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The treating centre must have completed stereotactic radiosurgery credentialing of the specific system(s) to be used in study patients. The treating centre must have completed IMRT credintialing of this specific IMRT systems to be used in study patients for the purposes of HA-WBRT.\n* Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each patient must sign a consent form prior to enrolment in the trial to document their willingness to participate.\n* A similar process must be followed for sites outside of Canada as per their respective cooperative group's procedures.\n* Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.\n* In accordance with CCTG policy, protocol treatment is to begin within 14 days of patient enrolment.\n* Women\u002Fmen of childbearing potential must have agreed to use a highly effective contraceptive method.\n\nExclusion Criteria:\n\n* Pregnant or nursing women.\n* Men or women of childbearing potential who are unwilling to employ adequate contraception.\n* Inability to complete a brain MRI.\n* Known allergy to gadolinium.\n* Prior cranial radiation therapy.\n* Planned cytotoxic chemotherapy within 48 hours prior or after the SRS or HA-WBRT.\n* Primary germ cell tumour, small cell carcinoma, or lymphoma.\n* Widespread definitive leptomeningeal metastasis. This includes cranial nerve palsy, leptomeningeal carcinomatosis, ependymal involvement, cranial nerve involvement on imaging, suspicious linear meningeal enhancement, or cerebrospinal fluid (CSF) positive for tumour cells.\n* A brain metastasis that is located ≤ 5 mm of the optic chiasm or either optic nerve.\n* Surgical resection of a brain metastasis (stereotactic biopsies will be allowed).\n* More than 15 brain metastases on a volumetric T1 contrast MRI (voxels of 1mm or smaller) performed within the past 14 days, or more than 10 metastases in the case of a non-volumetric MRI.\n* Prior allergic reaction to memantine.\n* Current alcohol or drug abuse.\n* Current use of NMDA antagonists, such as amantadine, ketamine, or dextromethorphan.\n* Diagnosis of chronic liver disease\u002Fcirrhosis of the liver (e.g. Child-Pugh class B or C).\n* Patients with architectural distortion of lateral ventricular systems, which, in the opinion of the local investigator, makes hippocampal delineation challenging","ALL","18 Years",{"count":1080,"type":1081},206,"ESTIMATED","INTERVENTIONAL",[1084],"PHASE3","Stereotactic radiosurgery (SRS) is a commonly used treatment for brain tumors. 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