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LDL-C \\>130 mg\u002FdL (3.4 mmol\u002FL) at screening\n* For participants 8 to \\\u003C12 years, on an optimal dose of statin (investigator's discretion) unless statin intolerant, with or without other lipid-lowering therapy (e.g. ezetimibe). For participants \\\u003C8 years, the use of background lipid-lowering treatment is based on investigator's discretion.\n* Participants on lipid-lowering therapies (such as statin and\u002For e.g. ezetimibe) must be on a stable dose for ≥30 days before screening with no planned medication or dose changes during study participation.\n\nExclusion Criteria:\n\n* Previous treatment (within 90 days of screening) with monoclonal antibodies directed towards PCSK9\n* Secondary hypercholesterolemia, e.g. hypothyroidism or nephrotic syndrome\n* Homozygous familial hypercholesterolemia (HoFH)\n* Body weight \\\u003C16 kg at the screening and\u002For randomization (Day 1) visit\n* Active liver disease defined as any known current infectious, neoplastic, or metabolic pathology of the liver or unexplained alanine aminotransferase (ALT), aspartate aminotransferase (AST) elevation \\>3x ULN, or total bilirubin elevation \\>2x ULN (except patients with Gilbert's syndrome)\n* Pregnant or nursing females\n* Recent and\u002For planned use of other investigational medicinal products or devices","ALL","6 Years","11 Years",{"count":694,"type":695},60,"ESTIMATED","INTERVENTIONAL",[698],"PHASE3","This is a pivotal phase III study designed to evaluate safety, tolerability, and efficacy of inclisiran in children (aged 6 to \\\u003C12 years) with heterozygous familial hypercholesterolemia (HeFH) and elevated low density lipoprotein cholesterol (LDLC).",[701],"Familial Hypercholesterolemia - Heterozygous",[703,704,705,706,707,708,709,710,711,712,713,714,715,716,717,718],"Heterozygous familial hypercholesterolemia (HeFH),","LDL-cholesterol (LDL-C),","Children,","pediatric,","small interfering ribonucleic acid (siRNA),","inclisiran,","Familial Hypercholesterolemia,","Heterozygous FH,","Hypercholesterolemia,","Lipoprotein(a),","Hyperlipidemia,","Dyslipidemia,","Heart Failure,","Cardiovascular Diseases,","Cholesterol,","Aortic Stenosis","2026-05-13",{"date":721,"type":722},"2026-05-15","ACTUAL",{"date":724,"type":722},"2024-12-09",{"date":726,"type":695},"2029-04-15",{"name":34,"class":6},66]