11,"zip":344,"country":49,"countryCode":50,"cosmosGeoPoint":345,"geoPoint":349,"contacts":350},"Lariboisière hospital, emergency department","Paris","75010",{"type":52,"coordinates":346},[347,348],2.3488,48.85341,{"lat":348,"lon":347},[351],{"name":352,"role":36,"phone":353,"phoneExt":11,"email":354},"Anthony Chauvin, Professor","0149956565","anthony.chauvin@aphp.fr",{"facility":356,"status":59,"city":343,"state":11,"zip":357,"country":49,"countryCode":50,"cosmosGeoPoint":358,"geoPoint":360,"contacts":361},"Saint-Antoine Hospital, Emergency department","75012",{"type":52,"coordinates":359},[347,348],{"lat":348,"lon":347},[362],{"name":363,"role":36,"phone":364,"phoneExt":11,"email":365},"Pierre-Clément Thiebault, Doctor","0149282743","pierre-clement.thiebaud@aphp.fr",{"facility":367,"status":179,"city":343,"state":11,"zip":368,"country":49,"countryCode":50,"cosmosGeoPoint":369,"geoPoint":371,"contacts":372},"La Pitié-Salpétrière Hospital, Emergency Department","75013",{"type":52,"coordinates":370},[347,348],{"lat":348,"lon":347},[373],{"name":374,"role":36,"phone":375,"phoneExt":11,"email":376},"Yonathan Freund, Doctor","01 42 16 00 00","yonathan.freund@aphp.fr",{"facility":378,"status":59,"city":343,"state":11,"zip":379,"country":49,"countryCode":50,"cosmosGeoPoint":380,"geoPoint":382,"contacts":383},"Cochin Hospital, Emergency department","75014",{"type":52,"coordinates":381},[347,348],{"lat":348,"lon":347},[384],{"name":385,"role":36,"phone":386,"phoneExt":11,"email":387},"Florence Dumas, Doctor","0158412707","florence.dumas@aphp.fr",{"facility":389,"status":59,"city":343,"state":11,"zip":379,"country":49,"countryCode":50,"cosmosGeoPoint":390,"geoPoint":392,"contacts":393},"St-Joseph Hospital, Emergency Department",{"type":52,"coordinates":391},[347,348],{"lat":348,"lon":347},[394],{"name":395,"role":36,"phone":396,"phoneExt":11,"email":397},"Camille Gerlier, Doctor","01 44 12 80 23","cgerlier@ghpsj.fr",{"facility":399,"status":59,"city":343,"state":11,"zip":400,"country":49,"countryCode":50,"cosmosGeoPoint":401,"geoPoint":403,"contacts":404},"HEGP, Emergency Department","75015",{"type":52,"coordinates":402},[347,348],{"lat":348,"lon":347},[405],{"name":406,"role":36,"phone":407,"phoneExt":11,"email":408},"Richard Chocron, Doctor","0156095876","richard.chocron@gmail.com",{"facility":410,"status":59,"city":343,"state":11,"zip":411,"country":49,"countryCode":50,"cosmosGeoPoint":412,"geoPoint":414,"contacts":415},"Bichat Hospital, Adult Emergency department","75018",{"type":52,"coordinates":413},[347,348],{"lat":348,"lon":347},[416],{"name":417,"role":36,"phone":418,"phoneExt":11,"email":419},"Donia Bouzid, Doctor","0140258080","donia.bouzid@aphp.fr",{"facility":421,"status":59,"city":422,"state":11,"zip":423,"country":49,"countryCode":50,"cosmosGeoPoint":424,"geoPoint":428,"contacts":429},"South Lyon University Hospital, Emergency department","Pierre-Bénite","69495",{"type":52,"coordinates":425},[426,427],4.82424,45.70359,{"lat":427,"lon":426},[430],{"name":431,"role":36,"phone":432,"phoneExt":11,"email":433},"Marion Douplat, Doctor","0478862854","marion.douplat@chu-lyon.fr",{"facility":435,"status":59,"city":436,"state":11,"zip":437,"country":49,"countryCode":50,"cosmosGeoPoint":438,"geoPoint":442,"contacts":443},"Poitiers University Hospital, Emergency department","Poitiers","86000",{"type":52,"coordinates":439},[440,441],0.34348,46.58261,{"lat":441,"lon":440},[444],{"name":445,"role":36,"phone":446,"phoneExt":11,"email":447},"Jérémy Guenezan, Doctor","0549444444","jeremy.guenezan@chu-poitiers.fr",{"facility":449,"status":59,"city":450,"state":11,"zip":451,"country":49,"countryCode":50,"cosmosGeoPoint":452,"geoPoint":456,"contacts":457},"Rennes University Hospital, Emergency department","Rennes","35000",{"type":52,"coordinates":453},[454,455],-1.67431,48.11109,{"lat":455,"lon":454},[458],{"name":459,"role":36,"phone":460,"phoneExt":11,"email":461},"Vincent Levrel, Doctor","0299284321","Vincent.LEVREL@chu-rennes.fr",{"facility":463,"status":179,"city":464,"state":11,"zip":465,"country":49,"countryCode":50,"cosmosGeoPoint":466,"geoPoint":470,"contacts":471},"Rouen University Hospital, Emergency Department","Rouen","76000",{"type":52,"coordinates":467},[468,469],1.09932,49.44313,{"lat":469,"lon":468},[472],{"name":473,"role":36,"phone":474,"phoneExt":11,"email":475},"Mélanie Roussel, Doctor","0232881879","melanie.roussel@chu-rouen.fr",{"facility":477,"status":59,"city":478,"state":11,"zip":479,"country":49,"countryCode":50,"cosmosGeoPoint":480,"geoPoint":484,"contacts":485},"Strasbourg University Hospital, Emergency Department","Strasbourg","67000",{"type":52,"coordinates":481},[482,483],7.74553,48.58392,{"lat":483,"lon":482},[486],{"name":487,"role":36,"phone":488,"phoneExt":11,"email":489},"Pierrick Le Borgne, Doctor","0388128690","pierrick.leborgne@chru-strasbourg.fr",{"facility":491,"status":59,"city":492,"state":11,"zip":493,"country":49,"countryCode":50,"cosmosGeoPoint":494,"geoPoint":498,"contacts":499},"Toulouse University Hospital, Emergency Department","Toulouse","31000",{"type":52,"coordinates":495},[496,497],1.44367,43.60426,{"lat":497,"lon":496},[500],{"name":501,"role":36,"phone":502,"phoneExt":11,"email":503},"Xavier Dubucs, Doctor","0561775919","xavier.dubucs@gmail.com",{"facility":505,"status":59,"city":506,"state":11,"zip":507,"country":49,"countryCode":50,"cosmosGeoPoint":508,"geoPoint":512,"contacts":513},"Vannes Hospital, Emergency Department","Vannes","56000",{"type":52,"coordinates":509},[510,511],-2.76205,47.65688,{"lat":511,"lon":510},[514],{"name":515,"role":36,"phone":516,"phoneExt":11,"email":517},"Bertrand Boulanger, Doctor","+33297014141","bertrand.boulanger@ghba.fr",{"type":519,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100531111","phase-3-rivaroxaban-versus-low-molecular-weight-heparin-in-patients-with-lower-limb-trauma-requiring-brace-or-casting-100531111",false,"NCT06195540","RIVAroxaban Versus Low-molecular Weight Heparin in Patients With Lower Limb Trauma Requiring Brace or CASTing","RIVACAST : RIVAroxaban Versus Low-molecular Weight Heparinin Patients With Lower Limb Trauma Requiring Brace or CASTing","RIVACAST","Inclusion Criteria:\n\n* Patient aged 18 or over ;\n* Consultation in an emergency department of a participating centre;\n* Trauma to the lower limb requiring rigid or semi-rigid orthopaedic immobilisation;\n* Expected duration of orthopaedic immobilisation of at least 2 weeks;\n* TRiP(cast) score ≥ 7 ;\n* Patient affiliated to or benefiting from a social security scheme;\n* Patient with prior informed consent.\n\nExclusion Criteria:\n\n* Patient that have to be hospitalized after emergency department for other reason than lower limb trauma\n* Active bleeding or high risk of bleeding,\n* Known contraindication to rivaroxaban or LMWH;\n* Taking any anticoagulant or antiplatelet agent before the trauma (only antithrombotic authorised: aspirin \\\u003C 325mg\u002Fd);\n* Pregnant or breastfeeding woman;\n* Any factor making 3-month follow-up impossible; 6. Patient subject to a legal protection measure, Imprisonment 7. Participation in any interventional study which modifies patient care or could influence study evaluation criteria","ALL","18 Years",{"count":531,"type":532},1424,"ESTIMATED","INTERVENTIONAL",[535],"PHASE3","Lower limb trauma requiring immobilization is a very frequent condition that is associated with an increased risk of developing venous thromboembolism (VTE). The TRiP(cast) score has been developed to provide individual VTE risk stratification and help in thromboprophylactic anticoagulation decision. The recent CASTING study had confirmed that patients with a TRiP(cast) score \\\u003C7 have a very low risk of VTE and could be safely manage without prophylactic treatment. Conversely, patients with a score ≥ 7 have a high-risk of VTE and require a prophylactic anticoagulant treatment. Low molecular weight heparins (LMWH) have been shown to be effective in this indication. However, in the CASTING study, the 3-month symptomatic VTE rate was 2.6% in this subgroup despite LMWH prophylactic treatment. This result suggests that LMWH are not sufficiently effective in this particular subgroup of high-risk patients. Direct oral anticoagulants, and in particular rivaroxaban, may be an effective and safe alternative to LMWH. In the PRONOMOS study, comparing LMWH with rivaroxaban in patients who had undergone non-major lower limb surgery, the relative risk of symptomatic VTE was 0.25 (95% CI = 0.09 - 0.75) in favor of rivaroxaban 10mg. No significant increase in bleeding was found. In addition, as LMWH treatment requires subcutaneous daily injections, the use of rivaroxaban may positively impact patients' quality of life as well as being effective in medico-economic terms.\n\nThe aims of this study are to demonstrate that rivaroxaban is at least as effective, easier to use and more efficient than LMWH in patients with trauma to the lower limb requiring immobilisation and deemed to be at risk of venous thromboembolism (TRiP(cast) score ≥ 7). High-risk patients are randomized to receive either rivaroxaban or LMWH. They are followed up at 45 days and 90 days to assess the occurrence of thrombotic events or bleeding, as well as their satisfaction with the treatment received.",[538,539,540,541,542,543],"Venous Thromboembolism","Deep Vein Thrombosis","Pulmonary Embolism","Lower Limb Trauma","Thromboprophylaxis","Immobilisation",[545,546,547,548,549,550],"Emergency department","direct oral anticoagulant","rivaroxaban","Low-Molecular-weight heparin","randomized control trial","Prevent VTE","2026-06-22",{"date":553,"type":554},"2026-06-25","ACTUAL",{"date":556,"type":554},"2024-07-19",{"date":558,"type":532},"2028-11-19",{"name":5,"class":6},37]