[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569308":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":482,"collaborators":18,"id":484,"slug":485,"hasResults":486,"nctId":487,"briefTitle":488,"officialTitle":489,"acronym":490,"eligibilityCriteria":491,"healthyVolunteers":486,"sex":492,"minAge":493,"maxAge":18,"enrollmentInfo":494,"targetDuration":18,"studyType":497,"phases":498,"briefSummary":500,"conditions":501,"keywords":503,"overallStatus":81,"whyStopped":18,"lastUpdateSubmitDate":506,"lastUpdatePostDateStruct":507,"startDateStruct":510,"completionDateStruct":512,"leadSponsor":514,"locationsCount":515},{"fullName":5,"class":6},"Centre Leon Berard","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Adjuvant radiotherapy","ACTIVE_COMPARATOR","Radiation therapy should be started within 8 to 12 weeks after surgery.\n\nAn equivalent dose of 45 to 50 Gy will be delivered on the operating bed. The irradiation techniques used may be either external radiation therapy with high-energy photons or electrons or brachytherapy. Patients will be monitored regularly until the date of the first local, regional or metastatic relapse, or until the date of death if they do not relapse.\n\nRegardless of the type of relapse, remedial treatments will be left to the The investigator's discretion; they will be collected in the data collection book as well as data on subsequent relapses, up to the first metastatic relapse.",[13],"Radiation: Adjuvant radiotherapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Surveillance","NO_INTERVENTION","Patients will not receive any treatment after surgery and will be monitored regularly until the date of their first local, regional or metastatic relapse, or until the date of death if they do not relapse.\n\nRegardless of the type of relapse, the treatment to be used is left to the discretion of the investigator; it will be collected in the data collection book as well as data on subsequent relapses up to the first metastatic relapse.",null,[20],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":18},"RADIATION","Patients will receive an adjuvant radiotherapy corresponding to an equivalent dose of 45 to 50 Gy (Equivalent Dose in 2 Gy Fractions \\[EQD2\\] with a tumor alpha\u002Fbeta ratio of 10 Gy) delivered on the operating bed.\n\nPatients will be treated by :\n\n* either external radiation therapy using high-energy electrons or photons:\n\n  * 45 Gy in 15 fractions of 3 Gy\n  * 50 Gy in 25 fractions of 2 Gy\n* or interstitial brachytherapy or brachytherapy via skin applicators:\n\n  * 36 Gy in 8 fractions of 4.5 Gy\n  * 36 Gy in 9 fractions of 4 Gy\n  * 40 Gy in 8 fractions of 5 Gy\n\nRadiation therapy should be started within 8 weeks after surgery (or 10 if delayed healing).\n\nPatients will be monitored regularly until the date of the first relapse (local, regional or metastatic), or until the date of death (if no relapse).\n\nRegardless of the type of relapse, remedial treatments will be left to the the investigator's discretion up to the first metastatic relapse.",[9],[25],{"name":26,"affiliation":5,"role":27},"Mona AMINI-ADLE, Dr","PRINCIPAL_INVESTIGATOR",[29],{"name":30,"role":31,"phone":32,"phoneExt":18,"email":33},"Julien GAUTIER","CONTACT","+33 4.26.55.68.29","julien.gautier@lyon.unicancer.fr",[35,49,68,79,96,113,124,134,144,154,172,187,203,218,246,256,274,298,326,348,361,379,398,420,436,446,456,472],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":18},"Centre Hospitalier Emile Roux","WITHDRAWN","Le Puy-en-Velay","Auvergne-Rhône-Alpes","43000","France","FR",{"type":44,"coordinates":45},"Point",[46,47],3.88523,45.04366,{"lat":47,"lon":46},{"facility":50,"status":51,"city":52,"state":39,"zip":53,"country":41,"countryCode":42,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Hospices Civils de Lyon - Centre Hospitalier Lyon Sud","NOT_YET_RECRUITING","Pierre-Bénite","69495",{"type":44,"coordinates":55},[56,57],4.82424,45.70359,{"lat":57,"lon":56},[60,63],{"name":61,"role":31,"phone":18,"phoneExt":18,"email":62},"Emmanuel MESNY, Dr","emmanuel.mesny@chu-lyon.fr",{"name":64,"role":31,"phone":65,"phoneExt":66,"email":67},"Nicolas POULALHON, Dr","04 78 86 45 69","04 78 86 13 29","nicolas.poulalhon@chu-lyon.fr",{"facility":69,"status":70,"city":71,"state":72,"zip":73,"country":41,"countryCode":42,"cosmosGeoPoint":74,"geoPoint":78,"contacts":18},"Centre Georges François Leclerc","ACTIVE_NOT_RECRUITING","Dijon","Bourgogne-Franche-Comté","21079",{"type":44,"coordinates":75},[76,77],5.01391,47.31344,{"lat":77,"lon":76},{"facility":80,"status":81,"city":82,"state":83,"zip":84,"country":41,"countryCode":42,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Centre Hospitalier Romans - Hopitaux Drôme Nord","RECRUITING","Romans-sur-Isère","Drôme","26102",{"type":44,"coordinates":86},[87,88],5.06602,45.0496,{"lat":88,"lon":87},[91,95],{"name":92,"role":31,"phone":93,"phoneExt":18,"email":94},"François SKOWRON, Dr","+33 4 75 05 75 80","f.skowron@hopitaux-drome-nord.fr",{"name":92,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":97,"status":51,"city":98,"state":83,"zip":99,"country":41,"countryCode":42,"cosmosGeoPoint":100,"geoPoint":104,"contacts":105},"Centre de Radiothérapie Marie Curie","Valence","26000",{"type":44,"coordinates":101},[102,103],4.90956,44.9256,{"lat":103,"lon":102},[106,109,110],{"name":107,"role":31,"phone":18,"phoneExt":18,"email":108},"Jean-Baptiste GUY, Dr","dr.guy@cmc-valence.org",{"name":107,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":111,"role":112,"phone":18,"phoneExt":18,"email":18},"Julien LANGRAND-ESCURE, Dr","SUB_INVESTIGATOR",{"facility":114,"status":81,"city":98,"state":83,"zip":99,"country":41,"countryCode":42,"cosmosGeoPoint":115,"geoPoint":117,"contacts":118},"Centre Hospitalier de Valence",{"type":44,"coordinates":116},[102,103],{"lat":103,"lon":102},[119,123],{"name":120,"role":31,"phone":121,"phoneExt":18,"email":122},"Florent GRANGE, Dr","+33 4 75 75 75 49","fgrange@valence.fr",{"name":120,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":125,"status":37,"city":126,"state":127,"zip":128,"country":41,"countryCode":42,"cosmosGeoPoint":129,"geoPoint":133,"contacts":18},"Centre Hospitalier Régional Universitaire de Brest - Hôpital Morvan","Brest","Finistère","29200",{"type":44,"coordinates":130},[131,132],-4.48628,48.39029,{"lat":132,"lon":131},{"facility":135,"status":51,"city":126,"state":127,"zip":128,"country":41,"countryCode":42,"cosmosGeoPoint":136,"geoPoint":138,"contacts":139},"Hôpital de la Cavale Blanche",{"type":44,"coordinates":137},[131,132],{"lat":132,"lon":131},[140],{"name":141,"role":31,"phone":142,"phoneExt":18,"email":143},"Gurvan DISSAUX, Dr","02 98 22 33 98","gurvan.dissaux@chu-brest.fr",{"facility":145,"status":70,"city":146,"state":147,"zip":148,"country":41,"countryCode":42,"cosmosGeoPoint":149,"geoPoint":153,"contacts":18},"Centre Hospitalier Universitaire de Bordeaux","Pessac","Gironde","33604",{"type":44,"coordinates":150},[151,152],-0.6324,44.80565,{"lat":152,"lon":151},{"facility":155,"status":81,"city":156,"state":157,"zip":158,"country":41,"countryCode":42,"cosmosGeoPoint":159,"geoPoint":163,"contacts":164},"Centre Hospitalier Annecy Genevois","Metz-Tessy","Haute-Savoie","74374",{"type":44,"coordinates":160},[161,162],6.10973,45.93343,{"lat":162,"lon":161},[165,169,170],{"name":166,"role":31,"phone":167,"phoneExt":18,"email":168},"Julie DE QUATREBARBES, Dr","+33 4 50 63 68 63","jdequatrebarbes@ch-annecygenevois.fr",{"name":166,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":171,"role":112,"phone":18,"phoneExt":18,"email":18},"Amélie DUTHEIL, Dr",{"facility":173,"status":51,"city":174,"state":175,"zip":176,"country":41,"countryCode":42,"cosmosGeoPoint":177,"geoPoint":181,"contacts":182},"Centre Hospitalier Universitaire de Rennes","Rennes","Ille-et-Vilaine","35033",{"type":44,"coordinates":178},[179,180],-1.67431,48.11109,{"lat":180,"lon":179},[183,186],{"name":184,"role":31,"phone":18,"phoneExt":18,"email":185},"Monica DINULESCU, Dr","monica.dinulescu@chu-rennes.fr",{"name":184,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":188,"status":51,"city":189,"state":190,"zip":191,"country":41,"countryCode":42,"cosmosGeoPoint":192,"geoPoint":196,"contacts":197},"Centre Hospitalier Universitaire de Grenoble-Alpes","La Tronche","Isère","38700",{"type":44,"coordinates":193},[194,195],5.74629,45.20507,{"lat":195,"lon":194},[198,202],{"name":199,"role":31,"phone":200,"phoneExt":18,"email":201},"Sabiha TRABELSI-MESSAI, Dr","+33 4 76 76 66 16","strabelsimessai@chu-grenoble.fr",{"name":199,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":204,"status":81,"city":205,"state":206,"zip":207,"country":41,"countryCode":42,"cosmosGeoPoint":208,"geoPoint":212,"contacts":213},"Centre Hospitalier Simone Veil de Blois","Blois","Loir-et-Cher","41016",{"type":44,"coordinates":209},[210,211],1.32912,47.59432,{"lat":211,"lon":210},[214,217],{"name":215,"role":31,"phone":18,"phoneExt":18,"email":216},"Guido BENS, Dr","bensgui@ch-blois.fr",{"name":215,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":219,"status":81,"city":220,"state":221,"zip":222,"country":41,"countryCode":42,"cosmosGeoPoint":223,"geoPoint":227,"contacts":228},"Centre Hospitalier Universitaire de Nantes - Hôtel-Dieu","Nantes","Loire-Atlantique","44093",{"type":44,"coordinates":224},[225,226],-1.55336,47.21725,{"lat":226,"lon":225},[229,233,234,236,238,240,242,244],{"name":230,"role":31,"phone":231,"phoneExt":18,"email":232},"Gaëlle QUEREUX, Dr","+33 2 40 08 31 44","gaelle.quereux@chu-nantes.fr",{"name":230,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":235,"role":112,"phone":18,"phoneExt":18,"email":18},"Lise BOUSSEMART, Dr",{"name":237,"role":112,"phone":18,"phoneExt":18,"email":18},"Casandra COLTOIU, Dr",{"name":239,"role":112,"phone":18,"phoneExt":18,"email":18},"Marie DAUDE, Dr",{"name":241,"role":112,"phone":18,"phoneExt":18,"email":18},"Fanny GOHARD, Dr",{"name":243,"role":112,"phone":18,"phoneExt":18,"email":18},"Sarah LE NAOUR, Dr",{"name":245,"role":112,"phone":18,"phoneExt":18,"email":18},"Marie PIROTH, Dr",{"facility":247,"status":70,"city":248,"state":249,"zip":250,"country":41,"countryCode":42,"cosmosGeoPoint":251,"geoPoint":255,"contacts":18},"Institut Godinot","Reims","Marne","51726",{"type":44,"coordinates":252},[253,254],4.02853,49.26526,{"lat":254,"lon":253},{"facility":257,"status":81,"city":258,"state":259,"zip":260,"country":41,"countryCode":42,"cosmosGeoPoint":261,"geoPoint":265,"contacts":266},"Institut de Cancérologie de Lorraine","Vandœuvre-lès-Nancy","MMeurthe-et-Moselle","54519",{"type":44,"coordinates":262},[263,264],6.17114,48.66115,{"lat":264,"lon":263},[267,271,272],{"name":268,"role":31,"phone":269,"phoneExt":18,"email":270},"Sophie RENARD, Dr","+33 3 83 59 86 10","s.renard@nancy.unicancer.fr",{"name":268,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":273,"role":112,"phone":18,"phoneExt":18,"email":18},"Florence GRANEL BROCARD, Dr",{"facility":275,"status":81,"city":276,"state":277,"zip":278,"country":41,"countryCode":42,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"Groupe Hospitalier Bretagne Sud","Lorient","Morbihan","56322",{"type":44,"coordinates":280},[281,282],-3.37177,47.74817,{"lat":282,"lon":281},[285,289,290,292,294,296],{"name":286,"role":31,"phone":287,"phoneExt":18,"email":288},"Caroline JACOBZONE-LEVEQUE, Dr","+33 6 16 98 31 79","c.jacobzoneleveque@ghbs.bzh",{"name":286,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":291,"role":112,"phone":18,"phoneExt":18,"email":18},"Christian SIRE, Dr",{"name":293,"role":112,"phone":18,"phoneExt":18,"email":18},"Claire-Alice DE SALINS, Dr",{"name":295,"role":112,"phone":18,"phoneExt":18,"email":18},"Guillaume BERA, Dr",{"name":297,"role":112,"phone":18,"phoneExt":18,"email":18},"Kévin CHASSAIN, Dr",{"facility":299,"status":51,"city":300,"state":301,"zip":302,"country":41,"countryCode":42,"cosmosGeoPoint":303,"geoPoint":307,"contacts":308},"CHU de Bordeaux - Hôpital Saint André","Bordeaux","New Aquitaine","33076",{"type":44,"coordinates":304},[305,306],-0.58046,44.84124,{"lat":306,"lon":305},[309,314,318,320,322,324],{"name":310,"role":31,"phone":311,"phoneExt":312,"email":313},"Emilie GERARD, Dr","05 56 79 47 05","05 56 79 49 75","emilie.gerard@chu-bordeaux.fr",{"name":315,"role":31,"phone":316,"phoneExt":18,"email":317},"Marie BEYLOT-BARRY, Dr","05 57 82 25 00","marie.beylot-barry@chu-bordeaux.fr",{"name":319,"role":112,"phone":18,"phoneExt":18,"email":18},"Léa DOUSSET, Dr",{"name":321,"role":112,"phone":18,"phoneExt":18,"email":18},"Caroline DUTRIAUX, Dr",{"name":323,"role":112,"phone":18,"phoneExt":18,"email":18},"Anne PHAM-LEDARD, Dr",{"name":325,"role":112,"phone":18,"phoneExt":18,"email":18},"Sorilla PREY, Dr",{"facility":327,"status":51,"city":328,"state":329,"zip":330,"country":41,"countryCode":42,"cosmosGeoPoint":331,"geoPoint":335,"contacts":336},"Centre De Radiothérapie Guillaume Le Conquérant","Le Havre","Normandy","76600",{"type":44,"coordinates":332},[333,334],0.10785,49.49346,{"lat":334,"lon":333},[337,341,344,346],{"name":338,"role":31,"phone":339,"phoneExt":18,"email":340},"Paul LESUEUR, Dr","02 35 13 66 13","p.lesueur@cglc.fr",{"name":342,"role":31,"phone":339,"phoneExt":18,"email":343},"Romain MALLET, Dr","r.mallet@cglc.fr",{"name":345,"role":112,"phone":18,"phoneExt":18,"email":18},"Laurent MARTIN, Dr",{"name":347,"role":112,"phone":18,"phoneExt":18,"email":18},"Renata PEREIRA, Dr",{"facility":349,"status":81,"city":350,"state":351,"zip":352,"country":41,"countryCode":42,"cosmosGeoPoint":18,"geoPoint":18,"contacts":353},"Centre hospitalier de Roanne","Roanne","Pays de la Loire Region","42300",[354,358,359],{"name":355,"role":31,"phone":356,"phoneExt":18,"email":357},"Amel BLANCHARD, Dr","+33 4 77 44 32 77","amel.blanchard@ch-roanne.fr",{"name":355,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":360,"role":112,"phone":18,"phoneExt":18,"email":18},"Petre LUPU BRATILOVEANU, Dr",{"facility":362,"status":81,"city":363,"state":351,"zip":364,"country":41,"countryCode":42,"cosmosGeoPoint":18,"geoPoint":18,"contacts":365},"Centre Hospitalier Universitaire de Saint-Etienne - Hôpital Nord","Saint Priest En Jarez","42271",[366,370,371,373,375,377],{"name":367,"role":31,"phone":368,"phoneExt":18,"email":369},"Elodie GUILLAUME, Dr","+33 4 77 91 71 02","elodie.guillaume@chu-st-etienne.fr",{"name":367,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":372,"role":112,"phone":18,"phoneExt":18,"email":18},"Jean-Luc PERROT, DrNicolas",{"name":374,"role":112,"phone":18,"phoneExt":18,"email":18},"Nicolas VIAL, Dr",{"name":376,"role":112,"phone":18,"phoneExt":18,"email":18},"Saïd SOLTANI, Dr",{"name":378,"role":112,"phone":18,"phoneExt":18,"email":18},"Eric JADAUD, Dr",{"facility":380,"status":51,"city":381,"state":382,"zip":383,"country":41,"countryCode":42,"cosmosGeoPoint":384,"geoPoint":388,"contacts":389},"Centre Antoine Lacassagne","Nice","Provence-Alpes-Côte d'Azur Region","06189",{"type":44,"coordinates":385},[386,387],7.26608,43.70313,{"lat":387,"lon":386},[390,394],{"name":391,"role":31,"phone":392,"phoneExt":18,"email":393},"Damien GIACCHERO, Dr","04 93 86 73 68","Damien.giacchero@gmail.com",{"name":395,"role":31,"phone":396,"phoneExt":18,"email":397},"Dorian CULIE, Dr","04 92 03 17 89","Dorian.culie@nice.unicancer.fr",{"facility":399,"status":81,"city":400,"state":401,"zip":402,"country":41,"countryCode":42,"cosmosGeoPoint":403,"geoPoint":407,"contacts":408},"Centre Hospitalier Universitaire Estaing","Clermont-Ferrand","Puy-de-Dôme","63033",{"type":44,"coordinates":404},[405,406],3.08682,45.77969,{"lat":406,"lon":405},[409,413,414,416,418],{"name":410,"role":31,"phone":411,"phoneExt":18,"email":412},"Sandrine MANSARD, Dr","+33 4 73 75 05 50","smansard@chu-clermontferrand.fr",{"name":410,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":415,"role":112,"phone":18,"phoneExt":18,"email":18},"Marie BACHELERIE, Dr",{"name":417,"role":112,"phone":18,"phoneExt":18,"email":18},"Jacques ROUANET, Dr",{"name":419,"role":112,"phone":18,"phoneExt":18,"email":18},"Michel D'INCAN, Dr",{"facility":421,"status":51,"city":422,"state":423,"zip":424,"country":41,"countryCode":42,"cosmosGeoPoint":425,"geoPoint":429,"contacts":430},"Centre Hospitalier Universitaire Rouen - Hôpital Charles Nicolle","Rouen","Seine-Maritime","76031",{"type":44,"coordinates":426},[427,428],1.09932,49.44313,{"lat":428,"lon":427},[431,435],{"name":432,"role":31,"phone":433,"phoneExt":18,"email":434},"Anne-Bénédicte DUVAL-MODESTE, Dr","+33 2 32 88 81 41","anne-benedicte.duval-modeste@chu-rouen.fr",{"name":432,"role":27,"phone":18,"phoneExt":18,"email":18},{"facility":437,"status":70,"city":438,"state":439,"zip":440,"country":41,"countryCode":42,"cosmosGeoPoint":441,"geoPoint":445,"contacts":18},"Centre Hospitalier Universitaire Amiens-Picardie","Amiens","Somme","80054",{"type":44,"coordinates":442},[443,444],2.3,49.9,{"lat":444,"lon":443},{"facility":447,"status":37,"city":448,"state":449,"zip":450,"country":41,"countryCode":42,"cosmosGeoPoint":451,"geoPoint":455,"contacts":18},"Hôpital d'instruction des armées Sainte-Anne","Toulon","Var","83800",{"type":44,"coordinates":452},[453,454],5.92836,43.12442,{"lat":454,"lon":453},{"facility":457,"status":81,"city":458,"state":18,"zip":459,"country":41,"countryCode":42,"cosmosGeoPoint":460,"geoPoint":464,"contacts":465},"Centre Léon Bérard","Lyon","69373",{"type":44,"coordinates":461},[462,463],4.84789,45.74906,{"lat":463,"lon":462},[466,469,470],{"name":26,"role":31,"phone":467,"phoneExt":18,"email":468},"+33 4 78 78 59 96","mona.amini-adle@lyon.unicancer.fr",{"name":26,"role":27,"phone":18,"phoneExt":18,"email":18},{"name":471,"role":112,"phone":18,"phoneExt":18,"email":18},"Adeline PETRE, Dr",{"facility":473,"status":70,"city":474,"state":475,"zip":476,"country":41,"countryCode":42,"cosmosGeoPoint":477,"geoPoint":481,"contacts":18},"Hôpital Bichat Claude-Bernard","Paris","Île-de-France Region","75877",{"type":44,"coordinates":478},[479,480],2.3488,48.85341,{"lat":480,"lon":479},{"type":483,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100569308","phase-3-study-of-a-strategy-integrating-adjuvant-radiation-therapy-versus-strategy-based-on-monitoring-in-the-treatment-of-carcinomas-spinocellular-with-high-risk-of-recurrence-100569308",false,"NCT06692556","Study of a Strategy Integrating Adjuvant Radiation Therapy Versus Strategy Based on Monitoring in the Treatment of Carcinomas Spinocellular With High Risk of Recurrence","Randomized Comparative Multicenter Phase III Study of a Strategy Integrating Adjuvant Radiation Therapy Versus Strategy Based on Monitoring in the Treatment of Carcinomas Spinocellular With High Risk of Recurrence","SPINO-RT","Inclusion Criteria:\n\nI1. Patients aged ≥ 18 years at the time of signing the informed consent form; I2. Patients with histologically confirmed localized cutaneous squamous cell carcinoma;\n\nNote: Patients with carcinoma of the external auditory canal may be included in the study;\n\nI3. Patients treated with complete surgical excision (R0), regardless of the margin (submillimeter or supramillimeter);\n\nI4. Disease with a high risk of recurrence defined by one of the following scenarios:\n\n* presence of microscopic EPN without any other risk factors;\n* presence of microscopic EPN with a single other risk factor;\n* presence of 2 risk factors other than microscopic EPN;\n* presence of 3 risk factors other than microscopic EPN;\n\nNote: The risk factors considered are immunosuppression (limited to untreated hematologic disease), a tumor diameter \\>20 mm (longest axis, measured preferably clinically, or, failing that, histologically), a specific location (lip\u002Fear\u002Ftemple), deep invasion (tumor thickness \\>6 mm (Breslow) or invasion beyond the subcutaneous fat), poor differentiation, or desmoplasia;\n\nI5. Patient informed and having signed a consent form to participate in the study; I6. Patient enrolled in a health insurance plan (or beneficiary of such a plan).\n\nExclusion Criteria:\n\nNI1. Patients with in situ or mixed CEC; NI2. History of CEC with a high risk of recurrence in the same lymphatic drainage area (head and neck, trunk, or limb) within 2 years prior to the randomization date; NI3. History of CEC treated with systemic therapy; NI4. Patients with SCC localized to the endonasal, intraoral, anogenital, or vulvar mucosa;\n\nNI5. Patients with recurrent SCC or SCC at very high risk of recurrence defined by one of the following criteria:\n\n* EPN with ≥ 2 other risk factors,\n* \\> 3 risk factors,\n* bone invasion,\n* immunosuppression due to immunosuppressive treatments (regardless of the reason). NI6. Patients with CEC presenting a single risk factor other than EPN; NI7. Patient with CEC and lymph node or distant metastasis; NI8. Patient with a history of cancer undergoing systemic and\u002For locoregional anticancer treatment;\n\nNote: Local treatment of cutaneous keratoses with fluoropyrimidines is permitted outside the theoretical radiation field);\n\nNI9. Patient with a contraindication to radiation therapy; NI10. Patient with a history of radiation therapy to the site of the lesion; NI11. Participation in another clinical trial that may interfere with the assessment of the primary endpoint; NI12. Patient under legal guardianship or conservatorship, or deprived of liberty; NI13. Pregnant or breastfeeding woman.","ALL","18 Years",{"count":495,"type":496},266,"ESTIMATED","INTERVENTIONAL",[499],"PHASE3","The goal of this clinical trial is to evaluate a strategy integrating adjuvant radiation therapy versus strategy based on monitoring in the treatment of carcinomas spinocellular with high risk of recurrence (SCC).\n\nThe investigators will compare the disease-free survival (DFS) of patients treated with adjuvant radiation therapy versus surveillance in high risk of recurrence SCC.\n\nThe main question it aims to answer is:\n\nIs DFS different between the \"adjuvant radiotherapy\" group and the \"surveillance\" group?\n\nParticipants will:\n\n* be distributed in one of the two arms\n* will be followed up every 4 months for 2 years, then every 6 months (clinical examination, identification of concomitant treatments, imaging, quality-of-life questionnaire)\n* followed up until their death or their progression whether local, regional or metastatic",[502],"Cutaneous Squamous Cell Carcinoma (CSCC)",[504,9,15,505],"Squamous cell carcinomas at high risk of recurrence","Peri Nervous System Sheathing","2026-04-21",{"date":508,"type":509},"2026-04-24","ACTUAL",{"date":511,"type":509},"2025-02-21",{"date":513,"type":496},"2031-06",{"name":5,"class":6},28]