[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631557":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":24,"locations":28,"responsibleParty":47,"collaborators":24,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":24,"eligibilityCriteria":56,"healthyVolunteers":53,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":24,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":77,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Lactoferrin","EXPERIMENTAL","Lactoferrin 250 mg orally twice daily (BID). The first dose will be given 1 hour preoperatively, followed by repeat doses every 12 hours for 48 hours postoperatively",[13],"Drug: Lactoferrin",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","will receive matching placebo capsules administered on the same schedule as the lactoferrin group (first dose 1 hour preoperatively, then every 12 hours for 48 hours).",[19],"Other: Placebo",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DRUG",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"matching placebo capsules administered on the same schedule as the lactoferrin group (first dose 1 hour preoperatively, then every 12 hours for 48 hours).",[15],[29],{"facility":30,"status":24,"city":31,"state":24,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Mansoura Hospital","Cairo","11856","Egypt","EG",{"type":36,"coordinates":37},"Point",[38,39],31.24967,30.06263,{"lat":39,"lon":38},[42],{"name":43,"role":44,"phone":45,"phoneExt":24,"email":46},"Khaled Samir Associate Professor of gynecology, MD","CONTACT","+201097452797","khalid_samir@mans.edu.eg",{"type":48,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Eman Mohamed El Mokadem","Lecturer of Pharmacy Practice and Clinical Pharmacy","100631557","phase-3-the-effect-of-lactoferrin-on-pain-management-following-cesarean-section-100631557",false,"NCT07502235","The Effect of Lactoferrin on Pain Management Following Cesarean Section","Inclusion Criteria:\n\n* Referred to elective (non-emergency) cesarean section\n* Undergoing spinal anesthesia) with American Society of Anesthesiologists (ASA) classification I and II\n* Term gestational age\n\nExclusion Criteria:\n\n* History of seizures\n* Pre-eclampsia or eclampsia\n* Hypertension\n* Use of narcotic painkillers for 24 h before the intervention\n* Medications inducing neuropathy including Amiodarone, Metronidazole, Phenytoin \\& Colchicine.\n* Prolongation of cesarean section (more than 1.5 h)\n* Increase in the size of the incision\n* Occurrence of any unusual complication during surgery,\n* Failure of spinal anesthesia and its conversion to general anesthesia\n* Contraindications to spinal anesthesia\n* Use of interacting medication: fluoroquinolones, loratadine, fexofenadine, alvimopan, armodafinil","FEMALE","18 Years","70 Years",{"count":61,"type":62},90,"ESTIMATED","INTERVENTIONAL",[65],"PHASE3","This study evaluates whether lactoferrin, a naturally occurring protein with anti-inflammatory and antioxidant properties, can improve pain control after cesarean section. Effective management of postoperative pain is essential to support maternal recovery, mobility, and the ability to care for the newborn, while minimizing reliance on opioid medications and their associated side effects.\n\nIn this randomized, double-blind, placebo-controlled trial, women undergoing elective cesarean section will receive either oral lactoferrin or a matching placebo in addition to standard postoperative analgesia. Lactoferrin will be administered starting before surgery and continued for 48 hours after delivery.\n\nThe study will assess whether lactoferrin reduces postoperative pain intensity and opioid consumption, and improves recovery outcomes such as time to mobilization, patient satisfaction, and incidence of common postoperative symptoms. Safety and tolerability will also be evaluated.",[68,69],"Cesarean Birth","Post Operative Analgesia",[71,72,73,74,75,76],"post operative pain","lactoferrin","analgesia","pain management","obstetric surgery","post operative analgesia","NOT_YET_RECRUITING","2026-03-25",{"date":80,"type":81},"2026-03-30","ACTUAL",{"date":83,"type":62},"2026-03-26",{"date":85,"type":62},"2026-09-26",{"name":5,"class":6},1]