[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634736":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":29,"locations":35,"responsibleParty":160,"collaborators":163,"id":166,"slug":167,"hasResults":168,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":171,"eligibilityCriteria":172,"healthyVolunteers":168,"sex":173,"minAge":174,"maxAge":11,"enrollmentInfo":175,"targetDuration":11,"studyType":178,"phases":179,"briefSummary":181,"conditions":182,"keywords":190,"overallStatus":38,"whyStopped":11,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":203},{"fullName":5,"class":6},"Skane University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Selenium 200mcg daily in addition to GDMT","ACTIVE_COMPARATOR",null,[13],"Dietary Supplement: Selenium Supplement",{"label":15,"type":16,"description":11,"interventionNames":17},"Placebo in addition to GDMT","PLACEBO_COMPARATOR",[18],"Dietary Supplement: Placebo",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"DIETARY_SUPPLEMENT","Selenium Supplement","Selenium will be provided as the Bio-SelenoPrecise supplement. Each Bio-SelenoPrecise tablet contains 200 μg of selenium in the form of the yeast-based compound SelenoPrecise yeast. The tablets also include excipients such as microcrystalline cellulose, dicalcium phosphate, crosscarmellose sodium, silica, magnesium stearate, and is coated with hydroxypropyl methylcellulose",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Placebo","Placebo tablet identical to active comparator",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":11,"email":34},"Martin Magnusson, Professor","CONTACT","+46186119515","siri_hf@ucr.uu.se",[36,51,65,76,84,95,106,116,127,138,149],{"facility":37,"status":38,"city":39,"state":11,"zip":11,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Oslo University Hospital","RECRUITING","Oslo","Norway","NO",{"type":43,"coordinates":44},"Point",[45,46],10.74609,59.91273,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":33,"phoneExt":11,"email":34},"Peder Langeland Myhre, 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Wodlin",{"facility":52,"status":38,"city":107,"state":11,"zip":11,"country":55,"countryCode":56,"cosmosGeoPoint":108,"geoPoint":112,"contacts":113},"Lund",{"type":43,"coordinates":109},[110,111],13.19321,55.70584,{"lat":111,"lon":110},[114],{"name":115,"role":32,"phone":33,"phoneExt":11,"email":34},"Gustav Smith, Professor",{"facility":117,"status":38,"city":118,"state":11,"zip":11,"country":55,"countryCode":56,"cosmosGeoPoint":119,"geoPoint":123,"contacts":124},"Örebro University Hospital","Örebro",{"type":43,"coordinates":120},[121,122],15.2066,59.27412,{"lat":122,"lon":121},[125],{"name":126,"role":32,"phone":33,"phoneExt":11,"email":34},"Barna Szabo",{"facility":128,"status":38,"city":129,"state":11,"zip":11,"country":55,"countryCode":56,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Karolinska University Hospital","Stockholm",{"type":43,"coordinates":131},[132,133],18.06871,59.32938,{"lat":133,"lon":132},[136],{"name":137,"role":32,"phone":33,"phoneExt":11,"email":34},"Camilla Hage, Ass. professor",{"facility":139,"status":38,"city":140,"state":11,"zip":11,"country":55,"countryCode":56,"cosmosGeoPoint":141,"geoPoint":145,"contacts":146},"Norrlands university Hospital","Umeå",{"type":43,"coordinates":142},[143,144],20.25972,63.82842,{"lat":144,"lon":143},[147],{"name":148,"role":32,"phone":33,"phoneExt":11,"email":34},"Therese Andersson",{"facility":150,"status":38,"city":151,"state":11,"zip":11,"country":55,"countryCode":56,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Akademiska University hospital","Uppsala",{"type":43,"coordinates":153},[154,155],17.63889,59.85882,{"lat":155,"lon":154},[158],{"name":159,"role":32,"phone":33,"phoneExt":11,"email":34},"Christina Christersson",{"type":64,"investigatorFullName":161,"investigatorTitle":162,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"John Molvin","Co-Principal Investigator",[164],{"name":165,"class":6},"Uppsala University","100634736","phase-3-selenium-intervention-registry-randomized-trial-in-heart-failure-100634736",false,"NCT07543562","Selenium Intervention Registry Randomized Trial in Heart Failure","SIRI-HF","Inclusion Criteria:\n\nTo be considered for inclusion in this study, patients must meet all of the following eligibility requirements:\n\n* 18 years of age\n* primary discharge diagnosis of HF coded as ICD-10: I50, as recorded in The SwedeHF registry\n* be able to provide documented informed consent by signing and dating the designated consent form.\n\nExclusion Criteria:\n\n* Not suitable in the opinion of the Investigator (for example due to severe or terminal comorbidity with poor prognosis, or characteristics, pregnancy etc.) that may interfere with adherence to trial protocol","ALL","18 Years",{"count":176,"type":177},4326,"ESTIMATED","INTERVENTIONAL",[180],"PHASE3","Heart failure is a serious condition in which the heart is unable to pump blood effectively, and it remains a leading cause of hospitalization and death worldwide despite advances in treatment.\n\nSelenium is an essential micronutrient that plays an important role in cellular energy production, antioxidant defense, and overall cardiovascular function. Low selenium levels are common among patients with heart failure in Northern Europe, and observational studies have shown that selenium deficiency is associated with an increased risk of hospitalization and death. In cases of severe deficiency, such as in Keshan disease, heart dysfunction can be reversed with selenium supplementation, suggesting a potential causal relationship.\n\nHowever, it is not yet known whether selenium supplementation can improve clinical outcomes in patients with heart failure when added to standard medical therapy.\n\nThe SIRI-HF trial is a randomized, placebo-controlled study designed to evaluate whether daily supplementation with 200 micrograms of selenium, in addition to guideline-directed medical therapy, improves outcomes in patients with heart failure.\n\nThe primary endpoint is a composite of recurrent heart failure hospitalizations and cardiovascular death. Secondary endpoints include all-cause mortality, changes in symptoms and functional status, and safety outcomes.\n\nThis study will include patients from Sweden and Norway and aims to determine whether correcting selenium deficiency can improve prognosis in heart failure.",[183,184,185,186,187,188,189],"Heart Failure","Heart Failure and Reduced Ejection Fraction","Heart Failure and Mildly Reduced Ejection Fraction","Heart Failure and Preserved Ejection Fraction","Selenium Supplementation","Selenium","Cognitive Functioning",[191,192,193,171],"heart failure","selenium","RRCT","2026-04-15",{"date":196,"type":197},"2026-04-22","ACTUAL",{"date":199,"type":197},"2026-04-01",{"date":201,"type":177},"2031-03",{"name":5,"class":6},11]