[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585356":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":30,"locations":37,"responsibleParty":402,"collaborators":29,"id":404,"slug":405,"hasResults":406,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":29,"eligibilityCriteria":410,"healthyVolunteers":406,"sex":411,"minAge":412,"maxAge":413,"enrollmentInfo":414,"targetDuration":29,"studyType":417,"phases":418,"briefSummary":420,"conditions":421,"keywords":424,"overallStatus":62,"whyStopped":29,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":430,"completionDateStruct":432,"leadSponsor":434,"locationsCount":435},{"fullName":5,"class":6},"Materia Medica Holding","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Raphamin","EXPERIMENTAL","Per os without food. The tablet should be kept in mouth until completely dissolved.\n\nOn day 1 of treatment, 8 tablets should be taken using the following regimen: 1 tablet every 30 minutes for the first 2 hours (5 tablets in total for 2 hours), then 1 more tablet 3 times at equal intervals during the same day. On day 2 and onwards, 1 tablet should be taken 3 times a day. The duration of treatment is 5 days.",[13],"Drug: Raphamin",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Placebo using the Raphamin dosage regimen.",[19],"Drug: Placebo",[21,27],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Oral administration",[9],[26],"MMH-407",{"type":22,"name":15,"description":23,"armGroupLabels":28,"otherNames":29},[15],null,[31],{"name":32,"role":33,"phone":34,"phoneExt":35,"email":36},"Mikhail Putilovskiy, MD,PhD","CONTACT","+74952761571","302","PutilovskiyMA@materiamedica.ru",[38,51,60,75,84,94,107,113,123,129,135,144,153,167,176,189,198,204,210,219,225,231,237,243,249,255,265,271,277,283,289,295,301,307,316,322,331,340,349,358,367,376,382,392],{"facility":39,"status":40,"city":41,"state":29,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":29},"Aramil city hospital","ACTIVE_NOT_RECRUITING","Aramil","624002","Russia","RU",{"type":46,"coordinates":47},"Point",[48,49],60.8369,56.6977,{"lat":49,"lon":48},{"facility":52,"status":53,"city":54,"state":29,"zip":29,"country":43,"countryCode":44,"cosmosGeoPoint":55,"geoPoint":59,"contacts":29},"Gatchina Clinical Interdistrict Hospital","COMPLETED","Gatchina",{"type":46,"coordinates":56},[57,58],30.12833,59.57639,{"lat":58,"lon":57},{"facility":61,"status":62,"city":63,"state":29,"zip":64,"country":43,"countryCode":44,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Baltic Federal University named after Immanuel Kant","RECRUITING","Kaliningrad","236016",{"type":46,"coordinates":66},[67,68],20.51102,54.70639,{"lat":68,"lon":67},[71,73],{"name":72,"role":33,"phone":29,"phoneExt":29,"email":29},"Ekaterina Andreeva, MD, PhD",{"name":72,"role":74,"phone":29,"phoneExt":29,"email":29},"PRINCIPAL_INVESTIGATOR",{"facility":76,"status":53,"city":77,"state":29,"zip":78,"country":43,"countryCode":44,"cosmosGeoPoint":79,"geoPoint":83,"contacts":29},"Kazan State Medical University\u002FDepartment of Infectious Diseases","Kazan'","420012",{"type":46,"coordinates":80},[81,82],49.12214,55.78874,{"lat":82,"lon":81},{"facility":85,"status":86,"city":87,"state":29,"zip":88,"country":43,"countryCode":44,"cosmosGeoPoint":89,"geoPoint":93,"contacts":29},"Kuban State Medical University\u002FDepartment of Infectious Diseases and Phthisiopulmonology","TERMINATED","Krasnodar","350063",{"type":46,"coordinates":90},[91,92],38.98178,45.04534,{"lat":92,"lon":91},{"facility":95,"status":62,"city":96,"state":29,"zip":97,"country":43,"countryCode":44,"cosmosGeoPoint":98,"geoPoint":102,"contacts":103},"City Polyclinic # 2 of the Moscow City Department of Health","Moscow","117556",{"type":46,"coordinates":99},[100,101],37.61781,55.75204,{"lat":101,"lon":100},[104,106],{"name":105,"role":33,"phone":29,"phoneExt":29,"email":29},"Margarita Dorofeeva, MD, PhD",{"name":105,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":108,"status":53,"city":96,"state":29,"zip":109,"country":43,"countryCode":44,"cosmosGeoPoint":110,"geoPoint":112,"contacts":29},"First Moscow State Medical University named after I.M. Sechenov\u002FDepartment of Ear, Nose and Throat Diseases","119991",{"type":46,"coordinates":111},[100,101],{"lat":101,"lon":100},{"facility":114,"status":62,"city":96,"state":29,"zip":115,"country":43,"countryCode":44,"cosmosGeoPoint":116,"geoPoint":118,"contacts":119},"National Medical Research Center of Otolaryngology","123182",{"type":46,"coordinates":117},[100,101],{"lat":101,"lon":100},[120,122],{"name":121,"role":33,"phone":29,"phoneExt":29,"email":29},"Olga Karneeva, MD, PhD",{"name":121,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":124,"status":53,"city":96,"state":29,"zip":125,"country":43,"countryCode":44,"cosmosGeoPoint":126,"geoPoint":128,"contacts":29},"Russian University of Medicine\u002FDepartment of Otolaryngology","127006",{"type":46,"coordinates":127},[100,101],{"lat":101,"lon":100},{"facility":130,"status":40,"city":96,"state":29,"zip":131,"country":43,"countryCode":44,"cosmosGeoPoint":132,"geoPoint":134,"contacts":29},"Moscow Regional Research Clinical Institute named after M.F. Vladimirsky","129110",{"type":46,"coordinates":133},[100,101],{"lat":101,"lon":100},{"facility":136,"status":53,"city":137,"state":29,"zip":138,"country":43,"countryCode":44,"cosmosGeoPoint":139,"geoPoint":143,"contacts":29},"LLC \"Persona Group of Companies\"","Nizhny Novgorod","603155",{"type":46,"coordinates":140},[141,142],44.00205,56.32867,{"lat":142,"lon":141},{"facility":145,"status":53,"city":146,"state":29,"zip":147,"country":43,"countryCode":44,"cosmosGeoPoint":148,"geoPoint":152,"contacts":29},"Novosibirsk State Medical University\u002FDepartment of Otolaryngology","Novosibirsk","630091",{"type":46,"coordinates":149},[150,151],82.93175,55.02259,{"lat":151,"lon":150},{"facility":154,"status":155,"city":156,"state":29,"zip":157,"country":43,"countryCode":44,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"LLC \"Clinical and Diagnostic Center \"Mediclinic\"","NOT_YET_RECRUITING","Penza","440071",{"type":46,"coordinates":159},[160,161],45.01075,53.19568,{"lat":161,"lon":160},[164,166],{"name":165,"role":33,"phone":29,"phoneExt":29,"email":29},"Natalia Pochinina, MD, PhD",{"name":165,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":168,"status":53,"city":169,"state":29,"zip":170,"country":43,"countryCode":44,"cosmosGeoPoint":171,"geoPoint":175,"contacts":29},"LLC \"Professor's Clinic\"","Perm","614070",{"type":46,"coordinates":172},[173,174],56.25017,58.01046,{"lat":174,"lon":173},{"facility":177,"status":155,"city":178,"state":29,"zip":179,"country":43,"countryCode":44,"cosmosGeoPoint":180,"geoPoint":184,"contacts":185},"LLC \"4D Ultrasound Clinic\"","Pyatigorsk","357502",{"type":46,"coordinates":181},[182,183],43.05036,44.05,{"lat":183,"lon":182},[186,188],{"name":187,"role":33,"phone":29,"phoneExt":29,"email":29},"Tatyana Rushnichenko, MD",{"name":187,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":190,"status":53,"city":191,"state":29,"zip":192,"country":43,"countryCode":44,"cosmosGeoPoint":193,"geoPoint":197,"contacts":29},"Rostov Central District Hospital","Rostov-on-Don","152155",{"type":46,"coordinates":194},[195,196],39.70769,47.21997,{"lat":196,"lon":195},{"facility":199,"status":40,"city":191,"state":29,"zip":200,"country":43,"countryCode":44,"cosmosGeoPoint":201,"geoPoint":203,"contacts":29},"LLC \"Otolaryngology Consultation Center\"","344000",{"type":46,"coordinates":202},[195,196],{"lat":196,"lon":195},{"facility":205,"status":40,"city":191,"state":29,"zip":206,"country":43,"countryCode":44,"cosmosGeoPoint":207,"geoPoint":209,"contacts":29},"Rostov-on-Don City Hospital of Emergency Medical Care","344068",{"type":46,"coordinates":208},[195,196],{"lat":196,"lon":195},{"facility":211,"status":40,"city":212,"state":29,"zip":213,"country":43,"countryCode":44,"cosmosGeoPoint":214,"geoPoint":218,"contacts":29},"North-West State Medical University named after I.I. Mechnikov\u002FDepartment of Otolaryngology","Saint Petersburg","191015",{"type":46,"coordinates":215},[216,217],30.31413,59.93863,{"lat":217,"lon":216},{"facility":220,"status":40,"city":212,"state":29,"zip":221,"country":43,"countryCode":44,"cosmosGeoPoint":222,"geoPoint":224,"contacts":29},"St. Petersburg Research Institute of Phthisiopulmonology","191036",{"type":46,"coordinates":223},[216,217],{"lat":217,"lon":216},{"facility":226,"status":53,"city":212,"state":29,"zip":227,"country":43,"countryCode":44,"cosmosGeoPoint":228,"geoPoint":230,"contacts":29},"City Polyclinic # 44","192071",{"type":46,"coordinates":229},[216,217],{"lat":217,"lon":216},{"facility":232,"status":40,"city":212,"state":29,"zip":233,"country":43,"countryCode":44,"cosmosGeoPoint":234,"geoPoint":236,"contacts":29},"City Polyclinic # 109","192283",{"type":46,"coordinates":235},[216,217],{"lat":217,"lon":216},{"facility":238,"status":53,"city":212,"state":29,"zip":239,"country":43,"countryCode":44,"cosmosGeoPoint":240,"geoPoint":242,"contacts":29},"LLC \"Energy of Health\"","194156",{"type":46,"coordinates":241},[216,217],{"lat":217,"lon":216},{"facility":244,"status":53,"city":212,"state":29,"zip":245,"country":43,"countryCode":44,"cosmosGeoPoint":246,"geoPoint":248,"contacts":29},"LLC \"Medical center \"Reavita Med SPb\"","194354",{"type":46,"coordinates":247},[216,217],{"lat":217,"lon":216},{"facility":250,"status":40,"city":212,"state":29,"zip":251,"country":43,"countryCode":44,"cosmosGeoPoint":252,"geoPoint":254,"contacts":29},"LLC \"Medical services\"","194356",{"type":46,"coordinates":253},[216,217],{"lat":217,"lon":216},{"facility":256,"status":155,"city":212,"state":29,"zip":257,"country":43,"countryCode":44,"cosmosGeoPoint":258,"geoPoint":260,"contacts":261},"LLC \"Our Health\"","195272",{"type":46,"coordinates":259},[216,217],{"lat":217,"lon":216},[262,264],{"name":263,"role":33,"phone":29,"phoneExt":29,"email":29},"Elena Shcherbakova, MD, PhD",{"name":263,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":266,"status":53,"city":212,"state":29,"zip":267,"country":43,"countryCode":44,"cosmosGeoPoint":268,"geoPoint":270,"contacts":29},"LLC \"Zvezdnaya Clinic\"","196158",{"type":46,"coordinates":269},[216,217],{"lat":217,"lon":216},{"facility":272,"status":53,"city":212,"state":29,"zip":273,"country":43,"countryCode":44,"cosmosGeoPoint":274,"geoPoint":276,"contacts":29},"First Saint Petersburg State Medical University named after I.P. Pavlov\u002FDepartment of Otolaryngology with clinic","197022",{"type":46,"coordinates":275},[216,217],{"lat":217,"lon":216},{"facility":278,"status":53,"city":212,"state":29,"zip":279,"country":43,"countryCode":44,"cosmosGeoPoint":280,"geoPoint":282,"contacts":29},"City Polyclinic # 34","197198",{"type":46,"coordinates":281},[216,217],{"lat":217,"lon":216},{"facility":284,"status":53,"city":212,"state":29,"zip":285,"country":43,"countryCode":44,"cosmosGeoPoint":286,"geoPoint":288,"contacts":29},"Institute of Experimental Medicine","197376",{"type":46,"coordinates":287},[216,217],{"lat":217,"lon":216},{"facility":290,"status":53,"city":212,"state":29,"zip":291,"country":43,"countryCode":44,"cosmosGeoPoint":292,"geoPoint":294,"contacts":29},"City Polyclinic # 106","198328",{"type":46,"coordinates":293},[216,217],{"lat":217,"lon":216},{"facility":296,"status":40,"city":212,"state":29,"zip":297,"country":43,"countryCode":44,"cosmosGeoPoint":298,"geoPoint":300,"contacts":29},"City Pokrovskaya Hospital","199106",{"type":46,"coordinates":299},[216,217],{"lat":217,"lon":216},{"facility":302,"status":40,"city":212,"state":29,"zip":303,"country":43,"countryCode":44,"cosmosGeoPoint":304,"geoPoint":306,"contacts":29},"LLC \"Meili\"","199406",{"type":46,"coordinates":305},[216,217],{"lat":217,"lon":216},{"facility":308,"status":40,"city":309,"state":29,"zip":310,"country":43,"countryCode":44,"cosmosGeoPoint":311,"geoPoint":315,"contacts":29},"Medical University \"Reaviz\"","Samara","443001",{"type":46,"coordinates":312},[313,314],50.13553,53.20767,{"lat":314,"lon":313},{"facility":317,"status":53,"city":309,"state":29,"zip":318,"country":43,"countryCode":44,"cosmosGeoPoint":319,"geoPoint":321,"contacts":29},"Samara State Medical University\u002FDepartment of Otolaryngology","443099",{"type":46,"coordinates":320},[313,314],{"lat":314,"lon":313},{"facility":323,"status":40,"city":324,"state":29,"zip":325,"country":43,"countryCode":44,"cosmosGeoPoint":326,"geoPoint":330,"contacts":29},"Saratov State Medical University named after V.I. Razumovsky\u002FDepartment of Faculty Therapy","Saratov","410012",{"type":46,"coordinates":327},[328,329],45.9901,51.54048,{"lat":329,"lon":328},{"facility":332,"status":53,"city":333,"state":29,"zip":334,"country":43,"countryCode":44,"cosmosGeoPoint":335,"geoPoint":339,"contacts":29},"LLC \"Uromed\"","Smolensk","214031",{"type":46,"coordinates":336},[337,338],32.05088,54.77826,{"lat":338,"lon":337},{"facility":341,"status":40,"city":342,"state":29,"zip":343,"country":43,"countryCode":44,"cosmosGeoPoint":344,"geoPoint":348,"contacts":29},"LLC \"Scientific Medical Center of General Therapy and Pharmacology\"","Stavropol","355000",{"type":46,"coordinates":345},[346,347],41.9642,45.03442,{"lat":347,"lon":346},{"facility":350,"status":53,"city":351,"state":29,"zip":352,"country":43,"countryCode":44,"cosmosGeoPoint":353,"geoPoint":357,"contacts":29},"Bashkir State Medical University\u002FDepartment of Internal Medicine","Ufa","450008",{"type":46,"coordinates":354},[355,356],55.96779,54.74306,{"lat":356,"lon":355},{"facility":359,"status":53,"city":360,"state":29,"zip":361,"country":43,"countryCode":44,"cosmosGeoPoint":362,"geoPoint":366,"contacts":29},"Ulyanovsk Regional Clinical Hospital","Ulyanovsk","432017",{"type":46,"coordinates":363},[364,365],48.38657,54.32824,{"lat":365,"lon":364},{"facility":368,"status":40,"city":369,"state":29,"zip":370,"country":43,"countryCode":44,"cosmosGeoPoint":371,"geoPoint":375,"contacts":29},"LLC \"Dr. Bogorodskaya's Clinic of Modern Medicine\"","Yaroslavl","150001",{"type":46,"coordinates":372},[373,374],39.87368,57.62987,{"lat":374,"lon":373},{"facility":377,"status":40,"city":369,"state":29,"zip":378,"country":43,"countryCode":44,"cosmosGeoPoint":379,"geoPoint":381,"contacts":29},"Clinical Hospital # 2","150030",{"type":46,"coordinates":380},[373,374],{"lat":374,"lon":373},{"facility":383,"status":62,"city":369,"state":29,"zip":384,"country":43,"countryCode":44,"cosmosGeoPoint":385,"geoPoint":387,"contacts":388},"LLC \"Medical center for diagnostics and prevention plus\"","150040",{"type":46,"coordinates":386},[373,374],{"lat":374,"lon":373},[389,391],{"name":390,"role":33,"phone":29,"phoneExt":29,"email":29},"Ekaterina Melnikova, MD, PhD",{"name":390,"role":74,"phone":29,"phoneExt":29,"email":29},{"facility":393,"status":394,"city":395,"state":29,"zip":396,"country":43,"countryCode":44,"cosmosGeoPoint":397,"geoPoint":401,"contacts":29},"Ural State Medical University\u002FDepartment of Surgical Dentistry, Otorhinolaryngology and Maxillofacial Surgery","WITHDRAWN","Yekaterinburg","620028",{"type":46,"coordinates":398},[399,400],60.61529,56.85733,{"lat":400,"lon":399},{"type":403,"investigatorFullName":29,"investigatorTitle":29,"investigatorAffiliation":29,"oldNameTitle":29,"oldOrganization":29},"SPONSOR","100585356","phase-3-the-efficacy-and-safety-of-raphamin-in-the-treatment-of-acute-rhinosinusitis-in-adult-patients-100585356",false,"NCT06901297","The Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients","Multicenter, Double-blind, Placebo-controlled, Randomized, Parallel-group Clinical Trial of the Efficacy and Safety of Raphamin in the Treatment of Acute Rhinosinusitis in Adult Patients","Inclusion Criteria:\n\n1. Male and female aged 18 - 75 years.\n2. Diagnosis of acute rhinosinusitis:\n\n   * 8-12 points on MSS scale;\n   * no more than 3 severe symptoms (3 points on the MSS scale)\n   * facial pain\u002Fheaviness in the facial area 1-2 points on the MSS scale.\n3. Disease duration up to 48 hours (from the onset of the first symptoms of the disease).\n4. Availability of a patient information sheet and an informed consent form for participation in the clinical trial signed by the patient.\n5. Patients who agreed to use a reliable method of contraception during the study (for men and women of reproductive potential).\n\nExclusion Criteria:\n\n1. Symptoms of acute bacterial rhinosinusitis (three or more of those below):\n\n   * fever of ≥ 38.0°C;\n   * the second wave of ARS symptoms;\n   * one-sided process;\n   * facial pain\u002Fpressure of 3 points (on the MSS scale).\n2. Recurrent ARS (≥4 episodes of ARS per year with complete resolution of symptoms between episodes).\n3. Odontogenic rhinosinusitis.\n4. Allergic (seasonal or year-round) rhinitis.\n5. Nasal polyps or clinically significant nasal septum deviation.\n6. Concomitant otitis.\n7. Use of intranasal or systemic corticosteroids for 30 days prior to the screening visit.\n8. Use of intranasal or systemic antibiotics for 30 days prior to the screening visit.\n9. Surgery for the nasal cavity and paranasal sinuses during the last 6 months before the screening visit.\n10. Any other surgery during the last 3 months.\n11. Clinical symptoms of severe influenza\u002FARVI requiring hospitalization.\n12. Suspected bacterial infection of any localization requiring the administration of antibiotics from the first day of disease.\n13. History\u002Fsuspicion of oncology of any localization (except for benign neoplasms).\n14. Exacerbation or decompensation of chronic diseases (diabetes mellitus, bronchial asthma, chronic bronchitis, chronic obstructive pulmonary disease, cystic fibrosis, primary ciliary dyskinesia, bronchopulmonary dysplasia, malformations of the respiratory and ENT organs, etc.) affecting the patient's ability to participate in the clinical trial.\n15. Previously diagnosed immunodeficiency of any etiology.\n16. Unstable angina or myocardial infarction during the last 6 months.\n17. Class III and IV chronic heart failure (according to the classification of the New York Heart Association, 1964).\n18. History of chronic kidney disease (classes C3-5 A3).\n19. History of liver failure (class C according to Child-Pugh).\n20. Malabsorption syndrome, including congenital or acquired lactase or other disaccharidase deficiency, galactosemia.\n21. Pregnancy, breast-feeding, and childbirth less than 3 months before inclusion in the trial.\n22. Hypersensitivity to any component of the medicines used in the treatment.\n23. Patients who used medications listed under \"Prohibited Concomitant Treatment\" within 1 month prior to inclusion in the trial or need medications prohibited for use in the trial.\n24. Patients who, from the investigator's point of view, will not comply with the observation requirements during the trial or follow the procedure for taking the test drugs.\n25. History of mental illness, alcoholism, drug abuse, which, from the investigator's point of view, will prevent the patient from following the trial procedures.\n26. Participation in other clinical trials within 3 months prior to inclusion in this trial.\n27. Patient is related to on-site research personnel directly involved in the trial, or is the immediate family member of the investigator. 'Immediate family members' mean spouses, parents, children, or siblings, whether related or adopted.\n28. Patient is employed by OOO \"NPF \"MATERIA MEDICA HOLDING\", i.e., is an employee of the company, a temporary contract employee, or a designated official responsible for conducting the trial or their immediate family member.","ALL","18 Years","75 Years",{"count":415,"type":416},552,"ESTIMATED","INTERVENTIONAL",[419],"PHASE3","Multicenter double-blind placebo-controlled randomized in parallel groups clinical trial of the efficacy and safety of Raphamin in the treatment of acute rhinosinusitis in adult patients.",[422,423],"Rhinosinusitis","Rhinosinusitis Acute",[422,425],"Acute","2026-03-12",{"date":428,"type":429},"2026-03-16","ACTUAL",{"date":431,"type":429},"2025-04-03",{"date":433,"type":416},"2027-12-31",{"name":5,"class":6},44]