[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100589884":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":507,"collaborators":11,"id":509,"slug":510,"hasResults":511,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":511,"sex":517,"minAge":518,"maxAge":11,"enrollmentInfo":519,"targetDuration":11,"studyType":522,"phases":523,"briefSummary":525,"conditions":526,"keywords":531,"overallStatus":48,"whyStopped":11,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":543},{"fullName":5,"class":6},"ADARx Pharmaceuticals, Inc.","INDUSTRY",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"ADX-324 Dose Level 1","EXPERIMENTAL",null,[13],"Drug: ADX-324",{"label":15,"type":10,"description":11,"interventionNames":16},"ADX-324 Dose Level 2",[13],{"label":18,"type":19,"description":11,"interventionNames":20},"Placebo","PLACEBO_COMPARATOR",[21],"Drug: Placebo",[23,30],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DRUG","ADX-324","siRNA duplex oligonucleotide",[9,15],[29],"siRNA",{"type":24,"name":18,"description":31,"armGroupLabels":32,"otherNames":33},"saline",[18],[34],"Saline",[36],{"name":37,"affiliation":5,"role":38},"Lauge Farnaes, MD","STUDY_DIRECTOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":11,"email":44},"Lupe Gallegos","CONTACT","877-232-7974","info@adarx.com",[46,60,69,78,86,95,104,112,121,130,139,147,156,164,172,181,188,196,207,217,228,238,249,258,267,277,285,293,303,311,320,328,339,348,356,364,375,384,394,405,413,420,429,437,445,455,463,473,483,491,499],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":11},"ADARx Clinical Site","RECRUITING","Litchfield Park","Arizona","85340","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-112.35794,33.49337,{"lat":58,"lon":57},{"facility":47,"status":48,"city":61,"state":62,"zip":63,"country":52,"countryCode":53,"cosmosGeoPoint":64,"geoPoint":68,"contacts":11},"Little Rock","Arkansas","72205",{"type":55,"coordinates":65},[66,67],-92.28959,34.74648,{"lat":67,"lon":66},{"facility":47,"status":48,"city":70,"state":71,"zip":72,"country":52,"countryCode":53,"cosmosGeoPoint":73,"geoPoint":77,"contacts":11},"San Diego","California","92122",{"type":55,"coordinates":74},[75,76],-117.16472,32.71571,{"lat":76,"lon":75},{"facility":47,"status":48,"city":79,"state":71,"zip":80,"country":52,"countryCode":53,"cosmosGeoPoint":81,"geoPoint":85,"contacts":11},"Walnut Creek","94598",{"type":55,"coordinates":82},[83,84],-122.06496,37.90631,{"lat":84,"lon":83},{"facility":47,"status":48,"city":87,"state":88,"zip":89,"country":52,"countryCode":53,"cosmosGeoPoint":90,"geoPoint":94,"contacts":11},"Orlando","Florida","32807",{"type":55,"coordinates":91},[92,93],-81.37924,28.53834,{"lat":93,"lon":92},{"facility":47,"status":48,"city":96,"state":97,"zip":98,"country":52,"countryCode":53,"cosmosGeoPoint":99,"geoPoint":103,"contacts":11},"Chevy Chase","Maryland","20815",{"type":55,"coordinates":100},[101,102],-77.07115,39.00287,{"lat":102,"lon":101},{"facility":47,"status":48,"city":105,"state":97,"zip":106,"country":52,"countryCode":53,"cosmosGeoPoint":107,"geoPoint":111,"contacts":11},"Wheaton","20902",{"type":55,"coordinates":108},[109,110],-77.05526,39.03983,{"lat":110,"lon":109},{"facility":47,"status":48,"city":113,"state":114,"zip":115,"country":52,"countryCode":53,"cosmosGeoPoint":116,"geoPoint":120,"contacts":11},"Detroit","Michigan","48202",{"type":55,"coordinates":117},[118,119],-83.04575,42.33143,{"lat":119,"lon":118},{"facility":47,"status":48,"city":122,"state":123,"zip":124,"country":52,"countryCode":53,"cosmosGeoPoint":125,"geoPoint":129,"contacts":11},"St Louis","Missouri","63141",{"type":55,"coordinates":126},[127,128],-90.19789,38.62727,{"lat":128,"lon":127},{"facility":47,"status":48,"city":131,"state":132,"zip":133,"country":52,"countryCode":53,"cosmosGeoPoint":134,"geoPoint":138,"contacts":11},"Las Vegas","Nevada","89128",{"type":55,"coordinates":135},[136,137],-115.13722,36.17497,{"lat":137,"lon":136},{"facility":47,"status":48,"city":140,"state":140,"zip":141,"country":52,"countryCode":53,"cosmosGeoPoint":142,"geoPoint":146,"contacts":11},"New York","10029",{"type":55,"coordinates":143},[144,145],-74.00597,40.71427,{"lat":145,"lon":144},{"facility":47,"status":48,"city":148,"state":149,"zip":150,"country":52,"countryCode":53,"cosmosGeoPoint":151,"geoPoint":155,"contacts":11},"Cincinnati","Ohio","45236",{"type":55,"coordinates":152},[153,154],-84.51439,39.12711,{"lat":154,"lon":153},{"facility":47,"status":48,"city":157,"state":149,"zip":158,"country":52,"countryCode":53,"cosmosGeoPoint":159,"geoPoint":163,"contacts":11},"Columbus","43235",{"type":55,"coordinates":160},[161,162],-82.99879,39.96118,{"lat":162,"lon":161},{"facility":47,"status":48,"city":165,"state":149,"zip":166,"country":52,"countryCode":53,"cosmosGeoPoint":167,"geoPoint":171,"contacts":11},"Toledo","43617",{"type":55,"coordinates":168},[169,170],-83.55521,41.66394,{"lat":170,"lon":169},{"facility":47,"status":48,"city":173,"state":174,"zip":175,"country":52,"countryCode":53,"cosmosGeoPoint":176,"geoPoint":180,"contacts":11},"Hershey","Pennsylvania","17033",{"type":55,"coordinates":177},[178,179],-76.65025,40.28592,{"lat":179,"lon":178},{"facility":47,"status":182,"city":183,"state":184,"zip":185,"country":186,"countryCode":187,"cosmosGeoPoint":11,"geoPoint":11,"contacts":11},"NOT_YET_RECRUITING","Capital Federal","Buenos Aires","C1425BEN","Argentina","AR",{"facility":47,"status":48,"city":184,"state":189,"zip":190,"country":186,"countryCode":187,"cosmosGeoPoint":191,"geoPoint":195,"contacts":11},"Buenos Aires F.D.","C1035AAT",{"type":55,"coordinates":192},[193,194],-58.37723,-34.61315,{"lat":194,"lon":193},{"facility":47,"status":48,"city":197,"state":198,"zip":199,"country":200,"countryCode":201,"cosmosGeoPoint":202,"geoPoint":206,"contacts":11},"Adelaide","South Australia","5000","Australia","AU",{"type":55,"coordinates":203},[204,205],138.59863,-34.92866,{"lat":205,"lon":204},{"facility":47,"status":48,"city":208,"state":11,"zip":209,"country":210,"countryCode":211,"cosmosGeoPoint":212,"geoPoint":216,"contacts":11},"Vienna","1090","Austria","AT",{"type":55,"coordinates":213},[214,215],16.37208,48.20849,{"lat":215,"lon":214},{"facility":47,"status":182,"city":218,"state":219,"zip":220,"country":221,"countryCode":222,"cosmosGeoPoint":223,"geoPoint":227,"contacts":11},"Edegem","Antwerpen","2650","Belgium","BE",{"type":55,"coordinates":224},[225,226],4.44504,51.15662,{"lat":226,"lon":225},{"facility":47,"status":48,"city":229,"state":11,"zip":230,"country":231,"countryCode":232,"cosmosGeoPoint":233,"geoPoint":237,"contacts":11},"Sofia","1000","Bulgaria","BG",{"type":55,"coordinates":234},[235,236],23.32415,42.69751,{"lat":236,"lon":235},{"facility":47,"status":182,"city":239,"state":240,"zip":241,"country":242,"countryCode":243,"cosmosGeoPoint":244,"geoPoint":248,"contacts":11},"Edmonton","Alberta","T6G 2R3","Canada","CA",{"type":55,"coordinates":245},[246,247],-113.46871,53.55014,{"lat":247,"lon":246},{"facility":47,"status":48,"city":250,"state":251,"zip":252,"country":242,"countryCode":243,"cosmosGeoPoint":253,"geoPoint":257,"contacts":11},"Ottawa","Ontario","K1H 1E4",{"type":55,"coordinates":254},[255,256],-75.69812,45.41117,{"lat":256,"lon":255},{"facility":47,"status":182,"city":259,"state":260,"zip":261,"country":242,"countryCode":243,"cosmosGeoPoint":262,"geoPoint":266,"contacts":11},"Montreal","Quebec","H2W 1R7",{"type":55,"coordinates":263},[264,265],-73.58781,45.50884,{"lat":265,"lon":264},{"facility":47,"status":48,"city":268,"state":11,"zip":269,"country":270,"countryCode":271,"cosmosGeoPoint":272,"geoPoint":276,"contacts":11},"Beijing","100730","China","CN",{"type":55,"coordinates":273},[274,275],116.39723,39.9075,{"lat":275,"lon":274},{"facility":47,"status":182,"city":278,"state":11,"zip":279,"country":270,"countryCode":271,"cosmosGeoPoint":280,"geoPoint":284,"contacts":11},"Harbin","150001",{"type":55,"coordinates":281},[282,283],126.65,45.75,{"lat":283,"lon":282},{"facility":47,"status":182,"city":286,"state":11,"zip":287,"country":270,"countryCode":271,"cosmosGeoPoint":288,"geoPoint":292,"contacts":11},"Zhengzhou","450003",{"type":55,"coordinates":289},[290,291],113.64861,34.75778,{"lat":291,"lon":290},{"facility":47,"status":48,"city":294,"state":11,"zip":295,"country":296,"countryCode":297,"cosmosGeoPoint":298,"geoPoint":302,"contacts":11},"Split","21000","Croatia","HR",{"type":55,"coordinates":299},[300,301],16.43915,43.50891,{"lat":301,"lon":300},{"facility":47,"status":48,"city":304,"state":11,"zip":305,"country":296,"countryCode":297,"cosmosGeoPoint":306,"geoPoint":310,"contacts":11},"Zagreb","10000",{"type":55,"coordinates":307},[308,309],15.97798,45.81444,{"lat":309,"lon":308},{"facility":47,"status":48,"city":312,"state":11,"zip":313,"country":314,"countryCode":11,"cosmosGeoPoint":315,"geoPoint":319,"contacts":11},"Hradec Králové","500 05","Czechia",{"type":55,"coordinates":316},[317,318],15.83277,50.20923,{"lat":318,"lon":317},{"facility":47,"status":48,"city":321,"state":11,"zip":322,"country":314,"countryCode":11,"cosmosGeoPoint":323,"geoPoint":327,"contacts":11},"Prague","15000",{"type":55,"coordinates":324},[325,326],14.42076,50.08804,{"lat":326,"lon":325},{"facility":47,"status":182,"city":329,"state":330,"zip":331,"country":332,"countryCode":333,"cosmosGeoPoint":334,"geoPoint":338,"contacts":11},"Nice","Alpes-Maritimes","06300","France","FR",{"type":55,"coordinates":335},[336,337],7.26608,43.70313,{"lat":337,"lon":336},{"facility":47,"status":48,"city":340,"state":341,"zip":342,"country":332,"countryCode":333,"cosmosGeoPoint":343,"geoPoint":347,"contacts":11},"Tours","Indre-et-Loire","37000",{"type":55,"coordinates":344},[345,346],0.70398,47.39484,{"lat":346,"lon":345},{"facility":47,"status":182,"city":349,"state":11,"zip":350,"country":332,"countryCode":333,"cosmosGeoPoint":351,"geoPoint":355,"contacts":11},"Montpellier","34295",{"type":55,"coordinates":352},[353,354],3.87635,43.61093,{"lat":354,"lon":353},{"facility":47,"status":48,"city":357,"state":11,"zip":358,"country":332,"countryCode":333,"cosmosGeoPoint":359,"geoPoint":363,"contacts":11},"Paris","75012",{"type":55,"coordinates":360},[361,362],2.3488,48.85341,{"lat":362,"lon":361},{"facility":47,"status":48,"city":365,"state":366,"zip":367,"country":368,"countryCode":369,"cosmosGeoPoint":370,"geoPoint":374,"contacts":11},"Tübingen","Baden-Wurttemberg","72076","Germany","DE",{"type":55,"coordinates":371},[372,373],9.05222,48.52266,{"lat":373,"lon":372},{"facility":47,"status":182,"city":376,"state":11,"zip":377,"country":376,"countryCode":378,"cosmosGeoPoint":379,"geoPoint":383,"contacts":11},"Hong Kong","111","HK",{"type":55,"coordinates":380},[381,382],114.17469,22.27832,{"lat":382,"lon":381},{"facility":47,"status":48,"city":385,"state":11,"zip":386,"country":387,"countryCode":388,"cosmosGeoPoint":389,"geoPoint":393,"contacts":11},"Budapest","1088","Hungary","HU",{"type":55,"coordinates":390},[391,392],19.04045,47.49835,{"lat":392,"lon":391},{"facility":47,"status":182,"city":395,"state":396,"zip":397,"country":398,"countryCode":399,"cosmosGeoPoint":400,"geoPoint":404,"contacts":11},"Ramat Gan","Tel Aviv","5262100","Israel","IL",{"type":55,"coordinates":401},[402,403],34.81065,32.08227,{"lat":403,"lon":402},{"facility":47,"status":182,"city":406,"state":11,"zip":407,"country":398,"countryCode":399,"cosmosGeoPoint":408,"geoPoint":412,"contacts":11},"Ashkelon","7830604",{"type":55,"coordinates":409},[410,411],34.57149,31.66926,{"lat":411,"lon":410},{"facility":47,"status":182,"city":396,"state":11,"zip":414,"country":398,"countryCode":399,"cosmosGeoPoint":415,"geoPoint":419,"contacts":11},"64239",{"type":55,"coordinates":416},[417,418],34.78057,32.08088,{"lat":418,"lon":417},{"facility":47,"status":48,"city":421,"state":11,"zip":11,"country":422,"countryCode":423,"cosmosGeoPoint":424,"geoPoint":428,"contacts":11},"Krakow","Poland","PL",{"type":55,"coordinates":425},[426,427],19.93658,50.06143,{"lat":427,"lon":426},{"facility":47,"status":48,"city":430,"state":11,"zip":431,"country":422,"countryCode":423,"cosmosGeoPoint":432,"geoPoint":436,"contacts":11},"Lodz","92-213",{"type":55,"coordinates":433},[434,435],19.47395,51.77058,{"lat":435,"lon":434},{"facility":47,"status":48,"city":438,"state":11,"zip":439,"country":422,"countryCode":423,"cosmosGeoPoint":440,"geoPoint":444,"contacts":11},"Wroclaw","50-556",{"type":55,"coordinates":441},[442,443],17.03006,51.10286,{"lat":443,"lon":442},{"facility":47,"status":48,"city":446,"state":11,"zip":447,"country":448,"countryCode":449,"cosmosGeoPoint":450,"geoPoint":454,"contacts":11},"Barcelona","08907","Spain","ES",{"type":55,"coordinates":451},[452,453],2.15899,41.38879,{"lat":453,"lon":452},{"facility":47,"status":48,"city":456,"state":11,"zip":457,"country":448,"countryCode":449,"cosmosGeoPoint":458,"geoPoint":462,"contacts":11},"Madrid","28007",{"type":55,"coordinates":459},[460,461],-3.70256,40.4165,{"lat":461,"lon":460},{"facility":47,"status":48,"city":464,"state":11,"zip":465,"country":466,"countryCode":467,"cosmosGeoPoint":468,"geoPoint":472,"contacts":11},"Taichung","40705","Taiwan","TW",{"type":55,"coordinates":469},[470,471],120.6839,24.1469,{"lat":471,"lon":470},{"facility":47,"status":48,"city":474,"state":11,"zip":475,"country":476,"countryCode":477,"cosmosGeoPoint":478,"geoPoint":482,"contacts":11},"Cambridge","CB2 0QQ","United Kingdom","UK",{"type":55,"coordinates":479},[480,481],0.11667,52.2,{"lat":481,"lon":480},{"facility":47,"status":48,"city":484,"state":11,"zip":485,"country":476,"countryCode":477,"cosmosGeoPoint":486,"geoPoint":490,"contacts":11},"Cardiff","CF14 4YS",{"type":55,"coordinates":487},[488,489],-3.18,51.48,{"lat":489,"lon":488},{"facility":47,"status":48,"city":492,"state":11,"zip":493,"country":476,"countryCode":477,"cosmosGeoPoint":494,"geoPoint":498,"contacts":11},"London","E1 1BB",{"type":55,"coordinates":495},[496,497],-0.12574,51.50853,{"lat":497,"lon":496},{"facility":47,"status":48,"city":500,"state":11,"zip":501,"country":476,"countryCode":477,"cosmosGeoPoint":502,"geoPoint":506,"contacts":11},"Southampton","SO16 6YD",{"type":55,"coordinates":503},[504,505],-1.40428,50.90395,{"lat":505,"lon":504},{"type":508,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100589884","phase-3-stop-hae-a-phase-3-study-of-adx-324-in-hae-100589884",false,"NCT06960213","STOP-HAE: A Phase 3 Study of ADX-324 in HAE","STOP-HAE: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of siRNA Targeting of Prekallikrein With ADX-324 in Participants With Hereditary Angioedema","STOP-HAE","Key Inclusion Criteria:\n\n* Age ≥18 years at the time of signing informed consent.\n* Have a documented diagnosis of HAE-1\u002FHAE-2 (Type I or II)\n* Experience ≥1 Investigator-confirmed HAE attack in the first 4 weeks of Screening or ≥2 Investigator-confirmed HAE attacks in 8 weeks of Screening\n* Able to use at least one acute therapy to treat HAE attacks (such as a plasma-derived or recombinant C1-INH concentrate or a BK2-receptor antagonist)\n\nKey Exclusion Criteria:\n\n* Concurrent diagnosis of another form of recurrent angioedema (such as acquired angioedema, HAE with normal C1-INH (previously known as HAE Type III), idiopathic angioedema, or recurrent angioedema associated with urticaria).\n* Any clinically significant renal disease\n* Any clinically significant hepatic disease\n* Have used any of the following for long-term prevention of HAE attacks:\n\n  1. C1-INH agent (CINRYZE, HAEGARDA, RUCONEST) within 2 weeks prior to Screening.\n  2. Berotralstat (ORLADEYO) within 3 weeks prior to Screening.\n  3. Lanadelumab (TAKHZYRO) within 8 weeks prior to the Screening.\n  4. Androgen use within 12 weeks prior to Screening.\n* Received prior treatment with any RNA\u002FDNA-based therapy for HAE or intolerant to any prior RNA\u002FDNA-based therapy for any condition, excluding vaccines.","ALL","18 Years",{"count":520,"type":521},90,"ESTIMATED","INTERVENTIONAL",[524],"PHASE3","This study will evaluate the efficacy and safety of ADX-324 in participants with Type 1 or Type 2 hereditary angioedema. The study will also evaluate safety, pharmacokinetics (PK), pharmacodynamics (PD), and health-related quality of life measures.",[527,528,529,530],"Hereditary Angioedema","HAE","Hereditary Angioedema - Type 1","Hereditary Angioedema - Type 2",[528,532,533],"Hereditary angioedema","onvuzosiran","2026-06-12",{"date":536,"type":537},"2026-06-16","ACTUAL",{"date":539,"type":537},"2025-08-28",{"date":541,"type":521},"2027-12-31",{"name":5,"class":6},51]