[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625478":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":41,"locations":51,"responsibleParty":70,"collaborators":45,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":74,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":45,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":97,"whyStopped":45,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Allama Iqbal Medical College","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Tranexamic Acid (TXA) Group","EXPERIMENTAL","Arm 1: Tranexamic Acid Group (TXA Group) Number of participants: 29 Description: Patients with placenta previa undergoing elective cesarean section receiving tranexamic acid prophylactically before surgery",[13],"Drug: Group A: Tranexamic acid",{"label":15,"type":10,"description":16,"interventionNames":17},"Vasopressin Group","Arm 2: Vasopressin Group Number of participants: 29 Description: Patients with placenta previa undergoing elective cesarean section receiving vasopressin prophylactically.",[18],"Drug: Group B: Vasopressin",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Group A: Tranexamic acid","Injection Tranexamic Acid 1 gram diluted in 20 mL of 5% dextrose will be administered intravenously 15 minutes before cesarean section.\n\n(prophylactically)",[9],[26],"Inj Transamin 1gm",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Group B: Vasopressin","Injection Vasopressin 4 units diluted in 20 mL of normal saline will be injected locally at the placenta implantation site after delivery of placenta.",[15],[32],"Novapressin",[34,38],{"name":35,"affiliation":36,"role":37},"Aiman Sattar, MBBS","Jinnah Hospital\u002FAIMC\u002FUHS","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":36,"role":40},"Shazia Saaqib, FCPS,MCPS","STUDY_DIRECTOR",[42,47],{"name":39,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","+923214708583",null,"shaziasaaqib@gmail.com",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},"Aimen Sattar, MBBS","+923190658053","aimansattar7@gmail.com",[52],{"facility":53,"status":45,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Jinnah Hospital","Lahore","Punjab Province","+92","Pakistan","PK",{"type":60,"coordinates":61},"Point",[62,63],74.35071,31.558,{"lat":63,"lon":62},[66,69],{"name":67,"role":43,"phone":68,"phoneExt":45,"email":46},"SHAZIA SAAQIB, FCPS, MCPS","0923214708583",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},{"type":71,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR","100625478","phase-3-tranexamic-acid-vs-vasopressin-in-placenta-previa-trial-100625478",false,"NCT07423156","Tranexamic Acid vs Vasopressin in Placenta Previa Trial","Comparison of Efficacy of Tranexamic Acid Versus Vasopressin in Blood Loss Among Placenta Previa Patients Undergoing Cesarean Section","TXA-VASO-PP","Inclusion Criteria:\n\nWomen of reproductive age\n\nAge 18-45 years\n\nDiagnosed placenta previa in current pregnancy\n\nScheduled for elective cesarean section\n\nSingleton pregnancy\n\nExclusion Criteria:\n\nEmergency cesarean section\n\nPlatelet or coagulation disorder\n\nUse of anti-platelet or anti-coagulant drugs\n\nPrevious history of postpartum hemorrhage\n\nChronic liver disease\n\nChronic kidney disease\n\nGestational diabetes\n\nPregnancy-related hypertensive disorders\n\n\\-","FEMALE","18 Years","45 Years",{"count":84,"type":85},58,"ESTIMATED","INTERVENTIONAL",[88],"PHASE3","Placenta previa is a major obstetric condition associated with increased risk of excessive blood loss during cesarean section, leading to maternal morbidity and mortality. Different pharmacological agents have been used to minimize intraoperative hemorrhage. Tranexamic acid is an antifibrinolytic agent, while vasopressin reduces blood loss by causing vasoconstriction and myometrial contraction at the injection site. Both drugs have been used separately in placenta previa cases, however direct comparison between tranexamic acid and vasopressin is limited.\n\nThis randomized controlled trial will be conducted at the Department of Obstetrics \\& Gynecology, AIMC\u002FJinnah Hospital Lahore. A total of 58 women (29 in each group), aged 18-45 years, with singleton pregnancy and diagnosed placenta previa undergoing elective cesarean section will be included. Participants will be randomly allocated into two groups. Group A will receive 1 gram tranexamic acid diluted in 20 ml of 5% dextrose intravenously 15 minutes before cesarean section. Group B will receive 4 units vasopressin diluted in 20 ml normal saline injected at placental implantation site after delivery of placenta.\n\nThe primary outcome will be intraoperative blood loss measured by gauze saturation assessment and suction drain measurement. The study will help determine which drug is more effective in reducing blood loss in placenta previa patients undergoing cesarean section.",[91],"Placenta Previa",[93,94,95,96],"Obstetric Hemorrhage","Cesarean Section","Tranexamic Acid","Vasopressin","NOT_YET_RECRUITING","2026-02-13",{"date":100,"type":101},"2026-02-20","ACTUAL",{"date":103,"type":85},"2026-03-01",{"date":105,"type":85},"2026-08-31",{"name":5,"class":6},1]