[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603891":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":19,"centralContacts":32,"locations":41,"responsibleParty":68,"collaborators":70,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":19,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":19,"enrollmentInfo":94,"targetDuration":19,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":44,"whyStopped":19,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"The Cooper Health System","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment Group","EXPERIMENTAL","This group will be prophylactically treated with topical antibiotics every day for 5 days prior to surgery. Participants will shower with Hibiclens antiseptic skin cleanser once daily and apply mupirocin ointment to the nares twice daily, in the morning and evening.",[13,14],"Drug: Chlorhexidine gluconate (4%)","Drug: Mupirocin 2% Ointment",{"label":16,"type":17,"description":18,"interventionNames":19},"Control Group","NO_INTERVENTION","This group will NOT be prophylactically treated with Hibiclens antiseptic skin cleanser and mupirocin ointment prior to surgery.",null,[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","Chlorhexidine gluconate (4%)","Chlorhexidine 4% solution will be applied from the neck down (avoiding the face, penis, and vagina), allowed to sit on the skin for one minute, then rinsed off in the shower every day for 5 days prior to surgery.",[9],[27],"Hibiclens",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":19},"Mupirocin 2% Ointment","Mupirocin 2% ointment will be applied to the inside of the nostrils twice daily, in the morning and evening, for 5 days prior to surgery. A small amount of the ointment will be placed on the tip of a cotton swab to facilitate application to each nostril.",[9],[33,38],{"name":34,"role":35,"phone":36,"phoneExt":19,"email":37},"Naomi Lawrence, MD","CONTACT","(856) 596-3040","lawrence-naomi@cooperhealth.edu",{"name":39,"role":35,"phone":36,"phoneExt":19,"email":40},"Faria Nusrat, BS","nusrat-faria@cooperhealth.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"The Center for Dermatologic Surgery at Cooper University Health Care","RECRUITING","Marlton","New Jersey","08053","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-74.92183,39.89122,{"lat":54,"lon":53},[57,59,60,62,65,66],{"name":34,"role":35,"phone":58,"phoneExt":19,"email":37},"856-596-3040",{"name":39,"role":35,"phone":36,"phoneExt":19,"email":40},{"name":34,"role":61,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"name":63,"role":64,"phone":19,"phoneExt":19,"email":19},"Tara Jennings, MD","SUB_INVESTIGATOR",{"name":39,"role":64,"phone":19,"phoneExt":19,"email":19},{"name":67,"role":64,"phone":19,"phoneExt":19,"email":19},"Kyle Lauck, MD",{"type":69,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[71,73,75,77,79,81,83],{"name":72,"class":6},"University of California, Davis",{"name":74,"class":6},"Washington University School of Medicine",{"name":76,"class":6},"Baylor College of Medicine",{"name":78,"class":6},"Princeton Healthcare System",{"name":80,"class":6},"The Cleveland Clinic",{"name":82,"class":6},"University of Georgia",{"name":84,"class":6},"St. Luke's Hospital and Health Network, Pennsylvania","100603891","phase-3-the-effect-of-bacterial-decolonization-before-skin-cancer-surgery-on-infection-rate-of-lower-extremity-wounds-left-open-to-heal-100603891",false,"NCT07142408","The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to Heal","The Effect of Pre-Operative Bacterial Decolonization on Post-Operative Infection Rate for Lower Extremity Wounds Healing by Second Intention","Inclusion Criteria:\n\n* Age at least 18 years old\n* Scheduled to undergo surgical treatment for skin cancer on the lower extremities and have no other surgeries scheduled in the coming weeks after the procedure\n* Will have a surgical wound that will be left open to heal by secondary intention\n\nExclusion Criteria:\n\n* Age under 18 years old\n* Have a known allergy to chlorhexidine or mupirocin\n* Have a history of Staphylococcus aureus infection\n* Have a history of heart valve or joint replacement surgery requiring pre-operative antibiotics","ALL","18 Years",{"count":95,"type":96},848,"ESTIMATED","INTERVENTIONAL",[99],"PHASE3","The goal of this clinical trial is to learn if reducing bacterial load on the skin and nostrils with topical antibacterial soap and ointment, respectively, reduces rate of infection in surgical sites on lower leg wounds left open to heal in adults undergoing skin cancer surgery.\n\nThe main question it aims to answer is:\n\nDoes Hibiclens antibacterial skin cleanser and mupirocin antibacterial ointment applied to nostrils prior to surgery lower the number of times participants develop an infection in their open wound on the lower leg?\n\nResearchers will compare the treatment group to the standard of care, which involves no treatment prior to surgery, to see if topical antibiotics applied prior to surgery affect infection rates between the two groups.\n\nParticipants randomized to the treatment group will:\n\nShower with Hibiclens once daily for 5 days prior to the day of surgery and apply mupirocin to the nostrils twice daily for 5 days prior to the day of surgery. They will then send pictures of their surgical site to monitor for signs of infection at 2-week and 4-week post-operation.\n\nParticipants randomized to the control group (standard of care) will:\n\nNOT apply the topical antibacterials prior to the day of surgery. They will then send pictures of their surgical site to monitor for signs of infection at 2-week intervals for 1 month after surgery.",[102],"Surgical Wound Infection",[104,105,106,107,108,109,110,111,112],"Lower Extremity Wound","Skin Cancer Surgery","Infection Rate","Prophylactic Topical Antibiotics","Chlorhexidine","Mupirocin","Wound Healing","Secondary Intention","Infection Prevention","2025-08-22",{"date":115,"type":116},"2025-08-26","ACTUAL",{"date":118,"type":116},"2023-03-13",{"date":120,"type":96},"2030-12",{"name":5,"class":6},1]