[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592709":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":40,"responsibleParty":63,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":25,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":25,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":25,"overallStatus":43,"whyStopped":25,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":97},{"fullName":5,"class":6},"Indiana University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CONTINUE TOPICAL STEROID NASAL IRRIGATION","ACTIVE_COMPARATOR","PARTICIPANTS WILL CONTINUE THEIR NASAL TREATMENT WHICH WAS ALREADY PRESCRIBED BY THEIR PHYSICIAN",[13],"Drug: CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID",{"label":15,"type":16,"description":17,"interventionNames":18},"STOP TOPICAL NASAL TREATMENT","EXPERIMENTAL","PARTICIPANTS IN THIS ARM WILL BE ASKED TO STOP THEIR NASAL TREATMENT",[19],"Other: STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"STOP NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID","PATIENT WILL STOP USING NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID",[15],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"DRUG","CONTINUE NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID","PATIENT WILL CONTINUE USING NASAL SALINE IRRIGATION WITH OR WITHOUT STEROID",[9],[32],{"name":33,"affiliation":5,"role":34},"Elisa Illing, MD","PRINCIPAL_INVESTIGATOR",[36],{"name":33,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","317-944-6467","eilling@iu.edu",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Indiana University Health","RECRUITING","Indianapolis","Indiana","46202","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-86.15804,39.76838,{"lat":53,"lon":52},[56,58,62],{"name":57,"role":37,"phone":38,"phoneExt":25,"email":39},"Elisa A Illing",{"name":59,"role":37,"phone":60,"phoneExt":25,"email":61},"Azeezat A Yekinni","317-529-6883","ayekinn@iu.edu",{"name":57,"role":34,"phone":25,"phoneExt":25,"email":25},{"type":34,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Elisa Illing","Associate Professor",[67],{"name":68,"class":6},"American Rhinologic Society","100592709","phase-3-sinonasal-therapies-and-histologic-correlations-of-patients-with-cystic-fibrosis-in-the-era-of-highly-effective-modulator-therapy-100592709",false,"NCT06996951","Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy","Sinonasal Therapies and Histologic Correlations for Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy","Inclusion Criteria:\n\n* Age 18 or older\n* Cystic Fibrosis diagnosis on HEMT\n* History of chronic rhinosinusitis\n* Using topical nasal irrigations +\u002F- additives (steroids, antibiotics)\n\nExclusion Criteria:\n\n* Below age of 18 years old\n* Cystic Fibrosis patient NOT on highly effective modulator therapy\n* Pregnant patients\n* Not currently using topical nasal irrigations +\u002F- additives (steroids, antibiotics)\n* History of sinonasal or nasopharyngeal tumors\n* Active sinonasal infection or pulmonary infection\n* Admission to hospital for pulmonary exacerbation within last 3 months\n* Oral antibiotics within last one month for upper respiratory or lower respiratory infection","ALL","18 Years",{"count":79,"type":80},64,"ESTIMATED","INTERVENTIONAL",[83],"PHASE3","The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)",[86,87],"Cystic Fibrosis (CF)","Chronic Rhinosinusitis (CRS)","2025-12-10",{"date":90,"type":91},"2025-12-16","ACTUAL",{"date":93,"type":91},"2025-07-02",{"date":95,"type":80},"2026-07",{"name":5,"class":6},1]