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Arms B versus C.",{"measure":25,"description":26,"timeFrame":12},"Objective Response Rate (ORR) (Cohort 1 and Cohort 2)","ORR is defined as the proportion of participants who have a confirmed CR or confirmed PR, per RECIST 1.1.",{"measure":28,"description":29,"timeFrame":12},"Duration of Response (DoR) (Cohort 1 and Cohort 2)","DoR (per RECIST 1.1) is derived for confirmed objective responses (CR or PR) only and is defined as the time from the date of first documented response (which is subsequently confirmed) until date of documented progression or death in the absence of disease progression (ie, date of PFS event - date of first response + 1).",{"measure":31,"description":32,"timeFrame":12},"Pharmacokinetics of sonesitatug vedotin (Cohort 1 and Cohort 2)","Pharmacokinetic parameters of sonesitatug vedotin (peak plasma concentration (Cmax))",{"measure":31,"description":34,"timeFrame":12},"Pharmacokinetic parameters of sonesitatug vedotin (trough plasma concentration (Cmin))",{"measure":36,"description":37,"timeFrame":12},"Immunogenicity of sonesitatug vedotin (Cohort 1 and Cohort 2)","Presence of ADAs for sonesitatug vedotin in serum (confirmatory results: positive or negative, titres).",{"measure":39,"description":40,"timeFrame":12},"Pharmacokinetics of rilvegostomig (Cohort 1)","Pharmacokinetic parameters of rilvegostomig (peak plasma concentration (Cmax))",{"measure":39,"description":42,"timeFrame":12},"Pharmacokinetic parameters of rilvegostomig (trough plasma concentration (Cmin))",{"measure":44,"description":45,"timeFrame":12},"Immunogenicity of rilvegostomig (Cohort 1)","Presence of ADAs for rilvegostomig in serum (confirmatory results: positive or negative, titres).",{"measure":47,"description":48,"timeFrame":12},"Safety and tolerability (Cohort 1 and Cohort 2)","Safety and tolerability as evaluated in terms of incidence of AEs and SAEs",null,{"allocation":51,"interventionModel":52,"interventionModelDescription":53,"primaryPurpose":54,"observationalModel":49,"timePerspective":49,"maskingInfo":55},"RANDOMIZED","PARALLEL","Cohort 1 (3-arm design) will evaluate sonesitatug vedotin in combination with rilvegostomig and capecitabine (Arm A) or sonesitatug vedotin in combination with nivolumab and capecitabine (Arm B), versus SoC nivolumab plus capecitabine plus oxaliplatin (CAPOX) or folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) (Arm C) in PD-L1 positive participants. Participants will be randomized 1:1:1 to Arms A, B, or C.\n\nCohort 2 (2-arm design) will evaluate sonesitatug vedotin in combination with capecitabine (Arm D) versus SoC (Arm E) in participants who are PD-L1 negative or ICI-ineligible. Participants will be randomised 1:1. SoC is CAPOX or FOLFOX alone or in combination with zolbetuximab.","TREATMENT",{"masking":56,"maskingDescription":57,"whoMasked":58},"SINGLE","This is an open-label study; however, it will be conducted 'sponsor blind' and the specific treatment to be taken by a participant will be assigned using an IRT\u002FRTSM.\n\nTo maintain the integrity of the study, sponsor access to treatment records will be restricted, unless a positive result is observed at an interim analysis and access is required as per protocol-defined procedures",[59],"OUTCOMES_ASSESSOR","The purpose of this Phase III study is to evaluate the efficacy and safety of sonesitatug vedotin in combination with capecitabine with or without rilvegostomig in 1L CLDN18.2-positive, HER2-negative gastric, GEJ, and esophageal adenocarcinoma, and the clinical performance of the investigation in vitro diagnostics (IVDs). The study will include 2 cohorts to provide a treatment option for all participants that are HER2-negative and CLDN18.2-positive. Cohort 1 will evaluate sonesitatug vedotin in combination with rilvegostomig with capecitabine in participants who are CLDN18.2-positive and programmed death-ligand 1 (PD-L1) positive. Cohort 2 will evaluate sonesitatug vedotin in combination with capecitabine in participants who are CLDN18.2-positive and PD-L1 negative or immune checkpoint inhibitor (ICI) ineligible.",[62,70,75,83,87],{"label":63,"type":64,"description":65,"interventionNames":66},"Arm A","EXPERIMENTAL","Sonesitatug vedotin + Rilvegostomig + Capecitabine",[67,68,69],"Drug: Sonesitatug vedotin","Drug: Rilvegostomig","Drug: Capecitabine",{"label":71,"type":64,"description":72,"interventionNames":73},"Arm B","Sonesitatug vedotin + Nivolumab + Capecitabine",[67,74,69],"Drug: Nivolumab",{"label":76,"type":77,"description":78,"interventionNames":79},"Arm C","ACTIVE_COMPARATOR","Nivolumab + CAPOX OR Nivolumab + FOLFOX\n\n* nivolumab, capecitabine, oxaliplatin\n* nivolumab, 5-Fluorouracil, leucovorin, oxaliplatin",[74,69,80,81,82],"Drug: 5-Fluorouracil","Drug: Oxaliplatin","Drug: Leucovorin",{"label":84,"type":64,"description":85,"interventionNames":86},"Arm D","Sonesitatug vedotin + 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Cohort 1: PD-L1 positive as determined by central IHC testing and the participant is deemed ICI eligible per investigator judgement.\n  2. 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