[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616732":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":39,"centralContacts":43,"locations":49,"responsibleParty":74,"collaborators":11,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":11,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":11,"enrollmentInfo":85,"targetDuration":11,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":52,"whyStopped":11,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Regeneron Pharmaceuticals","INDUSTRY",[8,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":12},"REGN5713-5715","EXPERIMENTAL",null,[13,14],"Drug: REGN5713","Drug: REGN5715",{"label":16,"type":10,"description":11,"interventionNames":17},"REGN5713",[13],{"label":19,"type":10,"description":11,"interventionNames":20},"REGN5715",[14],{"label":22,"type":23,"description":11,"interventionNames":24},"Placebo","PLACEBO_COMPARATOR",[25],"Drug: Placebo",[27,33,37],{"type":28,"name":16,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","Administered per protocol",[16,9],[32],"Bremzalerbart",{"type":28,"name":19,"description":29,"armGroupLabels":34,"otherNames":35},[9,19],[36],"Atisnolerbart",{"type":28,"name":22,"description":29,"armGroupLabels":38,"otherNames":11},[22],[40],{"name":41,"affiliation":5,"role":42},"Clinical Trial Management","STUDY_DIRECTOR",[44],{"name":45,"role":46,"phone":47,"phoneExt":11,"email":48},"Clinical Trials Administrator","CONTACT","844-734-6643","clinicaltrials@regeneron.com",[50,64],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":11},"Andover Eye Associates","RECRUITING","Andover","Massachusetts","01810","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-71.137,42.65843,{"lat":62,"lon":61},{"facility":65,"status":52,"city":66,"state":67,"zip":68,"country":56,"countryCode":57,"cosmosGeoPoint":69,"geoPoint":73,"contacts":11},"Somnos Clinical Research","Lincoln","Nebraska","68510",{"type":59,"coordinates":70},[71,72],-96.66696,40.8,{"lat":72,"lon":71},{"type":75,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100616732","phase-3-study-of-bet-v1-antibodies-effect-on-eye-allergy-symptoms-in-adolescents-and-adults-with-birch-pollen-allergy-100616732",false,"NCT07309432","Study of Bet v1 Antibodies Effect on Eye Allergy Symptoms in Adolescents and Adults With Birch Pollen Allergy","A Randomized, Double-Masked, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety of Bet v 1 Monoclonal Antibodies in Participants With Allergic Conjunctivitis Due to Birch Pollen Allergy","Key Inclusion Criteria:\n\n1. Positive SPT to birch allergen extract\n2. Positive allergen specific Immunoglobulin E (sIgE) tests for birch and Bet v 1\n3. Positive CAC criteria\n\nKey Exclusion Criteria:\n\n1. Significant and\u002For severe environmental allergies causing symptoms (outside of the challenge setting) that are expected to interfere with study assessments\n2. Presence of any ophthalmic disease\u002Fabnormality\u002Fcondition that may interfere with study assessments, affect the study outcomes or negatively impact participant safety\n3. A clinical history of asthma with treatment of asthma requiring systemic (oral or parenteral) corticosteroid treatment more than twice within prior 12 months or once within 3 months prior to screening visit 1 or has been hospitalized or has attended the Emergency Room\u002FUrgent Care facility for asthma in the 12 months prior to screening\n\nNote: Other protocol defined Inclusion\u002FExclusion criteria apply.","ALL","12 Years",{"count":86,"type":87},350,"ESTIMATED","INTERVENTIONAL",[90],"PHASE3","This study is researching 2 experimental drugs, REGN5713 and REGN5715. The study drugs will be either of these drugs given alone (either REGN5713 or REGN5715) or given together (REGN5713 and REGN5715) to reduce eye allergy signs and symptoms due to birch tree pollen allergy.\n\nThe aim of the study is to see how safe and effective the study drugs are at lowering eye allergy signs and symptoms compared with placebo.\n\nThe study will also evaluate whether the combination (REGN5713-5715) has different effectiveness than REGN5713 or REGN5715 alone.\n\nThe study is looking at several other research questions, including:\n\n* What side effects may happen from taking the study drugs\n* How much of the study drugs is in the blood at different times\n* Whether the body makes antibodies against the study drugs (which could make the drug less effective or could lead to side effects)",[93],"Allergic Conjunctivitis",[95,96,97],"Birch Pollen Allergy","Ocular allergy symptoms","Ocular allergy signs","2026-06-22",{"date":100,"type":101},"2026-06-23","ACTUAL",{"date":103,"type":101},"2026-01-10",{"date":105,"type":87},"2027-06-15",{"name":5,"class":6},2]