[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100318167":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":39,"centralContacts":44,"locations":51,"responsibleParty":125,"collaborators":127,"id":130,"slug":131,"hasResults":132,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":138,"sex":139,"minAge":49,"maxAge":49,"enrollmentInfo":140,"targetDuration":49,"studyType":143,"phases":144,"briefSummary":146,"conditions":147,"keywords":49,"overallStatus":68,"whyStopped":49,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":166},{"fullName":5,"class":6},"University of Utah","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Short course vaginal cuff brachytherapy","EXPERIMENTAL","Participants undergo short course vaginal cuff brachytherapy for 2 fractions with 1 week apart.",[13],"Radiation: Short course vaginal cuff brachytherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Vaginal cuff brachytherapy","ACTIVE_COMPARATOR","Participants undergo standard of care vaginal cuff brachytherapy for 3-5 fractions over no more than 3 weeks.",[19],"Radiation: Vaginal Cuff Brachytherapy",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"RADIATION","Vaginal Cuff Brachytherapy","Undergo standard of care vaginal cuff brachytherapy",[15],[27,28,29],"best practice","standard of care","standard therapy",{"type":22,"name":9,"description":31,"armGroupLabels":32,"otherNames":33},"Undergo short course vaginal cuff brachytherapy",[9],[34,35,36,37,38],"BRACHYTHERAPY","internal radiation","Internal Radiation Brachytherapy","Internal Radiation Therapy","Radiation Brachytherapy",[40],{"name":41,"affiliation":42,"role":43},"Cristina DeCesaris, MD","Huntsman Cancer Institute\u002F University of Utah","PRINCIPAL_INVESTIGATOR",[45],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":50},"Rachel Kingsford","CONTACT","801-585-0115",null,"Rachel.Kingsford@hci.utah.edu",[52,66,88,105,119],{"facility":53,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":49},"Stanford Cancer Center","COMPLETED","Palo Alto","California","94304","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-122.14302,37.44188,{"lat":64,"lon":63},{"facility":67,"status":68,"city":69,"state":70,"zip":71,"country":58,"countryCode":59,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Loyola University Medical Center","RECRUITING","Maywood","Illinois","60153",{"type":61,"coordinates":73},[74,75],-87.84312,41.8792,{"lat":75,"lon":74},[78,82,86],{"name":79,"role":47,"phone":80,"phoneExt":49,"email":81},"Carly Quick, RN","708-327-3255","Carly.quick@luhs.org",{"name":83,"role":47,"phone":84,"phoneExt":49,"email":85},"Lorena Leon","464-220-9395","lleon4@luc.edu",{"name":87,"role":43,"phone":49,"phoneExt":49,"email":49},"William Small, MD",{"facility":89,"status":68,"city":90,"state":91,"zip":92,"country":58,"countryCode":59,"cosmosGeoPoint":93,"geoPoint":97,"contacts":98},"MD Anderson","Houston","Texas","77030",{"type":61,"coordinates":94},[95,96],-95.36327,29.76328,{"lat":96,"lon":95},[99,103],{"name":100,"role":47,"phone":101,"phoneExt":49,"email":102},"Mathew G Geena","713-792-4594","geenag@mdanderson.org",{"name":104,"role":43,"phone":49,"phoneExt":49,"email":49},"Anuja Jhingran, MD",{"facility":106,"status":68,"city":107,"state":108,"zip":109,"country":58,"countryCode":59,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Huntsman Cancer Institute\u002FUniversity of Utah","Salt Lake City","Utah","84112",{"type":61,"coordinates":111},[112,113],-111.89105,40.76078,{"lat":113,"lon":112},[116,118],{"name":46,"role":47,"phone":48,"phoneExt":49,"email":117},"rachel.kingsford@hci.utah.edu",{"name":41,"role":43,"phone":49,"phoneExt":49,"email":49},{"facility":120,"status":54,"city":107,"state":108,"zip":121,"country":58,"countryCode":59,"cosmosGeoPoint":122,"geoPoint":124,"contacts":49},"Intermountain Medical Center \u002F LDS Hospital","84143",{"type":61,"coordinates":123},[112,113],{"lat":113,"lon":112},{"type":126,"investigatorFullName":49,"investigatorTitle":49,"investigatorAffiliation":49,"oldNameTitle":49,"oldOrganization":49},"SPONSOR",[128],{"name":129,"class":6},"Huntsman Cancer Institute","100318167","phase-3-short-course-vaginal-cuff-brachytherapy-in-treating-participants-with-stage-i-ii-endometrial-cancer-100318167",true,"NCT03422198","Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer","Short Course Adjuvant Vaginal Cuff Brachytherapy (VCB) in Early Endometrial Cancer Compared to Standard of Care (SAVE)","SAVE","Inclusion Criteria:\n\n* Histologically confirmed endometrial carcinoma: endometrioid type, serous, and clear cell, to include tumors originating in the cervix, but are primarily located in the uterus, and for whom vaginal cuff brachytherapy is indicated. Carcinosarcoma and other sarcomas are permitted; Federation of Gynecology and Obstetrics (FIGO) stage I and stage II, with one of the following combinations of stage and grade:\n\n  * Stage IA, grade 1 with LVSI, 2, 3\n  * Stage IB, grades 1-3\n  * Stage II, grades 1-3\n  * Stage IIIA, grades 1-3, not receiving EBRT as part of adjuvant therapy.\n* Participants post-hysterectomy and free from residual disease.\n* World Health Organization (WHO)\u002FEastern Cooperative Oncology Group (ECOG)-performance status 0-2.\n* Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines.\n* Life expectancy of \\>2 years.\n\nExclusion Criteria:\n\n* Stages of endometrial carcinoma other than described.\n* Previous pelvic radiotherapy.\n* Concurrent malignancy requiring non-protocol anti-cancer treatment other than surgery.",false,"ALL",{"count":141,"type":142},188,"ESTIMATED","INTERVENTIONAL",[145],"PHASE3","This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer. Short course vaginal cuff brachytherapy, also known as internal radiation therapy, uses (over a shorter period) radioactive material placed directly into or near a tumor in the upper portion of the vagina to kill tumor cells.\n\nAfter completion of cohort 1 (108 participants), the protocol was expended to add a second cohort of 80 additional participants, and re-opened study recruitment.",[148,149,150,151,152,153,154,155,156],"Endometrial Clear Cell Adenocarcinoma","Endometrial Endometrioid Adenocarcinoma","Endometrial Serous Adenocarcinoma","Stage I Uterine Corpus Cancer","Stage IA Uterine Corpus Cancer","Stage IB Uterine Corpus Cancer","Stage II Uterine Corpus Cancer","Uterine Corpus Carcinosarcoma","Uterine Corpus Sarcoma","2025-11-25",{"date":159,"type":160},"2025-12-12","ACTUAL",{"date":162,"type":160},"2018-02-02",{"date":164,"type":142},"2029-10-31",{"name":5,"class":6},5]