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The bone marrow sample should be from the first aspiration (i.e., first pull). Aspirate needle should be redirected if needed to get first pull bone marrow aspirate. It should be obtained as soon after pre-registration as possible to confirm registration eligibility\n* STEP 0: Patients must be diagnosed with CLL\u002FSLL according to International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2018 criteria that includes all of the following:\n\n  * ≥ 5 x10\\^9 \u002FL B lymphocytes (5000\u002FμL) in the peripheral blood (CLL) or a lymph node biopsy demonstrating SLL with the below immunophenotype (SLL)\n  * On morphologic review, the leukemic cells must be small mature lymphocytes\n  * Immunophenotype of CLL cells (performed locally) must reveal a clonal B-cell population, which coexpress the B cell surface markers of CD19 and CD20, as well as the T-cell antigen CD5. Patients with bright surface immunoglobulin expression or lack of CD23 expression in \\> 10% of cells must lack t(11;14) translocation by interphase cytogenetics\n* STEP 0: Patients must meet criteria for treatment as defined by IWCLL 2018 guidelines which includes at least one of the following criteria:\n\n  * Evidence of marrow failure as manifested by the development or worsening of anemia or thrombocytopenia (not attributable to autoimmune hemolytic anemia or thrombocytopenia), typically hemoglobin (Hb) \\\u003C 10 g\u002FdL, platelet count \\\u003C 100,000\u002Fmm\\^3\n  * Massive (\\> 6 cm below the costal margin), progressive or symptomatic splenomegaly\n  * Massive nodes (ie, \\> 10 cm in longest diameter) or progressive or symptomatic lymphadenopathy\n  * Autoimmune anemia and\u002For thrombocytopenia that is poorly responsive to standard therapy\n  * Constitutional symptoms, which include any of the following:\n\n    * Unintentional weight loss of ≥ 10% within the previous 6 months\n    * Significant fatigue (ie. Eastern Cooperative Oncology Group \\[ECOG\\] performance status \\[PS\\] ≥ 2)\n    * Fevers \\>100.5 °F or 38.0°C for 2 weeks or more without evidence of infection\n    * Night sweats \\> 1 month without evidence of infection\n* STEP 0: Patients must not have had prior therapy for CLL (except palliative steroids or treatment of autoimmune complications of CLL with rituximab or steroids)\n* STEP 0: Treatment with rituximab and\u002For high-dose corticosteroids for autoimmune complications of CLL must be completed prior to enrollment. Palliative steroids must be at a dose not higher than 20 mg\u002Fday of prednisone or equivalent corticosteroid at the time of registration\n* STEP 0: Age ≥ 65 years\n* STEP 0: ECOG performance status ≤ 2\n* STEP 0: Patients with known HIV infection on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial\n* STEP 0: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated\n* STEP 0: Patients with a history of hepatitis C virus (HCV), infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load\n* STEP 0: Patients must not be receiving active systemic anticoagulation with warfarin. Patients must be off warfarin therapy for at least 5 half-lives washout and with normal INR prior to enrollment\n* STEP 0: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients must be class 2B or better.\n\nPatients with acute cardiac events within 6 months prior to registration should be carefully evaluated for their suitability for enrollment\n\n* STEP 0: No patients with a history of a severe bleeding disorder or a history of hemorrhagic stroke or intracranial hemorrhage\n* STEP 0: No patients with known active progressive central nervous system (CNS) disease\n* STEP 0: No known medical condition causing an inability to swallow oral formulations of agents\n* STEP 1: The adaptive report confirming a measurable and trackable B cell clone\n* STEP 1: Patients may not have had major surgery within 7 days of enrollment, or minor surgery within 5 days of enrollment. Examples of minor surgery include dental surgery, insertion of a venous access device, skin biopsy, or aspiration of a joint. The decision about whether a surgery is major or minor can be made at the discretion of the treating physician\n* STEP 1: No patients with ongoing active fungal, bacterial or viral infection requiring systemic therapy except those described in the protocol document\n* STEP 1: Patients must not require more than 20 mg prednisone or equivalent corticosteroid daily\n* STEP 1: Patients must not have uncontrolled active systemic infection requiring intravenous antibiotics\n* STEP 1: Patients must not have continued requirement for therapy with a strong CYP3A4\u002F5 inhibitor or inducer. Any such inhibitor or inducer must have been discontinued at least 14 days or 5 half-lives (whichever is shorter) before the first dose of study drug\n* STEP 1: Absolute neutrophil count (ANC) ≥ 1,000\u002Fmm3 unless due to marrow involvement\n* STEP 1: Platelet count ≥ 30,000\u002Fmm3\n* STEP 1: Total bilirubin ≤ 1.5 x upper limit of normal (ULN) (unless due to liver involvement, hemolysis or Gilbert's disease)\n* STEP 1: Aspartate aminotransferase (AST)(serum glutamic oxaloacetic transaminase \\[SGOT\\])\u002F alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase \\[SGPT\\]) ≤ 3.0 x upper limit of normal (ULN) unless due to disease infiltration of the liver\n* STEP 1: Calculated (calc.) creatinine clearance by Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI) ≥ 30 mL\u002Fmin\n* STEP 1: Urine protein to creatinine ratio \\\u003C 1 or urine protein ≤ 1+\n* STEP 2: Detectable MRD ≥ 10 residual clonal cells per million nucleated cells in peripheral blood at the C15 restaging evaluation from ClonoSEQ\n* STEP 2: Response of PR, PR-L, CR, CCR or CRi to zanubrutinib sonrotoclax therapy","ALL","65 Years",{"count":1976,"type":1977},466,"ESTIMATED","INTERVENTIONAL",[1980],"PHASE3","This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)\u002Fsmall lymphocytic lymphoma (SLL). Sonrotoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib is in a class of medications called kinase inhibitors. It blocks a protein called BTK, which is present on B-cell (a type of white blood cells) cancers such as mantel cell lymphoma at abnormal levels. This may help keep cancer cells from growing and spreading. Giving sonrotoclax and zanubrutinib may be more effective than zanubrutinib alone for the treatment of untreated CLL\u002FSLL.",[1983,1984],"Chronic Lymphocytic Leukemia","Small Lymphocytic Leukemia","2026-07-01",{"date":1987,"type":1988},"2026-07-02","ACTUAL",{"date":1990,"type":1988},"2026-04-30",{"date":1992,"type":1977},"2038-09-30",{"name":5,"class":6},152]